LIPOSOMES FOR FUNCTIONAL FOODS AND NUTRACEUTICALS From Research to Application LIPOSOMES FOR FUNCTIONAL FOODS AND NUTRACEUTICALS From Research to Application Edited by Sreerag Gopi, PhD Preetha Balakrishnan, PhD First edition published 2022 Apple Academic Press Inc. CRC Press 1265 Goldenrod Circle, NE, 6000 Broken Sound Parkway NW, Palm Bay, FL 32905 USA Suite 300, Boca Raton, FL 33487-2742 USA 4164 Lakeshore Road, Burlington, 2 Park Square, Milton Park, ON, L7L 1A4 Canada Abingdon, Oxon, OX14 4RN UK © 2022 Apple Academic Press, Inc. Apple Academic Press exclusively co-publishes with CRC Press, an imprint of Taylor & Francis Group, LLC Reasonable efforts have been made to publish reliable data and information, but the authors, editors, and publisher cannot assume responsibility for the validity of all materials or the consequences of their use. 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For works that are not available on CCC please contact [email protected] Trademark notice: Product or corporate names may be trademarks or registered trademarks and are used only for identification and explanation without intent to infringe. Library and Archives Canada Cataloguing in Publication Title: Liposomes for functional foods and nutraceuticals : from research to application / edited by Sreerag Gopi, PhD, Preetha Balakrishnan, PhD. Names: Gopi, Sreerag, editor. | Balakrishnan, Preetha, editor. Description: First edition. | Includes bibliographical references and index. Identifiers: Canadiana (print) 20210381736 | Canadiana (ebook) 20210381795 | ISBN 9781774637548 (hardcover) | ISBN 9781774637555 (softcover) | ISBN 9781003277361 (ebook) Subjects: LCSH: Liposomes. | LCSH: Functional foods. Classification: LCC QH602 .L59 2022 | DDC 571.6/55—dc23 Library of Congress Cataloging‑in‑Publication Data CIP data on file with US Library of C o ngress ISBN: 978-1-77463-754-8 (hbk) ISBN: 978-1-77463-755-5 (pbk) ISBN: 978-1-00327-736-1 (ebk) About the Editors Sreerag Gopi, PhD Chief Scientific Officer, ADSO Naturals, India; Vice President, CureSupport, The Netherlands, Mobile: +91-8594023331, E-mail: [email protected] Sreerag Gopi, PhD, is a Chief Scientific Officer at ADSO Naturals, India, and Vice President at CureSup port, The Netherlands. He graduated with a degree in Chemistry from Calicut University, Kerala, India, and an advanced degree from Madras Christian College, Chennai, India. He is a recipient of a prestigious Erasmus Mundus Fellowship from the European Union during his PhD period. He is a materials chemist and nanomaterials scientist and has expertise in nanomaterial synthesis, characterization, biocomposites for natural products, and biomedical and water purification experiments. He has published over 20 peer-reviewed international papers and several book chapters and has book projects in the works with several publishers, including the Royal Society of Chemistry, Springer, and Wiley. He was selected as an Associate Member of the Royal Society of Chemistry in 2018, and he is a chartered member of the Royal Australian Chemical Institute. vi About the Editors Preetha Balakrishnan, PhD Principal Scientist, QA/QC, ADSO Naturals, India, and CureSupport, The Netherlands, Mobile: +91-7025921175, E-mails: [email protected]; [email protected]; [email protected] Preetha Balakrishnan, PhD, is the Principal Scientist, QA/QC at ADSO Naturals, India, and at CureSupport, The Netherlands. She graduated in Chemistry from Calicut University, Kerala, India, and earned her postgraduate degree at Mahatma Gandhi University, Kerala, with a gold medal and first rank. She is a recipient of the prestigious INSPIRE Fellowship from the Government of India. She was a postdoc toral researcher in the research group of Professor Sabu Thomas, Vice Chancellor, a renowned scientist in this area who has sustained interna tional acclaim for his work in polymer science and engineering, polymer nanocomposites, elastomers, polymer blends, interpenetrating polymer networks, polymer membranes, green composites and nanocomposites, nanomedicine, and green nanotechnology. She completed her PhD in Chemistry at Mahatma Gandhi University under Dr. Thomas’s guidance. She has visited many foreign universities as a part of her research activities and has published over 15 