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Journal of Neuropathology and Experimental Neurology 1997: Vol 56 Table of Contents PDF

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Preview Journal of Neuropathology and Experimental Neurology 1997: Vol 56 Table of Contents

Contents of Volume LVI NUMBER 1, JANUARY, 1997 Methylazoxymethanol Acetate-induced Apoptosis in the External Granule Cell Layer of the Developing Cerebel- lum of the Rat is Associated with Strong c-Jun Expression and Formation of High Molecular Weight c-Jun Complexes. IsiDRE FERRER, ESTHER POZAS, MARTA MARTI, ROSA BLANCO, AND ANNA M. PLANAS. Barcelona, Spain Immunocytochemical Characterization of the Expression of Inducible and Constitutive Isoforms of Nitric Oxide Synthase in Demyelinating Multiple Sclerosis Lesions. Cor.ine J. A.D E Groot, PHD, SiGrip R. RuuLs, PHD, JAN WILLEM M. THEEUWES, BSc, CHRISTINE D. DukstrRA, MD, PHD, AND PAUL VAN DER VALK, MD, PHD. Amsterdam, The Netherlands .................00.0000000+ soloist 9a 9skeoa uspee al voilarstposansp came mina eee nese afaieioad oni atiay ada Altered Calcium Homeostasis and Ultrastructure in Motoneurons of Mice Caused by Passively Transferred Anti- motoneuronal IgG. Jozsrer 1. ENGELHARDT, MD, PHD, LAsz_o SikLos, PHD, AND STANLEY H. APPEL, MD. Szeged, nr AUN IIE IND oo ss x sisisicic vane w oarnascdicmmeb owed etre ea mamas eka a SRS Oca ea rialenaulane xian isteate Rotauas puneaN a meemon ot Developmental Regulation of Presenilin mRNA Expression Parallels Notch Expression. OKSANA BEREZOVSKA, PHD, MENGQ! XIA, MD, PHD, KEITH PAGE, PHD, WILMA Wasco, PHD, RUDOLPH E. TANZI, PHD, AND BRADLEY T. HYMAN, MD, PHD. Boston, Massachusetts Exercise Induces Myonuclear Ubiquitination and Apoptosis in Dystrophin-deficient Muscle of Mice. Marco SAn- DRI, MARZENA PODHORSKA-OKOLOW, VANNA GEROMEL, CORRADO RIZZI, PAOLA ARSLAN, CLAUDIO FRANCESCHI, AND UGo CARRARO. Wroclaw, Poland and Padova and Modena, Italy Increased Apoptosis of T Lymphocytes and Macrophages in the Central and Peripheral Nervous Systems of Lewis Rats with Experimental Autoimmune Encephalomyelitis Treated with Dexamethasone. Kim B. NGUYEN, Pa- MELA A. MCCOMBE, AND MICHAEL P. PENDER. Brisbane, Australia Distribution, Levels, and Activity of Glycogen Synthase Kinase-3 in the Alzheimer Disease Brain. JiN-JiNG PEI, MD, MS, TosHinisA TANAKA, MD, PHD, YUNN-CHYN TUNG, MS, EVA BRAAK, PHD, KHALID IQBAL, PHD, AND INGE GRUNDKE-IQBAL, PHD. Staten Island, New York and Frankfurt, Germany Paired Helical Filaments Are Twisted Ribbons Composed of Two Parallel and Aligned Components: Image Re- construction and Modeling of Filament Structure Using Atomic Force Microscopy. MICHAEL S. POLLANEN, PHD, PETER MARKIEWICZ, MSc, AND M. CYNTHIA GOH, PHD. Toronto, Ontario, Canada Bax Protein Expression Is Increased in Alzheimer’s Brain: Correlations with DNA Damage, Bcl-2 Expression, and Brain Pathology. JosepH H. Su, MD, GANGMIN DENG, PHD, AND CARL W. COTMAN, PHD. Irvine, Cali- fornia Preferential Subsarcolemmal Localization of Dystrophin and B-dystroglycan mRNA in Human Skeletal Muscles. TAKAO Mitsui, MD, HisAomi KAwAI, MD, MASAYUKI SHONO, PHD, MASAKAZU KAWAJIRI, MD, MAKOTO KUNISHIGE, MD, AND SuHiRO Saito, MD. Tokushima, Japan Book Reviews Neurology in Clinical Practice. Walter Bradley, Robert Daroff, Gerald Fenichel, and David Marsden, eds. (JOHN O. FLEMING, MD) Biopsy Diagnosis of Peripheral Neuropathy. G. Midroni and J. M. Bilbao. (STEVEN A. Moore, MD, PHD) Honors The John Jay Dystel prize for outstanding achievements in Multiple Sclerosis research to Cedric S. Raine. ......... Letters to the Editor Increasing Brain Tumor Rates: Is There a Link to Aspartame? W. GARY FLAMM, PHD, FACT Adalbert Koestner, DVM, PhD NUMBER 2, FEBRUARY, 1997 The Pathobiology of the Oligodendrocyte. SAMUEL K. LUupwin, MBBCH, FRCPC. Kingston, Ontario, Canada Immunocytochemical Co-localization of the Proteasome in Ubiquitinated Structures in Neurodegenerative Diseases and the Elderly. Kunio li, MD, PHD, Hiperumi Iro, MD, Kevi TANAKA, MD, AND ASAO HIRANO, MD. Tokushima and Osaka, Japan and New York, New York The Subthalamic Nucleus in Parkinson’s Disease and Progressive Supranuclear Palsy. CrAic D. HARDMAN, BSc (Hons), GLENDA M. HALLIDAY, PHD, DEBORAH A. MCRITCHIE, PHD, AND JOHN G. L. Morris, DM. Westmead and Randwick, Australia Microglial Cell Activation in Aging and Alzheimer Disease: Partial Linkage with Neurofibrillary Tangle Burden in the Hippocampus. Pier Luici DiP4TRE, MD AND BENJAMIN B. GELMAN, MD, PHD. Galveston, Texas Apoptosis-related Proteins in Skeletal Muscle Fibers of Spinal Muscular Atrophy. Dominiqur S. TEws, MD AND Hans H. GoreBeL, MD. Mainz, Germany Prevalence and Disease Associations of Argyrophilic Grains of Braak. P. MARTINEZ-LAGE, MD, PHD AND D. G. Munoz, FRCP(C). London, Ontario, Canada The Effects of Additional Pathology on the Cognitive Deficit in Alzheimer Disease. ZSUZSANNA NAGy, MD, DPHIL, MArGareT M. Esiri, DM, FRCPaTH, Kim A. Jopst, DM, MRCP, JAMes H. Morris, MA, DPHIL, MRCPATH, ELIz- ABETH M.