Immunobiology of HLA: Volume II: Immunogenetics and Histocompatibility

636 Pages·1989·28.359 MB·English

by  Walter F. Bodmer (auth.), Bo Dupont (eds.)

Immunobiology of HLA
Bo Dupont
Editor
Immunobiology
of HLA
Volume II
Immunogenetics and
Histocompatibility
With 188 Illustrations, 8 in Full Color
Springer Science+Business Media, LLC
Bo Dupont
Member, Sloan-Kettering Institute for Cancer Research;
Professor of Immunology
Cornell University Graduate School of Medical Science
New York, New York 10021, USA
Library of Congress Cataloging-in-Publication Data
Immunobiology of HLA I Bo Dupont, editor.
p. em.
Proceedings of the Tenth International Histocompatibility Workshop
and Conference, held in Princeton, N.J. and New York City, Nov.
12-23, 1987.
Dedicated to the memory of Ruggero Ceppellini.
Contents: v. I. Histocompatibility testing 1987 - v. 2.
Immunogenetics and histocompatibility.
Includes bibliographies and indexes.
I. Histocompatibility testing-Congresses. 2. HLA
histocompatibility antigens-Congresses. I. Dupont, Bo.
II. Ceppellini, Ruggero. III. International Histocompatibility
Workshop and Conference (10th: 1987: Princeton, N.J. and New York,
N.Y.)
[DNLM: I. Histocompatibility Testing-congresses. 2. HLA
Antigens-immunology-congresses. WO 680 13237 1987]
QR187.H57145 1989
616.07'9-dcl9
DNLM/DLC
88-39761
© 1989 by Springer Science+B usiness Media New York
Originally published by Springer-Verlag New York, Inc. in 1989
Softcover reprint of the hardcover 1st edition 1989
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ISBN 978-3-662-38980-5 ISBN 978-3-662-39946-0 (eBook)
DOI 10.1007/978-3-662-39946-0
Preface to Volume II
This publication contains six invited review papers covering major topics on the molecular
biology of HLA (Part I) and 253 original contributions (Part 2) selected from the 540
abstracts presented at the Histocompatibility Conferences in New York City, November
18-23, 1987.
The format of organizing an international conference on immunogenetics and histocom
patibility in conjunction with the international histocompatibility workshop occurred for
the first time in 1980 at the Eighth International Histocompatibility Workshop in Los
Angeles. This arrangement was repeated in 1984 when the Ninth Workshop meeting
took place in Munich and the conference in Vienna. The back-to-back organization of
histocompatibility workshop and histocompatibility conference takes advantage of the
fact that investigators with primary interest and active participation in the histocompatibil
ity workshops constitute only a subset of the scientific community involved in research
on the major histocompatibility complex in man. Conversely, many immunogeneticists,
biochemists, and molecular biologists who are not engaged in histocompatibility testing
are keenly interested in and wish to communicate and interact with their colleagues en
gaged in the application of immunogenetics.
The scope of the histocompatibility and immunogenetic conference was further ex
panded on this occasion because it was possible to arrange the 13th annual meeting of
the American Society for Histocompatibility and Immunogenetics (ASHI) immediately
folloWing the international conference. The scientific programs for these two meetings
were coordinated and planned jointly, allowing a comprehensive coverage of many timely
issues.
The organization and planning of these two conferences required close collaboration
between the Council and Program Committee of ASHI and the Organizing Committee of
the International Histocompatibility Workshop. I wish to express my thanks for the pro
ductive collaboration with Herbert A. Perkins, Chairman, 13th Annual Meeting; Rene
Duquesnoy, President, ASHI; Peter Parham, Scientific Program, ASHI; Adriana Zeevi,
Abstract Committee, ASHI; and David Eckels, Educational Program, ASHI.
The attendance at the two conferences in New York City far exceeded our expectations.
More than I ,400 active participants attended the meetings, and we reached the limit of
what the hotel conference center could accommodate. It was indeed a very exciting expe
rience to see the vibrant and engaged participation of colleagues who have been active in
this field for more than 25 years as well as the many students, fellows, and other younger
investigators.
This publication is designed with the intent of providing a handbook on the "state of
the art" primarily concerning molecular biology and immunogenetics of the HLA system.
The review papers included in Part 1 were prepared during the spring of 1988 and the
authors of the papers in Part 2 have been requested to update their manuscripts to reflect
the changes made by the WHO Nomenclature Committee. It is my hope that this publica
tion will be useful as an easily accessible reference source for several years to come. The
references in each paper are provided with full titles for this purpose.
New York, New York, USA Bo Dupont
Chairman
Tenth International Histocompatibility
Workshop and Conference
v
Contents of Volume II
Preface to Volume II . . . . . . . . . . . . . . . . . . . . . . .. .. . . . . .. . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . v
Contents of Volume I . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xx1x
Color Plates . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xlix
Part 1
Summary Reports
HLA 1987
WALTER F. BODMER ........................................................................... .
HLA-A,B,C: Patterns of Polymorphism in Peptide-Binding Proteins
PETER PARHAM, DAVID A. LAWLOR, RUSSELL D. SALTER,
CATHERINE E. LOMEN, PAMELA J. BJORKMAN, and PETER D. ENNIS .. .. ....... .. ...... 10
HLA Class I Gene Family: Characterization of Genes Encoding
Non-HLA-A,B,C Proteins
HARRY T. ORR................................................................................... 33
Molecular Structure of Human Class II Antigens
JOHN I. BELL, JOHN A. TODD, and HUGH 0. MCDEVITT . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 40
Regulation of HLA Class II Gene Expression
s.
JANET LEE..................................................................................... 49
Molecular Genetics of the Class III Region of the HLA Complex
PERRIN c. WHITE................................................................................ 62
Part 2: Original Contributions
Section I Genetic Organization of the HLA Region:
MHC Mapping
Mapping of the Human Major Histocompatibility Complex by
Pulsed Field Gel Electrophoresis
IAN DUNHAM, CAROLE A. SARGENT, JOHN TROWSDALE,
and R. DUNCAN CAMPBELL ......................................... ·........................... 73
Towards a Physical Map of the HLA Complex
ANDREAS ZIEGLER, KATHERINA BLOEMER, HElKE POHLA, ELISABETH WEISS,
PETER SCHNEIDER, and JIANNIS RAGOUSSIS.................................................. 75
Organization of the HLA Class I Region
PIERRE PONTAROTTI, GIOVANNA CHIMINI, CATHERINE NGUYEN, JOELLE BORETTO,
and BERTRAND R. JORDAN..................................................................... 79
Mapping of HLA Class II Genes by Pulsed Field Gel Electrophoresis
and Size Polymorphism
HIDETOSHI INOKO, KIMIYOSHI TSUJI, VICKY GROVES, and JOHN TROWSDALE.......... 83
Vll
The Tumor Necrosis Factor (TNFA) and Lymphotoxin (TNFB) Genes Map
Between the HLA Class III and Class I Regions
J. RAGOUSSIS, K. BLOEMER, E. H. WEISS, and A. ZIEGLER .. .. .. .. .. .. .. .. .. .. .. .. .. . . . 86
A Human t-Complex-Related Gene (TCPl) Is not Closely Linked
to the HLA Complex
ANDREAS ZIEGLER, GEORG GRADL, JIANNIS RAGOUSSIS,
and CHRISTA FONATSCH ........................................................................ 87
Section II Class I Histocompatibility Antigens: Genes, Structure,
and Allotypes
Molecular Characterization of Serologic Recognition Sites in the HLA-A2
Molecule Using Oligonucleotide-Generated Site-Specific Mutants
JESUS SANTOS-AGUADO, JUAN J. YUNIS, E. MILFORD, EDMOND J. YUNIS,
and JACK L. STROMINGER . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 93
Molecular Characterization of Allospecific Cytotoxic T-Lymphocyte
Recognition Sites in the HLA-A2 Molecule Using Oligonucleotide-Generated
Site-Specific Mutants
JESUS SANTOS-AGUADO, MARY A.V. CRIMMINS, STEVEN J. MENTZER,
JACK L. STROMINGER, and STEVEN J. BURAKOFF . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 97
Mapping of Serologic and CTL-Defined Epitopes on HLA-A2 by
Site-Directed Mutagenesis
KEVIN T. HOGAN, JOHN P. RIDGE, SCOTI F. WALK, PETER PARHAM,
and VICTOR H. ENGELHARD ................................................................... 101
Cytotoxic T Cell and Antibody Recognition of HLA-A2,A28 Molecules Analyzed
by Site Directed Mutagenesis
RUSSELL D. SALTER, CAROL CLAYBERGER, CATHERINE E. LoMEN,
ALAN M. KRENSKY, and PETER PARHAM .................................................... 103
Peptides Derived From HLA-A2 Modulate Lysis by HLA-A2-Specific
Cytotoxic T Lymphocytes
ALAN M. KRENSKY, PETER PARHAM, JONATHAN ROTHBARD, DAVIDS. LUDWIG,
GARY K. SCHOOLNIK, and CAROL CLA YBERGER............................................ 105
Variant and Mutant HLA-A2 Molecules Affect Recognition of Influenza Matrix
Peptide 56-68 by Cytotoxic T Lymphocytes
ANDREW J. MCMICHAEL, FRANCES M. GOTCH, JONATHAN B. ROTHBARD,
JESUS SANTOS-AGUADO, and JACK L. STROMINGER . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 107
Class I-Presented Influenza Peptides Predicted by an Algorithm
that Selects Class 11-Presented Peptides
VICTOR E. REYES, L. THOMAS CHIN, and ROBERT E. HUMPHREYS . . . . . . . . . . . . . . . . . . . . . 110
Structure of HLA-B27 Subtypes: Evolutionary Implications
SUSANA ROJO and JOSE LOPEZ DE CASTRO . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Ill
Cellular Allorecognition of HLA-B27: Clonal Heterogeneity and Identification
of Immunodominant Sites
PEDRO APARICIO, DoLORES JARAQUEMADA, and JOSE A. LOPEZ DE CASTRO .......... 112
Molecular Analysis of the Variant Alloantigen HLA-B27d Identifies
a Unique Single Amino Acid Substitution
SUNG YOON CHOO, THOMAS ST. JOHN, HARRY T. ORR, and JOHN A. HANSEN ....... 113
viii
CTL Recognize Certain Bacterial Antigens in Association with HLA-B27
CARMEL M. EDWARDS, JOHNS. SULLIVAN, LINDA I. UPFOLD,
and ANDREW F. GECZY......................................................................... 115
HLA-BW62 Variants Identified by a Cytotoxic T-Lymphocyte Clone
and lsoelectric Focusing Gel Electrophoresis
LI-AN FAN, SUNG YOON CHOO, PATRICK G. BEATTY, and JOHN HANSEN ............... 117
Comparison of the Amino Acid Sequences Encoded by the HLA-Bw47 and
HLA-Bl3 Genes
JACQUELINE ZEMMOUR. PETER D. ENNIS, PETER PARHAM, and Bo DUPONT ........... 120
Cloning and Analysis of the eDNA Encoding New HLA-C Antigen Cx52
HAJIME TAKATA, HIDETOSHI INOKO, ASAKO ANDO. BUNJI WATANABE,
KIMIYOSHI TSUJI, and HISAMI IRI. . . . .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. . . . . . .. .. . 122
A C-Locus-Related HLA Class I Molecule on Human Trophoblast
SHIRLEY A. ELLIS, TOM STRACHAN, and ANDREW J. MCMICHAEL ...................... 124
How Similar Are Chimpanzee and Human Class I Antigens?
DAVID A. LAWLOR. FRANCES E. WARD. and PETER PARHAM ............................ 126
Serological and Biochemical Studies of an HLA-A Locus Public Epitope
DOLORES J. SCHENDEL and ANDREAS ZIEGLER ............................................. 127
Characteristics of HLA Class I Antigens in Human Sera
LIA M.E. DOBBE. NICO J. STAM. JACQUES J. NEEFJES. and MARIUS J. G!PHART ..... 128
The H-2Kkmi Mutation: A Single Nucleotide Substitution Causes
Multiple Functional Differences in a Murine Class I MHC Molecule
J.M. MARTINKO, J.C. SOLHEIM, and J. GELIEBTER ........................................ 129
Molecular Mapping of Antigenic and Cytotoxic T Lymphocyte
Recognition Determinants on the Major Histocompatibiity Complex
Class I Molecule Kb Using In Vitro Mutant Cell Lines
PARTHASARATHI AJITKUMAR. STEVEN GEIER. FRANCESCOPAOLO BORRIELLO,
MAYUMA NAKAGAWA. JEFFREY BLUESTONE. and STANLEY NATHENSON ............... 130
Section III Class I Histocompatibility Antigens:
Transfection and Gene Expression
Isolation of an HLA-A,B,C Null Human Cell Line Capable
of Expressing Transferred Class I Genes
YOJI SHIMIZU and ROBERT DEMARS .......................................................... 135
Selective Increase of Expression of HLA Class I Molecules by HLA-A3,
HLA-B7, and HLA-Cw3 Transfected P815 Mastocytoma Cells After Subsequent
Transfection by the Human ~2-Microglobulin Gene
B.M. PERARNAU, A. GILLET, M. BARAD, R. HAKEM, and F.A. LEMONNIER ......... 136
The Cloning, Exon Shuffling, and Expression of the HLA-Cwl Gene
SHINICHI MIZUNO. JENNIFER NG, Bo DUPONT. and Sao YOUNG YANG ................. 138
Weak Stimulation of Murine Cytotoxic T Cells by Human Class I Molecules Maps
to the al + a2 Domains
VICTOR H. ENGELHARD, MARK HOLTERMAN, and AI-XU ANT. LE ...................... 140
IX
Section IV Class I Histocompatibility Antigens: Regulation
Phorbol Ester (PMA)-Activated Protein Kinase C Phosphorylates
the Class I HLA Heavy Chain
JENNIFER NG, SHINICHI MIZUNO, Bo DUPONT, and Sao YOUNG YANG ................. 145
Differential Modulation by Anti-HLA Class I Monoclonal Antibodies
ofT-Cell Proliferation Induced via C02 and CD3 Pathways
MARIA CATERINA TURCO, MARIO DE FELICE, Sao YOUNG YANG,
SOLDANO FERRONE, and SALVATORE VENUTA .............................................. 147
Anti-HLA Class I Antibodies Alter Gene Expression
in Human Natural Killer Cells
JACKI KORNBLUTH and RICHARD G. HOOVER............................................... 150
Adenovirus Inversely Modulates Target Cell Class I Antigen Expression and
Sensitivity to Natural Killing
W.J. STORKUS, P. CRESSWELL, E.B. PATTERSON, and J.R. DAWSON .................. 152
Differential Regulation of HLA-B Antigen Expression by Interferon
HELMUTH SCHMIDT, ELISABETH WEISS, VOLKER GEKELER, HANS-JORG BOHRING,
GABRIELE ENGLER-BLUM, ULRIKE REICHMANN, and CLAUDIA MOLLER .. .. .. .. .. .. .. .. 155
Section V Class I Histocompatibility Antigens: New Class I, TL/Qa-Like,
and Others
Transfer and Expression of Human Non-A,B,C Class I Genes
in Human HLA-A,B,C Null Lymphoblastoid Cells
Yon SHIMIZU, BEVERLY H. KOLLER, DANIEL E. GERAGHTY, HARRY T. ORR,
and ROBERT DEMARS........................................................................... 159
Activated T-Cells Express a Non-HLA-ABC Class I Gene that
Is Inducible with Gamma-Interferon
SHINICHI MIZUNO, JOSEPH A. TRAPANI, Bo DUPONT, and Sao YOUNG YANG ......... 161
A Novel Class I HLA Gene
P. ANDREW BIRO, BARBARA HERBUT, and HILLIARD FESTENSTEIN ...................... 163
Isolation from the Human MHC of a Class I Gene Encoding a Nonubiquitous
Antigen Expressed on Activated Cells
P. PAUL. R. FAUCHET, M.Y. BOSCHER, P. VILLEDIEU, M. MASSET,
G. MERDRIGNAC, J. DAUSSET, L. DEGOS, and D. COHEN ................................ 166
Cellular Distribution and Expression Regulation of HA Molecules
(New Class I-Like Antigens)
R. FAUCHET, M. BOSCHER, N. GENETET, 0. BOUHALLIER, P. PAUL,
and B. GENETET .. .. . . . . . . .. .. . . .. .. .. .. .. . . . . . . . . . . . . . . . . . .. . . . . . . . . . . .. . . . . . . . . . .. .. .. .. .. .. .. . 170
A Human T-Cell Clone Recognizes a Qa- or Tla-Like Antigen in Man
RUOOLFWANK ................................................................................... 174
Comparative Analysis of TLb and TLc Gene Organization
G. DALON BROWN, GREGORY EGAN, YECHIN CHOI. and DANIEL MERUELO ........... 175
Study of an Endogenous Retrovirus-Like Locus Reveals
Genetic Polymorphisms Related to Mouse TLA Haplotypes
C. PAMPENO and D. MERUELO ................................................................ 177
X
Section VI Class I Histocompatibility Antigens: HLA-DRBl
Analysis of lsotypic and Allotypic Sequence Variation in the HLA-DRI3 Region
Using the In Vitro Enzymatic Amplification of Specific DNA Segments
HENRY A. ERLICH. STEPHEN J. SCHARF. CHRISTOPHER M. LONG.
and GLENN T. HORN ............................................................................ 181
Two different T-Cell Perspectives on the DR! Alloantigen
DAVID D. ECKELS. THOMAS W. SELL. JAY B. HUNTER. and SUSAN A. HACKBARTH 185
Polymorphism of the DR! Haplotype: Structural and Functional Analysis
BARBARA L. ZIFF, CAROLYN KATOVICH HURLEY. SANDRA ROSEN-BRONSON,
TING TANG, ROBERT HARTZMAN, JACK SILVER, PETER GREGERSEN,
DAVID ECKELS, and ARMEAD H. JOHNSON .................................................. 187
The Heterogeneity of HLA-DR2
MACHTELD 0UDSHOORN, ERNETTE D. DU TOIT, ROBERT W. MARTELL,
and DEREK G. TALJAARD ....................................................................... 190
Correlation of Primary Sequence and Functional Determinants
of HLA Class II Molecules
N.L. REINSMOEN and F.H. BACH ............................................................. 191
Molecular Studies of a Rare HLA Haplotype: Implications
for Mechanisms of Generating Class II Gene Polymorphisms
CHIH-PIN LiU, SHAOKEE Wu, and FRITZ H. BACH .............................. : ........... 194
Identification of Dw2, Dwl2, and "Short" DR2 Splits
with Sequential Exon-Specific DRI3, DQI3, and DQa eDNA Probes
JEFFREY L. BIDWELL, ELIZABETH A. BIDWELL, DAVID A. SAVAGE,
DEREK MIDDLETON, CELINE CULLEN, PETER T. KLOUDA,
and BEN A. BRADLEY........................................................................... 198
Subdivision of Haplotype HLA-DR3 by Biochemical and Functional Analysis
S.H. SACKS, A. BUSHELL, K.J. WOOD, and A.J. MCMICHAEL .......................... 199
Characterization of Multiple HLA-DR3 Haplotypes
TOM COTNER, ELIZABETH MELLINS, and DONALD A. PIOUS .............................. 200
DR3 Heterogeneity in American Blacks
ARMEAD H. JOHNSON, TING FANG-TANG, SANDRA ROSEN-BRONSON,
FU-MEEJ ROBBINS, NORIKO STEINER, ROBERT J. HARTZMAN, PETER K. GREGERSEN,
JACK SILVER, BARBARA ZIFF and CAROLYN R. HURLEY .................................. 202
Correlation Between Function and Expression of the Two DR Molecules
in DR3 Haplotypes
DOMINIQUE JAQUES, JOSE BERDOZ, EDUARDO MARTINEZ, MICHEL JEANNET,
BERNARD MACH, and CLAUDE IRLE ........................................................... 204
Single Amino Acid Substitutions Within the HLA-DR413 Chain
1
Create Multiple T -Cell Recognition Sites
J. GOROZNY and C.M. WEYAND .............................................................. 207
DR4 Recognized by PL T Clones
T. KANEKO, M. 0HKUBO, K. ITOH, and N. KASHIWAGI .................................. 210
A Novel DR 5 B 1 (DR w 11) Chain with a Distinctive Third Diversity Region
RICHARD M. CRAPPER, PETER K. GREGERSEN, SICY H. LEE,
ANTONIO NUNEZ-ROLDAN, PARVIN MERRYMAN,
and ROBERT J. WINCHESTER ................................................................... 212
xi