International Collaborations in Imaging

16 Pages·2017·0.93 MB·English

International Collaborations in

Imaging: Vascular & Beyond

Monday May 1st, 2017
8:00 - 17:00
Brotman Auditorium, UW South Lake Union
850 Republican Street
Seattle, WA 98109
Welcome Remarks
Thomas S.
Hatsukami, MD Chun Yuan, PhD

Drs. Chun Yuan and Thomas S. Hatsukami , co-directors of the University of
Washington Vascular Imaging Lab at South Lake Union would like to welcome you
to a one-day symposium entitled: "International Collaborations in Imaging: Vascular
and Beyond” on May 1, 2017. Investigators from China, Japan and the Pacific
Northwest have been invited to present their current research interests and discuss
possible future collaborations.
The symposium is being organized by the Vascular Imaging Laboratory, UW. The
symposium features a full day of presentations and exploration into collaborative
opportunities followed by a demonstration of the latest research in artificial
intelligence and its potential application in medical imaging.
The presentations are organized into three panels: 1) International Collaborations:
Current Status and Future Opportunities; 2) Cardiac, Vascular Brain and Functional
Imaging; and 3) Quantitative Imaging, Data Integration, and Deep Learning.
We look forward welcoming you to Seattle and to an active, productive day of
discussion!

1
Agenda
Monday May 1st, 2017, 8:00 - 17:00, Brotman Auditorium, UW South
Lake Union, 850 Republican Street, Seattle, WA 98109
8:00 Registration and Coffee

8:10 Opening Remarks

Session I: International Collaborations: Current Status and Future Opportunities

8:15 Efforts in Stroke Diagnosis and Prevention – Role of Vessel Wall Imaging
Chun Yuan, PhD, University of Washington
8:30 M R Vessel Wall Imaging-Based Clinical Trials in China: Design and Achievements
Xihai Zhao, MD, PhD, Tsinghua University

The Role of Magnetic Resonance and Optical Frequency Domain Imaging in Carotid Artery
8:50
Stenting: the MR-CAS Study
Kiyofumi Yamada, MD, PhD, Hyogo College of Medicine

Prevalence of Atherosclerotic Disease in Multivascular Beds in Chinese Older Adults: CROP
9:10
Study
( IJniatenrwneanti oLunoa,l PChoDlla, bTsoirnagthiounas U inn iIvmerasgitiny g: A Perspective from Philips Research)

9:30 Philips Healthcare Clinical Research Board and International Collaborations in Imaging
Matthew R. Rielly, PhD, Clinical Research at Philips Healthcare
9:40 Discussion
9:50 Tea break (10 minutes)

Session II: Cardiac, Vascular, and Neuro (morning session)
10:00 C ontrast Agents in Cardiovascular MRI
Greg Wilson, MD, PhD, University of Washington

10:20 Myocardium Characterization with Quantitative Cardiac MRI
Haiyan Ding, PhD, Tsinghua University

10:40 4D Flow MRI and Its Applications
Rui Li, PhD, Tsinghua University

11:00 Cerebrovascular Imaging Of Degenerative Diseases
Swati Rane, PhD, University of Washington

11:20 Intracranial Vessel Wall MRI: Applications and Implications
Mahmud Mossa-Basha, MD, University of Washington

11:40 Advanced Diffusion MRI and Applications in Neuroradiology
Hua Guo, PhD, Tsinghua University

12:00 Discussion

12:10 Lunch (30 minutes)

2
Session III: Cardiac, Vascular, Brain, and Functional (Afternoon Session)

Reduced Iodine Dose Dual Energy CT of the Aorta
12:40
William Schuman, MD, University of Washington
13:00 Contrast Enhanced Ultrasound in Atherosclerosis
Mike Averkiou, PhD, University of Washington
13:20 U ltrasound Elasticity Imaging of the Vessels
Jianwen Luo, PhD, Tsinghua University

