journal of controlled release Journal of Controlled Release 58 (1999) 379-381 Contents Volume 58 (1999) Vol. 58, No. 1 (8 MARCH 1999) Polymer water-soluble derivatives of polypeptide antibiotic, gramicidin-S based on reactive copolymers of N-(2- hydroxypropyl) methacrylamide M. Solovskij, E. Panarin (St. Petersburg, Russian Federation) l Preparation of non-porous microspheres with high entrapment efficiency of proteins by a (water-in-oil)-in-oil emulsion technique N.B. Viswanathan, P.A. Thomas (Pune, India), J.K. Pandit (Varanasi, India), M.G. Kulkarni (Pune, India) and R.A. Mashelkar (New Delhi, India) 9 Effect of Ca**-alginate gel dissolution on release of dextran with different molecular weights A. Kikuchi, M. Kawabuchi, A. Watanabe, M. Sugihara, Y. Sakurai, T. Okano (Tokyo, Japan) 21 Release of testosterone from an osmotic pump tablet utilizing (SBE),..-B-cyclodextrin as both a solubilizing and an osmotic pump agent K. Okimoto (Osaka, Japan) and R.A. Rajewski, V.J. Stella (Lawrence, KS, USA) 29 Buccal mucosa in vitro experiments. I. Confocal imaging of vital staining and MTT assays for the determination of tissue viability D. Imbert, C. Cullander (San Francisco, CA, USA) 39 Absorption and biodistribution of '''indium-labelled desferrioxamine ('''In-DFO) after subcutaneous injection of '''In-DFO liposomes N.S. Postma (Utrecht, The Netherlands), O.C. Boerman, W.J.G. Oyen, J. Zuidema (Nijmegen, The Netherlands) and G. Storm (Utrecht, The Netherlands) 51 Synthesis and characterisation of poly(p,L-lactic acid)—idoxuridine conjugate M.G. Rimoli, L. Avallone (Naples, Italy), P. de Caprariis (Sassari, Italy), A. Galeone (Naples, Italy) and F. Forni, M.A. Vandelli (Modena, Italy) 61 Short term stability of freeze-dried, lyoprotected liposomes E.C.A. van Winden, D.J.A. Crommelin (Utrecht, The Netherlands) 69 Control of medicine release from solid dispersion composed of the poly(ethylene oxide)-carboxyvinylpolymer interpolymer complex by varying molecular weight of poly(ethylene oxide) T. Ozeki, H. Yuasa, Y. Kanaya (Tokyo, Japan) 87 In vivo human skin permeability enhancement by oleic acid: a laser Doppler velocimetry study H. Tanojo (San Francisco, CA, USA) and E. Boelsma, H.E. Junginger, M. Ponec, H.E. Boddé (Leiden, Netherlands) Book Reviews Award News 109 Calendar Vol. 58, No. 2 (29 MARCH 1999) Optimization of preparative conditions for poly-DL-lactide-polyethylene glycol microspheres with entrapped Vibrio Cholera antigens X.M. Deng, X.H. Li, M.L. Yuan, C.D. Xiong (Chengdu, P.R. China), Z.T. Huang (Beijing, P.R. China) and W.X. Jia, Y.H. Zhang (Chengdu, P.R. China) 380 Contents Volume 58 (1999) Modification of release rates of cyclosporin A from polyl(L-lactic acid) microspheres by fatty acid esters and in-vivo evaluation of the microspheres T. Urata, K. Arimori, M. Nakano (Kumamoto, Japan) 133 Stabilization of proteins against methylene chloride/ water interface-induced denaturation and aggregation H. Sah (Memphis, TN, USA) Micellar delivery of doxorubicin and its paramagnetic analog, ruboxyl, to HL-60 cells: effect of micelle structure and ultrasound on the intracellular drug uptake N.Y. Rapoport, J.N. Herron (Salt Lake City, UT, USA), W.G. Pitt (Provo, UT, USA) and L. Pitina (Salt Lake City, UT, USA) 153 Structural parameters involved in the permeation of propranolol HCI by iontophoresis and enhancers S. Chesnoy (Chdatenay-Malabry, France), D. Durand, J. Doucet (Orsay, France) and G. Couarraze (Chatenay- Malabry, France) 163 Positively and negatively charged submicron emulsions for enhanced topical delivery of antifungal drugs M.P. Youenang Piemi (Chatenay-Malabry, France), D. Korner, S. Benita (Jerusalem, Israel) and Jean-Paul Marty (Chatenay-Malabry, France) 177 Biodegradable cross-linked prodrug of the bronchial dilator Vephylline’ .2 . Kinetics and quantum chemical studies on the release mechanism G. Heun (Muenster, Germany) and N. Lambov, A. Zlatkov, P. Peikov, I. Doytchinova, K. Gesheva (Sofia, Bulgaria) 189 Evaluation of peroral silicone dosage forms in humans by gamma-scintigraphy F. Kedzierewicz, P. Thouvenot, J. Lemut (Nancy, France), A. Etienne (Labége, France) and M. Hoffman, P. Maincent (Nancy, France) 195 Phospholipids affect stratum corneum lipid bilayer fluidity and drug partitioning into the bilayers M. Kirjavainen, J. Ménkkonen, M. Saukkosaari (Kuopio, Finland), R. Valjakka-Koskela, J. Kiesvaara (Turku, Finland) and A. Urtti (Kuopio, Finland) 207 A pH-dependent colon targeted oral drug delivery system using methacrylic acid copolymers. I. Manipulation of drug release using Eudragit® L100-55 and Eudragit® S100 combinations M.Z.1. Khan, Z. Prebeg, N. Kurjakovié (Zagreb, Croatia) nr N Biodegradable microparticles of influenza viral vaccine: comparison of the effects of routes of administration on the in vivo immune response in mice S.C. Chattaraj, A. Rathinavelu, 8.K. Das (Ft Lauderdale, FL, USA) Phase inversion dynamics of PLGA solutions related to drug delivery P.D. Graham, K.J. Brodbeck, A.J. McHugh (Urbana, IL, USA) Book Reviews Acknowledgement to Reviewers Vol. 58, No. 3 (19 APRIL 1999) Synthesis of theophylline—polyrotaxane conjugates and their drug release via supramolecular dissociation T. Ooya, N. Yui (Ishikawa, Japan) Development of nonionic surfactant/phospholipid o/w emulsion as a paclitaxel delivery system P. Kan, Z.-B. Chen, C.-J. Lee, I.-M. Chu (Hsinchu, R.O.C.) Release of 5-amino salicylic acid from acrylic type polymeric prodrugs designed for colon-specific drug delivery S. Davaran, J. Hanaee, A. Khosravi (Tabriz, Iran) Flow cytometric and optical microscopic evaluation of poly(p,L-lactide-co-glycolide) microspheres phagocytosis by pig alveolar macrophages A.-M. Torché (Rennes, France), E. Albina (Ploufragan, France), P. Le Corre (Rennes, France), A. Jestin (Ploufragan, France) and R. Le Verge (Rennes, France) 289 The potential use of mixed films of pectin, chitosan and HPMC for bimodal drug release G.S. Macleod, J.H. Collett, J.T. Fell (Manchester, UK) 303 Modulated release of IdUrd from poly (p,L-lactide-co-glycolide) microspheres by addition of poly (p,L-lactide) oligomers A. Géze, M.-C. Venier-Julienne, P. Saulnier (Angers, France), P. Varlet, C. Daumas-Duport (Paris, France), P. Devauchelle (Maisons Alfort, France) and J.-P. Benoit (Angers, France) Contents Volume 58 (1999) An analysis of solute structure—human epidermal transport relationships in epidermal iontophoresis using the ionic mobility: pore model P.M. Lai, M.S. Roberts (Brisbane, Australia) 323 Adsorption of serum albumin to thin films of poly(lactide-co-glycolide) S.M. Butler (Pittsburgh, PA, USA), M.A. Tracy (Cambridge, MA, USA) and R.D. Tilton (Pittsburgh, PA, USA) 335 The percutaneous penetration of prostaglandin E, and its alkyl esters H.-O. Ho, M.-C. Hwang, S.-L. Tseng, L.-H. Lin, K.-T. Chen, H.-S. Chiang (Taipei, R.O.C.), B.W. Spur, P.Y.-K. Wong (Stratford, NJ, USA) and M.-T. Sheu (Taipei, R.O.C.) 349 FTIR characterization of the secondary structure of proteins encapsulated within PLGA microspheres K. Fu (Cambridge, MA, USA), K. Griebenow (San Juan, Puerto Rico) and L. Hsieh, A.M. Klibanov, R. Langer (Cambridge, MA, USA) 357 Book Review 367 Calendar of Events 369 Author Index Volume 58 373 Subject Index Volume 58 377 Contents Volume 58