Mechanism of Toxic Action on Some Target Organs: Drugs and Other Substances Proceedings of the European Society of Toxicology Meeting held in Berlin (West), June 25—28, 1978 PDF
Preview Mechanism of Toxic Action on Some Target Organs: Drugs and Other Substances Proceedings of the European Society of Toxicology Meeting held in Berlin (West), June 25—28, 1978
Archives of Toxicology, Supplement 2 Mechanism of Toxic Action on Some Target Organs Drugs and Other Substances Proceedings of the European Society of Toxicology Meeting held in Berlin (West), June 25-28, 1978 Edited by P. L. Chambers and P. Giinzel Springer-Verlag Berlin Heidelberg New York 1979 Dr. PHILIP L. CHAMBERS Dept. of Pharmacology, Trinity College, Dublin 2, Ireland Dr. PETER GDNZEL Schering AG, Dept. of Exp. Toxicology, 1000 Berlin-Bergkamen, FRG With 150 Figures ISBN-13: 978-3-540-09305-3 e-ISBN-13: 978-3-642-67265-1 DOl: 10.1007/978-3-642-67265-1 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically those of translation, reprinting, re-use of illustrations, broadcasting, reproduction by photocopying machine or similar means, and storage in data banks. Under § 54 of the German Copyright Law, where copies are made for other than private use, a fee is payable to the publisher, the amount of the fee to be determined by agreement with the publisher. © by Springer-Verlag Berlin Heidelberg 1979 Sofkover reprint of the hardcover 1st edition 1979 The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Contents Young Scientists Award Lecture 1978: Studies on the Role of Acetylhydrazine in Isoniazid Hepatotoxicity. J. A. TIMBRELL. With 3 Figures .......................................... . The Influence of the Neuro-Endocrine System on the Toxic Reactions Due to Hormones and Other Compounds Evaluation of Effects of Sexual Steroids on the Hypothalamic-Pituitary System of Animals and Man. M. F. EL ETREBY, K.-J. GRAF', P. GiiNZEL, and F. NEUMANN. With 19 Figures... 11 Ultrastructure of Intermediate Lobe of the Pituitary and Melanocyte-Stimulating Hor mone Secretion in Oestrogen-Induced Kidney Tumors in Male Hamsters. P. G. SALUJA, J. M. HAMILTON, A. J. THODY, A. A. ISMAIL, and J. KNOWLES. 41 Role of Neuroendocrine System in Regulation of Mammary Tumors in Different Spe cies. J. MEITES .. , ........................................... " ....... , .. . . . . . 47 Evaluation oft he Carcinogenic Effects of Estrogens, Progestins and Oral Contraceptives on Cervix, Uterus and Ovary of Animals and Man. V. A. DRILL ............................................................ 59 Assessment of ACTH-Adrenal Activity After Treatment with a Glucocorticoid and an Antiandrogenic Steroid. J. GIRARD, J. B. BAUMANN, S. GRAF, G. VAN HEES, M. ROSENTHAL, and K. ZUPPINGER. With 1 Figure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 85 Neuroendocrine Effects of Neuropsychotropic Drugs and Their Possible Influence on Toxic Reactions in Animals and Man - The Role of the Dopamine-ProlactiI\ Sys tem. R. HOROWSKI and K.-J. GRAF'. With 4 Figures.............................. 93 Motility and Stereotyped Behaviour Induced by Amphetamine and Apomorphine on Hypophysectomized and on Thyroidectomized Rats. A. BENAKIS. With 3 Figures .............................................. 105 VI Contents Induction of Adaptive and Malignant Liver Growth by Drugs and Environmental Pollutants Adaptive Liver Growth Induced by Xenobiotic Compounds: Its Nature and Mecha nism. R. SCHULTE-HERMANN. With 2 Figures..................................... 113 Growth Control in Regenerating Rat Liver. K. WEINBREN ........................................................... 125 Control of Liver Growth by Growth Inhibitors (Chalones). C. NADAL. With 2 Figures................................................ 