TPS23x31-2|15.09.14-12:42 TPS23x31-2|15.09.14-12:42 TPS23x31-2|15.09.14-12:42 Interventional Ultrasound A Practical Guide and Atlas Christoph F. Dietrich, MD Professor and Head Physician Medical Clinic 2 Caritas Hospital Bad Mergentheim gGmbH Bad Mergentheim, Germany Dieter Nuernberg, MD Professor and Head Physician Medical Clinic B Ruppiner Hospitals GmbH Neuruppin, Germany 380 illustrations Thieme Stuttgart (cid:129) New York (cid:129) Delhi (cid:129) Rio TPS23x31-2|15.09.14-12:42 LibraryofCongressCataloging-in-PublicationData Important note: Medicine is an ever-changing science InterventionellerUltraschall.English. undergoing continual development. Research and clinical Interventional ultrasound : a practicalguide and atlas / experience are continually expanding our knowledge, in [editedby]ChristophF.Dietrich,DieterNuernberg; particular our knowledge of proper treatment and drug translator,TerryC.Telger;illustrator,HelmutHoltermann. therapy.Insofarasthisbookmentionsanydosageorappli- p.;cm. cation,readers may rest assured that theauthors,editors, Includesbibliographicalreferencesandindex. andpublishershavemadeeveryefforttoensurethatsuch ISBN978-3-13-170821-2–ISBN978-3-13-170831-1(eISBN) referencesareinaccordancewiththestateofknowledgeat I. Dietrich, Christoph Frank, editor. II. Nuernberg, Dieter, thetimeofproductionofthebook. editor. III. Title. Nevertheless,thisdoesnotinvolve,imply,orexpressany [DNLM:1. Ultrasonography,Interventional. WN208] guaranteeorresponsibilityonthepartofthepublishersin RC78.7.U4 respecttoanydosageinstructionsandformsofapplications 616.07'543–dc23 stated in the book. Every user is requested to examine 2014028919 carefully the manufacturers’ leaflets accompanying each drugandtocheck,ifnecessaryinconsultationwithaphy- ThisbookisanauthorizedtranslationoftheGermanedition sicianorspecialist,whetherthedosageschedulesmentioned published and copyrighted 2011 by Georg Thieme Verlag, thereinorthecontraindicationsstatedbythemanufacturers Stuttgart. Title of the German edition: Interventionelle differfromthestatementsmadeinthepresentbook.Such Ultraschall: Lehrbuch und Atlas für die Interventionelle examination is particularly important with drugs that are Songraphie eitherrarelyusedorhavebeennewlyreleasedonthemarket. Translator:TerryC.Telger,FortWorth,TX,USA Everydosagescheduleoreveryformofapplicationusedis entirelyattheuser’sownriskandresponsibility.Theauthors Illustrator:HelmutHoltermann,Dannenberg,Germany andpublishersrequesteveryusertoreporttothepublishers any discrepancies or inaccuracies noticed. 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Any use, exploitation, or commercialization outsidethenarrowlimitssetbycopyrightlegislationwithout ThiemePublishersNewYork thepublisher’sconsentisillegalandliabletoprosecution. 333SeventhAvenue,NewYork,NY10001,USA Thisappliesinparticulartophotostatreproduction,copying, 1-800-782-3488,[email protected] mimeographing preparation of microfilms, and electronic dataprocessingandstorage. ThiemePublishersDelhi A-12,SecondFloor,Sector-2,Noida-201301 UttarPradesh,India +911204556600,[email protected] ThiemePublishersRio, ThiemePublicaçõesLtda. ArgentinaBuilding,16thFloor,AlaA, 228PraiadoBotafogoRiodeJaneiro 22250-040Brazil +55213736-3631 Coverdesign:ThiemePublishingGroup TypesettingbyThomsonDigital,India PrintedinGermanybyAprintaDruck,Wemding ISBN978-3-13-170821-2 Alsoavailableasane-book: eISBN978-3-13-170831-1 Dietrich-InterventionalUltrasound|15.09.14-14:06 Contents Foreword................................................................................ xviii Preface.................................................................................. xix Acknowledgments..................................................................... xx Contributors............................................................................ xxi Abbreviations........................................................................... xxiii GeneralAspectsofInterventionalUltrasound 1 InterventionalUltrasound:IntroductionandHistoricalBackground ............. 2 H.Lutz 1.1 TheViennaCongress................. 2 1.2.4 RisksofInterventionalUltrasound....... 9 1.2 TheIntroductionofUltrasoundinto 1.3 LaterDevelopments:Ultrasound- RoutineClinicalUse.................. 3 GuidedTherapeuticInterventional Procedures.......................... 10 1.2.1 TheEvolutionofUltrasoundImaging Techniques........................... 3 1.4 Outlook............................. 10 1.2.2 TechnicalEvolutionofUltrasound-Guided Biopsies.............................. 4 References ........................... 11 1.2.3 ClinicalApplication.................... 7 2 InterventionalMaterialsandEquipment ............................................ 13 2.1 GeneralConsiderationson 2.2.6 Complications ........................ 22 InterventionalProcedures............ 13 2.2.7 NeedleTechniques .................... 23 U.Gottschalk,C.F.Dietrich 2.2.8 SpecialNeedleTypes................... 23 2.2.9 TrocarTechnique...................... 23 2.1.1 BriefHistoricalIntroduction............ 13 2.2.10 SeldingerTechnique................... 24 2.1.2 BiopsyPrinciplesandTechniques........ 13 2.2.11 Peel-AwaySheath..................... 24 2.1.3 NeedleSystems....................... 15 2.2.12 AnchorSystems,SutureTechniques...... 25 2.2.13 Guidewires........................... 26 2.2 TherapeuticInterventions............ 20 2.2.14 Dilators.............................. 27 2.2.15 DrainageCatheters.................... 27 2.2.1 Introduction.......................... 20 2.2.16 OtherDrainageSystems................ 29 2.2.2 BriefHistoricalReview................. 20 2.2.17 Accessories........................... 29 2.2.3 PatientPreparation.................... 21 References ........................... 31 2.2.4 AccessRoutes......................... 21 2.2.5 IndicationsandContraindications ....... 21 3 InformedConsent...................................................................... 32 D.Nuernberg,A.Jung 3.1 WhatShouldBeDisclosed?........... 32 3.2 MeansofDisclosure.................. 32 3.1.1 Indication............................ 32 3.2.1 ConsentForm......................... 32 3.1.2 ExplainingtheProcedure............... 32 3.2.2 InformedConsentDiscussion ........... 32 3.1.3 RisksandComplications................ 32 3.2.3 DelegatingInformedConsent........... 33 v Dietrich-InterventionalUltrasound|15.09.14-14:06 Contents 3.3 Documentation...................... 33 3.5.2 PatientsLackingtheCapacity toConsent ........................... 33 3.4 TimingoftheConsentProcess........ 33 3.5.3 Minors............................... 33 3.5.4 LanguageBarriers..................... 34 3.5 SpecialSituations.................... 33 3.5.5 WaivingofInformedConsent........... 34 References ........................... 34 3.5.1 ImpliedConsent ...................... 33 4 Medications,Equipment,andSetupRequirements ................................ 35 D.Nuernberg,A.Jung 4.1 Medications......................... 35 4.2.3 Positioning,PreprocedureExamination, andMarking.......................... 37 4.1.1 Premedication........................ 35 4.2.4 MonitoringDuringtheProcedure........ 37 4.1.2 Analgesia............................. 35 4.2.5 PostprocedureMonitoring.............. 37 4.1.3 Coagulation .......................... 36 4.2.6 Facilities(ProcedureRoom)............. 37 4.1.4 LocalAnesthesia ...................... 36 4.2.7 FunctionalandDesignRequirements..... 38 4.2.8 OperationalandOrganizational 4.2 EquipmentandSetupRequirements .. 37 Requirements......................... 38 References ........................... 