Journal of Cell Body 2012: Vol 199 Index & Table of Contents

2012·0.74 MB·English

THE JOURNAL OF CELL BIOLOGY
EDITOR-IN-CHIEF EDITORIAL BOARD
TOM MISTELI JOHN AITCHISON ULRICH HARTL ROY PARKER
NORMA ANDREWS RAMANUJAN HEGDE ROBERT G. PARTON
EDITORS BEN BARRES NOBUTAKA HIROKAWA MARK PEIFER
PIER PAOLO Dl FIORE HUGO BELLEN ERIKA HOLZBAUR THOMAS RANDO
VANN BENNETT ARTHUR HORWICH DANIEL B. RIFKIN
ELAINE FUCHS
JEFFREY BENOVIC ALAN RICK HORWITZ DAVID RON
ALAN HALL MONICA BETTENCOURT-DIAS M. ANDREW HOYT MICHAEL ROUT
REBECCA HEALD CEDRIC BLANPAIN MARTIN HUMPHRIES MICHAEL RUDNICKI
IRA MELLMAN TONY BRETSCHER ANNA HUTTENLOCHER ERIK SAHAI
JODI NUNNARI MARIANNE BRONNER LUISA IRUELA-ARISPE JOSHUA SANES
LOUIS F. REICHARDT DON W. CLEVELAND GERARD KARSENTY JOSEPH SCHLESSINGER
KENNETH M. YAMADA PASCALE COSSART ALEXEY KHODJAKOV DANNY SCHNELL
GAUDENZ DANUSER AKIHIRO KUSUMI TRINA SCHROER
JUNYING YUAN
PIETRO DE CAMILLI THOMAS LANGER MARTIN SCHWARTZ
TITIA DE LANGE JEANNE LAWRENCE JEAN SCHWARZBAUER
NEWS EDITOR
ARSHAD DESAI VERONIQUE LEFEBVRE JOAN STEITZ
BENJAMIN SHORT RAY DESHAIES DANNY LEW HARALD STENMARK
IVAN DIKIC HAIFAN LIN ANDREAS STRASSER
REVIEWS EDITOR STEVE DOXSEY JIRI LUKAS RON VALE
PRIYA PRAKASH BUDDE WILLIAM EARNSHAW IAN MACARA WIM VERMEULEN
SCOTT EMR VIVEK MALHOTRA LOIS WEISMAN
JEFFREY ESKO JOAN MASSAGUE MATT WELCH
HIRONORI FUNABIKI JACOPO MELDOLESI TIM YEN
LARRY GERACE RANDALL T MOON TAMOTSU YOSHIMORI
FRANK GERTLER SEAN MUNRO RICHARD YOULE
DAVID GILBERT ANDRE NUSSENZWEIG MARINO ZERIAL
MARK GINSBERG KAREN OEGEMA YIXIAN ZHENG
GILLIAN GRIFFITHS ERIC OLSON
SERGIO GRINSTEIN LESLIE PARISE
EXECUTIVE EDITOR COPYEDITING
LIZ WILLIAMS AND PRODUCTION
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PREFLIGHT COORDINATOR
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LAURA SMITH
ASSOCIATE EDITOR COPY EDITORS
PAMELA CARPENTIER MARGUERITE SPELLMAN
Phone: [phone] MARY VASQUEZ
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ASSISTANT PRODUCTION EDITOR
email: [email protected]
JASON ROTHAUSER
EDITORIAL ASSISTANTS PRODUCTION EDITOR
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NEWS PRODUCTION EDITOR
DIEDRA HOWSON-BARKER
SATI MOTIERAM RITA E. SULLIVAN
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email: [email protected]
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ERINN A. GRADY
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THE ROCKEFELLER
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VOLUME 1SS.