-F KiNG, BA, RGN, BRENDAN McDONALD, BSc, MB, CHB, MRCPATH, CATHARINE JOACHIM, MD, SUZANNE LITCHFIELD, BSc, LIN BARNETSON, MA, AND A. DAvip SMITH, DPHIL, Dsc. Oxford, UK Light and Electron Microscopic Analysis of the Central and Peripheral Nervous Systems of Acid Sphingomyelinase- deficient Mice Resulting from Gene Targeting. THOMAS ALFRED KUEMMEL, ROLAND SCHROEDER, AND WILHELM STOFFEL. Cologne, Germany Amplification and Overexpression of MDM2 in Primary (de novo) Glioblastomas. WojCIECH BIERNAT, MD, PAUL KLEIHUES, MD, YASUHIRO YONEKAWA, MD, AND HIROKO OHGAKI, PHD. Lyon, France and Zurich, Switzerland Distinct Neurodevelopmental Patterns of Bcl-2 and Bcl-x Expression Are Altered in Glioneuronal Hamartias of the Human Temporal Lobe. ANTHONY T. YACHNIS, MD, SUZANNE Z. POWELL, MD, Juby J. OLMSTED, MS, AND THOMAS A. EsKIN, MD. Gainesville, Florida Human Fascia Dentata Anatomy and Hippocampal Neuron Densities Differ Depending on the Epileptic Syndrome and Age at First Seizure. GARY W. MATHERN, MD, PAULA A. KUHLMAN, BS, DELIA MENDOZA, BS, AND JAMEs K. Pretorius, MS. Los Angeles, California Letters to the Editor The Pathogenesis of Alzheimer Disease: An Alternative to the Amyloid Hypothesis (1996;55:1023-—25). WILLIAM I. ROSENBLUM, MD ANDREW J. LARNER a ae OD oc bs wesctrewrevnonedaeuo ncumimaadsnnareevionesecanandinmbasendatavssapeaseeadeotes a Mark A. SMITH, PHD AND GEORGE PERRY, PHD NUMBER 3, MARCH, 1997 Developmental Neuropathology and Impact of Perinatal Brain Damage. Il: White Matter Lesions of the Neocortex. MIGUEL MARIN-PADILLA, MD. Hanover, New Hampshire Expression of the Homeobox-containing Genes EN/ and EN2 in Human Fetal Midgestational Medulla and Cere- bellum. Natasa Zec, MD, PHD, Davip H. RowitcH, MD, PHD, Mark J. Bitcoop, BA, AND HANNAH C. KINNEY, MD. Boston and Cambridge, Massachusetts Action Potential-generating Cells in Human Glioblastomas. CHARALAMPOS LABRAKAKIS, STEPHAN PATT, MD, PATRICK WEyDT, JORGE CERVOS-NAVARRO, MD, PHD, REINHARD MEYER, MD, AND HELMUT KETTENMANN, PHD. Berlin and Jena, Germany No Evidence for Axonal Atrophy in Human Diabetic Polyneuropathy. JANEAN K. ENGELSTAD, HT, JENNY L. Davies, BA, CATERINA GIANNINI, MD, PETER C. O’ BrRIEN, PHD, PETER J. Dyck, MD. Rochester, Minnesota Accumulation of Alzheimer Amyloid-8 Peptide in Cultured Myocytes is Enhanced by Serum and Reduced by Cerebrospinal Fluid. BoZENA MAZUR-KOLECKA, JANUSZ FRACKOWIAK, RICHARD T. CARROLL, AND HENRYK M. WIs- NIEWSKI. Staten Island, New York, Crakow, Poland, and Ann Arbor, Michigan Association of Vascular Amyloid 6 and Cells of the Mononuclear Phagocyte System in Hereditary Cerebral Hemorrhage with Amyloidosis (Dutch) and Alzheimer Disease. Marion L. C. MAAT-SCHIEMAN, SJOERD G. VAN DUINEN, ANNEMIEKE J. M. ROZEMULLER, JoostT HAAN, AND RAYMUND A. C. Roos. Leiden and Leiderdorp, Am- sterdam Glial-Neuronal Interactions in Alzheimer Disease: Progressive Association of IL-la*+ Microglia and S100B* As- trocytes with Neurofibrillary Tangle Stages. JIN G. SHENG, MD, RoBert E. MrAk, MD, PHD, AND W. Sue T. GRIFFIN, PHD. Little Rock, Arkansas and Shanghai, China Cyclin and Cyclin-Dependent Kinase Expression in Human Astrocytoma Cell Lines. PETER B. Dirks, SHERRI LYNN HUBBARD, MASAJI MURAKAMI, AND JAMES T. RUTKA. Toronto, Ontario, Canada Role of Protein Kinase C in Microglia-induced Neurotoxicity in Mesencephalic Cultures. MICHAEL K. MCMILLIAN, PHD, Petri J. VAINIjOo, MD, AND RaAImMo K. TUOMINEN, MD, PHD. Helsinki, Finland Distinct Pathological Features of the Gallyas- and Tau-positive Glia in the Parkinsonism-Dementia Complex and Amyotrophic Lateral Sclerosis of Guam. Kiyomitsu GYANAGI, MD, TAKAO MakiFucHi, MD, TAKASHI OHTOH, MD, KWANG-MING CHEN, MD, D. CARLETON GAJDUSEK, MD, AND THOMAS N. CHaAsE, MD. Tokyo and Niigata, Japan and Bethesda, Maryland Book Reviews Metabolic and Degenerative Diseases of the Central Nervous System: Pathology, Biochemistry, and Genetics. Jorge Cervés-Navarro and Henry Urich. (JaMEs M. Powers, MD) Cancer in the Nervous System. V.A. Levin, ed. (RoDNEY D. McComs, MD) Free Radicals in Brain Physiology and Disorders. Lester Packer, Midori Hiramatsu, and Toshikazu Yoshikawa, eds. (LARRY W. OBERLEY) In Memoriam Richard Paul Bunge, MD (Gabriele M. Zu Rhein, MD and Ian D. Duncan, BVMS, PhD) NUMBER 4, APRIL, 1997 The Pathogenesis of Senile Plaques. DENNis W. Dickson, MD. Bronx, New York Cerebellar Cortex Delayed Maturation in Sudden Infant Death Syndrome. FELIx EFC ruz-SANCHEZ, JOAQUIN LUCENA, CarLos Ascaso, EDUARDO TOLOSA, LLORENG QUINTO, AND Marco L. Rossi. Barcelona, Spain and Liverpool, Impact Acceleration Injury in the Rat: Evidence for Focal Axolemmal Change and Related Neurofilament Sidearm Alteration. J. T. PovLisHock, PHD, A. MARMAROU, PHD, T. McINTosH, PHD, J. Q. TROJANOWSKI, MD, PHD, AND J. Morot, MD. Philadelphia, Pennsylvania, and Richmond, Virginia Neurodegeneration of Somatostatin-immunoreactive Neurons in HIV Encephalitis. Laura Fox, BS, MicHAgL AL- FORD, BA, Cris ACHIM, MD, PHD, MARGARET MALLOory, BS, AND ELIEZER MASLIAH, MD. San Diego and La Joila, California and Pittsburgh, Pennsylvania Variant Late Infantile Neuronal Ceroid-lipofuscinosis: Pathology and Biochemistry. J. TyyNELA, J. SUOPANKI, P. SANTAVUORI, M. BAUMANN, AND M. HALTIA. Helsinki, Finland Astrocyte-Apolipoprotein E Associations in Senile Plaques in Alzheimer Disease and Vascular Lesions: A Regional Immunohistochemical Study. Y ANPING SHAO, PHD, MARLA GEARING, PHD, AND SUZANNE S. MIRRA, MD. Atlanta and Decatur, Georgia Immunohistochemical Detection of Schwannomin and Neurofibromin in Vestibular Schwannomas, Ependymomas and Meningiomas. DUONG P. HUYNH, VICTOR MAUTNER, MICHAEL E. BASER, D. STAVROU, AND STEFAN-M. PuLst. Hamburg, Germany and Los Angeles, California Quantitative Chromatin Pattern Description in Feulgen-stained Nuclei as a Diagnostic Tool to Characterize the Oligodendroglial and Astroglial Components in Mixed Oligo-astrocytomas. CHRISTINE DECAESTECKER, PHD, M. BEATRIZ S. Lopes, MD, LAURENCE GORDOWER, ISABELLE CAMBY, PHD, PATRICK CRAS, MD, JEAN-JACQUES MARTIN, MD, RosertT Kiss, PHD, Scott R. VANDENBERG, MD, PHD, AND ISABELLE SALMON, MD. Brussels, Belgium and Charlottesville, Virginia Clinical and Neuropathological Study of Six Patients with Spastic Paraparesis Associated with HTLV-I: An Ax- omyelinic Degeneration of the Central Nervous System. Luis M. Cartier, MD, J. GABRIEL CEA, MD, CARMEN VERGARA, FERNANDO ARAYA, MD, AND PERCY Born, MD. Santiago and Antofagasta, Chile Relationships between Regional Neuronal Loss and Neurofibrillary Changes in the Hippocampal Formation and Duration and Severity of Alzheimer Disease. MAcIEJ BoBINSKI, MD, PHD, JERZY WEGIEL, VMD, PHD, MICHAL TARNAWSKI, MD, MARGARET BoBINSKI, DDS, BARRY REISBERG, MD, Mony J. DE LEON, EDD, DouGLas C. MILLER, MD, PHD, AND HENRYK M. WISNIEWSKI, MD, PHD. New York and Staten Island, New York Motor and Sensory Specificity of Host Nerve Axons Influence Nerve Allograft Rejection. RAasiv MipHA, MD, MSc, FRCS (C), CATHERINE A. MUNRO, Msc, SUSAN E. MACKINNON, MD, FRCS (C), AND LEE C. ANG, MD, FRCP (C). St. Louis, Missouri and Toronto, Ontario, Canada Correlation of Endothelin-1 and Transforming Growth Factor B1 with Malignancy and Vascularity in Human Gliomas. JEFFREY D. STILEs, PHD, PETER T. Ostrow, MD, PHD, Lucia L. BALOos, MD, STEVEN J. GREENBERG, MD, ROBERT PLUNKETT, MD, WALTER GRAND, MD, AND REID R. HEFFNER, JR., MD. Buffalo, New York Changes of NMDA Receptor Subunit (NR1, NR2B) and Glutamate Transporter (GLT1) mRNA Expression in Huntington’s Disease—An In Situ Hybridization Study. THOMAS ARZBERGER, MD, KLAUS KRAMPFL, BSc, SUSANNE LEIMGRUBER, DMV, ADOLF WEINDL, MD, PHD. Munich, Germany Books Received Handbook of Muscle Disease. Russell J. M. Lane, ed. (MICHAEL NoEL HART, MD) Oppenheimer’s Diagnostic Neuropathology, Second edition. Margaret M. Esiri. (MICHAEL NoEL HART, MD) ... Book Reviews Amyotrophic Lateral Sclerosis: Progress and Perspectives in Basic Research and Clinical Applications. Imaharu Nakano and Asao Hirano, eds. (LARRY W. OBERLEY, PHD) Atlas of the Human Brainstem. George Paxinos and Xu-Feng Huang. (SHAHRIAR SALAMAT, MD, PHD) Protocols for Neural Cell Culture, 2nd ed. Sergey Fedoroff and Arleen Richardson, eds. (SEAN MURPHY) Letter to the Editor Pathologic Alterations in the Diabetic Neuropathies of Humans. P. J. Dyck and C. Giannini. (ANDERS A. F SIMA, MD, PHD) NUMBER 5, MAy, 1997 Transforming Growth Factor a Expression as a Response of Murine Motor Neurons to Axonal Injury and Mutation-induced Degeneration. FABRiIcE Lisovoski, MD, STEPHANE BLoT, DVM, PHD, CHANTAL LACOMBE, JEAN- PIERRE BELLIER, PATRICK A. DREYFUS, MD, PHD, AND MARIE-PIERRE JUNIER, PHD. Créteil, France Frequency of Neuropathological Abnormalities in Very Low Birth Weight Infants. JEFFREY A. GOLDEN, FLOYD H. GILLES, RAOUL RUDELLI, AND ALAN LEVITON. Boston, Massachusetts, Los Angeles, California, New York, New York, and Philadelphia, Pennsylvania Transforming Growth Factor-B1 in Polymyositis and Dermatomyositis Correlates with Fibrosis but not with Mononuclear Cell Infiltrate. PAOLO CONFALONIERI, MD, PIA BERNASCONI, PHD, FERDINANDO CoRNELIO, MD, AND RENATO MANTEGAZZA, MD. Milan, Italy Meningioangiomatosis Is Associated with Neurofibromatosis 2 but not with Somatic Alterations of the NF2 Gene. ANAT O. STEMMER-RACHAMIMOV, MD, MICHAEL A. HORGAN, MD, ANA LIA TARATUTO, MD, DAvip G. Munoz, MD, THOMAS W. SmitH, MD, MATTHEW P. Froscu, MD, PHD, AND