131 Nucleic Acid and Pyrimidine Nucleotide Metabolism During Liver Growth Induced by Xenobiotic Compounds (Abstract). J. SEIFERT and E. BUCHAR ............................................... 143 Early Biological Markers During Liver Carcinogenesis. P. BANNASCH, H.-J. HACKER, and D. MAYER. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 145 Correlation of Liver Growth and Function During Liver Regeneration and Hepatocarci nogenesis. H. BARBASON, V. SMOLIAR, and J. VAN CANTFORT. With 7 Figures 157 Liver Growth and Tumorigenesis in Rats. P. GRASSO. With 10 Figures. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 171 Liver Tumors and Steroid Hormones in Rats and Mice. J. SCHUPPLER and P. GfINZEL. With 5 Figures. . . . . . . . . . . . . . . . .. . . . . . . . . . . . . 181 The Effects of Dieldrin, Diet and Other Environmental Components on Enzyme Func tion and Tumor Incidence in Livers of CF-l Mice. H. A. TENNEKES, A. S. WRIGHT, and K. M. DIX ........................... 197 Organotropy as a Toxicological Phenomenon Enzymes as Regulators of Toxic Reactions by Electrophilic Metabolites. F. OESCH. With 8 Figures ................................................ 215 Pharmacokinetic Parameters Influencing Tissue Specificity in Chemical Carcinogene sis. H.-G. NEUMANN............................ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 229 Organ Specificity of Induction of Activating and Inactivating Enzymes by Cigarette Smoke and Cigarette Smoke Condensate. J. E. GIELEN, F. GOUJON, J. SELE, and J. VA N CANTFORT. With 6 Figures. . . . . 239 DNA Repair as Regulatory Factor in the Organotropy of Alkylating Carcino gens. P. KLEIHUES, G. DOERJER, J. A. SWENBERG, E. HAUENSTEIN, J. BUCHELER, and H. K. COOPER. With 4 Figures. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 253 Contents VII Physiological Mechanisms of Diethylstilbestrol Organotropic Carcinogenesis. J.-G. FORSBERG......................................................... 263 Diethylstilbestrol Metabolic Transformation in Relation to Organ Specific Tumor. Mani festation. M. METZLER and J. A. McLACHLAN. With 3 Figures........................ 275 Organotropic Mutagenesis in Tissues of Chinese Hamsters Induced by Chemical Carci nogens. B. J. DEAN, G. HODSON-WALKER, and K. R. SENNER....................... 281 Modulation of the in vivo Covalent Binding of the Carcinogen Benzo(a)pyrene to Rat Liver DNA by Selective Induction of Microsomal and Nuclear Aryl Hydrocarbon Hydroxylase Activity. A. VIVIANI and W. K. LUTZ. With 1 Figure ................................ 285 TCDD - Seveso Estimation of the TCDD Toxic Potential in the Light of the Seveso Accident. G. REGGIANI. With 1 Figure.............................................. 291 Free Communications and Poster Sessions Biological Threshold Limits for Benzene Based on Pharmacokinetics ofInhaled Benzene in Man. M. BERLIN, S. HOLM, P. KNUTSSON, and A. TUNEK. With 4 Figures. . . . . . . . . . . 305 Short Term Effects of Clophen A 50 and of Dichlorobiphenyl in Rats. M. BAUMANN. With 3 Figures . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 311 Toxic Effects of Di-n-octyltin Dichloride on the Thymus in Mice. G. HENNINGHAUSEN and P. LANGE. With 2 Figures......................... 315 2-Hydroxyoestradiol and (+ )-Cyanidanol-3 Prevent Lipid Peroxidation ofIsolated Rat Hepatocytes. H. KAPPUS, D. KOSTER-ALBRECHT, and H. REMMER. With 3 Figures.......... 321 Accentuation of White Phosphorus Induced Fatty Liver by Phenobarbitone in Male Rats Compared to Female Rats. A. JACQUESON, M. THEVENIN, J.-M. WARNET, J.-R. CLAUDE, and R. TRUHAUT. 327 Fatty Liver Induced by High Doses of Rifampicin in the Rat: Possible Relation with an Inhibition of RNA Polymerases in Eukariotic Cells. A. PIRIOU, J.-M. WARNET, A. JACQUESON, J.-R. CLAUDE, and R. TRUHAUT .... 333 An Experimental Model for the Study of Hepatic Transport and Metabolism of Toxic Compounds. M. SCHWENK, V. L6PEZ DEL PINO, and H. REMMER. With 3 Figures.......... 339 VIII Contents Effects of Subacute Toluene Inhalation on its Metabolism and Disposition in Rat. E. ELOVAARA, H. SAVOLAINEN, P. PFAFFLI, and H. VAINIO ................... 345 Drug-Nitrite Interactions: Species and Sex Differences in the Formation of Dimethylni trosamine and its Effects on the Hepatic Enzyme Activities. Y. OMORI, A. TAKAHASHI, Y. OHNO, H. ISHIWATA, and A. TANIMURA ......... 349 Monoamine Oxidase Inhibiting and Toxic Effects of Acetyl-Phenylhydrazide on Rat Liver in vivo. K. QUIRING, V. SCHMIDT, H. CHRISTEN, and L. HAMM. With 2 Figures........ 355 Side Effects of Colloidal Plasmasubstitutes on Hemostasis in Patients with Terminal Renal Failure. W. KIRCH, H. KOHLER, and CH. v. GIZYCKI. With 3 Figures................. 359 Accelerated Renal Elimination of Thallium in the Rat Due to Treatment with Furose mide or Potassium Ions (Abstract). W. LAMEIJER............................................................ 365 Entrance into Brain of Dextropropoxyphene and the Toxic Metabolite Norpropoxy phene. W. L. WAY and J. SCHOU. With 1 Figure .................................. 367 Comparison of the Acute Toxicity of Clioq ui no I, Histamine, and Chloroform in Differ ent Strains of Mice. C. PERICIN and P. THOMANN ............................................. 371 Prostaglandins in Rat Placenta Following Acute and Chronic Administration of Mor phine. G. M. SCOTO, C. SPADARO, S. SPAMPINATO, N. NOSSAN, R. ARRIGo-REINA, and S. FERRI. With 4 Figures ................................................... 375 Effects of Two Structurally Different Antispermatogenic Compounds on the Synthesis of Steroids in Rat Testes. J. GURTLER and P. DONATSCH. With 2 Figures............................. 381 Ultrastructural Alterations Induced by Two Different Antispermatogenic Agents in the Seminiferous Epithelium of Rat Testes. A. HAUSLER and C. HODEL. With 2 Figures. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 387 Therapeutic Effects of the Bis-Pyridinium Salts HGG-12, HGG-42 and Atropine, Benactyzine in Organophosphate Poisoning of Dogs. W. HAUSER and N. WEGER. With 2 Figures................................ 393 Hormonal Control of Prothrombin Synthesis in Rat Liver Microsomes, with Special Reference to the Role of Estradiol, Testosterone and Prolactin. Y. NISHINO. With 2 Figures. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 397 Lifespan Studies on Male and Female Mice and Rats Under SPF-Laboratory Condi tions. P. SUTER, H. LUETKEMEIER, N. ZAKOVA, P. CHRISTEN, K. SACHSSE, and R. HESS. With 3 Figures ............................................................... 403 Contents IX The Loss of Creatine Phosphokinase (CK) from Intramuscular Injection Sites in Rab bits. A Predictive Tool for Local Toxicity (Abstract). O. SVENDSEN, F. RASMUSSEN, P. NIELSEN, and E. STEINESS .................. 409 In vivo Covalent Binding of Chemicals to DNA as a Short-Term Test for Carcinogeni city. W. K. LUTZ and CH. SCHLATTER.......................................... 411 A Dynamic System for Long-Term Toxicity Studies in Fish Under Laboratory Condi tions. R. BATHE. With 3 Figures................................................ 417 Effect ofIntratracheal and Oral Application of Corticosteroids on the Adrenal Function Test in Beagle Dogs After ACTH-Stimulation. A. S. BHARGAVA, P. STABEN, F. SmGMUND, CH. SCHOBEL, and P. GiiNZEL. With 6 Figures ................................................................. 425 Drug Actions in Rats with Arteriosclerosis Induced by Toxic Doses of Vita min Dr Y. M. BARAKA and H. BEKEMEIER. With 2 Figures.......................... 