Magnetic Nanoparticles: Particle Science, Imaging Technology, and Clinical Applications PDF
Preview Magnetic Nanoparticles: Particle Science, Imaging Technology, and Clinical Applications
Proceedings of the First International Workshop on Magnetic Particle Imaging MAGNETIC NANOPARTICLES Particle Science, Imaging Technology, and Clinical Applications 7938tp.indd 1 6/28/10 4:41 PM Proceedings of the First International Workshop on Magnetic Particle Imaging MAGNETIC NANOPARTICLES Particle Science, Imaging Technology, and Clinical Applications Institute of Medical Engineering, University of Lübeck, Germany 18 – 19 March 2010 Editors T M Buzug University of Lübeck, Germany J Borgert Philips Research Europe, Hamburg T Knopp University of Lübeck, Germany S Biederer University of Lübeck, Germany T F Sattel University of Lübeck, Germany M Erbe University of Lübeck, Germany K Lüdtke-Buzug University of Lübeck, Germany World Scientific NEW JERSEY • LONDON • SINGAPORE • BEIJING • SHANGHAI • HONG KONG • TAIPEI • CHENNAI 7938tp.indd 2 6/28/10 4:41 PM Published by World Scientific Publishing Co. Pte. Ltd. 5 Toh Tuck Link, Singapore 596224 USA office: 27 Warren Street, Suite 401-402, Hackensack, NJ 07601 UK office: 57 Shelton Street, Covent Garden, London WC2H 9HE British Library Cataloguing-in-Publication Data A catalogue record for this book is available from the British Library. MAGNETIC NANOPARTICLES Particle Science, Imaging Technology, and Clinical Applications Proceedings of the First International Workshop on Magnetic Particle Imaging Copyright © 2010 by World Scientific Publishing Co. Pte. Ltd. All rights reserved. This book, or parts thereof, may not be reproduced in any form or by any means, electronic or mechanical, including photocopying, recording or any information storage and retrieval system now known or to be invented, without written permission from the Publisher. For photocopying of material in this volume, please pay a copying fee through the Copyright Clearance Center, Inc., 222 Rosewood Drive, Danvers, MA 01923, USA. In this case permission to photocopy is not required from the publisher. ISBN-13 978-981-4324-67-0 ISBN-10 981-4324-67-1 Printed in Singapore. Chelsea - Magnetic Nanoparticles.pmd 1 6/11/2010, 2:51 PM TThhiiss ppaaggee iiss iinntteennttiioonnaallllyy lleefftt bbllaannkk FOREWORD AND ACKNOWLEDGEMENTS This volume comprises the accepted contributions of the First International Workshop on Magnetic Particle Imaging (IWMPI). The workshop has been organized by the Institute of Medical Engineering at the University of Lübeck, Germany, in March 2010. It gives an overview on recent results of a novel imaging modality based on magnetic nanoparticles. The magnetic particle imaging (MPI) concept falls into the category of functional imaging and, hence, the magnetic nanoparticles may serve as tracers of metabolic processes. Since the particles of choice consist of super-paramagnetic iron oxide (SPIO) cores coated with biopolymers, imaging of the metabolism may be possible without any radioactive agents. These particles are subjected to an oscillating magnetic field and, subsequently, react with a nonlinear re- magnetization. This behavior can be detected with appropriate receive coils. Due to the nonlinearity, the induced signal in the receive coils contains harmonics of the fundamental frequency of the drive field. These harmonics can be used to determine the nanoparticle concentration. For spatial encoding an additional magnetic gradient field, is superimposed onto the drive field such that a field-free point is established within the volume of interest. Only particles located at the field-free point contribute to the desired signal in the receive coils. Particles outside are saturated and do not further show any re-magnetization dynamics upon the excitation by the drive field. Today, there are quite interesting challenges within the practical set-up of a scanning device and also in the design of new MPI nanoparticles. Scientists from chemical engineering, biology, electrical engineering, physics, computer sciences and medicine (see Fig. 1) discussed the promises and challenges of magnetic particle imaging during the workshop in spring 2010. As chair of the workshop I would like the thank my co-chair, J. Borgert, Philips Research Hamburg, and the members of the program committee for the selection of works included in this book: C. Alexiou, University Erlangen; J. Barkhausen, University Clinics Schleswig-Holstein, Campus