David N. Louts, MD. Boston, Massachusetts, Portland, Oregon, Worcester, Massachusetts, Buenos Aires, Argentina, and London, Ontario, Canada Xenogeneic Adrenal Medulla Graft Rejection Rather Than Survival Leads to Increased Rat Striatal Tyrosine Hydroxylase Immunoreactivity. MARA BRESJANAC, MD, PHD, JACQUELINE SAGEN, PHD, GAIL SEIGEL, PHD, CARLOS L. PAINO, PHD, JEFFREY KORDOWER, PHD, AND DON M. GASH, PHD. Ljubljana, Slovenia Dementia with Lewy Bodies Versus Pure Alzheimer Disease: Differences in Cognition, Neuropathology, Cholin- ergic Dysfunction, and Synapse Density. WILLIAM SAMUEL, MD, PHD, MICHAEL ALFORD, C. RICHARD HOFSTETTER, PHD, AND LAWRENCE HANSEN, MD. San Diego, California Anatomic Relationships of the Human Arcuate Nucleus of the Medulla: A Dil-Labeling Study. Natasa Zec, MD, PHD, JAMEs J. FILIANO, MD, AND HANNAH C. KINNEY, MD. Boston, Massachusetts and Lebanon, New Hamp- shire Aggregation of Mutant Cu/Zn Superoxide Dismutase Proteins in a Culture Model of ALS. H. D. DurHAM, PHD, J. Roy, BSc, L. DONG, MS, AND D. A. FIGLEwicz, PHD. Montreal, Quebec, Canada and Rochester, New York The Mean AB Load in the Hippocampus Correlates with Duration and Severity of Dementia in Subgroups of Alzheimer Disease. Grace T. BARTOO, PHD, David NocHLIN, MD, DoOYONG CHANG, YONGMIN KIM, PHD, AND S. MARK Sumi, MD. Seattle, Washington Soluble TNF-a Receptors Are Constitutively Shed and Downregulate Adhesion Molecule Expression in Malignant Gliomas. THOMAS C. CHEN, MD, PHD, Davin R. Hinton, MD, BriAN D. Sippy, MD, PHD, AND FLORENCE M. HOFMAN, PHD. Los Angeles, California Atypical Central Neurocytoma. FIGEN SOYLEMEZOGLU, BERND W. SCHEITHAUER, JACQUES ESTEVE, AND PAUL KLEI- HUES. Ziirich, Switzerland, Rochester, Minnesota, and Lyon, France Binding of Malignant Lymphoid Cells to the White Matter of the Human Central Nervous System: Role of Different CD44 Isoforms, B1, B2 and B7 Integrins, and L-selectin. RitraA AHo, MD, HANNU KALIMo, MD, Marko SALMI, MD, Davip SmitH, PHD, AND SirPA JALKANEN, MD. Turku, Finland Book Review Molecular Mechanisms of Dementia. Wilma Wasco and Rudolph E. Tanzi, eds. (CHRISTINE HULETTE, MD) Abstracts—73rd Annual Meeting of the American Association of Neuropathologists, Inc. ................................. NUMBER 6, JUNE, 1997 Mast Cell Interactions with the Nervous System: Relationship to Mechanisms of Disease. KEviN C. Dines, PHD AND HENRY C. PowELL, MD, DSc, FRCPatu. La Jolla, California High IL-6 and Low IL-10 in the Central Nervous System Are Associated with Protracted Relapsing EAE in DA Rats. Asim Dias, Jie ZHU, BAO Guo XIAO, MAHA MuSTAFA, AND HANS LINK. Stockholm and Huddinge, Sweden .. Interleukin (IL)-1B and IL-1B mRNA Expression in Normal and Diseased Skeletal Muscle Assessed by Immu- nocytochemistry, Immunoblotting and Reverse Transcriptase-nested Polymerase Chain Reaction. LAURENT BELEC, MD, PHD, FRANCOIS-JEROME AUTHIER, MD, BENEDICTE CHAZAUD, PHD, CECILE PIEDOUILLET, TA, GEORGIA BARLOVATZ-MEIMON, PHD, AND ROMAIN K. GHERARDI, MD. Paris, France Multiple Sclerosis: Altered Expression of 70- and 27-kDa Heat Shock Proteins in Lesions and Myelin. DENNis A. AQuINO, PHD, ELISABETTA CAPELLO, MD, JASON WEISSTEIN, MPH, VIRGINIA SANDERS, PHD, CARMEN Lopez, BS, WALLACE W. TouRTELLOTTE, MD, PHD, CELIA E BROSNAN, PHD, CeEpric S. RAINE, PHD, DSc, AND WILLIAM T. Norton, PHD. Bronx, New York and Los Angeles, California Inhibition of Tyrosine Hydroxylase Expression within the Substantia Nigra of Mice Infected with Canine Dis- temper Virus. ANNA BENCSIK, PHD, HIDEO AKAOKA, PHD, PASCALE GIRAUDON, PHD, MARIE-FRANCOISE BELIN, PHD, AND ARLETTE BERNARD, PHD. Lyon, France The Neuropathology of HIV-infected African Children in Abidjan, Céte d’Ivoire. J. E. BELL, MD, FRCPatH, S. Lowrik, K. Korri, MD, M. HonpeE, MD, J. ANDOH, MD, K. M. DE Cock, MD, FRCP, DTH&H, Anp S. B. Lucas, FRCP, FRCPATH. Edinburgh, Scotland Mice Deficient in All Forms of Lysosomal B-hexosaminidase Show Mucopolysaccharidosis-like Pathology. KiINUKO SuzuKI, MD, KazuNori SANGO, MD, PHD, RICHARD L. PRoIA, PHD, AND CLARITA LANGAMAN, DDS. Chapel Hill, North Carolina and Bethesda, Maryland The Interaction of Growth Rates and Diffusion Coefficients in a Three-dimensional Mathematical Model of Glio- mas. PATRICIA K. BURGESS, MSc, PAUL M. KULESA, PHD, JAMES D. Murray, DSc, AND ELLSwWoRTH C. ALVoORD, i I INN oxic are sipsion asinsaienamnp eemaa ee uaa ba Deas Ue ak coum wulaniren maaan ance eae eal aae aaa ata Cues Laterality in the Histological Effects of Injections of Amyloid-B 25-35 into the Amygdala of Young Fischer Rats. EINAR M. SIGURDSSON, JOHN M. LEE, XIN -W. DONG, MATTHEW J. HEJNA, AND STANLEY A. LoRENS. Maywood, Illinois Cortical Degeneration in Progressive Supranuclear Palsy. A Comparison with Cortical-Basal Ganglionic Degen- eration. C. BERGERON, MD, M.S. POLLANEN, PHD, L. WEYER, MLT, AND