431 Apparent Tropism of a Vasodilator, Mecinarone, for Melanin-Containing Tissues and Activation of Melanogenesis in the Beagle (Abstract). Y. BAILLY and G. RAYNAUD .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 437 Estrogenic Partial Effect of Nore thisterone Enanthate in Relation to Tumor Induction in Rat Mammary Gland. Y. NISHINO and F. NEUMANN. With 1 Figure............................... 439 The Special Suitability of Inbred Syrian Hamsters for Carcinogenesis Testing. F. HOMBURGER, R. A. ADAMS, and E. SOTO . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 445 Proliferation of Rat Liver Cells in Preneoplastic Nodules After Stimulation of Liver Growth by Xenobiotic Inducers. G. OHDE, J. SCHUPPLER, R. SCHULTE-HERMANN, and H. KEIGER. With 3 Fig- ures . . .. .. . . .. .. . . . .. . . . .. .. .. .. .. . . . . .. . . . . . . .. . . .. .. .. .. . . . . .. . . . . . .. . 451 The Regulative Role of Food Consumption in the Induction of Rat Liver Cell Prolifera tion by Drugs and Environmental Pollutants. V. HOFFMANN and R. SCHULTE-HERMANN. With 3 Figures................... 457 Induction of Pre-Malignant Hepatic Lesions: Comparative Effects of Vinyl Chloride and Trichloroethylene (Abstract). R. J. LAID, G. STOCKLE, and H. M. BOLT ................•................. 463 Microsomal Vinyl Oxide Synthetase: Modification of its Kinetic Parameters by Chemi cal Carcinogens. E. MALVOISIN, M. ROBERFROID, and M. MERCIER. With 3 Figures ............ 465 Influence of Drugs on Activation and Inactivation of Hepatocarcinogenic Nitrosa mines. K. E. ApPEL, R. RICKART, M. SCHWARZ, and H. W. KUNZ. With 3 Figures.... 471 x Contents Effect of DMN, Phenobarbital and Halothane on the Sedimentation Characteristics of Rat Liver DNA. ' M. SCHWARZ, K. E. ApPEL, R. RICKART, AND H. W. KUNz. With 1 Figure.... 479 Activities of Polycyclic Hydrocarbon Activating and Inactivating Enzymes in Human Lungs of Smokers, Non-Smokers, Lung-Cancer and Non-Cancer Patients. J. LoRENZ, H. SCHMASSMANN, E. OHNHAUS, and F. OESCH .................. 483 Demonstration of Drug-Ethanol Interactions by Changes in Activity of Hepatic Micro somal Oxidase/Oxygenase Cytochrome P-450 Function. G. HEINEMEYER, A. G. HILDEBRANDT, I. ROOTS, L. LEHNE, and S. NIGAM. With 3 Figures.. .. . .. .. . . . .. .... . . . . . . . . .. .. . . . . . . . . . . .. .. .. .. .. . .. .. .. . . . .. . .. 491 Alcohol and Aldehyde Dehydrogenase on Chronic Ethanol Intoxication. Effect of Acetaldehyde and Fat Diet. (Abstract). M. CASCALES, S. CERDAN, M. R. SANTOS-RUIZ, B. FEIJ60, and A. SANTOS-RUIZ 497 Polycystic Changes in Rat Kidney Induced by Biphenyl Fed in Different Diets. D. SONDERGAARD and L. BLOM. With 2 Figures ............................ 499 Unscheduled DNA Synthesis in Male Rabbit Germ Cells Induced by Methylmethane Sulfonate, Cyclophosphamide and Adriamycin. B. SCHMID and G. ZBINDEN. With 3 Figures................................ 503 Plasma Proteins - Animal Assays on Possible Cardiovascular Side-Effects. H. RONNEBERGER. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 509 Exploitation of Toxicological Results and its Problems. A Call for Normalisation of Their Presentation, Apropos of a Pilot Factual Data Bank (Abstract). J. P. FOURNEAU, M. RAVIART, and R. GERDAY ............................. 515 Computer Analysis and Integration of Animal Pathology Data. J. M. FACCINI, and D. NAYLOR. With 2 Figures............................ 517 Author Index. . . . . .. .. .. .. .. .. . . . . .. . . . . . .. . . . .. . . . .. .. .. . .. . . . . . . . . .. . . . 521 Subject Index ........................................................... 523
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