13:40 Future Applications in Cardiovascular PET and CT

Adam Alessio, PhD, University of Washington

14:00 Non-invasive Imaging of Transplanted Cell Fate and Function

Anna Naumova, PhD, University of Washington

14:20 Physiological Quantitative MR Imaging Using DCE-MRI
Huijun Chen, PhD, Tsinghua University

14:40 The Measurement Of Volume Flow Using 3D Ultrasound - Opportunities and Challenges
James Jago, PhD, Philips Healthcare

15:00 Discussion

15:10 Tea Break (10 minutes)

Session IV: Quantitative Imaging, Data Integration, and Deep Learning

15:20 Quantitative Imaging of Carotid Intraplaque Hemorrhage: a Case Study
Jie Sun, MD, University of Washington

15:40 Vascular Brain Injury, Brain Degeneration and Cognitive Decline: Imaging Opportunities
Thomas Grabowski, MD, University of Washington

16:00 Deep Learning for Image Recognition
Jenq-Neng Hwang, PhD, University of Washington

16:20 InnerEye: Assitive AI for Cancer Treatment
Ivan Tarapov, Microsoft Research

16:40 Discussion

16:50 Closing Remarks
Thomas Hatsukami, MD, University of Washington
17:00 Reception (1 hour)

3
Speaker Biography

Chun Yuan, PhD

“Efforts in stroke diagnosis and prevention – Role of
vessel wall imaging”

Dr. Chun Yuan received his B.S. in physics at Beijing Normal University and his Ph.D. in Biomedical
Physics at the University of Utah. He became Senior Research Analyst of GE Medical Systems
immediately thereafter. He has pioneered multiple high-resolution MRI techniques to detect
vulnerable atherosclerotic plaques and led numerous MRI studies examining carotid
atherosclerosis. He is a member of the editorial board for the following Journals: JACC CV imaging,
Journal of Cardiovascular MR, and the Journal of Geriatric Cardiology. He also serves as manuscript
reviewer for about 20 other peer-reviewed journals involving magnetic resonance, arteriosclerosis,
stroke and cardiovascular sciences.
Through his stint in the University of Washington, he has mentored 32 postdocs who have moved on to
become professors, chief research scientists, clinician-researchers, heads of departments and other
positions of responsibility in both private and government or public institutions in the USA, China,
Germany, and around the world.
Because of his expertise in the field of cardiovascular imaging and magnetic resonance, he has been an
invited speaker or keynote speaker, lecturer, moderator or faculty for many international and US
meetings in the imaging field. He has over 210 articles in peer-reviewed journals. His research is
supported by several NIH and private grants and currently supervises several postdoctoral fellows,
research scientists and graduate students, as well as teaches courses in Bioengineering and Radiology.

Xihai Zhao, MD, PhD

“MR vessel wall imaging-based clinical trials in China:
design and achievements”

Dr. Xihai Zhao obtained his bachelor of clinical Medicine from Harbin Medical University in 1999,
master of medicine (radiology) from Shanghai Jiao Tong University School of Medicine in 2004, and
his Ph.D. (radiology) from Chinese People’s Liberation Army (PLA) Postgraduate Medical School in
2007. He was working in Yangzhou No.1 People’s hospital as a radiologist from 1999 to 2007 and
qualified as an attending physician in 2004. He is a Senior Research Fellow at University of
Washington in Seattle from 2007 to 2010. He joined a research group of Tsinghua University School of
Medicine as a principle investigator since 2010. His research interest is development and clinical
application of cardiovascular MR imaging techniques, particularly using CMR for Chinese population-
based cohort studies and clinical trials. He has published 52 papers in peer-reviewed international
journals. He is the member of ISMRM and AHA. He has served as an academic editor of journal of
PLoS ONE, Chinese Journal of Medical Imaging and the reviewer of Stroke, JMRI, MRI, American
Journal of Neuroradiology, etc.