Lübeck; J. Borgert, Philips Research Hamburg; J. Bulte, Johns Hopkins University, School of Medicine, Baltimore; T. M. Buzug, University of Lübeck; S. Conolly, UC Berkeley; O. Dössel, University of Karlsruhe; S. Dutz, IPHT Jena; Z. A. Fayad, Mount Sinai School of Medicine, NY; D. Finas, University Clinics Schleswig-Holstein, Campus v vi Lübeck; V. Fuster, Mount Sinai School of Medicine, NY; B. Gleich, Philips Research Hamburg; J. Haueisen, Technical University Ilmenau; K. Krishnan, University of Washington; M. Kuhn, Philips Healthcare Hamburg; M. Magnani, Università degli Studi di Urbino; M. Port, Guerbet Roissy CDG; M. Schilling, TU Braunschweig; G. Schütz, Bayer Schering Pharma Berlin; M. Taupitz, Charité Berlin; L. Trahms, PTB Berlin; J. B. Weaver, Dartmouth Medical School; J. Weizenecker, University of Applied Sciences Karlsruhe. Fig. 1. Participants of the First International Workshop on Magnetic Particle Imaging, University of Lübeck, March 2010. For supporting the workshop I have to thank the German Society of Biomedical Engineering (DGBMT) and the Arbeitsgemeinschaft Medizintechnik Schleswig- Holstein (AGMT). For financial support I would like to thank Philips Health Care, Bruker BioSpin, Bayer-Schering, Lanxess and Olympus. Last but not least warm thanks go to the members of the local organization team at the Institute of Medical Engineering, University of Lübeck. Thorsten M. Buzug Institute of Medical Engineering Workshop Chair University of Lübeck Lübeck, March 2010 [email protected] CONTENTS Keynote ............................................................................................... 1 Particle Dynamics of Mono-Domain Particles in Magnetic Particle Imaging J. Weizenecker, B. Gleich, J. Rahmer, J. Borgert ...................................................... 3 Magnetic Nanoparticles ................................................................... 17 The Effects of Molecular Binding on the Phase of MSB Measurements J. B. Weaver, A. M. Rauwerdink .............................................................................. 19 SPIO Nanoparticles Encapsulation into Human Erythrocytes for MPI Application D. Markov, H. Boeve, B. Gleich, J. Borgert, A. Antonelli, C. Sfara, M. Magnani ... 26 Use of Resovist in Magnetic Particle Imaging G. Schütz, J. Lohrke, J. Hütter ................................................................................. 32 Larger Single Domain Iron Oxide Nanoparticles for Magnetic Particle Imaging S. Dutz, R. Müller, M. Zeisberger ............................................................................ 37 Superparamagnetic Iron Oxide Nanoparticles for Magnetic Particle Imaging K. Lüdtke-Buzug, S. Biederer, M. Erbe, T. Knopp, T. F. Sattel, T. M. Buzug .......... 44 Magnetic Particle Spectrometry ..................................................... 51 Size-Optimized Magnetite Nanoparticles for Magnetic Particle Imaging R. M. Ferguson, A. P. Khandar, K. R. Minard, K. M. Krishnan .............................. 53 A Spectrometer to Measure the Usability of Nanoparticles for Magnetic Particle Imaging S. Biederer, T. F. Sattel, T. Knopp, M. Erbe, K. Lüdtke-Buzug, F. M. Vogt, J. Barkhausen, T. M. Buzug ..................................................................................... 60 Evidence of Aggregates of Magnetic Nanoparticles in Suspensions Which Determine the Magnetisation Behaviour D. Eberbeck, F. Wiekhorst, L. Trahms ..................................................................... 66 Investigation of The Magnetic Particle Imaging Signal’s Dependency on Ferrofluid Concentration J.-P. Gehrcke, M. A. Rückert, T. Kampf, W. H. Kullmann, P. M. Jakob, V. C. Behr ................................................................................................................. 73 vii viii Magnetization Harmonics as a Remote Method for Monitoring Endocytosis of Nanoparticles A. M. Rauwerdink, A. J. Giustini, P. J. Hoopes, J. B. Weaver ................................. 79 Magnetic Particle Spectrometry for the Evaluation of Field-Dependent Harmonics Generation T. Wawrzik, J. Hahn, F. Ludwig, M. Schilling ......................................................... 86 Magnetic Particle Imaging .............................................................. 91 Narrowband Magnetic Particle Imaging in a Mouse P. Goodwill, S. Conolly ............................................................................................ 93 Two-Dimensional Magnetic Particle Imaging T. Wawrzik, F. Ludwig, M. Schilling ...................................................................... 