Induction of bone formation in primates : the transforming growth Factor-beta 3

210 Pages·2016·55.904 MB·English

by  Ripamonti, Ugo

Induction of
Bone Formation
in Primates
The Transforming Growth Factor-beta 3

Induction of
Bone Formation
in Primates
The Transforming Growth Factor-beta 3
Edited by
Ugo Ripamonti
CRC Press
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Version Date: 20150827
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Contents
Foreword: A Short History of Bone and Embryonic Induction ix
Contributors xiii
1 Introduction: The Discovery of Redundancy
and the Bone Induction Prerogative
of the Three Mammalian Transforming
Growth Factor-β Isoforms 1
UGO RIPAMONTI
1.1 Induction of Bone Formation before Redundancy
and the Discovery of the Induction of Bone
Formation by the Mammalian Transforming
Growth Factor-β Isoforms 1
References 10
2 Regenerative Medicine, the Induction
of Bone Formation, Bone Tissue Engineering,
and the Osteogenic Proteins of the Transforming
Growth Factor-β Supergene Family 15
UGO RIPAMONTI
2.1 Regenerative Medicine and Bone: Formation
by Autoinduction 15
v
vi CONTeNTs
2.2 Induction of Bone Formation: Osteogenesis
in Angiogenesis 21
2.3 Homologous but Molecularly Different
Pleiotropic Proteins of the TGF-β Supergene
Family Initiate Endochondral Bone Formation 32
Acknowledgments 37
References 39
3 Rapid Induction of Bone Formation by the
Transforming Growth Factor-β Isoform 47
3
UGO RIPAMONTI
3.1 The Transforming Growth Factor-β Isoform 47
3
3.2 TGF-β Isoform and the Induction
3
of Bone Formation in Primates 51
3.3 Coral-Derived Macroporous Bioreactors
as Delivery System for the Biological Activity
of the Recombinant hTGF-β Isoform 56
3
3.4 hTGF-β Master Gene and Gene Product:
3
Transfiguration of Neoplastic Masses into Bone 68
References 70
4 Induction of Bone Formation by the
Mammalian Transforming Growth Factor-βs:
Molecular and Morphological Insights 75
RAQUeL DUARTe, KURT LIGHTFOOT,
AND UGO RIPAMONTI
4.1 Introduction 75
4.2 Role of TGF-β in Differentiation of Osteoblasts 77
Canonical and Noncanonical TGF
Signaling in Bone Formation: Evidence
from Genetic Mouse Models 79
Canonical TGF-β Signaling Pathway 79
Noncanonical TGF-β Signaling
Pathways 83
TGF-β Signaling Cross Talk in Bone
Formation 84
TGF-β and MAPK Signaling 84
Wnt and TGF-β Signaling 85
TGF-β and PTH Signaling 87
CONTeNTs vii
TGF-β and FGF 87
TGF-β and BMP Signaling Cross Talk 87
4.3 Role of TGF-β in Bone Formation: Lessons
3
from the Non-Human Primate Papio ursinus 89
4.4 Perspectives 94
References 96
5 Regeneration of Mandibular Defects
in Non-Human Primates by the Transforming
Growth Factor-β and Translational Research
3
in Clinical Contexts 105
UGO RIPAMONTI AND CARLO FeRReTTI
5.1 Tissue Induction and Regeneration
of Craniomandibulofacial Defects 105
5.2 Rapid Induction of Bone Formation by the
hTGF-β Osteogenic Device in Mandibular
3
Defects of the Chacma Baboon (P. ursinus) 112
References 117
6 Synergistic Induction of Bone Formation
by Relatively Low Doses of Transforming
Growth Factor-β and -β in Binary Application
1 3
with Recombinant Human Osteogenic Protein-1 123
UGO RIPAMONTI
6.1 Homologous but Molecularly Different
Multiple Isoforms of the TGF-β
Supergene Family Initiate the Induction
of Bone Formation in Primate Species 123
6.2 Tissue Morphogenesis and Synergistic
Interaction by Interposed Homologous
Recombinant Morphogens 126
6.3 Synergistic Induction of Bone Formation 131
6.4 Temporal Expression of Markers of Bone
Differentiation by Induction: Mechanistic
Insights into the Synergistic Induction
of Bone Formation 137
6.5 Synergistic Induction of Bone Formation
in Full-Thickness Mandibular Defects
of P. ursinus 141
viii CONTeNTs
Acknowledgments 142
References 144
7 Induction of Periodontal Tissue Regeneration
by Recombinant Human Transforming Growth
Factor-β with and without Myoblastic/Pericytic
3
Stem Cells in Papio ursinus 149
JeAN-CLAUDe PeTIT AND UGO RIPAMONTI
7.1 Introduction 149
7.2 Origins 151
7.3 Periodontal Tissue Regeneration
by the Osteogenic Proteins of the TGF-β
Supergene Family 156
7.4 Periodontal Tissue Regeneration by Naturally
Derived, Highly Purified and Recombinant
Human Bone Morphogenetic Proteins 158
7.5 Induction of Periodontal Tissue Regeneration
by Recombinant Human TGF-β in P. ursinus 173
3
7.6 Challenges and Perspectives in Regenerative
Medicine of the Periodontal Tissues
by the hTGF-β Isoform 178
3
References 184