4
Kiyofumi Yamada, MD, PhD

“The role of Magnetic Resonance and optical frequency
domain imaging in carotid artery stenting: the mr-cas
study”

Kiyofumi Yamada received his M.D. from Gifu University, Japan in 2002 and his Ph. D from Gifu
University Graduate School of Medicine (Neurosurgery) in 2011. He was a Senior Research Fellow in
the Vascular Imaging Laboratory of Department of Radiology, University of Washington from 2011 to
2013 under the mentorship of Dr. Chun Yuan and Dr. Thomas Hatsukami.
Currently, Dr. Yamada is an Assistant Professor of Neurosurgery of Hyogo College of Medicine,
Japan. His research interest is clinical application of plaque imaging including MRI for the prevention
and treatment of carotid artery stenosis and ischemic stroke.

Jianwen Luo, PhD

“Ultrasound carotid elastography of atherosclerotic
plaques validated by MRI”

Jianwen Luo received the B.S. and Ph.D. (with honors) degrees in Biomedical Engineering from
Tsinghua University, Beijing, China, in 2000 and 2005, respectively. He was a Postdoctoral Research
Scientist from 2005 to 2009, and an Associate Research Scientist from 2009 to 2011, in the Department
of Biomedical Engineering, Columbia University. He became an Associate Professor in the
Department of Biomedical Engineering in 2011. He was enrolled in the Thousand Young Talents
Program of China in 2012, and received the Excellent Young Scientists Fund from the National Natural
Science Foundation of China (NSFC) in 2013. He was supported by the Young Scientists Project of
National Key R&D Program of China in 2016. His research interest includes ultrasound elasticity
imaging, fluorescence molecular imaging and signal processing. He has authored or coauthored over
110 papers in international journals, 50 conference proceedings papers, and 120 conference abstracts.
He is a Senior Member of IEEE and serves as an Advisory Editorial Board member of Journal of
Ultrasound in Medicine, Associate Editor of Medical Physics, Faculty Member of Faculty of 1000, and
Member of IEEE Engineering in Medicine and Biology Society (EMBS) Technical Committee on
Biomedical Imaging and Image Processing (BIIP).

Matthew Rielly, Ph.D.

“Philips Healthcare clinical research board and

international collaborations in imaging”

Matthew Rielly received his undergraduate degree at Leeds University and his Ph.D. in Physics at the
University Bath UK. Following his Ph.D. Matthew moved to Seattle to join Philips Ultrasound.
During his time in the business Matthew has managed SW and System Architecture teams, as well as
5
holding multiple program management roles on several new ultrasound products. He has been an
author of IEC international safety standards for ultrasound and also supported the NGO Imaging the
World studying the impact of ultrasound diagnosis on maternal and perinatal mortality in low
resource environments. Recently Matthew spent three years in Bangalore, India, leading a multi-
discipline R&D team to develop a tablet ultrasound system, VISIQ.

Currently Matthew is a Regional Director for the Philips Healthcare Clinical Research Board. In this
role Matthew manages the research collaborations between Philips Healthcare and major hospitals
and research institutions in western USA. The goal for this position is to create research programs that
fuse Philips technology with the clinical desire to improve healthcare delivery in order to support the
creation of future practices that are both clinically and cost effective.

Greg Wilson, MD, PhD

“Contrast agents in cardiovascular MRI”

Greg Wilson received undergraduate degrees in Physics and Mathematics at the University of
Washington and PhD in Physics at the University of Wisconsin. His post-doctoral fellowship at the
Puget Sound VA HCS focused on clinical MRI and advancements in MR angiography with Dr. Jeffrey
Maki, MD, PhD. He spent the next ten years working as a clinical scientist for Philips MR under the
guidance of Stefan Fischer, PhD.

Currently, Dr. Wilson is a Research Scientist in Radiology at the University of Washington. He
continues to work with Dr. Maki and others on advancements in MR angiography, focusing on
optimization of contrast agent injections, as well as cardiac MR and MR lymphangiography. Recently,
his quantitative measurements of contrast agent relaxivity in whole blood have led to a fruitful
collaboration with Dr. Charles S. Springer, Jr., PhD at the Oregon Health and Science University.
Together, they are pursuing non-contrast methods of mapping cellular metabolic activity with MR.