38 4.2.1 BiopsyEquipment..................... 37 4.2.2 InterventionalMaterials................ 37 5 PathologyandCytology............................................................... 40 A.Tannapfel,C.F.Dietrich 5.1 Pathology........................... 40 5.4.2 Grading.............................. 43 5.2 Biopsies............................. 40 5.5 SpecificAnalysis ..................... 43 5.2.1 TypesofBiopsyProcedure.............. 40 5.5.1 LymphNodes......................... 43 5.5.2 Lymphomas.......................... 45 5.3 HistologyorCytology?............... 40 5.6 HormoneGrowthFactorReceptor 5.3.1 SourcesofError....................... 41 Analysis............................. 47 5.4 Typing,Grading,andStaging ......... 41 References ........................... 48 5.4.1 Classification(Typing).................. 41 6 FineNeedleAspirationCytology...................................................... 49 C.Jenssen,T.Beyer 6.1 SpecimenCollection ................. 49 6.3.1 BasicPrinciples ....................... 55 6.3.2 AirDryingandRomanowskyStains...... 55 6.1.1 Ultrasound-GuidedBiopsy ............. 49 6.3.3 WetFixationandPapanicolaouStaining.. 55 6.1.2 NeedleMovementandAspiration ....... 49 6.3.4 AncillaryTests........................ 56 6.2 SpecimenPreparation................ 49 6.4 CytomorphologicEvaluation.......... 58 6.2.1 FluidAspirates........................ 49 6.4.1 RapidOn-SiteEvaluation............... 58 6.2.2 CentrifugingEffusions ................. 49 6.4.2 FinalCytologicDiagnosis............... 63 6.2.3 AspiratesfromSolidLesions............ 50 6.5 Conclusions ......................... 64 6.3 FixationandStaining................. 55 References ........................... 64 vi Dietrich-InterventionalUltrasound|15.09.14-14:06 Contents 7 InfectionsandDiagnosticMicrobiology ............................................. 68 T.Glueck,H.J.Linde,C.F.Dietrich 7.1 GeneralPrinciplesofMicrobiological 7.2.6 LimitationsofMicrobiologicalMethods .. 72 Testing.............................. 68 7.2.7 SpecimenReceiptduringOff-hours (Nights,Weekends,Holidays)........... 72 7.1.1 MicrobiologicalSpecimens ............. 68 7.1.2 PrerequisitesforMicrobiologicalTesting.. 68 7.3 SpecificGuidelinesforMicrobiological TestingandDifferentialDiagnosisby 7.2 MicrobiologicalTechniques........... 69 OrganSystemsandSyndromes ....... 73 7.2.1 Stains................................ 69 7.3.1 InvestigationofEnlargedLymphNodes... 73 7.2.2 CultureTechniques.................... 71 7.3.2 MicrobiologicalTestingandAntimicrobial 7.2.3 NucleicAcidAmplificationTechniques ... 71 TherapyforSuspectedTuberculosis...... 76 7.2.4 Serology............................. 71 7.3.3 LiverMassSuspiciousforanAbscess 7.2.5 WhenAreMicrobiologicalTestResults (IncludingAmebicAbscess)............. 77 Available?............................ 72 References ........................... 81 8 HygieneManagement................................................................. 82 H.Martiny,D.Nuernberg 8.1 GeneralHygienicRequirements....... 82 8.3 UltrasoundProbeandAccessories..... 84 8.1.1 PersonalProtectiveEquipmentand 8.3.1 DecontaminationoftheUltrasound Coverings............................ 82 Probe................................ 84 8.1.2 DisposableProbeCovers ............... 83 8.3.2 DecontaminationofUltrasound 8.1.3 UltrasoundGel........................ 83 Accessories........................... 85 References ........................... 85 8.2 HandAntisepsisandSkin Preparation.......................... 83 9 Contraindications,Complications,andComplicationManagement.............. 86 C.Jenssen,C.F.Dietrich 9.1 InterventionalRisk................... 86 9.3.5 PreventionofInfection................. 93 9.3.6 OptimalApproachandAlternatives...... 93 9.1.1 ComplicationRatesandMortality ....... 