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QUALITY AND INTEGRITY 1901

NEWS
In This Issue
s • B23 steals to stop cell-killing pair
• microRNA’s big role in preventing tumors
• Dynein’s helper not so helpful
M. Leslie
In Focus THE JOURNAL OF CELL BIOLOGY
3 • Cytoskeleton key
M. Leslie VOL. 199, NO. 1, OCTOBER 1. 2012
People & Ideas
4 • Cedric Blanpain: The stories stem cells tell
C. Sedwick
Editorials
7 Cell biology: At the center of modern biomedicine
Priya Prakash Budde, Elizabeth H. Williams, and Tom Misteli
Features
s Progeria; Translational insights from cell biology
Leslie B. Gordon, Kan Caa, and Francis S. Collins
1 5 The genesis of Zelboraf: Targeting mutant B-Raf in melanoma
Matthew J. Davis and Joseph Schlessinger
S1 Antisense-based therapy for the treatment of spinal
muscular atrophy
Frank Rigo, Yimin Hua, Adrian R. Krainer, and C. Frank Bennett
RESEARCH ARTICLES
Reports
27 Mad2 and the APC/C compete for the same site on Cdc20
to ensure proper chromosome segregation
Daisuke Izawa and Jonathon Pines
On the cover
39 Structural basis of the junctional anchorage of the cerebral
Shen et al. investigate how the actin-
cavernous malformations complex nucleating protein WHAMM coordinates
Alexandre R. Gingras, Jian J. Liu, and Mark H. Ginsberg the octin and microtubule cytoskeletons
during membrane remodeling. In the
foreground, o 3D reconstruction shows
Articles the structure of WHAMM molecules
49 PML promotes MHC class II gene expression by stabilizing (green) bound to o microtubule (gray).
the class II transactivator A single WHAMM molecule is colored
pink. The background fluorescence
Tobias Ulbricht, Mohammad Aizrigat, Almut Horch, Nina Reuter,
image shows that WHAMM-decorated
Anna von Mikecz, Viktor Steimie, Eberhard Schmitt, Oliver H. Kramer,
microtubules (green) can recruit lipid
Thomas Stamminger, and Peter Hemmerich
vesicles (red).
Image courtesy of Qing-Tao Shen.
6S S-nitrosylation of B23/nucleophosmin by GAPDH protects See page 111.
cells from the SlAHl-GAPDH death cascade
Sang Bae Lee, Chung Kwan Kim, Kyung-Hoon Lee, andJee-Yin Ahn
77 Differentiation-associated microRNAs antagonize the Rb-E2F
pathway to restrict proliferation
MatteoJ. Marzi, Eleonora M. R. Puggioni, Valentina Dall'Olio, Gabriele Bucci,
Loris Bernard, Fabrizio Bianchi, Marco Crescenzi, Pier Paolo Di Fiore,
and Francesco Nicassio
Articles with related stories in the IN THIS ISSUE section have page numbers in RED; articles
related to the IN FOCUS feature have page numbers in BLUE.
97 Cortical dynein is critical for prop>er spindle positioning
in human cells
Sochin Kotak, Coralie Busso, and Pierre Gdnczy
Structural insights into WHAMM-mediated cytoskeletal
coordination during membrane remodeling
Qing-Tao Shen. Peter P. Hsiue, Charles V. Sindelar, Matthew D. Welch,
Kenneth G. Campellane, and Hong-Wei Wang
In a wild-type Drosophila embryo
Biogenesis of the mitochondrial Hsp70 chaperone
(left), a fusion<ompetent myoblast
Marta Blamawska, Walter Neupert, and Kai Hell {pseudocolored pink) inserts actin-rich
fingers into a neighboring multinucleate
The Cbp3-Cbp6 complex coordinates cytochrome b synthesis myotube to initiate fusion of the two cells.
with bc'i complex assembly in yeast mitochondria These invasive fingers are absent, and
fusion is defective, in embryos lacking
Steffi Gruschke, Katharina Rompler, Markus Hildenbeutel, Kirsten Kehrein,
the p21-activated kinase DPak3 (right).