Haiyan Ding, PhD

“Myocardium characterization with quantitative cardiac
MRI"

Dr. Haiyan Ding is MR scientist of Center of Biomedical Imaging Research, Department of
Biomedical Engineering and School of Medicine of Tsinghua University. Dr. Ding received her
bachelor degree from the Department of Electrical Engineering and both her Master and PhD degrees
from the Department of Biomedical Engineering of Tsinghua University in 1998 and 2005
respectively. Dr. Ding was lecturer in the Department of Biomedical Engineering at Tsinghua
University in 2005. She became a visiting faculty in the Medical Imaging Lab of Biomedical
Engineering Department at Johns Hopkins University since 2009, where she got trained on cardiac MR
imaging. She joined in Center of Biomedical Imaging Research in 2011. Her current research interests
are developing high-resolution cardiac MRI sequences especially for quantification of myocardium
relaxiometry. Her 3D whole heart coverage T1 and T2 mapping techniques have been applied in
6
preclinical and clinical diagnosis on myocardial diseases.

Rui Li, PhD

“4D flow MRI and its applications”

Dr. Rui Li received his Ph.D. and Bachelor degree at Electronic Engineering Department, Tsinghua
University, in 2005 and 2000 respectively, majored in Signal Professing. He was an engineer of
Wandong Medical Equipment Company from 2005 to 2009 after his graduation, in charge of MRI
sequence development and spectrometer design. He worked as a senior fellow in University of
Washington, Seattle, WA from 2009 to 2010, focused on high resolution carotid atherosclerotic plaque
MRI sequence design. He was recruited as a research associate professor of Tsinghua University in
2011. His current research interesting is cardiovascular imaging, especially imaging sequences and
reconstruction algorithms.

Swati Rane, PhD

“Cerebrovascular imaging of degenerative diseases”

Swati Rane is an imaging scientist with a focus on functional and perfusion-based neuroimaging. Her
specifically interesting in understanding the neuro-vascular coupling mechanisms in health and in
degenerative diseases. Her research objectives are three-fold. (i) To develop novel non-invasive MR
imaging sequences to quantify perfusion characteristics in the brain, (ii) To leverage such non-invasive
approaches for monitoring intervention strategies and longitudinal follow-up, and (iii) To develop
analysis and interpretation tools for the new approaches for deployment in a clinical workflow.

Mahmud Mossa-Basha, MD

“Intracranial vessel wall mri: applications and
implications”

Mahmud Mossa-Basha received his undergraduate degree from University of Michigan and medical
degree from the University of Toledo College of Medicine. Following his residency training in
diagnostic radiology at Henry Ford Hospital in Detroit, MI, Mahmud performed a 2-year
neuroradiology fellowship at Johns Hopkins University.
Currently, Dr. Mossa-Basha is an assistant professor in radiology in the division of neuroradiology. He
also serves as the director of cross-sectional neurovascular imaging and the co-director of intravascular
contrast policy. Dr. Mossa-Basha’s research is focused on cerebrovascular imaging, specifically vessel
wall MRI, CTA and MRA techniques and their clinical applications. Dr. Mossa-Basha is evaluating the
ability of vessel wall MRI to differentiate types of intracranial vasculopathies and its added value over
7
clinical diagnostic algorithms, in addition to its ability to characterize vascular injury and aneurysms.
He is also working with Drs. Yuan and Hatsukami on prospective trials characterizing intracranial
atherosclerosis, its longitudinal evolution and its association with downstream symptoms. Dr. Mossa-
Basha also is conducting prospective studies evaluating the prognostic value of DTI in trauma and
radiation therapy, as well as evaluating spinal cord segmentation of MRI techniques.