research articles and over 20 book chapters. She has edited 10 books with leading publishers, including Elsevier, Springer, Wiley, and the Royal Society of Chemistry. Dr. Balakrishnan has received a number of national and international presentation awards. She also worked as a guest lecturer in chemistry at the Department of Chemistry, Morning Star Home Science College, Angamaly, Kerala, India. Contents Contributors ........................................................................................................ix Abbreviations ................................................................................................... xiii Preface .............................................................................................................xvii 1. Liposomes: Methods and Protocols ..........................................................1 Thais Aragão Horoiwa, Valker Feitosa, and Hossein Adelnia 2. Liposome Preparation and Related Technique ..................................... 41 Ameeduzzafar Zafar, Nabil K. Alruwaili, Khalid Saad Alharbi, Nasser Hadal Alotaibi, and Mohammed Jafar 3. Liposomes as Drug Carriers ................................................................... 65 Mohamad Taleuzzaman, Farheen Fatima Qizilbash, Chandra Kala, Dipak Kumar Gupta, and Sadaf Jamal Gilani 4. Microencapsulation Liposomal Technologies in Bioactive Functional Foods and Nutraceuticals .................................... 85 Shuqin Xia, Chen Tan, Xingwei Wang, and Chunli Fan 5. Liposomal Carrier Systems ................................................................... 145 Syed Sarim Imam, Sultan Alshehri, Mohammed Jafar, Mohammed Asadullah Jahangir, Mohamad Taleuzzaman, and Ameeduzzafar Zafar 6. Formulation and Challenges in Liposomal Technology in Functional Food and Nutraceuticals .................................................... 165 Mohammed Asadullah Jahangir, Abdul Muheem, M. Akiful Haque, Chettupalli Ananda, Mohamad Taleuzzaman, and Chandra Kala 7. Liposomes as Robust Anti‑Tubercular and Anticancer Drugs Delivery System .......................................................................... 197 Ameer Khusro and Chirom Aarti 8. Liposomal Supplements......................................................................... 235 Niloufar Maghsoudnia, Maryam Edalat, Mohammad Hajimolaali, Sheida Iranpour, Parsa Khoshkhat, Parinaz Inanloo, Reza Baradaran Eftekhari, Sophia G. Antimisiaris, and Farid Abedin Dorkoosh Index ................................................................................................................. 279 Contributors Chirom Aarti Research Department of Plant Biology and Biotechnology, Loyola College, Chennai – 600034, Tamil Nadu, India Hossein Adelnia Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, QLD, Australia; School of Pharmacy, University of Queensland, Woolloongabba, QLD, Australia Khalid Saad Alharbi Department of Pharmacology, College of Pharmacy Jouf University, Aljouf, KSA Nasser Hadal Alotaibi Department of Clinical Pharmacy, College of Pharmacy Jouf University, Aljouf, KSA Nabil K. Alruwaili Department of Pharmaceutics, College of Pharmacy, Jouf University, Aljouf, KSA Sultan Alshehri Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh – 11451, Saudi Arabia Chettupalli Ananda Department of Pharmaceutics, Center for Nanomedicine, School of Pharmacy, Anurag University, Venkatapur, Ghatkesar, Hyderabad – 500088, Telangana, India Sophia G. Antimisiaris Laboratory of Pharmaceutical Technology, Dept. of Pharmacy, School of Health Sciences, University of Patras, Rio 26504, Greece Foundation for Research and Technology Hellas, Institute of Chemical Engineering Sciences, FORTH/ICE-HT, Rio 26504, Greece Preetha Balakrishnan ADSO Naturals, India, and CureSupport, The Netherlands, Mobile: +91-7025921175, E-mails: [email protected]; [email protected]; [email protected] Farid Abedin Dorkoosh Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran; Postal address: No. 1462, Kargar Ave, Tehran – 1439804448, Iran, Telephone/Fax: +982188009440, E-mail: [email protected] Maryam Edalat Pharmaceutical Sciences Research Center, Islamic Azad University, Tehran Medical Sciences University (IAUTMU), Tehran, Iran Reza Baradaran Eftekhari Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran