Immunophenotypic Analysis PDF
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Boca Raton London New York CRC Press is an imprint of the Taylor & Francis Group, an informa business MEDICAL INTELLIGENCE UNIT Immunophenotypic Analysis Second Edition Katalin Pal6czi, M.D., Ph.D., D.Sc. Professor and Chair of Immunology Faculty of Health Sciences Semmelweis University National Institute of Haematology and Immunology Budapest, Hungary Boca Raton London New York CRC Press is an imprint of the Taylor & Francis Group, an informa business IMMUNOPHENOTYPIC ANALYSIS SECOND EDITION Medical Intelligence Unit First published 2005 by Landes Bioscience Published 2018 by CRC Press Taylor & Francis Group 6000 Broken Sound Parkway NW, Suite 300 Boca Raton, FL 33487-2742 © 2005 by Taylor & Francis Group, LLC CRC Press is an imprint of Taylor & Francis Group, an Informa business No claim to original U.S. Government works ISBN-13: 978-1-58706-101-l (hbk) This book contains information obtained from authentic and highly regarded sources. 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Visit the Taylor & Francis Web site at http://www.taylorandfrancis.com and the CRC Press Web site at http://www.crcpress.com While the authors, editors and publisher believe chat drug selection and dosage and the specifications and usage of equipment and devices, as set fonh in this book, are in accord with current recommend- ations and practice at the time of publication, they make no warranty, expressed or implied, with respect to material described in this book. In view of the ongoing research, equipment development, changes in governmental regulations and the rapid accumulation of information relating to the biomedical sciences, the reader is urged to carefully review and evaluate the information provided herein. Library of Congress Cataloging-in-Publication Data Pal6czi, Katalin. Immunophenotypic analysis / Katalin Pal6czi. --2nd ed. p. ; cm. -- (Medical intelligence unit) Rev. ed. of: Clinical applications ofimmunophenotypic analysis. cl 994. Includes bibliographical references and index. ISBN 1-58706-101-5 I. Immunophenotyping. 2. Hematopoietic stem cell disorders --Diagnosis. I. Pal6czi, Katalin. Clinical applications of im- munophenotypic analysis. II. Title. III. Series: Medical intelli- gence unit (Unnumbered : 2003) [DNLM: I. lmmunophcnotyping. 2. Bone Marrow--immuno- logy. 3. Hematopoietic Stem Cells--immunology. 4. Leukemia --immunology. 5. Lymphoma, Non-Hodgkin--immunology. QY 250 Pl818i 2004] RC644.5.P25 2004 616.07' 582--dc2 l 2001004704 To our family members whose patience and unwavering support have allowed us to share important new information with those dedicated to the conquest of malignant disease Tay or & Francis & Taylor Francis Group http://taylorandfrancis.com CONTENTS------------- Preface.....................................................................................................................viii 1. Normal Hematopoietic Cell Differentiation.....................................................1 Gyongyi Szabo and Angela Dolganiuc Immunologic Marker Analysis of Cells in the Various Stages of Hematopoietic Differentiation................................................................ 1 International Nomenclature and Functional Characterization of Immunologic Markers..............................................................................20 2. Application of Monoclonal Antibodies to the Diagnosis and Classification of Acute Leukemias............................................................29 Νότα Regiczy More than Routine Immunophenotyping of Acute Leukemias................29 Immunological Classification of ALL............................................................32 Immunophenotypic Classification of Acute Myeloblastic Leukemia .... 37 Biphenotypic Acute Leukemia..........................................................................41 Undifferentiated Acute Leukemia...................................................................42 Minimal Residual Disease in Acute Leukemia.............................................42 Multidrug-Resistance in Acute Leukemia.....................................................43 3. Immunophenotypic Markers in the Diagnosis of Non-Hodgkin’s Lymphomas.........................................................................48 Andrds Matolcsy Lineage of Non-Hodgkin’s Lymphomas........................................................48 B-Cell Non-Hodgkin’s Lymphomas...............................................................49 T-Cell Non-Hodgkin’s Lymphomas...............................................................53 4. Clinical Application of Immunophenotyping in Immunodeficiencies.........................................................................................62 