Manual of Allergy and Immunology PDF
Preview Manual of Allergy and Immunology
MANUAL OF ALLERGY AND IMMUNOLOGY Fifth Edition MANUAL OF ALLERGY AND IMMUNOLOGY Fifth Edition Editor Daniel C. Adelman, MD Adjunct Professor of Medicine Allergy and Immunology University of California, San Francisco San Francisco, California Thomas B. Casale, MD Professor of Medicine Chief, Division of Allergy/Immunology Department of Medicine Creighton University Omaha, Nebraska Jonathan Corren, MD Associate Clinical Professor of Medicine University of California Director, Research Allergy Medical Clinic Los Angeles, California Acquisitions Editor: Frances DeStefano Product Manager: Leanne Vandetty Developmental Editor: Lisa Consoli Production Manager: Alicia Jackson Senior Manufacturing Manager: Benjamin Rivera Marketing Manager: Kimberly Schonberger Design Coordinator: Teresa Mallon Production Service: SPi Global Copyright © 2012 by LIPPINCOTT WILLIAMS & WILKINS, a WOLTERS KLUWER business Two Commerce Square 2001 Market Street Philadelphia PA 19103 USA LWW.com Fourth Edition © 2002 by Lippincott Williams & Wilkins Printed in China All rights reserved. This book is protected by copyright. No part of this book may be reproduced in any form by any means, including photocopying, or utilized by any information storage and retrieval system without written permission from the copyright owner, except for brief quotations embodied in critical articles and reviews. Materials appearing in this book prepared by individuals as part of their official duties as U.S. government employees are not covered by the above-mentioned copyright. Library of Congress Cataloging-in-Publication Data Manual of allergy and immunology / edited by Daniel C. Adelman, Thomas B. Casale, Jonathan Corren. -- 5th ed. p. ; cm. Includes bibliographical references and index. ISBN-13: 978-1-4511-2051-6 ISBN-10: 1-4511-2051-6 I. Adelman, Daniel C. II. Casale, Thomas B. III. Corren, Jonathan. [DNLM: 1. Immune System Diseases--Handbooks. 2. Hypersensitivity--Handbooks. WD 301] 616.07’9--dc23 2011036312 Care has been taken to confirm the accuracy of the information presented and to describe generally accepted practices. However, the authors, editors, and publisher are not responsible for errors or omissions or for any consequences from application of the information in this book and make no warranty, expressed or implied, with respect to the currency, completeness, or accuracy of the contents of the publication. Application of the information in a particular situation remains the professional responsibility of the practitioner. The authors, editors, and publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accordance with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new or infrequently employed drug. Some drugs and medical devices presented in the publication have Food and Drug Administration (FDA) clearance for limited use in restricted research settings. It is the responsibility of the health care provider to ascertain the FDA status of each drug or device planned for use in their clinical practice. To purchase additional copies of this book, call our customer service department at (800) 638-3030 or fax orders to (301) 223-2320. International customers should call (301) 223-2300. Visit Lippincott Williams & Wilkins on the Internet: at LWW.com. Lippincott Williams & Wilkins customer service representatives are available from 8:30 am to 6 pm, EST. 10 9 8 7 6 5 4 3 2 1 To my wife, Deborah, and children, Arielle, Nathan, and Gabriel, for their patience, tolerance, and understanding; and to my parents, Barnet and Beverly, for the years of support and encouragement. Daniel C. Adelman, MD To my wife, Jean, my son, Jeffrey, my brother, Bill, and my sister, Mary Ann, for their loving support and encouragement. Thomas B. Casale, MD To the memory of my parents, Herman and Mildred Corren, for their inspiration and encouragement, and to my wife, Martha, and children, Jeremy and Rachel, for their loving support. Jonathan Corren, MD Contributors Shradha Agarwal, MD Assistant Professor Department of Medicine Mount Sinai School of Medicine Assistant Professor Division of Clinical Immunology Department of Medicine Mount Sinai Hospital New York, New York Shefalee Admin, MD Fellow Physician Pulmonary and Critical Care Medicine University of California, Los Angeles Los Angeles, California Marcella Aquino, MD Clinical Instructor of Medicine Department of Internal Medicine State University of New York at Stony Brook Stony Brook, New York Attending, Allergy & Immunology Department of Internal Medicine Winthrop University Hospital Mineola, New York Robert W. Ausdenmoore, MD Professor Department of Pediatrics Children’s Hospital Medical Center Cincinnati, Ohio Zuhair K. Ballas, MD Professor and Director Division of Immunology Internal