A.E. LANG, MD. Toronto, Ontario, Canada Expression of NF2-encoded Merlin and Related ERM Family Proteins in the Human Central Nervous System. ANAT O. STEMMER-RACHAMIMOYV, CHARO GONZALEZ-AGOSTI, LIN XU, JENNIFER A. BURWICK, ROBERTA BEAUCHAMP, DENISE PINNEY, DAviD N. Louis, AND VAYA RAMESH. Boston, Massachusetts Detection of Malignant Cells in Cerebrospinal Fluid Using Fluorescence In Situ Hybridization. RoBert J. vAN OOSTENBRUGGE, MD, ANTON H. N. HOPMAN, PHD, MARIE H. LENDERS, PETER VAN HEERDE, MD, PHD, JAN-WILLEM ARENDS, MD, PHD, FRANS C. S. RAMAEKERS, PHD, AND ALBERT TWIJNSTRA, MD, PHD. Maastricht and Amsterdam, The Netherlands Books Received Neurotransmitter Transporters: Structure, Function, and Regulation. Maarten E. A. Reith, ed. (WILLIAM O. WHETSELL, JR., MD) The Gaba Receptor. S. J. Enna and B. G. Bowery, eds. (WILLIAM O. WHETSELL, JR., MD) NUMBER 7, JULY, 1997 Differences between the Pathogenesis of Senile Plaques and Congophilic Angiopathy in Alzheimer Disease. MARCEL M. VERBEEK, PIET EIKELENBOOM, AND ROBERT M. W. DE WAAL. Nijmegen, The Netherlands. .............2000.0e0eeeee00 In Situ Hybridization Analysis of Girk2 Expression in the Developing Central Nervous System in Normal and Weaver Mice. JiIANJUN WEI, MD, STEPHEN R. DLOUHY, PHD, SHIRLEY BAYER, PHD, ROBERTO PivA, PHD, TATYANA VERINA, YI WANG, YUE FENG, BM, BRENDA Dupree, M. E. Hopes, MD, PHD, AND BERNARDINO GHETTI. MD. Indianapolis, Indiana High-grade Human Brain Tumors Exhibit Increased Expression of Myelin Transcription Factor 1 (MYT1), a Zinc Finger DNA-binding Protein. REGINA C. ARMSTRONG, PHD, ALAIN MIGNEAULT, MARYA L. SHEGOG, JIN G. Kim, PHD, LYNN D. Hupson, PHD, AND RICHARD B. HESSLER, MD. Bethesda, MD Determination of p53 Mutations, EGFR Overexpression, and Loss of p16 Expression in Pediatric Glioblastomas. ULRICH SuRE, MD, DaNniELA RUEDI, MS, OSAMU TACHIBANA, MD, YASUHIRO YONEKAWA, MD, HIROKO OHGAKI, PHD, PAUL KLEIHUES, MD, AND MONIKA E. HEGI, PHD. Zurich, Switzerland BDNF and TrkB Co-localize in CA1 Neurons Resistant to Transient Forebrain Ischemia in the Adult Gerbil. IsIDRE FERRER, MD, PHD, Jorpi BALLABRIGA, MD, EULALIA Marti, PHD, ESTHER PozAs, ANNA MARIA PLANAS, PHD, AND JOAN BLAS!I, PHD. Barcelona, Spain A Comparison of the Predictive Power for Survival in Gliomas Provided by MIB-1, Bromodeoxyuridine and Proliferating Cell Nuclear Antigen with Histopathologic and Clinical Parameters. PAuL E. MCKEEveER, MD, PHD, DonaLp A. Ross, MD, My.a S. STRAWDERMAN, MS, JAMES A. BRUNBERG, MD, HARRY S. GREENBERG, MD, AND LARRY JUNCK, MD. Ann Arbor, MI A Novel Splice Site Associated Polymorphism in the Tuberous Sclerosis 2 (TSC2) Gene May Predispose to the Development of Sporadic Gangliogliomas. MICHAEL PLATTEN, BIRGIT MEYER-PUTTLITZ, INGMAR BLUMCKE, MD, ANDREAS WAHA, HELMUT K. WoLF, MD, Markus M. NOTHEN, MD, Davip N. Louis, MD, JULIAN R. SAMpson, MD, AND ANDREAS VON DEIMLING, MD. Bonn and Mainz, Germany, Boston, Massachusetts, and Cardiff, Wales .......... Heterozygous P, Knockout Mice Develop a Peripheral Neuropathy that Resembles Chronic Inflammatory De- myelinating Polyneuropathy (CIDP). MicHareL E. SHy, MD, EDGARDO ARROYO, JOHN SLADKY, MD, DANIELA MENICHELLA, MD, HUIYUAN JIANG, MD, PHD, WeNBO Xu, MD, JOHN KAMHOLZ, MD, PHD, AND STEVEN S. SCHERER, MD, PHD. Detroit, Michigan, Philadelphia, Pennsylvania, and Atlanta, Georgia Characterization of Diffuse Axonal Pathology and Selective Hippocampal Damage following Inertial Brain Trau- ma in the Pig. DouGLAs H. SmitH, MD, XIAO-HAN CHEN, MD, BAI-NAN Xu, MD, Tracy K. McINntTosH, PHD, THOMAS A. GENNARELLI, MD, AND DAviD EF MEANEY, PHD. Philadelphia, Pennsylvania Reduced Expression of the P, Form of the Gap Junction Pretein Connexin43 in Malignant Meningiomas. KAzur- uM! SATO, MD, CATHERINE GRATAS, PHD, JOHANNES LAMPE, MD, WoiJciECH BIERNAT, MD, PAUL KLEIHUES, MD, HiROSHI YAMASAKI, MSc, PHD, AND HIROKO OHGAKI, PHD. Lyon, France and Zurich, Switzerland Book Review Autoimmune Neurologic Disease. Michael P. Pender and Pamela A. McCombe. (MICHAEL NOEL HART, MD) .... Letter to the Editor Pathologic Alterations in the Diabetic Neuropathies of Humans. (Response) PETER JAMES Dyck, MD AND CATERINA GIANNINI, MD NUMBER 8, AUGUST, 1997 Review of Rett Syndrome. DAWNA DUNCAN ARMSTRONG, MD. Houston, Tex ........0..0ccccccececcecceccecceccncecceccuceceecss Myofibrillar Myopathy. Lil. Abnormal Expression of Cyclin-dependent Kinases and Nuclear Proteins. SATOSHI NAKANO, ANDREW G. ENGEL, ICHIRO AKIGUCHI, AND JUN KIMURA. Kyoto, Japan and Rochester, Minnesota Use of MIB-1 (Ki-67) Immunoreactivity in Differentiating Grade II and Grade III Gliomas. Dora W. Hsu, Davip N. Louts, Jimmy T. EFIRD, AND E. TESSA HEDLEY-WHYTE. Boston, Massachusetts ...........0.0ccccccceccececcececcecceceecees 4-Hydroxy-2-Nonenal Pyrrole Adducts in Human Neurodegenerative