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407 Pages·1997·11.234 MB·English
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Lactoferrin Experimental Biology and Medicine 28. Lactoferrin: Interactions and Biological 14. Methods in Protein Sequence Analysis • Functions, edited by T. William 198(, edited by Kenneth A. Walsh, Hutchens and Bo LOnnerdal, 1997 1987 27. Nutrients in Cancer Prevention and 13. Regulation of Immune Gene Expression, Treatment, edited by Kedar N. edited by Marc Feldmann and An· Prasad, Leonida Santamaria, and R. drew McMichael, 1986 Michael Williams, 1995 12. Biological Methylation and Drug Design: 26. The Resistance Arteries: Integration of Experimental and Clinical Roles of S- the Regulatory Pathways, edited by Adenosylmethionine, edited by Ronald William Halpern, John Bevan, Jo- T. Borchardt, Cyrus R. Creveling, seph Brayden, Harriet Dustan, Mark and Per Magne Ueland, 1986 Nelson, and George Osol, 1994 11. Retroviruses and Human Pathology, 25. Neoplastic Transformation in Human edited by Robert C. Gallo, Domin- Cell Culture: Mechanisms of ique Stehelin, and Oliviero E. Carcinogenesis, edited by Johng S. Vamier, 1986 Rhim and Anatoly Dritschilo, 1991 10. Vitamins and Cancer, edited by Frank 24. Epstein-Barr Virus and Human Disease Meyskens, Jr., 1986 • 1990, edited by D. V. Ablashi, A. T. 9. Human T Cell Clones: A New Approach Huang,J. S. Pagano, G. R. Pearson, to Immune Regulation, edited by Marc and C. S. Yang, 1991 Feldmann, Jonathan R. Lamb, and 23. Nutrients and Cancer Prevention, ed- James N. Woody, 1985 ited by Kedar N. Prasad and Frank L. 8. Immune Regulation, edited by Marc Meyskens, Jr., 1990 Feldmann and N. A. Mitchison, 22. Hepatic Encephalopathy, edited by 1985 Roger F. Butterworth and Gilles 7. Directed Drug Delivery, edited by Pomier Layrargues, 1989 Ronald T. Borchardt, Arnold Repta, 21. Molecular Mechanisms of Alcohol, and Valentino Stella, 1985 edited by Grace Y. Sun, P. Kevin 6. Inositol and Phosphoinositides: Metabo- Rudeen, W. Gibson Wood, Yau Huei lism and Regulation, edited by John E. Wei, and Albert Y. Sun, 1989 Bleasdale,Joseph Eichberg, and 20. Epstein Barr Virus and Human Disease George Hauser, 1985 • 1988, edited by D. V. Ablashi, A. 5. Growth, Cancer, and the Cell Cycle, Faggioni, G. R. F. Krueger,J. S. edited by Philip Skehan and Susan J. Pagano, and G. R. Pearson, 1989 Friedman, 1984 19. Macromolecular Biorecognition, edited by 4. IR Genes: Past, Present, and Future, Irwin Chaiken, Emilia Chiancone, edited by Carl W. Pierce, Susan E. Angelo Fontana, and Paolo Neri, 1988 Cullen, Judith A. Kapp, Benjamin D. 18. Molecular Basis of Lymphokine Action, Schwartz, and Donald C. Shreffler, edited by David R. Webb, Carl W. 1983 Pierce, and Stanley Cohen, 1987 3. Methods in Protein Sequence Analysis, 17. Tumor Cell Differentiation, edited by edited by Marshall Elzinga, 1982 Jarle Aarbakke, 1987 2. Inflammatory Diseases and Copper, 16. Biology of Copper Complexes, edited by edited by John R. J. Sorenson, JohnR.J. Sorensen, 1987 1982 15. Epstein-Barr Virus and Human Disease, 1. Membrane Fluidity: Biophysical Tech- edited by P. H. Levine, D. V. niques and Cellular Regulation, edited Ablashi, M. Nonoyama, G. R. by Morris Kates and Arnis Kuksis, Pearson, and R. Glaser, 1987 1980 Lactoferrin Interactions and Biological Functions Edited by T. William Hutchens Department ofF ood Science and Technology, University of California, Davis, CA and Bo Lonnerdal Department of Nutrition, University of California, Davis, CA *- Humana Press • Totowa, New Jersey © 1997 Humana Press Inc. Sotlcover reprint ofthe hardcover 1s t edition 1997 999 Riverview Drive, Suite 208 Totowa, New Jersey 07512 All rights reserved. No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilm ing, recording, or otherwise without written permission from the Publisher. All authored papers, comments, opinions, conclusions, or recommendations are those ofthe author(s), and do not necessarily reflect the views of the publisher. Cover illustration: Figure 4 in "Difference in Binding and Fate of Lactotransferrin in Jurkat Human Lymphoblastic T-Cells and in T-47D Human Breast Cancer Cells," by Bao Yuan Bi, Elisabeth Elass, Dominique Legrand, Florence Deplace, Genevieve Spik, and Joel Mazurier. Cover design by Patricia F. Cleary. This publication is printed on acid-free paper. 0 ANSI Z39.48-1984 (American National Standards Institute) Permanence of Paper for Printed Library Materials. For additional copies, pricing for bulk purchases, and/ or information about other Humana titles, contact Humana atthe above address or at any of the following numbers: Tel.: 201-256- 1699; Fax: 201-256-8341; E-mail: [email protected], or visit our Website: http:/ / humanapress.com Photocopy Authorization Policy: Authorization to photocopy items for internal or personal use, or the internal or personal use of specific clients, is granted by Humana Press Inc., provided that the base fee of US $8.00 per copy, plus US $00.25 per page, is paid directly to the Copyright Clearance Center at 222 Rosewood Drive, Danvers, MA 01923. For those organizations that have been granted a photocopy license from the CCc, a separate system of payment has been arranged and is acceptable to Humana Press Inc. The fee code for users of the Transactional Reporting Service is: [O-89603-366-X/97 $8.00 + $00.25]. Library of Congress Cataloging in Publication Data Lactoferrin: interactions and biological function/edited by T. William Hutchens and Bo Lonnerdal. p. cm.-(Contemporary neuroscience) Based on the Second International Symposium on Lactoferrin Structure and Function, held in Honolulu, Hawaii, 1995. Includes index. ISBN-13: 978-1-4612-8439-0 e-1SBN-13: 978-1-4612-3956-7 DOl: 10.1007/978-1-4612-3956-7 1. Lactoferrins-Congresses. I. Hutchens, T. William. II. Lonnerdal, Bo, 1938- III. International Symposium on Lactoferrin Structure and Function (2nd: 1995: Honolulu, Hawaii). IV. Series. [DNLM: 1. Lactoferrin-physiology-congresses. QU 55 L1505 1997] QP552.L345L326 1997 572'.6-dc21 DNLM/DLC for Library of Congress 96-52990 CIP Preface The number of investigators focusing their attention on lactoferrin has increased dramatically in recent years. Lactoferrin is a protein with more than one known structure and a number of proposed biological functions, including several with important regulatory consequences. In many ways it has been an easy pro tein to investigate; however, there have been difficulties under standing specific structure / function relationships, particularly as it functions in vivo. Research funding dedicated to this protein has previously been limited, but is now increasing. As lactoferrin begins to emerge formally as a protein of significance to the medi cal profession and industry, it is more important than ever to coor dinate and integrate research efforts whenever possible and to share the results of these efforts within the expanding array of medical and scientific diSciplines involved. It was our intention to provide a forum to summarize and disseminate the most recent advances in this field. Included in Lactoferrin: Interactions and Biological Functions are selected presentations representing the many disciplines involved in defining lactoferrin function in terms of its known structural features, including its carbohydrate side-chains, receptor binding sites, its capacity to bind different metal ions, and other newly discovered bioactive domains. Several of the possible physiologi cal functions of lactoferrin are described and summarized in detail, including the role of laetoferrin in bacterial killing, its in volvement in cell growth and proliferation, in the modulation of immune function, and in iron absorption. The biological functions of lactoferrin in several different cell types and tissues are empha sized. New techniques for the investigation of lactoferrin process ing and distribution in vivo are also introduced. New knowledge regarding the molecular biology of lactoferrin, including regula- v vi Preface tion of gene expression, are addressed, as are commercially viable large-scale production techniques and important new industrial applications. Lactaferrin: Interactions and Biological Functions should provide the interested reader a thorough insight into our present know ledge of lactoferrin. Particular attention was given to lactoferrin functions in the regulation of normal and diseased states. Acknowledgments The organizers and participants would like to thank the following sponsors of the Second International Symposium on Lactoferrin: Interactions and Biological Functions: Agennix, Inc., DMV International, Milupa AG, Morinaga Milk Industry Co., Wei-Chuan Foods, and Wyeth-Ayerst Research. T. William Hutchens Bo Lonnerdal Contents Preface .......................................................................................................... v List of Contributors .................................................................................. xi PART I: LACTOFERRIN STRUCTURE AND FUNCTION ............•.....•••....... 1 1. Lactoferrin Structure-Function Relationships: An Overview Jeremy H. Brock ................................................................................... 3 2. Altered Domain Closure and Iron Binding in Lactoferrin Mutants H. Rick Faber, Bryan F. Anderson, Heather M. Baker, Tony Bland, Catherine L. Day, Hale Nicholson, Steven Shewry, John W. Tweedie, and Edward N. Baker ....... 25 3. Affinity Mass Spectrometry: Probes with Surfaces Enhanced for Affinity Capture (SEA C) of Lactoferrin Tai-Tung Yip and T. William Hutchens ......................................... 39 PART II: LACTOFERRIN G ENE EXPRESSION ........................................ 59 4. Variants and Biotechnological Use of the Bovine Lactoferrin-Encoding Gene Hans-Martin Seyfert, Uta Klu{3mann, Uta Maria Steinhoff, lens Vanselow, Dirk Koczan, and Gerd Hobom ...................... 61 5. Posttranscriptional Regulation of Bovine and Human Lactoferrin: Species Differences and Influence of mRNA Regions Floyd L. Schanbacher, Surapon Pattanajitvilai, and Margaret C. Neville .............................................................. 81 6. Mutagenesis of Human Lactoferrin and Expression in Baby Hamster Kidney Cells John W. Tweedie, Edward N. Baker, Catherine L. Day, Bhavwanti Sheth, and H. Hale Nicholson ............................... 97 vzz viii Contents 7. Structural Determination of Two N-Linked Glycans Isolated from Recombinant Human Lactoferrin Expressed in BHK Cells Dominique Legrand, Valerie Salmon, Bernadette Coddeville, Monique Benai'ssa, Yves Plancke, and Genevieve Spik ........ 111 8. Distribution of the Iron-Binding Protein Lactoferrin in the Pathological L~sions of Neurodegenerative Diseases Beatrice Leveugle, Genevieve Spik, Daniel P. Perl, Constantin Bouras, Howard M. Fillit, and Patrick R. Hot ..................................................................... 119 9. Lactoferrin Almost Absent from Lactating Rat Mammary Gland Is Replaced by Transferrin Annick Pierce, Hector Escriva, Bernadette Coddeville, Monique Benai'ssa, Didier Leger, Genevieve Spik, and Mercedes Pamblanco .......................................................... 125 10. Estrogen Regulation of Human Lactoferrin Gene Activity: Transcriptional Synergism Between Estrogen Receptorand Related Orphan Receptor Christina T. Teng and Nengyu Yang ............................................. 135 11. Expression and Functional Analysis of Recombinant Human Lactoferrin Pauline P. Ward, Christopher S. Piddington, Grainne Cunningham, Xiaodong Zhou, Roger D. Wyatt, and Orla M. Conneely ................................. 155 12. Structural and Functional Flexibility of Lactoferrin Edward N. Baker, Bryan F. Anderson, Heather M. Baker, Rick Faber, Clyde A. Smith, and Andrew J. Sutherland-Smith ............................................. 177 13. Difference in Binding and Fate of Lactotransferrin in Jurkat Human Lymphoblastic T-Cells and in T-47D Human Breast Cancer Cells Bao Yuan Bi, Elisabeth Elass, Dominique Legrand, Florence Deplace, Genevieve Spik, and Joel Mazurier ......... 193 Contents zx 14. The Impact of Phagocyte-Lactoferrin Interactions on Inflammation Bradley E. Britigan, Troy S. Lewis, Oyebode Olakanmi, Michael L. McCormick, and Rachel A. Miller ...................... 211 15. Regulation of Lymphocyte Proliferation by Lactoferrin Jeremy H. Brock and Abdelhakim Djeha .................................... 233 16. Recombinant Human Lactoferrin and Its Variants: Receptor Binding in Human Intestinal Brush-Border Membranes Suhasini lyer, Bo Lonnerdal, Catharine Day, Edward N. Baker, John Tweedie, Tai-Tung Yip, and T. William Hutchens .......................................................... 245 PART III: FUNCTIONS RELATED TO LACTOFERRIN INTERACTIONS WITH PROKARYOTIC AND EUKARYOTIC CELLS .......................... 257 17. Influence of Lactoferrin on Host-Microbe Interactions Satyanarayan Naidu and Roland R. Arnold ............................. 259 18. Bacterial Lactoferrin Receptors in the Neisseriaceae Robert A. Bonnah, Rong-hua Yu, and Anthony B. Schryvers ......................................................... 277 19. Bacteriostatic Effects of Orally Administered Bovine Lactoferrin on Intestinal Bacteria in the Gut of Mice Fed Bovine Milk Susumu Teraguchi, Kouichirou Shin, Kazuhiro Ozawa, Satoko Nakamura, Yasuo Fukuwatari, Seiichi Shimamura, and Mamoru Tomita .............................. 303 20. Functional Significance of the Binding of Lactoferrin to DNA Philip Furmanski, Jianglin He, Li Ying, Joann Bezault, Ramesh Bhimani, and Kin/an Ho ............................................ 313 21. Specific Binding of Ferrilactoferrin and Ferritransferrin in the Protozoan Leishmania chagasi Michael L. McCormick, Mary E. Wilson, Troy S. Lewis, Robert W. Vorhies, and Bradley E. Britigan .......................... 333 x Contents PART IV: LACTOFERRIN METABOLISM ................................................. 343 22. Observations on the Metabolism and Cellular Interactions of Lactoferrin Erwin Regoeczi ................................................................................ 345 23. Lactoferrin as a Possible Transcriptional Regulator: Downmodulation of the Granulocyte-Macrophage Colony-Stimulating Factor Promoter Silvana Penco, Sandra Pastorino, Claudia Gramigni, Giovanna Bianchi-Scarra, Roberto Ravazzolo, and Cecilia Garre ........................................................................ 359 PART V: THE USE OF LACTOFERRIN AS A FOOD ADDITIVE ............ 375 24. Modification of Infant Formula: The Case of Lactoferrin Eric L. Lien ....................................................................................... 377 25. Lactoferrin in Infant Formulas: How and Why? Gunther Sawatzki ........................................................................... 389 Index ......................................................................................................... 399

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