Inge Kuhl, Nathalie Bonnefoy, and Martin Ott
See pege IBS.
The role of retrograde intraflagellar transport in flagellar assembly,
maintenance, and function
Benjamin D. Engel, Hiroaki Ishikawa, Kimberly A. Wemmer, Stefan Geimer,
Ken-ichi Wakabayashi, Masafumi Hirono, Branch Craige, Gregory J. Pazour,
George B. Witman, Ritsu Kamiyo, and Wallace F. Marshall
Group I PAKs function downstream of Rac to promote podosome
invasion during myoblast fusion in vivo
Rui Duan, Peng Jin, Fengbao Luo, Guofeng Zhang, Nathan Anderson,
and Elizabeth H. Chen
NEWS
In This Issue
■IBS • The mystery of the (not) missing coenzyme
• Sec and Tat share the workload
• Tiam I increases turnover
B. Short
In Focus THE JOURNAL OF CELL BIOLOGY
IBS • Fyn regeneration
B. Short
VOL. 199, NO. 2, OCTOBER 15. 2012
People & Ideas
130 • Laurie Boyer: Stem cell circuitry for commitment
C. Sedwick
Features
133 Hedgehog pathway inhibition and the race against tumor evolution
Scott X. Atwood, Anne Lynn S. Chong, and Anthony E, Oro
133 Fixing cystic fibrosis by correcting CFTR domain assembly
Tsukoso Okiyonedo and Gergely L. Lukocs
BOS Exploring the therapeutic space around NAD"^
Riekelt H. Houtkooper and Johan Auwerx
REVIEWS
Comments
3 T T Guilt by association: What p 120-catenin has to hide
Mima Perez-Moreno and Elaine Fuchs
On the cover
RESEARCH ARTICLES 30 min after injury, activated Src family
kinases (green) and ERK (magenta) are
Reports apparent in the epithelium of a wounded
a T 5 The submitochondrial distribution of ubiquinone affects respiration zebrafish tail fin. Yoo et al. demonstrate
in long-lived MclkJ^'~ mice that these early signaling events, as well
as a short burst of intracellular calcium
Jerome Lapointe, Ying Wang, Eve Bigras, and Siegfried Hekimi
release, are required for the regeneration
of the fin several days later.
BBS Early redox, Src family kinase, and calcium signaling integrate Image © 2012 Yoo et al.
wound responses and tissue regeneration in zebrafish See pege SS5.
Sa Kan Yoo, Christina M. Freisinger, Danny C. LeBert, and Anna Huttenlocher
Articles
B3S PARPl promotes nucleotide excision repair through DDB2
stabilization and recruitment of ALCl
Alex Pines, Mischa G. Vrauwe, Jurgen A. Marteijn, Dimitris Typas,
Martijn S. Luijsterburg, .Medine Cansoy, Paul Hensbergen, Andre Deelder,
Anton de Groot, Syota Matsumoto, Kaoru Sugasawa, Nicolas Thoma,
Wim Vermeulen, Harry Vrieling, and Leon Mullenders
as 'l Haspin inhibitors reveal centromeric functions of Aurora B
in chromosome segregation
Fangwei Wang, Natalia P. Ulyanova, John R. Daum, Debasis Patnaik,
Anna V. Kateneva, GaryJ. Gorbsky, and Jonathan M.G, Higgins
BBS A small-molecule inhibitor of Haspin alters the kinetochore
functions of Aurora B
Anno De Antoni, Stefono Moffini, Stefan Knapp, Andrea Musacchio,
and Stefano Santaguida
Articles with related stories in the IN THIS ISSUE section have page numbers in RED; articles
related to the IN FOCUS feature have page numbers in BLUE; articles with COMMENTS
have page numbers in GREEN.
Cdkl and Plkl mediate a CLASP2 phospho-switch that stabilizes
kinetochore-microtubule attachments
Ana R.R. AAoia, Zaira Garcia, Lilian Kabeche, Marin Barisic, Slefano Maftini,
Sandra Macedo-Ribeiro, lain M. Cheeseman, Duane A. Compton, Irina Kaverina,
and Helder Maiato
Co-operation between different targeting pathways during
integration of a membrane protein
Rebecca Keller, Jeanine de Keyzer, Arnold J.M. Driessen, and Tracy Palmer
Rap I-interacting adapter molecule (RIAM) associates with
the plasma membrane via a proximity detector
f-
Joseph P. Wynne, Jinhua Wu, Wenjuan Su, Adam AAor, Nikolaos Patsoukis,
Vassiliki A. Boussiotis, Sfevan R. Hubbard, and Mark R. Philips
Tiaml interaction with the PAR complex promotes talin-mediated
Racl activation during polarized cell migration
Shujie Wang, Takashi Watanabe, Kenji Matsuzawa, Akira Katsumi, Mai Kakeno,
Toshinori Matsui, Feng Ye, Kazuhide Sato, Kiyoko Murase, Ikuko Sugiyama,
Kazushi Kimura, Akira Mizoguchi, Mark H. Ginsberg, John G. Collard,
and Kozo Kaibuchi
miR-24 triggers epidermal differentiation by controlling actin Sahly et al. reveal that proteins
adhesion and cell migration associated with the hearing and vision
Ivano Amelio, Anna Maria Lena, Giuditta Viticchie, Ruby Shalom-Feuerstein, loss of Usher syndrome, including
Alessandro Terrinoni, David Dinsdale, Giandomenico Russo, Claudia Fortunato, protocadherin-15 (green), localize to
Elena Bonanno, Luigi Giusto Spagnoli, Daniel Aberdam, Richard Austen Knight, microvillus-like calyceal processes at the
Eleonora Candi, and Gerry AAelino base of the outer segments of rod and
cone photoreceptors in primates (cone
outer segments are labeled red). Mouse
pl20-catenin binding masks an endocytic signal conserved photoreceptors lack calyceal processes,
in classical cadherins potentially explaining why mice lacking
Benjamin A. Nanes, Christine Chiasson-MacKenzie, Anthony M. Lowery, Usher syndrome proteins don't display
Noboru Ishiyama, Victor Faundez, Mitsuhiko Ikura, Peter A. Vincent, retinal degeneration.
and Andrew P. Kowaiczyk Image © 2012 Sahly et al.
See pege 381.
Localization of Usher 1 proteins to the photoreceptor calyceal
processes, which are absent from mice
Iman Sahly, Eric Dufour, Cataldo Schietroma, Vincent Michel, Amel Bahloul,
Isabelle Perfettini, Elise Pepermans, Amrit Estivalet, Diane Carette,
Asadollah Aghaie, Inga Ebermann, Andrea Lelli, Maria Iribarne,
Jean-Pierre Hardelin, Dominique Weil, JoseAlain Sahel, Aziz El-Amraoui,
and Christine Petit
JCB
NEWS
In This Issue
402 • HIV’s kinesin chauffeur
• Only skin deep, thanks to microtubules
• N-WASP helps cancer cells open up
M. Leslie
In Focus
403 • Stay-at-home transcription factor saves axons 1
M. Leslie 1 VOL. 199. NO. 3, OCTOBER 29. 2012
I
People & Ideas
404 • Fumiyo Ikeda; Ubiquitin lines up for action 1
X
V-.
C. Sedwick 1
Features
407 Discovering the first microRNA-targeted drug
’H
Morten Lindow and Sakari Kauppinen \
413 The discovery of natalizumab, a potent therapeutic for
multiple sclerosis
Lawrence Steinman . ■
, *'
417 Hypertrophic cardiomyopathy: Translating cellular cross talk 1 ^•
into therapeutics
Polakit Teekokirikul, Robert F. Podera, J.G. Seidmon, and Christine E. Seidmon
5
- .
