Mechanisms of Work Production and Work Absorption in Muscle PDF
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MECHANISMS OF WORK PRODUCTION AND WORK ABSORPTION IN MUSCLE ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY Editorial Board: NA THAN BACK, State University of New York at Buffalo lRUN R. COHEN, The Weizmann Institute of Science DAVID KRITCHEVSKY, Wistar Institute ABEL LAJTHA, N. S. Kline Institute for Psychiatric Research RODOLFO PAOLETTI, University of Milan Recent Volumes in this Series Volume 445 MATHEMA TICAL MODELING IN EXPERIMENTAL NUTRITION Edited by Andrew J. Clifford and Hans-Georg Muller Volume 446 MOLECULAR AND CELLULAR MECHANISMS OF NEURONAL PLASTICITY: Basic and Clinical Implications Edited by Yigal H. Ehrlich Volume 447 LIPOXYGENASES AND THEIR METABOLITES: Biological Functions Edited by Santosh Nigam and Cecil R. Pace-Asciak Volume 448 COPPER TRANSPORT AND ITS DISORDERS: Molecular and Cellular Aspects Edited by Arturo Leone and Julian F. B. Mercer Volume 449 VASOPRESSIN AND OXYTOCIN: Molecular, Cellular, and Clinical Advances Edited by Hans H. Zingg, Charles W. Bourque, and Daniel G. Bichet Volume 450 ADV ANCES IN MODELING AND CONTROL OF VENTILATION Edited by Richard L. Hughson, David A. Cunningham, and James Duffin Volume 451 GENE THERAPY OF CANCER Edited by Peter Walden, Uwe Trefzer, Wolfram Sterry, and Farzin Farzaneh Volume 452 MECHANISMS OF LYMPHOCYTE ACTIVATION AND IMMUNE REGULATION VII: Molecular Determinants of Microbial Immunity Edited by Sudhir Gupta, Alan Sher, and Rafi Ahmed Volume 453 MECHANISMS OF WORK PRODUCTION AND WORK ABSORPTION IN MUSCLE Edited by Haruo Sugi and Gerald H. Pollack Volume 454 OXYGEN TRANSPORT TO TISSUE XX Edited by Antal G. Hudetz and Duane F. Bruley A Continuation Order Plan is available for this series. A continuation order will bring delivery of each new volume immediately upon publication. Volumes are billed only upon actual shipment. For further information please contact the pub Ii sher. MECHANISMS OF WORK PRODUCTION AND WORK ABSORPTION IN MUSCLE Edited by Haruo Sugi Teikyo University Tokyo, Japan and Gerald H. Pollack University of Washington Seattle, Washington Prepared under the auspices of the International Union of Physiological Sciences PLENUM PRESS • NEW YORK AND LONDON Library of Congress Cataloging-in-Publication Data Mechanisms of work production and work absorption in muscle I edited by Haruo Sugi and Gerald H, Pollack; prepared under the auspices of the International Union of Physiological Sciences. p. cm. -- (Advances in experimental medicine and biology; v. 453) "Proceedings of a Symposium on Mechanisms of Work Productionand Work Absorption in Muscle, held October 27-31, 1997, in Hakone, Japan"--T.p, verso. Includes bibliographical references and indexes. ISBN-13: 978-1-4684-6041-4 e-ISBN-13: 978-1-4684-6039-1 001: 10.1007/978-1-4684-6039-1 1. Muscle contraction--Congresses. 2. Muscles--Molecular aspects -Congresses. 3. Actomyos 1 n--Congresses. I. Sug i, Haruo, 1933- II. Pollack, Gerald H. III. International Unlon of Physiological Sciences. IV. Symposium on Mechanisms of Work Production and Work Absorption in Muscle (1997 Hakone-machi, Japan) V. Series. QP321.M3395 1998 573.7'54--dc21 98-31319 CIP Proceedings of a Symposium on Mechanisms of Work Production and Work Absorption in Muscle, held October 27 - 31, 1997, in Hakone, Japan © 1998 Plenum Press, New York Softcover reprint ofthe hardcover I st edition 1998 A Division of Plenum Publishing Corporation 233 Spring Street, New York, N.Y. 10013 http://www.plenum.com 1098765432 1 All rights reserved No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise, without written permission from the Publisher PREFACE This volume presents the proceedings ofa symposium organized by one of us (H.S.) that was held on October 27-31, 1997 in Hakone, Japan, under the title "Mechanisms of Work Production and Work Absorption in Muscle." We have already published similar proceedings four times in the past: in 1978 under the title, "Cross-bridge Mechanism in Muscle Contraction" (University of Tokyo Press); in 1984 under the title, "Contractile Mechanism in Muscle Contraction" (Plenum); in 1988 under the title, "Molecular Mecha nism of Muscle Contraction" (Plenum); and in 1993 under the title, "Mechanism of Myofilament Sliding in Muscle Contraction" (Plenum). In contrast to common practice, we have always tried to include as many discussions held at the meeting in our proceed ings as possible, so as to enable readers to properly evaluate each paper presented, as well as to learn of future prospects in this field of research. Although the policy of including discussions occasions a long publication delay, we believe that it is worth repeating in our future publications, as we have met a number of young investigators fascinated by the dis cussions in our proceedings. The 1997 Hakone Symposium was somewhat different from the previous ones. Since 1993, I have chaired the Commission on Muscle Physiology of the International Un ion of Physiological Sciences (!uPS), and have participated in !UPS official meetings, re alizing that the IUPS executive members' main concern is to take every opportunity to emphasize the importance of "classical" or "integrative" physiology. At the end of 1996, Dr. Erwin Neher, Vice-president of the IUPS, suggested to me that I make a proposal to organize an international symposium based on this IUPS policy. In response to his sugges tion, I presented a proposal to organize a symposium on "Mechanisms of Work Production and Work Absorption in Muscle," in which I included several prominent cardiac physiolo gists, so as to realize the general theme of the IUPS, "From Molecules to Humans." Fortu nately, my proposal was approved and granted. This symposium is therefore organized under the auspices of the IUPS, and is partly supported by an IUPS grant. In the concluding remarks in this volume, Dr. Hugh E. Huxley, a principal architect of the sliding filament mechanism of muscle contraction, states that the molecular mecha nism of myofilament sliding remains mysterious to all of us. We hope that this volume will stimulate muscle investigators to design and perform novel experiments to clarify the mysteries in muscle contraction. Haruo Sugi Gerald H. Pollack ACKNOWLEDGMENTS The editors would like to express their sincere thanks to the International Union of Physiological Sciences and Teikyo University (Dr. Shoichi, Okinaga, President) for gener ous financial support, which made this symposium possible. Our thanks are also due to Uehara Science Foundation and Kanagawa Science Acad emy Foundation for their additional financial support. We owe a debt of gratitude to Ms. Sarah Richards at the University of Washington and Ms. Naoko Itagaki at Teikyo University for their enormous efforts in preparing the discussion records, and to Drs. Teizo Tsuchiya, Takenori Yamada, Suechika Suzuki, Shig eru Chaen, Yasutake Saeki, Takakazu Kobayashi, and Ms. Ibuki Shirakawa for compiling the indices. vii CONTENTS 1. Introductory Remarks Haruo Sugi I. Molecular Mechanism of Actin-Myosin Interaction, Part I 2. Linear and Rotary Molecular Motors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 Kazuhiko Kinosita, Jr. 3. Measurement of ATPase Activities of Myosin at the Level of Tracks and Single Molecules .. :................................................ 15 Paul B. Conibear, Philip A. Kuhlman, and Clive R. Bagshaw 4. Evanescent Excitation Microscopy: Its Application to the Study of Single Molecular Process Kinetics of Actomyosin Motor ................... 