Katalin Pdldczi Congenital (Primary) Immunodeficiencies...................................................62 Cellular and Combined Immunodeficiency Diseases.................................63 Predominantly Antibody Deficiency Diseases..............................................68 Phagocytic Cell Disorders..................................................................................71 Use of Immunophenotyping in Clinical Evaluation of Patients with Primary Immunodeficiencies..............................................................73 Human Immunodeficiency Virus Infection and Acquired Immunodeficiency Syndrome......................................................................74 5. Immunophenotyping in Hematopoietic Stem Cell Transplantation .... 78 Katalin Pdldczi Use of CD34 for Identification of Hematopoietic Progenitors...............78 Reconstitution of Hematopoiesis Posttransplant and Normal Hematopoiesis During Ontogeny...............................................................79 Multi-Tissue Potential of HSC.........................................................................86 Index..........................................................................................................................89 Tay or & Francis & Taylor Francis Group http://taylorandfrancis.com EDITOR Katalin FiUai, M.D., PK.D., D.Sc. Professor and Chair of Immunology Faculty of Health Sciences Semmelweis University National Institute of Haematology and Immunology Budapest, Hungary E-mail: [email protected] Chapters 4, 5 = CONTRIBUTORS = Angela Dolganiuc, M.D., Ph.D. Department of Medicine University of Massachusetts Medical School Worcester, Massachusetts, U.S.A. Chapter 1 Andras Matolcsy, M.D., Ph.D., D.Sc. Associate Professor Department of Pathology Faculty of Medicine Pecs University Pecs, Hungary E-mail: [email protected] Chapter 3 Nora Regeczy, M.D., Ph.D. Membrane Biology and Immunopathology Research Group Hungarian Academy of Sciences National Institute of Haematology and Immunology Budapest, Hungary E-mail: [email protected] Chapter 2 Gyongyi Szabo, M.D., Ph.D. Professor Department of Medicine University of Massachusettes Medical School Worcester, Massachusetts, U.S.A. E-mail: [email protected] Chapter 1 Tay or & Francis & Taylor Francis Group http://taylorandfrancis.com PREFACE The first edition of Clinical Application of Immunophenotypic Analysis appeared in 1994. This work was intended to be a comprehensive and up- to-date book developed to serve a diverse group of individuals ranging from practicing general immunologists, hematologists, students of the field, basic scientists involved in research of cell surface antigens, as well as practicing internists and pediatricians. The science and practice of flow cytometry and immunophenotyping have continued to evolve. With more and more clinical information and evaluation demonstrating the value of immunophenotypic analysis, this has become an established clinical proce dure. The rapid advancement of this field has necessitated the creation of a second edition, in order that the book remains current and useful to our readers. Besides, there is a need to put a great deal of effort into promoting the value of clinical flow cytometric tests which can be more efficiently per formed and provide more definitive results than many of the classical proce dures. This is especially important in areas of clinical immunology and hematology. We retained the features of the first edition that were regarded by our audience as most valuable, but altered the second edition as required to fur ther enhance the quality of the book. We have incorporated much new in formation regarding normal immune cell development as well as diagnosis of acute leukemias, malignant lymphomas and characterization of stem cells for transplantation. To accommodate these new insights without significandy increasing the size of the book, we have reduced discussions of historical debates that are now resolved by experiments. All chapters have been rewritten and extensively updated to reflect the explosion of knowledge. Beside the editor four excellent contributors have been involved in creating the second edition and all the authors are working leaders in their subjects. Most of the authors confront their clinical prob lems on a daily basis and have that uniquely urgent spur to keep them at the cutting edge. As a result of the collective labor of a creative people, we now have a book, which hopefully fills a real need in one of the most exciting branches of modern medicine. The contributors to this edition have done an outstanding job, and the editor is indebted to them for their diligence, perseverance, and scholarly presentations. The Editor
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