..if'
1 REVIEWS 1
Comments On the cover
4S3 Using force to visualize conformational activation of integrins Macrophages infected with HIV-1 (green)
Dovid Boettiger develop into giant cells with multiple
nuclei (blue) and highly organized
networks of microtubules (red) and actin
(cyan). Gaudin et al. reveal that the
microtubule-based kinesin motor KIF3A
1 RESEARCH ARTICLES is important for the intracellular transport
of virus<ontaining compartments and
Reports
for the release of HIV-1 from infected
4S5 Phosphocaveolin-1 is a mechanotransducer that induces caveola macrophages.
biogenesis via Egrl transcriptional regulation Image © 2012 Gaudin et al.
Bharat Joshi, Michele Bastiani, Scott S. Strugnell, Cecile Boscher, See page 467.
Robert G. Parton, and Ivan R. Nabi
Articles
437 Local axonal function of STAT3 rescues axon degeneration
in the pmn model of motoneuron disease
Bhuvaneish Thangaraj Selvoraj, Nicolas Frank, Florian L.P Bender, Esther Asan,
and Michael Sendtner
453 Rbms3 functions in craniofacial development by
posttranscriptionally modulating TGF-P signaling
Chathurani S. Jayasena and Marianne E. Bronner
467 Critical role for the kinesin KIF3A in the HIV life cycle in primary
human macrophages
Raphael Gaudin, Bruna Cunha de Alencar, Mabel Jouve, Stefano Berre,
Emmanuel Le Bouder, Michael Schindler, Aditi Varthaman,
Francois-Xavier Gobert, and Philippe Benaroch
Articles with related stories in the IN THIS ISSUE section have page numbers in RED; articles
related to the IN FOCUS feature have page numbers in BLUE; articles with COMMENTS
have page numbers in GREEN.
481 TspanCS tetraspanins regulate ADAM lO/Kuzbanian trafficking
and promote Notch activation in flies and mammals
Emmanuel Dornier, Franck Coumailleau, Jean-Frangois Ottavi, Julien Moretti,
Claude Boucheix, Philippe AAauduit, Frangois Schweisguth, ond Eric Rubinstein
ObseiA ing force-regulated conformational changes and ligand
dissociation from a single integrin on cells
Wei Chen.Jizhong Lou, Evan A. Evans, and Cheng Zhu
513 Noncentrosomal microtubules and type II myosins potentiate
epidermal cell adhesion and barrier formation
At a wound edge, actomyosin
Kaelyn D. Sumigray, Henry P. FcxDte, and Terry Lechler
contractility—indicated by activated
myosin light chain (green) —is higher in
5S7 N-WASP coordinates the delivery and F-actin-mediated capture epithelial cells plated on a rigid substrate
of MTl-MMP at invasive pseudopods (right) than in cells plated on a softer
Xinzi Yu. Tobias Zech, Laura McDonald, Esther Garcia Gonzalez, Ang Li, surface (left). Intercellular adhesions
lain Maepherson, Juliane P. Schwarz, Heather Spence, Kinga Futo, Paul Timpson, propagate this contractility to cells farther
back in the epithelial sheet, allowing
Colin Nixon, Yafeng AAa, Ines M. Anton, Balazs Visegrady, Robert H. Insall,
the cells to coordinate their collective
Karin Oien, Karen Blyth, Jim C. Norman, and Laura M. Machesky
migration so that they move faster and
more persistently on stiffer substrates.
545 Substrate stiffness regulates cadherin-dependent collective migration The cells are also stained for actin (red)
through myosin-ll contractility and DNA (blue).
Mei Rosa Ng, Achim Besser, Gaudenz Danuser, and Joan S. Brugge Image © 2012 Ng et al.
See page S45.