29 Hidetake Miyata, Shigeru Chaen, Seiryo Sugiura, and Haruo Sugi 5. Three-Dimensional Image Analysis of Myosin Head in Function as Captured by Quick-Freeze Deep-Etch Replica Electron Microscopy ............... 37 Eisaku Katayama, Gouki Ohmori, and Norio Baba 6. Fluctuation Correlation in the Sliding Movement Generated by Protein Motors in Vitro. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47 K. Tawada, M. Toyoda, Y. Imafuku, and A. Yamada 7. ATP-Induced Axial Movement of Myosin Heads in Living Thick Filaments Recorded with a Gas Environmental Chamber Attached to the Electron Microscope .................................................. 53 Haruo Sugi, Tsuyoshi Akimoto, Shigeru Chaen, and Suechika Suzuki 8. Design Principles and Applications of a Cooled CCD Camera for Electron Microscopy .................................................. 63 A. R. Faru.qi ix x Contents II. Molecular Mechanism of Actin-Myosin Interaction, Part II 9. Structure of the Monomeric Actin-Myosin Head Complex as Revealed by X-Ray Solution Scattering ...................................... 73 T. Arata, S. Kimura, Y. Sugimoto, Y. Takezawa, N. Iwasaki, and K. Wakabayashi 10. The Use of Fast Kinetic Systems for the Study ofng-Ilg Quantities of Purified Muscle Proteins . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 79 Michael A. Geeves and Igor Chizhov ll. Inhibitory Actions of Synthetic Actin Peptides and 2,3-Butanedion Monoxime on Actomyosin System ......................................... 91 Yoh Okamoto, Akihisa Hobo, and Koichi Kamisawada 12. Smooth Muscle Myosin: Amino Acid Residues Responsible for the Hydrolysis of ATP ...................................................... 99 Hirofumi Onishi, Manuel F. Morales, Shin-ichiro Kojima, Kazuo Katoh, and Keigi Fujiwara 13. The Molecular Biology and Pathophysiology of Hypertrophic Cardiomyopathy Due to Mutations in the Beta Myosin Heavy Chains and the Essential and Regulatory Light Chains . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 105 Neal D. Epstein 14. Cross-Bridge Dynamics in the Contracting Heart 117 Jon N. Peterson and Norman R. Alpert 15. Distinct Kinetic Properties of Cardiac Myosin Isoforms Revealed by in Vitro Studies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 125 Seiryo Sugiura, Naoshi Kobayakawa, Hideo Fujita, Shin-ichi Momomura, Shigeru Chaen, and Haruo Sugi 16. Functional Characterization of Dictyostelium discoideum Mutant Myosins Equivalent to Human Familial Hypertrophic Cardiomyopathy . . . . . . . . . . 131 Hideo Fujita, Seiryo Sugiura, Shin-ichi Momomura, Haruo Sugi, and Kazuo Sutoh 17. Hydrodynamic Properties of Water in Contractile System 139 Michihiko Ogata 18. IH-NMR Spectroscopy of the Intracellular Water of Resting and Rigor Frog Skeletal Muscle. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 145 Takenori Yamada Contents xi III. Molecular Mechanism of Regulation of Actin-Myosin Interaction 19. The Crystal Structure ofTroponin C in Complex with N-Terminal Fragment of Troponin I: The Mechanism of How the Inhibitory Action of Troponin I Is Released by Ca2+-Binding to Troponin C ........................... 157 Dmitry G. Vassylyev, Soichi Takeda, Soichi Wakatsuki, Kayo Maeda, and Yuichiro Maeda 20. Molecular Switches in Troponin . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 169 John Gergely 21. Fluorescence ofNBD-Labelled Troponin-I as a Probe for the Kinetics of Thin Filament Activation in Skeletal Muscle Fibers. . . . . . . . . . . . . . . . . . . . . . . 177 B. Brenner, Th. Kraft, and 1. M. Chalovich 22. Skeletal Muscle Regulatory Proteins Enhance F-Actin in Vitro Motility ....... 187 A. M. Gordon, Y. Chen, B. Liang, M. LaMadrid, Z. Luo, and P. B. Chase 23. Signal Transmission and Transduction in Excitation-Contraction Coupling. . . . . 199 Noriaki Ikemoto and Roque EI-Hayek 24. Regulation of Contraction in Heart Muscle: A Ca2+ Gradient Model for the Ca2+-Induced Ca2+-Release of the Sarcoplasmic Reticulum ............ 