Disease. K. S. MONTINE, P. J. Kim, S. J. OLSON, W. R. MARKESBERY, AND T. J. MONTINE. Nashville, Tennessee and Lexington, Kentucky Adenovirus-mediated Wild-type p53 Gene Transfer and Overexpression Induces Apoptosis of Human Glioma Cells Independent of Endogenous p53 Status. HEwei Li, PHD, HANNS LOCHMULLER, MD, VOON WEE YONG, PHD, GEORGE KARPATI, MD, AND JOSEPHINE NALBANTOGLU, PHD. Montreal, Quebec, Canada Loss of Alkaline Phosphatase Activity in Meningiomas: A Rapid Histochemical Technique Indicating Progression- associated Deletion of a Putative Tumor Suppressor Gene on the Distal Part of the Short Arm of Chromosome 1. ISOLDE NIEDERMAYER, MD, WOLFGANG FEIDEN, MD, WOLFRAM HENN, MD, HEIKE STEILEN-GIMBEL, PHD, WOLF- INGO STEUDEL, MD, AND KLAus DIETER ZANG, MD. Homburg, Germany DNA Damage Distribution in the Human Brain as Shown by In Situ End Labeling; Area-specific Differences in Aging and Alzheimer Disease in the Absence of Apoptotic Morphology. P. J. LucAssSEN, PHD, W. C. J. CHUNG, MSc, W. KampuHorst, MD, PHD, AND D. E Swaas, MD, PHD. Amsterdam, The Netherlands ..............2.4.+.0000000+: Glutamate Transporter Alterations in Alzheimer Disease Are Possibly Associated with Abnormal APP Expression. Sui Li, PHD, MARGARET MALLory, BS, MICHAEL ALFORD, BA, SEIGO TANAKA, PHD, AND ELIEZER MASLIAH, MD. La Jolla, California Roie of Vascular Endothelial Growth Factor in Blood-Brain Barrier Breakdown and Angiogenesis in Brain Trau- ma. SukRiTI NAG, MD, PHD, FRCPC, JenNirer L. TAKAHASHI, BSc, DANIEL W. KiLty, BSc. Toronto, Ontario, Canada Amyloid 6-protein (AB) Accumulation in the Leptomeninges during Aging and in Alzheimer Disease. TADANORI HAMANO, MD, MASAHIRO YOSHIMURA, MD, TSUNEO YAMAZAKI, MD, YASUHISA SHINKAI, MD, KATSUHIKO YANAGI- SAWA, MD, Masaru KuriyAMA, MD, AND YASUO IHARA, MD. Tokyo, Aichi and Fukui, Japan Loss of the Presynaptic Vesicle Protein Synaptophysin in Hippocampus Correlates with Cognitive Decline in Alzheimer Disease. CHUN-I1 Sze, MD, JUAN C. Troncoso, MD, CLaupIA KAwas, MD, PETER Mouton, PHD, DONALD L. Price, MD, AND LEE J. MARTIN, PHD. Denver, Colorado and Baltimore, Maryland NUMBER 9, SEPTEMBER, 1997 CADASIL: Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy. MARIE-MAGDELEINE RUCHOUX, MD, PHD, AND CLAUDE-ALAIN MAURAGE, MD. Lille, France APP.,. Transgenic Mice Develop Age-related AB Deposits and Neuropil Abnormalities, but no Neuronal Loss in CA1. MICHAEL C. IRIZARRY, MD, MEGAN McNamara, BS, KERRI FEDORCHAK, BS, KAREN Hsiao, MD, PHD, AND BRADLEY T. HYMAN, MD, PHD. Boston, Massachusetts and Minneapolis, Minnesota A Neuronal and Neuroanatomical Correlate of HIV-1 Encephalopathy Relative to HIV-1 Encephalitis in HIV-1- infected Children. ANNA DA CUNHA, DPHIL, MARK MINTZ, MD, LEE E. E1peN, PHD, AND LEROY R. SHARER, MD. Bethesda, Maryland and Camden and Newark, New Jersey Disproportionate Loss of CA, Parvalbumin-immunoreactive Interneurons in Patients with Ammon’s Horn Scle- rosis. ZHEN-QING ZHU, MD, DAWNA L. ARMSTRONG, MD, WINIFRED J. HAMILTON, PHD, AND ROBERT G. GROSSMAN, NINOS, INI oi occ. ciarsN ipso ncssine Simsw avee rewi niolo spe nicesiaamelestadlersa uesa cted od alee annie de oa eae aE aaa anaes aki ac eee ER eee ise Detection of p16 Gene Deletions in Gliomas: A Comparison of Fluorescence in Situ Hybridization (FISH) Versus Quantitative PCR. Arie Perry, MD, TsuToMU Nosor!, PHD, NING Ru, KARI ANDERL, THOMAS J. BORELL, GAYATRY MOHAPATRA, BurT G. FEUERSTEIN, MD, PHD, RoBerT B. JENKINS, MD, PHD, AND DENNIS A. CARSON, MD. Rochester, Minnesota and San Diego, La Jolla, and San Francisco, California Neuronal Expression and Intracellular Localization of Presenilins in Normal and Alzheimer Disease Brains. DuonGc P. HuyNH, HARRY V. VINTERS, DIANE H. D. Ho, ViINH V. Ho, AND STEFAN-M. Pu cst. Los Angeles, California The Loss of GluR2(3) Immunoreactivity Precedes Neurofibrillary Tangle Formation in the Entorhinal Cortex and Hippocampus of Alzheimer Brains. MiLos D. IkonomMovic, MD, KATsUYOsH! MIZUKAMI, MD, PHD, PETER Davies, PHD, RONALD HAMILTON, MD, ROXANNE SHEFFIELD, AND DAVID M. ARMSTRONG, PHD. Pittsburgh, Pennsylvania, Ibaraki, Japan, and Bronx, New York Dystrophic Axonal Swellings Develop as a Function of Age and Diabetes in Human Dorsal Root Ganglia. ROBERT E. ScHMipT, DENISE Dorsey, CurTIS A. PARVIN, LucIE N. BEAUDET, SANTIAGO B. PLURAD, AND KEVIN A. ROTH. St. Louis, Missouri Predominant Localization of the LIS Family of Gene Products to Cajal-Retzius Cells and Ventricular Neuroepi- thelium in the Developing Human Cortex. Gary D. CLARK, MD, MASAsHI MizuGuCHI, MD, BARBARA ANTALFFY, JAMES BARNES, AND DAWNA ARMSTRONG, MD. Houston, Texas and Tochigi, Japan Myelination Delay in the Cerebral White Matter of Immature Rats with Kaolin-induced Hydrocephalus Is Re- versible. M. R. DeL BiGio, MD, PHD, FRCPC, J. N. KANFER, PHD, AND