NEWS
In This Issue
BBS • ARL-13 SUMO wrestles receptors into cilia
• Dnm 1 ’s recruitment strategy
• The fellowship of the Z ring
B. Short
THE JOURNAL OF CELL BIOLOGY
In Focus
BBT • Cdc42 helps cancer cells make their exit
B. Short VOL. 199, IMO. 4, NOVEMBER 12, 2012
People & Ideas
BBS • Gaudenz Danuser: The symphony of the cell
C. Sedwick
Features
B71 Cell biology: A key driver of therapeutic innovation
Oliver Hontschel and Giulio Superti-Furgo
S77 New frontiers in human cell biology and medicine; Can pluripotent
stem cells deliver?
Lawrence S.B. Goldstein
B83 Development of proteasome inhibitors as research tools
and cancer drugs
Alfred L. Goldberg
On the cover
Prostate cancer cells (yellow, left)
RESEARCH ARTICLES
extend multiple protrusions toward the
Repot cs endothelial cells (red) lining blood vessels
in the mouse lung, whereas prostate
BBS SUMOylation of the small GTPase ARL-13 promotes ciliary
cancer cells lacking Cdc42 (blue, right)
targeting of sensory receptors
remain rounded and show reduced
Yujie Li, Qing Zhang, Qing Wei, Yuxia Zhang, Kun Ling, andjinghua Hu spreading on the vessel walls. Reymond
et al. reveal that Cdc42 promotes
metastasis by inducing the expression
Articles
of pi-integrin, boosting cancer cells'
B99 Characterization of the insertase for |3-barrel proteins of the outer attachments to endothelial cells and the
mitocnondrial membrane underlying basement membrane.
Astrid Klein, Lars Israel, Sebastian W.K. Lackey, Frank E. Nargang, Axel Imhof, Image © 2012 Reymond et al.
Wolfgang Baumeister, Walter Neupert, and Dennis R. Thomas See pege 653.
913 A novel motif in the yeast mitochondrial dynamin Dnm I
is essential for adaptor binding and membrane recruitment
Huyen T. Bui, Mary A. Karren, Debjani Bhar, and Janet M. Shaw
BS3 Distinct functions of chloroplast FtsZl and FtsZ2 in Z-ring
structure and remodeling
Allan D. TerBush and Katherine W. Osteryoung
B39 A flagellar A-kinase anchoring protein with two amphipathic
helices forms a structural scaffold in the radial spoke complex
Priyanka Sivadas, Jennifer M. Dienes, Martin St. Maurice, William D. Meek,
and Pinfen Yang
BB3 Cdc42 promotes transendothelial migration of cancer cells
through (31 integrin
Nicolas Reymond, Jae Hong Im, Ritu Garg, Francisco M. Vega,
Barbara Borda d'Agua, Philippe Riou, Susan Cox, Ferran Valderrama,
RuthJ. Muschel, and AnneJ. Ridley
Articles with related stories in the IN THIS ISSUE section have page numbers in RED; articles
related to the IN FOCUS feature have page numbers in BLUE.
663 Crawling from soft to stiff matrix polarizes the cytoskeleton
and phosphoregulates myosin-ll heavy chain
Matthew Raab, Joe Swih, P.C. Dave P. Dingat, Palak Shah, Joe-Won Shin,
and Dennis E. Discher
685 Drosophila PATJ supports adherens junction stability by modulating
Myosin light chain activity Cells tend to migrate from softer to
Arnob Sen, Zsanett NagyZsver-Vadas, and Michael P. Krahn stiffer matrices, a phenomenon known
as durotaxis. Raab et al. demonstrate
that this process relies on myosin-IIB
633 The C-terminal unique region of desmoglein 2 inhibits its
(green), which is distributed uniformly
internalization via tail-tail interactions
in cells migrating on soft matrices (left)
Jing Chen, Oxana E. Nekrasova, Dipal M. Patel, Jodi L. Klessner, Lisa M. Godsel, but polarizes toward the rear of the cell
Jennifer L. Koetsier, Evangeline V. Amargo, Bhushan V. Desai, and Kathleen J. Green on stiffer ones (right). The cells are also
stained for F-actin (red).
Image © 2012 Raab et al.
See pege BBS.