209 Tsukasa Tameyasu 25. Role of Calcium and Crossbridges in Modulation of Rates of Force Development and Relaxation in Skinned Muscle Fibers ............... 219 Jack A. RaIl and Philip A. Wahr 26. Structure and Function of Smooth Muscle Myosin Light Chain Kinase. . . . . . .. 229 Hiroko Kishi, Li-Hong Ye, Akio Nakamura, Tsuyoshi Okagaki, Akiko Iwata, Takeshi Tanaka, and Kazuhiro Kohama 27. Regulation of Scallop Myosin by Calcium: Cooperativity and the "Off' State 235 Vassilios N. Kalabokis and Andrew G. Szent-Gyorgyi 28. Modulatory Effect of MgATP on Smooth Muscle Myosin Phosphatase Activity 241 Yasuo Ogawa and Osamu-Sato IV. X-Ray Diffraction Studies on the Structural Changes during Contraction 29. Studies on the l4.5NM Meridional X-Ray Diffraction Reflection during Length Changes ofIntact Frog Muscle Fibres ............................. 247 P. 1. Griffiths, H. Amenitsch, C. C. Ashley, M. A. Bagni, S. Bemstorff, G. Cecchi, B. Colombini, and G. Rapp 30. On the Working Stroke Elicited by Steps in Length and Temperature 259 Gabriella Piazzesi, Natalia Koubassova, Malcolm Irving, and Vincenzo Lombardi xii Contents 31. Myosin Head Movements during Isometric Contraction Studied by X-Ray Diffraction of Single Frog Muscle Fibres . . . . . . . . . . . . . . . . . . . . . . . . . .. 265 Massimo Reconditi, Ian Dobbie, Malcolm Irving, Olivier Diat, Peter Boesecke, Marco Linari, Gabriella Piazzesi, and Vincenzo Lombardi 32. X-Ray Diffraction Studies of the Cross-Bridge Intermediate States. . . . . . . . . .. 271 S. Xu, S. Malinchik, S. Frisbie, 1. Gu, T. Kraft, G. Rapp, 1. M. Chalovich, B. Brenner, and L. C. Yu 33. Spacing Changes in the Actin and Myosin Filaments during Activation, and Their Implications . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 281 Hugh E. Huxley, Alex Stewart, and Tom Irving 34. Structural Features of Force-Generating Cross-Bridges: A 2D-X-Ray Diffraction Study. . . . . . . . . . . . . . . . . . . . . . .. . . . . .. . . . . .. . . . . . . .. . . . . . . . . . .. 289 T. Kraft, T. Mattei, and B. Brenner 35. Myosin Crossbridge Configurations in Equilibrium States of Vertebrate Skeletal Muscle: Heads Swing Axially or Turn Upside-Down between Resting and Rigor. .. . . . . .. . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . .. 297 Jeff Harford, Marie Cantino, Michael Chew, Richard Denny, Liam Hudson, Pradeep Luther, Robert Mendelson, Ed Morris, and John Squire 36. Extensibility of the Actin and Myosin Filaments in Various States of Skeletal Muscle as Studied by X-Ray Diffraction ........................... 309 Yasunori Takezawa, Yasunobu Sugimoto, and Katsuzo Wakabayashi V. Contraction Characteristics in Skeletal Muscle 37. Contractile Properties of Thin (Actin) Filament-Reconstituted Muscle Fibers. .. 319 Shin'ichi Ishiwata, Takashi Funtasu, and Hideaki Fujita 38. The ATPase Activity in Isometric and Shortening Skeletal Muscle Fibres 331 Zhen-He He, Rod K. Chillingworth, and Michael A. Ferenczi 39. Force Generation Simplified: Insights from Laser Temperature-Jump Experiments on Contracting Muscle Fibers ......................... 343 Julien S. Davis 40. Evidence for Two Distinct Cross-Bridge Populations in Tetanized Frog Muscle Fibers Stretched with Moderate Velocities . . . . . . . . . . . . . . . . . . . . . . . . .. 353 Takakazu Kobayashi, Shoichi Kosuge, and Haruo Sugi 41. Implications of Quantal Motor Action in Biological Systems . . . . . . . . . . . . . . .. 361 Gerald H. Pollack, Felix Blyakhman, Tatyana Shklyar, Anna Tourovskaya, Tsukasa Tameyasu, and Paul Yang 42. Calcium Dependence of the Apparent Rate of Force Generation in Single Striated Muscle Myofibrils Activated by Rapid Solution Changes ... . . .. 373 F. Colomo, S. Nencini, N. Piroddi, C. Poggesi, and C. Tesi
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