Y. W. ZHANG, MD. Manitoba, Winnipeg, Canada Book Received Dementia with Lewy Bodies. Robert Perry, lan McKeith, and Elaine Perry, eds. (MICHAEL NoeEL HART, MD) .... Book Review Apoptosis Techniques and Protocols. Judes Poirier, ed. (CAROL K. PeTITO, MD) News of the American Association of Neuropathologists, Inc. Erratum In Memoriam Meta A. Neumann (ROBERT COHN, MD) NUMBER 10, OCTOBER, 1997 The Future of Neuroscience—An Ontogeny and Teleology. G.W. BRuUYN. Leiden, The Netherlands Editorial on Consensus Recommendations for the Postmortem Diagnosis of Alzheimer Disease from the National Institute on Aging and the Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer Disease. BRADLEY T. HYMAN, MD, PHD, AND JOHN Q. TROJANOWSKI, MD, PHD. Boston, Massachusetts and Philadelphia, Pennsylvania Molecular Genetic Evidence for Subtypes of Oligoastrocytomas. DAviD MAINTZ, KLAUS FIEDLER, JENS KOOPMANN, BRITTA ROLLBROCKER, STEFAN NECHEV, Doris LENARTZ, ARMIN P. STANGL, David N. Louis, JOHANNES SCHRAMM, Ormar D. WIESTLER, AND ANDREAS VON DEIMLING. Bonn and Cologne, Germany and Boston, Massachusetts ....... Dendritic Translocation of RC3/Neurogranin mRNA in Normal Aging, Alzheimer Disease and Fronto-Temporal Dementia. JULIA W. CHANG, PHD, Eric SCHUMACHER, BS, PHILLIP M. CouLTER II, MS, Harry V. VINTERS, MD, AND JOSEPH B. WATSON, PHD. Redwood City and Los Angeles, California Distribution of Parvalbumin-Immunoreactive Neurons in Brain Correlates with Hippocampal and Temporal Cor- tical Pathology in Creutzfeldt-Jakob Disease. M. GUENTCHEV, MS, J.-A. HAINFELLNER, MD, G.R. TRABATTONI, MD, AND H. BupkaA, MD. Wien, Austria Detection of Chromosomal Changes by Interphase Cytogenetics in Biopsies of Recurrent Astrocytomas and Oli- godendrogliomas. S.M. Rosso, H. vAN DEKKEN, MD, PHD, K.K. KRISHNADATH, MD, J.C. ALERS, AND J.M. Kros, ee es IN DIN gc oc cis ce re bnackuenneeancasae de veceminlceddaneaceneeuietitaeuacaGuNoNsuanseeuuesbnsaindoues s Temporal and Regional Patterns of Axonal Damage following Traumatic Brain Injury: A Beta-amyloid Precursor Protein Immunocytochemical Study in Rats. HELEN M. BRAMLETT, MS, SUSAN KRAyYDIEH, BS, EDWARD J. GREEN, PHD, AND W. DALTON DieTRICH, PHD. Miami, Florida Expression of Telomerase RNA Component Correlates with the MIB-1 Proliferation Index in Ependymomas. ELISABETH J. RUSHING, MD, Kazuo YASHIMA, MD, DANIEL EF Brown, MD, CHARLES L. Wuite, III, MD, JERRY W. SHAY, PHD, RICHARD C. RissER, MS, AND Api EF Gazpar, MD. Dallas, Texas Neuropathological Findings in Eight Children with Cerebro-oculo-facio-skeletal (COFS) Syndrome. Marc R. DEL Bicio, MD, PHD, FRCPC, CHERYL R. GREENBERG, MD, CM, FRCPC, Lucy B. RorKE, MD, RHONDA SCHNUR, MD, Donna M. McDoNnALD-McGINN, MSc, AND ELAINE H. ZACKAI, MD. Philadelphia, Pennsylvania and Winnipeg, Canada Human Mucopolysaccharidosis IID: Clinical, Biochemical, Morphological and Immunohistochemical Character- istics. MARGARET Z. JONES, JOSEPH ALROY, JOSEPH C. RUTLEDGE, JOHN W. TAYLOR, ELLSWORTH C. ALVORD, JR., JENNIFER TOONE, DEREK APPLEGARTH, JOHN J. Hopwoop, EHUD SKUTELSKY, CHRISTOPHER IANELLI, DAVID THORLEY- LAWSON, CYNTHIA MITCHELL-HERPOLSHEIMER, ALBERT ARIAS, PETER SHARP, W. EVANS, DAVID SILLENCE, AND KEVIN T. CAVANAGH. East Lansing, Michigan, Boston, Massachusetts, Seattle and Port Orchard, Washington, Vancouver, BC, Canada, Adelaide, Westmead and Parametta, Australia, and Tel-Aviv, Israel Reflections on a Workshop. CLAYTON A. WILEY, MD, PHD. In Memoriam Matthew T. Moore (JAMES M. Powers, MD) NUMBER 11, NOVEMBER, 1997 Molecular Cytogenetics of Brain Tumors. SANDRA H. BIGNER, MD, AND EVELIN SCHROCK, MD. Bethesda, Maryland, and Durham, North Carolina Alteration of E-cadherin and Alpha N-catenin Immunoreactivity in the Mouse Spinal Cord following Peripheral Axotomy. AKIRA SeETO, MD, MitsuHIRO HASEGAWA, MD, PHD, Naoyuki UCHtyAMA, MD, PHD, TeTSUMoRI YA- MASHIMA, MD, PHD, AND JUNKOH YAMASHITA, MD, PHD. Kanazawa, Japan Identification of Post-mitotic Oligodendrocytes Incapable of Remyelination within the Demyelinated Adult Spinal Cord. HAns S. KEIRSTEAD, PHD, AND WILLIAM FE BLAKEMORE, SCD. Cambridge, United Kingdom Comparison of Two Quantitative Methods for the Evaluation of Neuronal Number in the Frontal Cortex in Alzheimer Disease. IAN PAUL EvERALL, PHD, MRCPsycu, RICHARD DETERESA, BS, ROBERT TERRY, MD, AND ELIEZER MASLIAH, MD. London, United Kingdom, and San Diego and La Jolla, California Pathology of the Central Nervous System in Chester-Erdheim Disease: Report of Three Cases. HOMA ADLE- BIASSETTE, MD, JEROME CHETRITT, MD, ANNE MARIE BERGEMER-FOUQUET, MD, JANINE WECHSLER, MD, JEAN MARIE MussIini, MD, AND FRANCOISE GRAY, MD, PHD. Créteil, Nantes, Paris, and Garches, France Membranous Ultrastructure of Human Arachnoid Cells. MitsuHiIRO HASEGAWA, MD, PHD, TETSUMORI YAMASHIMA, MD, PHD, SHINYA KipA, MD, PHD, AND