Hua Guo, PhD

“Advanced diffusion MRI and applications in
neuroradiology”

Dr. Hua Guo is a tenured associate professor at Center for Biomedical Imaging Research, Department
of Biomedical Engineering at Tsinghua University in Beijing. He received his Ph.D. from the
department of Biomedical Engineering at Duke University in 2006. He was an assistant professor in
department of radiology of New York University from 2008 to 2010. Before that he once worked in
Siemens as a scientist and at the University of Hong Kong as a postdoc. He has extensive research
experience in MRI physics, advanced imaging method development and preclinical studies. His
primary research interest focuses on two core areas in MRI. The first one is MRI physics including
novel sequence design and image reconstruction, which can potentially provide high spatiotemporal
resolution and multi-parametric quantitative imaging. Particularly, he is working on high resolution
diffusion weighted imaging at present. The second area is the translational application of advanced
MRI techniques for accurate diagnosis and disease management.

William Shuman, MD, FACR, FSCBTMR
FSCCT

“Reduced iodine dose dual energy CT of the aorta”

Willliam P. Shuman MD FSCCT, FACR, FSCBTMR is Medical Director of Radiology at UW Medical
Center and Interim Chairman of the UW School of Medicine Department of Radiology. He has been
involved in CT technology evolution since 1982 and currently serves on several medical advisory
boards to industry. Along with Kelley Branch, he began the cardiac CT program at UWMC in 2005.
Most recently, that program has ventured into dual energy cardiac CT applications including perfusion
and wide detector cardiac CT at high heart rates. His areas of research include impact of cardiac CT on
ED chest pain patients, long term outcomes followup after negative cardiac CT, radiation dose
reduction techniques in cardiac CT, and iodine dose reduction in aorta studies using dual energy CT.
He has lectured and published in wide detector TAVR planning CT technique as well.

8
Mike Averkiou, PhD

“Contrast enhanced ultrasound in atherosclerosis”

Mike Averkiou is associate professor at the Department of Bioengineering of the University of
Washington since 2015. He received a BS, an MS and a PhD in 1987, 1989 and 1994, respectively, all
in Mechanical Engineering with specialization in Nonlinear Acoustics/Biomedical Ultrasound, from the
University of Texas at Austin. He was a Postdoctoral Fellow at the Applied Physics Laboratory of the
University of Washington from 1994 to 1996 and worked on lithotripsy, bubble dynamics, and
therapeutic ultrasound. He joined Philips Medical Systems (1996-2005), and worked on diagnostic
ultrasound imaging and specifically tissue harmonic imaging, and ultrasound contrast agents. He was
associate professor at the Department of Mechanical and Manufacturing Engineering of the University
of Cyprus (2005-2015). He is a senior member of IEEE, an Acoustical Society of America fellow and
was awarded the Marie Curie Chair of Excellence from the European Commission. He has authored
and co-authored over 80 journal articles and conference proceedings, and 5 book chapters. He holds 38
U.S. and international patents on diagnostic and therapeutic applications of ultrasound.
Mike develops new ultrasound imaging and therapy technology for disease detection, improved cancer
treatment and monitoring, improved drug delivery to targeted cells, and heart disease. Using advanced
nonlinear imaging techniques and microbubble contrast agents, he is able to detect the earliest stages of
tumor angiogenesis and atherosclerosis, and closely monitor their treatment. He focuses on transferring
innovations from preclinical research into clinical use.

Adam Alessio, PhD, DABSNM

“Future applications in cardiovascular PET and CT”

Adam M. Alessio, Professor, Department of Radiology, Adjunct Professor of Bioengineering
and Mechanical Engineering, University of Washington. Prof. Alessio’s research focuses on
tomographic image reconstruction and data analysis for PET and CT systems. He is involved
in numerous translational research projects for topics including cardiac perfusion imaging,
myocardial wall assessment, radiation dose optimization for PET and CT, accurate system
modeling, and statistical estimation of parametric images. He received his Ph.D. in Electrical
Engineering from the University of Notre Dame and has been at UW since 2003. Dr. Alessio is
board certified in Nuclear Medicine Physics and Instrumentation by the American Board of
Science in Nuclear Medicine. Details can be found at http://faculty.washington.edu/aalessio/.

Anna V. Naumova, PhD

“Non-invasive imaging of transplanted cell fate and
function”

9