86 9.1.2 FactorsthatInfluenceInterventional 9.4 Contraindications.................... 93 Risk ................................. 86 9.4.1 Coagulopathies ....................... 93 9.2 FrequentComplicationsandTheirRisk 9.4.2 ProcoagulantTherapyandAntiplatelet Factors.............................. 86 Drugs................................ 94 9.4.3 “Risky”LesionsandAccessRoutes....... 94 9.2.1 PainandVasovagalReactions ........... 86 9.2.2 BleedingComplications................ 87 9.5 ManagementofComplications ....... 95 9.2.3 NeedleTractSeeding .................. 88 9.2.4 SpecificComplications................. 89 9.5.1 PostinterventionalCareandDetectionof Complications ........................ 95 9.3 PreventionofComplications.......... 89 9.5.2 TreatmentofComplications............. 95 9.3.1 RiskAssessmentandPatient 9.6 SpecificBiopsySites.................. 95 Selection............................. 89 9.3.2 ModificationofRiskFactors............. 90 9.6.1 LiverBiopsy .......................... 95 9.3.3 RiskReductionTechniques ............. 92 9.6.2 RenalBiopsy.......................... 99 9.3.4 LocalAnesthesiaandIntravenous 9.6.3 PancreaticBiopsy ..................... 99 Sedation............................. 92 9.6.4 SplenicBiopsy........................ 100 vii Dietrich-InterventionalUltrasound|15.09.14-14:06 Contents 9.6.5 BiopsyofGastrointestinalHollowOrgans 9.7.3 TransrectalProstaticBiopsy............. 102 andMesentericMasses................. 100 9.7.4 Ultrasound-GuidedDrainage(ofCysts, 9.6.6 AdrenalBiopsy........................ 100 Pseudocysts,Abscesses,Cholecystitis).... 102 9.6.7 Lungs,Pleura,andMediastinum......... 101 9.7.5 Ultrasound-GuidedPTCDand Cholecystotomy....................... 103 9.7 SpecificInterventions................ 101 9.7.6 Ultrasound-guidedTumorAblation Therapy.............................. 103 9.7.1 EUS-FNA,EUS-TCB,EBUS-TBNA ......... 101 References ........................... 104 9.7.2 EUS-GuidedTherapeuticInterventions... 101 10 AssistanceinUltrasoundInterventions.............................................. 109 U.Gottschalk,C.F.Dietrich 10.1 BasicPrinciples ...................... 109 10.6 Sedation ............................ 111 10.2 DutiesofAssistingPersonnel......... 109 10.7 DrainPlacement..................... 111 10.3 DiagnosticUltrasound................ 110 10.8 Endosonography..................... 113 10.4 DiagnosticInterventions ............. 110 References ........................... 113 10.5 TherapeuticInterventions............ 111 11 SedationinInterventions ............................................................. 114 U.Gottschalk,C.F.Dietrich 11.1 Introduction......................... 114 11.6 Complications ....................... 115 11.2 Medications......................... 114 11.7 Summary............................ 115 11.3 PersonnelRequirements.............. 114 References ........................... 115 11.4 MonitoringRequirements............ 115 11.5 PostprocedureCare.................. 115 SpecificUltrasound-GuidedProcedures:Abdomen 12 IndicationsforDiagnosticInterventionsintheAbdomenandThorax (Liver,Pancreas,Spleen,Kidneys,Lung,OtherSites)............................... 120 H.Kinkel,D.Nuernberg 12.1 Liver ................................ 120 12.5 Lung................................ 125 12.1.1 DiffuseLiverDiseases.................. 120 12.6 AdrenalGland ....................... 125 12.1.2 FocalLiverLesions..................... 121 12.7 LymphNodes........................ 125 12.2 Pancreas ............................ 123 12.8 OtherLesions........................ 126 12.3 Spleen .............................. 123 References ........................... 126 12.4 Kidneys ............................. 124 viii
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