Metallomics: Recent Analytical Techniques and Applications PDF
Preview Metallomics: Recent Analytical Techniques and Applications
Yasumitsu Ogra · Takafumi Hirata Editors Metallomics Recent Analytical Techniques and Applications Metallomics Yasumitsu Ogra (cid:129) Takafumi Hirata Editors Metallomics Recent Analytical Techniques and Applications Editors YasumitsuOgra TakafumiHirata GraduateSchoolofPharmaceutical GraduateSchoolofScience Science TheUniversityofTokyo ChibaUniversity Tokyo Chiba Japan Japan ISBN978-4-431-56461-4 ISBN978-4-431-56463-8 (eBook) DOI10.1007/978-4-431-56463-8 LibraryofCongressControlNumber:2017931358 ©SpringerJapanKK2017 Thisworkissubjecttocopyright.AllrightsarereservedbythePublisher,whetherthewholeorpartof the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilarmethodologynowknownorhereafterdeveloped. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publicationdoesnotimply,evenintheabsenceofaspecificstatement,thatsuchnamesareexempt fromtherelevantprotectivelawsandregulationsandthereforefreeforgeneraluse. Thepublisher,theauthorsandtheeditorsaresafetoassumethattheadviceandinformationinthis book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained hereinor for anyerrors oromissionsthat may havebeenmade. Thepublisher remainsneutralwith regardtojurisdictionalclaimsinpublishedmapsandinstitutionalaffiliations. Printedonacid-freepaper ThisSpringerimprintispublishedbySpringerNature TheregisteredcompanyisSpringerJapanKK Theregisteredcompanyaddressis:ChiyodaFirstBldg.East,3-8-1Nishi-Kanda,Chiyoda-ku,Tokyo 101-0065,Japan Preface The term “metallomics” was coined by Professor Hiroki Haraguchi (Nagoya University, Japan) in 2002. To develop both the basic principles and the applica- tionsofmetallomics,thefirstInternationalSymposiumonMetallomics(ISM)was held in Nagoya, Japan, in 2007. Thereafter, ISM was held biennially in different locations around the world, including Cincinnati, USA, in 2009; Münster, Ger- many,in2011;Oviedo,Spain,in2011;andBeijing,China,in2015.ThesixthISM will be held in Vienna, Austria, in 2017. The dawn of metallomics research was furtherenhancedbythelaunchofthejournalMetallomicsinJanuary2009bythe Royal Society of Chemistry. Metallomics is widely acknowledged as one of the youngestmembersofomicsresearch. The history of metallomics is discussed in detail by Professor Haraguchi, the fatherofmetallomics,inChap.1ofthisbook.Giventhatmorethan10yearshave passedsinceitsbirth,weareoftheopinionthatmetallomicshasreachedtheendof the first stage of growth. In the early days of metallomics, scientists in Japan, the birthplace of metallomics, made exciting contributions tothe development of this field.Inparticular,thedevelopmentofanalyticaltechniques,pharmacologicaland medical applications, and applications to environmental sciences was pursued in earnest. This book contains the latest information on metallomics, including recent analytical techniques and strategies as well as applications in molecular biology, medicine, and pharmaceutical sciences by Japanese pioneers of metallomics. Besides new insights into the study of metallomics, significant effort has been made to include educational contents for the benefit of students, young scientists, andclinicalpersonnel.Thus,thisbookoffersinvaluableinformationforresearchers inmetallomics. Webelievethatthepublicationofthisbookistimelyforreviewingtheaccom- plishments of metallomics research, which seems to be ready to start the second stageofgrowth.Weareconfidentthatreaderswillrecognizethevalueofthisbook v vi Preface in learning, teaching, lectures, and other outreach activities that will help make known to the public the importance of metallomics. Finally, we express our heartfelt thanks to all the authors for their outstanding work and to Springer for givingustheopportunitytopublishthisbook,whichisexpectedtopavethewayto achievingourgoal. Chiba,Japan YasumitsuOgra Tokyo,Japan TakafumiHirata Contents PartI Overview 1 Metallomics:IntegratedBiometalScience. . . . . . . . . . . . . . . . . . . 3 HirokiHaraguchi PartII AnalyticalTechniquesandStrategiesSurroundingMetallomics 2 SpeciationandIdentificationofChalcogen-Containing Metabolites. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 43 YasumitsuOgra 3 VisualizationofIntracellularElementsUsingScanningX-Ray FluorescenceMicroscopy. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 63 MariShimura,LukaszSzyrwiel,SatoshiMatsuyama,andKazuto Yamauchi 4 QuantitativeElementalBioimagingProtocolUsingFemtosecond- LaserAblation-ICP-MassSpectrometryCoupledwithGlass StandardReferenceMaterial. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 93 YoshikiMakino,SeiyaOhara,MarinaYamada,ShoMukoyama, KentaroHattori,ShuheiSakata,YukiTanaka,ToshihiroSuzuki, AtsukoShinohara,TakehisaMatsukawa,KazuhitoYokoyama, andTakafumiHirata 5 SingleCellAnalysisbyUsingICP-MS. . . . . . . . . . . . . . . . . . . . . . 107 Shin-ichiMiyashita,Shin-ichiroFujii,KaoriShigeta, andKazumiInagaki 6 SynchrotronRadiationX-RayAnalysisofMetal-Accumulating Plants. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 125 AkikoHokuraandEmikoHarada vii viii Contents 7 77SeNMRSpectroscopyforSpeciationAnalysisofSelenium Compounds. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 147 NoriyukiSuzukiandYasumitsuOgra 8 ProteinQuantificationandQuantitativePhosphorylation AnalysisbytheDeterminationofHeteroAtoms(SandP) byMeansofnanoHPLC-ICPMS. . . . . . . . . . . . . . . . . . . . . . . . . . . 157 YoshinariSuzukiandNaokiFuruta 9 AnalysisofDrugActivePharmaceuticalIngredientsand BiomoleculesUsingTripleQuadrupoleICP-MS. . . . . . . . . . . . . . . 181 NaokiSugiyamaandYasuyukiShikamori 10 HighlySensitiveAnalysisofProteinsandMetabolitesbyMetal TaggingUsingLC-ICP-MS. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 197 DaigoIwahata PartIII ApplicationofMetallomicsinMolecularBiology, MedicineandPharmaceuticalSciences 11 ComprehensiveElementAnalysisofProkaryoticandEukaryotic CellsaswellasOrganellesbyICP-MS. . . . . . . . . . . . . . . . . . . . . . 219 TomonariUmemura,YuichiroMatsui,ShinnosukeSakagawa, TakuFukai,EijiFujimori,HidetoshiKumata,andMotohideAoki 12 IronIsotopeSignatureinRedBloodCellSamples fromJapaneseFemaleDonorsofVariousAges. . . . . . . . . . . . . . . 239 Yu-kiTanaka,KohshiroTakata,TakahiroKawasaki, AtsukoShinohara,KazukoIshikawa-Takata,andTakafumiHirata 13 RolesofZincTransportersinCellularTransportofCadmium andManganese. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 265 SeiichiroHimenoandHitomiFujishiro 14 LinkBetweenMetalHomeostasisandNeurodegenerativeDiseases: CrosstalkofMetalsandAmyloidogenicProteinsattheSynapse. . . 285 DaiMizunoandMasahiroKawahara 15 NewInsightintoMetallomicsinCognition. . . . . . . . . . . . . . . . . . . 315 AtsushiTakedaandHanunaTamano 16 FrontierofDevelopmentforMetallodrugsontheBasisof MetallomicPharmacologyandMedicinalInorganicChemistry. . . 341 HiroyukiYasuiandYutakaYoshikawa Part I Overview Chapter 1 Metallomics: Integrated Biometal Science HirokiHaraguchi Abstract The historical aspects of metallomics, which were proposed as inte- gratedbiometalsciencein2004bythepresentauthor,aredescribed.Thesignificant development of analytical atomic spectrometry since the late 1960s allowed the all-element analyses of various biological samples as well as chemical speciation analysisoftraceelements.Suchaprogressoftracemetalanalysisopenednewera oftracemetalscience invariousscientificfieldstocooperatewithomicssciences such as genomics, proteomics, and metabolomics. Under such situations in life science, it was desired to integrate biometal science as one of omics sciences for further development. So far, the international symposiums of metallomics were heldfivetimesaroundtheworldsince2007inNagoya,andtheacademicjournalof metallomics has been publishedsince 2009from the Royal Society of Chemistry. Furthermore, essentiality and toxicity of trace metals, a simplified model of the biologicalsystem,theresearchfieldsinmetallomics,andsofortharediscussedin thischapter. Keywords Metallomics•Omicsscience•Genomics•Proteomics•Lifescience• Analytical atomic spectrometry • All-Element Present Theory • Chemical speciation•Biologicalsystem•Biologicalessentiality 1.1 Introduction Inthispaper,“Metallomics”isproposedasanewscientificfieldinordertointegratethe research field related to biometals. Metallomics shouldbe a scientific field in symbiosis withgenomicsandproteomics,becausesynthesesandmetabolicfunctionsofgenes(DNA and RNA) and proteins cannot be performed without the aid of various metal ions and metalloenzymes. In metallomics, metalloproteins, metalloenzymes and other metal- containingbiomoleculesaredefinedas“metallomes”,inasimilarmannertogenomein genomicsandproteomeinproteomics.Sinceidentificationofmetallomesandtheelucida- tionoftheirbiologicalorphysiologicalfunctionsinthebiologicalsystemsarethemain researchtargetofmetallomics,chemicalspeciationforspecificidentificationofbioactive metallomesisoneofthemostimportantanalyticaltechnologiestoestablishmetallomicsas H.Haraguchi(*) NagoyaUniversity,525-1-3-506,Shinanocho,Totsuka-ku,Yokohama244-0801,Japan e-mail:[email protected] ©SpringerJapanKK2017 3 Y.Ogra,T.Hirata(eds.),Metallomics,DOI10.1007/978-4-431-56463-8_1
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