JUNKOH YAMASHITA, MD, PHD. Kanazawa, Japan Apolipoprotein E Accumulates with the Progression of AB Deposition in Transgenic Mice. YUKIFUSA IGETA, MD, TAKESHI KAWARABAYASHI, MD, PHD, MASAHIRO SATO, PHD, NOBUHIRO YAMADA, MD, PHD, ETsuRO MATSUBARA, MD, PHD, Kosi IsHiGuro, MD, PHD, Mitsuyasu KANAI, MD, YASUSHI TOMIDOKORO, MD, JuNICHI OsuGA, MD, PHD, KoicHi OKAMOTO, MD, PHD, SHUNSAKU HiRAI, MD, PHD, AND MIkIo SHOJI, MD, PHD. Gunma, Kanagawa, and Tokyo, Japan p53 Mutations versus EGF Receptor Expression in Giant Cell Glioblastomas. AURELIA PERAUD, MD, KUNIHIKO WATANABE, MD, Kart H. PLATE, MD, YASUHIRO YONEKAWA, MD, PAUL KLEIHUES, MD, AND HIROKO OHGAKI, PHD. Lyon, France, Zurich, Switzerland, and Freiburg, Germany Putative Control of Angiogenesis in Hemangioblastomas by the von Hippel-Lindau Tumor Suppressor Gene. REM- BERT STRATMANN, PHD, MARION KriEG, PHD, RICHARD HAAS, AND KARL H. PLATE, MD. Freiburg, Germany Decreased Kainate Receptor Binding in the Arcuate Nucleus of the Sudden Infant Death Syndrome. AsHoK PANIGRAHY, AB, JAMES J. FiLiAno, MD, LYNN A. SLEEPER, SCD, FREDERICK MANDELL, MD, Marie VALDES-DaAPENA, MD, Henry FE Krous, MD, LuciANA A. RAvA, AB, EDM, W. Frost WHITE, PHD, AND HANNAH C. KINNEY, MD. Boston and Watertown, Massachusetts, Lebanon, New Hampshire, Miami, Florida, San Diego, California, and Groton, Connecticut Axonal Damage Revealed by Accumulation of B-APP in HIV-positive Individuals without AIDS. SHu E An, MD, PHD, BRUNO GIOMETTO, MD, MIKE Groves, MSc, ROBERT F MILLER, MBBS, FRCP, ANprew A. J. BECKETT, FIBMS, FRANCOISE GRAY, MD, PHD, BRUNO TAVOLATO, MD, AND FRANCESCO SCARAVILLI, MD, PHD. London, United King- dom, Padova, Italy, and Créteil, France NUMBER 12, DECEMBER, 1997 Aging-associated Changes in Human Brain. Ropert E. Mrak, MD, PHD, W. Sue T. GrirFin, PHD, AND Davin I. GRAHAM, MD, PHD. Little Rock, Arkansas and Glasgow, Scotland, United Kingdom White Matter Neuronal Heterotopia in Temporal Lobe Epilepsy: A Morphometric and Ir istochemical Study. JACQUELINE A. Emery, MD, S.N. Roper, MD, AND AMYN M.ROJIANI, MD, PHD. Gainesville, Florida Expression of Different Isoforms of Nitric Oxide Synthase in Experimentally Denervated and Reinnervated Skel- etal Muscle. Dominique S. Tews, MD, Hans H. GoeBeL, MD, IMMA SCHNEIDER, MD, ANDREAS GUNKEL, MD, EBERHARD STENNERT, MD, AND WOLFRAM FE NEIss, MD. Mainz, and Cologne, Germany BDNF Attenuates Functional and Structural Disorders in Nerves of Galactose-fed Rats. ANDREW P. Mizisin, PHD, MARYANNE BACHE, PETER S. DISTEFANO, PHD, ANN ACHESON, PHD, RONALD M. LINDSAY, PHD, AND NIGEL A. CALcuTT, PHD. San Diego and La Jolla, California and Tarrytown, New York Hydrocephalus in Mice Infected with a Theiler’s Murine Encephalomyelitis Virus Variant. [kKUo TsUNopA, MD, PHD, INGEBORG J. McCRriGHT, PHD, Li-QING KUANG, MD, ANDREAS ZURBRIGGEN, DVM, PHD, AND Rosert S. FUJINAMI, PHD. Salt Lake City, Utah and Bern, Switzerland c-Jun, JNK/SAPK Kinases and Transcription Factor NF-«B Are Selectively Activated in Astrocytes, but not Motor Neurons, in Amyotrophic Lateral Sclerosis. ANTONIO MIGHELI, MD, PHD, ROBERTO Piva, PHD, CRISTIANA ATZORI, PHD, Dirk Troost, MD, AND DAVIDE SCHIFFER, MD. Turin, Italy and Amsterdam, The Netherlands ..................- Spinal Cord Neuropathology in Rat Experimental Autoimmune Encephalomyelitis: Modulation by Oral Admin- istration of Myelin Basic Protein. PHiLLip G. PopovicH, PHD, JENNY Y. Yu, AND CAROLINE C. WHITACRE, PHD. Columbus, Ohio An Immunohistochemical Study of Radial Glial Cells in the Mouse Brain Prenatally Exposed to y-irradiation. XUE-ZHI SUN, MINORU INOUYE, YOSHIHIRO FUKUI, SETSUJI HISANO, KAZUHIKO SAWADA, HISAKO MURAMATSU, TAKASHI MurRAMATSU. Nagoya, Japan Human Telomerase RNA Expression and MIB-1 (Ki-67) Proliferation Index Distinguish He g tomas from Metastatic Renal Cell Carcinomas. DANIEL EF Brown, MD, Api EF Gazpar, MD, CHaRLeEs L. Wuire, TI, MD, KAzUO YASHIMA, MD, JERRY W. SHAY, PHD, AND ELISABETH J. RUSHING, MD. Dallas, Texas .............2c0c00ceeeeeeee The Amyloid B Protein Induces Oxidative Damage of Mitochondrial DNA. PETER BOzNER, MD, PHD, VALENTINA GRISHKO, PHD, SUSAN P. LEDoux, PHD, GLENN L. WiL_son, PHD, Y-C CYAN, PHD, AND MIGUEL A. PAPPOLLA, MD. Mobile, Alabama Diffuse Plaques in the Striatum in Alzheimer Disease (AD): Relationship to the Striatal Mosaic and Selected Neuropeptide Markers. MARLA GEARING, PHD, ALLAN I. Levey, MD, PHD, AND SUZANNE S. MirRA, MD. Atlanta, Georgia Book Received The Neuropathology of Dementia. Margaret M. Esiri and James H. Morris, eds. (MNH) Book Review Fundamental Neuroscience. Duane E. Haines, PhD, ed. (JONATHAN FRATKIN, MD) Letter to the Editor Neuropathology: Art and Science. ELLSworRTH C. ALVorD, JR, MD, AND JOSEPH R. SIEBERT, PHD Author Index Subject Index

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