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Lippincott’s Illustrated Review of Histology Illustrated Interactive Q & A Guiyun Zhang, MD, PhD Assistant Professor Department of Pathology, Anatomy and Cell Biology Jefferson Medical College Thomas Jefferson University Philadelphia, Pennsylvania Bruce A. Fenderson, PhD Professor Department of Pathology, Anatomy and Cell Biology Jefferson Medical College Thomas Jefferson University Philadelphia, Pennsylvania 0002076913.INDD 1 3/25/2014 2:14:27 PM Acquisitions Editor: Crystal Taylor Product Manager: Amy Weintraub Production Project Manager: Marian A. Bellus Manufacturing Manager: Margie Orzech Designer: Doug Smock Compositor: SPi Global Copyright © 2015 Wolters Kluwer Health Two Commerce Square 2001 Market Street Philadelphia, PA 19103 USA LWW.com Printed in China All rights reserved. This book is protected by copyright. No part of this book may be reproduced in any form or by any means, including photocopying, or utilized by any information storage and retrieval system without written permission from the copyright owner. The publisher is not responsible (as a matter of product liability, negligence, or otherwise) for any injury resulting from any material contained herein. This publication contains information relating to general principles of medical care that should not be construed as specific instructions for individual patients. Manufacturers’ product information and package inserts should be reviewed for current information, including contraindications, dosages, and precautions. Library of Congress Cataloging-in-Publication Data Zhang, Guiyun, author. Lippincott’s illustrated Q & A review of histology / Guiyun Zhang, Bruce A. Fenderson. p. ; cm. Illustrated Q & A review of histology Includes index. ISBN 978-1-4511-8830-1 I. Fenderson, Bruce A., author. II. Title. III. Title: Illustrated Q & A review of histology. [DNLM: 1. Histology—Examination Questions. QS 518.2] QM32 611.0076—dc23 2013051149 The publishers have made every effort to trace the copyright holders for borrowed material. If they have inadvertently overlooked any, they will be pleased to make the necessary arrangements at the first opportunity. To purchase additional copies of this book, call our customer service department at (800) 638-3030 or fax orders to (301) 223-2320. International customers should call (301) 223-2300. Visit Lippincott Williams & Wilkins on the Internet: http://www.LWW.com. Lippincott Williams & Wilkins customer service representatives are available from 8:30 am to 6:00 pm, EST. 0002076913.INDD 2 3/25/2014 2:14:27 PM To my husband, Biao Zuo, and my son, Ran Zuo, whose love, humor, and unconditional support have accompanied me on my academic path and made this project most enjoyable; To all of my students, whose excitement and passion for learning provided great initial stimulation for this project. —Guiyun— To my parents, Douglas and Joyce, who shared their time and love, showed me the joy of learning, encouraged me to read books and practice my violin, clarified the difference between playing notes and making music, emphasized the virtues of honesty and hard work, taught me by example, and set me on a good path in life. —Bruce— 0002076913.INDD 3 3/25/2014 2:14:27 PM 0002076913.INDD 4 3/25/2014 2:14:27 PM Reviewers Thomas Erickson Marielle Kulling University of North Dakota School of Medicine Michigan State University College of and Health Sciences Osteopathic Medicine Grand Forks, ND Lansing, MI Adam Burch Tyler Barnes College of Osteopathic Medicine of the Mercer University School of Medicine Pacific-Northwest Savannah, GA Western University of Health Sciences Lebanon, OR v 0002076913.INDD 5 3/25/2014 2:14:27 PM 0002076913.INDD 6 3/25/2014 2:14:27 PM Preface Lippincott’s Illustrated Q&A Review of Histology presents the key concepts of modern tissue structure and function in the form of clinical vignette-style questions. Using the format of the National Board of Medical Examiners (NBME), the questions address the major topics in histology and cell biology presented in primary textbooks and atlases such as (1) Ross & Pawlina: Histology: A Text and Atlas; (2) Mescher: Junqueira’s Basic Histology; (3) Gartner & Hiatt: Color Atlas of Histology; (4) Cui: Atlas of Histology with Functional and Clinical Correlations; and (5) Eroschenko: diFiore’s Atlas of Histology. In addition to being a learning companion to these excellent textbooks, our illustrated questions and answers will serve as a stand-alone resource for self-assessment and board review. The questions are prepared at a level appropriate for all preclinical basic science students. They provide a roadmap for students learning histology and pathology and preparing for the United States Medical Licensing Examination (USMLE). Students in the allied health sciences (e.g., nursing and phy- sician assistant programs) will also find considerable didactic value in clinical vignette-style questions. Clinical vignette-style questions strengthen problem-solving skills and simulate the practice of medicine. This book is also intended for undergraduate students of cellular and developmental biology. Histology is the science of biological design at the cellular and tissue level of complexity. Mastery of this body of knowledge enables students to evaluate normal tissue differentiation and provides a foundation for basic research in cell biology. The questions and answers in this book address core concepts of form and function. They are suitable for all students of biology and do not assume prior training in pathology or medicine. From this perspective, the clinical vignettes provide a human context for basic science. Key features of this illustrated histology text include • Multiple choice questions that follow the USMLE template. Each vignette is followed by a question stem that addresses a key concept in cell biology/histology. • Answer choices appear homogeneous and are listed alphabetically to avoid unintended cueing. • Explanations are linked to the clinical vignettes and address key concepts. Incorrect answers are explained in context. • Over 480 full-color images illustrate important histologic features and highlight the complexity of life. • Tissues with similar histological features are compared, providing a challenging comprehensive review. • Side-by-side comparisons of normal tissue and histopathology provide a bridge to clinical problem solving and diagnostic pathology. We hope that this illustrated review of histology will help students appreciate the complexity and beauty of human form and function. We also hope that our selection of images and questions will help future generations of health professionals think critically and make informed decisions. One way that students can practice critical thinking is to formulate their own questions concerning tissue organization and mechanisms of disease. We are mindful of the words of James Thurber, who penned, “It is better to know some of the questions than all of the answers.” We wish our students success in their life-long learning adventure. Have fun with your basic science training and never stop learning. Guiyun Zhang Bruce A. Fenderson vii 0002076913.INDD 7 3/25/2014 2:14:27 PM 0002076913.INDD 8 3/25/2014 2:14:27 PM