100 Resolution Distribution in Single-Sided Magnetic Particle Imaging T. F. Sattel, T. Knopp, S. Biederer, M. Erbe, K. Lüdtke-Buzug, T. M. Buzug ........ 106 The Effect of Relaxation on Magnetic Particle Imaging Y. Wu, Z. Yao, G. Kafka, D. Farrell, M. Griswold, R. Brown ................................ 113 Efficient Field-Free Line Generation for Magnetic Particle Imaging T. Knopp, S. Biederer, T. F. Sattel, K. Lüdtke-Buzug, M. Erbe, T. M. Buzug ........ 120 3D Real-Time Magnetic Particle Imaging: Encoding and Reconstruction Aspects J. Rahmer, B. Gleich, J. Borgert, J. Weizenecker .................................................. 126 Imaging Technology and Safety Aspects ..................................... 133 Concept for a Digital Amplifier with High Quality Sinusoidal Output Voltage for MPI Drive Field Coils C. Loef, P. Luerkens, O. Woywode ........................................................................ 135 A Novel Compensated Coil System with High Homogeneity and low Strayfields R. Hiergeist, J. Lüdke, R. Ketzler, M. Albrecht, G. Ross ........................................ 141 JFET Noise Modelling for MPI Receivers I. Schmale, B. Gleich, J. Borgert, J. Weizenecker .................................................. 148 Noise Within Magnetic Particle Imaging I. Schmale, B. Gleich, J. Borgert, J. Weizenecker .................................................. 154 Calculation and Evaluation of Current Densities and Thermal Heating in the Body During MPI J. Bohnert, O. Dössel ............................................................................................. 162 A Surveillance Unit for Magnetic Particle Imaging Systems S. Kaufmann, S. Biederer, T. F. Sattel, T. Knopp, T. M. Buzug ............................. 169 ix Magneto-Relaxometry ................................................................... 175 Cancer Therapy with Magnetic Nanoparticles Visualized with X-Ray- Tomography, Magnetorelaxometry and Histology S. Lyer, R. Tietze, L. Trahms, S. Odenbach, C. Alexiou ......................................... 177 Localization and Quantification of Magnetic Nanoparticles by Multichannel Magnetorelaxometry for Thermal Ablation Studies H. Richter, F. Wiekhorst, U. Steinhoff, L. Trahms, M. Kettering, W. A. Kaiser, I. Hilger .................................................................................................................. 184 Imaging of Magnetic Nanoparticles Based on Magnetorelaxation and Minimum Norm Estimations D. Baumgarten, J. Haueisen .................................................................................. 191 Medical Applications ..................................................................... 199 Developing Cellular MPI: Initial Experience J. W. M. Bulte, P. Walczak, S. Bernard, B. Gleich, J. Weizenecker, J. Borgert, H. Aerts, H. Boeve .................................................................................................. 201 Sentinel Lymphnode Detection in Breast Cancer by Magnetic Particle Imaging Using Superparamagnetic Nanoparticles D. Finas, B. Ruhland, K. Baumann, T. Knopp, T. Sattel, S. Biederer, K. Luedtke-Buzug, T. M. Buzug, K. Diedrich ......................................................... 205 Magnetic Sensing Methods and Materials for Medical Applications B. Ten Haken, M. Visscher, M. Sobik, A. H. Velders ............................................. 211 Superparamagnetic Iron Oxides for MR-Visualization of Textile Implants I. Slabu, T. Schmitz-Rode, M. Hodenius, U. Klinge, J. Otto, G. A. Krombach, N. Krämer, H. Donker, M. Baumann ..................................................................... 217 Detection of Autologous Chondrocytes at Polyethylene Scaffolds in Vivo - Experimental Study I. Schoen, F. Angenstein, K. Neumann, E. Roepke ................................................. 224 Current Iron Oxide Nanoparticles - Impact on MRI and MPI F. M. Vogt, J. Barkhausen, S. Biederer, T. F. Sattel, T. Knopp, K. Lüdtke-Buzug, T. M. Buzug ............................................................................................................ 231 Short Contributions ....................................................................... 235 Colloidal Stability of Water Based Dispersions Containing Large Single Domain Particles of Magnetite N. Buske, S. Dutz ................................................................................................... 237
The list of books you might like