Medicine University of Iowa Carver College of Medicine Iowa City, Iowa Leonard Bielory, MD Professor Center for Environmental Prediction Rutgers University STARx Allergy & Asthma Center Springfield, New Jersey Attending Medicine, Allergy and Immunology Robert Wood Johnson University Hospital New Brunswick, New Jersey Jack J.H. Bleesing, MD, PhD Associate Professor Department of Pediatrics University of Cincinnati Attending Physician Division of Bone Marrow Transplantation and Immune Deficiency Cincinnati Children’s Hospital Medical Center Cincinnati, Ohio Stephen R. Boden, MD Fellow Department of Pediatrics Division of Allergy and Immunology Duke University Medical Center Durham, North Carolina Mark Boguniewicz, MD Professor Department of Pediatrics University of Colorado School of Medicine National Jewish Health Division of Pediatric Allergy-Immunology Denver, Colorado Candace Bouler Anz, MD Fellow, Allergy and Immunology Section of Pulmonary, Critical Care Allergy and Immunologic Diseases Department of Internal Medicine Wake Forest University School of Medicine Fellow, Allergy and Immunology Department of Internal Medicine Wake Forest Baptist Medical Center Winston-Salem, North Carolina Lori Broderick, MD, PhD Allergy and Immunology Fellow Department of Medicine University of California, San Diego La Jolla, California David Broide, MB, ChB Professor of Medicine Department of Medicine University of California, San Diego La Jolla, California Terri F. Brown-Whitehorn, MD Assistant Professor of Clinical Pediatrics Department of Pediatrics Perelman School of Medicine University of Pennsylvania Children’s Hospital of Philadelphia Philadelphia, Pennsylvania A. Wesley Burks, MD Chair Department Of Pediatrics University Of North Carolina Professor Pediatric Allergy and Immunology Duke University Chief Pediatric Allergy and Immunology Duke University Medical Center Durham, North Carolina Robert K. Bush, MD Professor Emeritus Allergy and Clinical Immunology University of Wisconsin, Madison Madison, Wisconsin Jason W. Caldwell, DO Assistant Professor of Internal Medicine and Pediatrics Section of Pulmonary, Critical Care Allergy and Immunologic Diseases Department of Internal Medicine Wake Forest School of Medicine Attending Physician Department of Internal Medicine Wake Forest Baptist Medical Center Winston-Salem, North Carolina Jonathan Corren, MD Associate Clinical Professor Department of Medicine University of California Director, Research Allergy Medical Clinic Los Angeles, California Charlotte Cunningham-Rundles, MD, PhD Professor Department of Medicine and Pediatrics Mount Sinai School of Medicine New York, New York Taylor A. Doherty, MD Assistant Professor of Medicine Department of Medicine University of California, San Diego La Jolla, California Mark S. Dykewicz, MD Professor of Internal Medicine Director, Allergy and Immunology Section of Pulmonary, Critical Care Allergy and Immunologic Diseases Department of Internal Medicine Center for Human Genomics and Personalized Medicine Wake Forest University School of Medicine Director, Allergy and Immunology Department of Internal Medicine Wake Forest Baptist Medical Center Winston-Salem, North Carolina Nkiruka U. Erekosima, MD, MPH Assistant Professor Department of Medicine Division of Allergy and Clinical Immunology Johns Hopkins University School of Medicine Associate Clinical Director Division of Allergy and Clinical Immunolog Johns Hopkins University School of Medicine Baltimore, Maryland Thomas A. Fleisher, MD Chief Department of Laboratory Medicine National Institutes of Health Bethesda, Maryland Luz Fonacier, MD Professor of Clinical Medicine Department of Internal Medicine State University of New York at Stony Brook Stony Brook, New York Head of Allergy and Training Program Director Department of Internal Medicine Winthrop University Hospital Mineola, New York David B.K. Golden, MD Associate Professor Department of Medicine Johns Hopkins University Director of Allergy Services Department of Medicine Sinai Hospital of Baltimore Baltimore, Maryland Kernika Gupta, BA Research Coordinator Division of Gastroenterology and Nutrition The Children’s Hospital of Philadelphia Philadelphia, Pennsylvania Joel M. Hartman, MD Fellow Internal Medicine (Allergy/Immunology) Wake Forest School of Medicine Wake Forest Baptist Health Winston-Salem, North Carolina John M. Kelso, MD Clinical Professor of Pediatrics and Internal Medicine University of California, San Diego School of Medicine Division of Allergy, Asthma and Immunology Scripps Clinic San Diego, California David A. Khan, MD Professor of Internal Medicine & Pediatrics Department of Internal Medicine Division of Allergy & Immunology University of Texas Southwestern Medical Center Staff Department of Internal Medicine
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