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Histopathological Image Analysis in Medical Decision Making Nilanjan Dey Techno India College of Technology, India Amira S. Ashour Tanta University, Egypt Harihar Kalia Seemantha Engineering College, India R.T. Goswami Techno India College of Technology, India Himansu Das KIIT University, India A volume in the Advances in Medical Technologies and Clinical Practice (AMTCP) Book Series Published in the United States of America by IGI Global Medical Information Science Reference (an imprint of IGI Global) 701 E. Chocolate Avenue Hershey PA, USA 17033 Tel: 717-533-8845 Fax: 717-533-8661 E-mail: [email protected] Web site: http://www.igi-global.com Copyright © 2019 by IGI Global. All rights reserved. No part of this publication may be reproduced, stored or distributed in any form or by any means, electronic or mechanical, including photocopying, without written permission from the publisher. Product or company names used in this set are for identification purposes only. Inclusion of the names of the products or companies does not indicate a claim of ownership by IGI Global of the trademark or registered trademark. Library of Congress Cataloging-in-Publication Data Names: Dey, Nilanjan, 1984- editor. | Ashour, Amira, 1975- editor. | Kalia, Harihar, editor. | Goswami, R. T., editor. | Das, Himansu, editor. Title: Histopathological image analysis in medical decision making / Nilanjan Dey, Amira S. Ashour, Harihar Kalia, R.T. Goswami, and Himansu Das, editors. Description: Hershey, PA : Medical Information Science Reference, [2019] | Includes bibliographical references. Identifiers: LCCN 2018008106| ISBN 9781522563167 (hbk.) | ISBN 9781522563174 (ebook) Subjects: | MESH: Histological Techniques | Image Processing, Computer-Assisted | Clinical Decision-Making | Pattern Recognition, Automated Classification: LCC RC78.7.D53 | NLM QS 26.5 | DDC 616.07/54--dc23 LC record available at https://lccn.loc.gov/2018008106 This book is published in the IGI Global book series Advances in Medical Technologies and Clinical Practice (AMTCP) (ISSN: 2327-9354; eISSN: 2327-9370) British Cataloguing in Publication Data A Cataloguing in Publication record for this book is available from the British Library. All work contributed to this book is new, previously-unpublished material. The views expressed in this book are those of the authors, but not necessarily of the publisher. For electronic access to this publication, please contact: [email protected]. Advances in Medical Technologies and Clinical Practice (AMTCP) Book Series ISSN:2327-9354 EISSN:2327-9370 Editor-in-Chief: Srikanta Patnaik, SOA University, India & Priti Das, S.C.B. Medical College, India Mission Medical technological innovation continues to provide avenues of research for faster and safer diagnosis and treatments for patients. Practitioners must stay up to date with these latest advancements to provide the best care for nursing and clinical practices. The Advances in Medical Technologies and Clinical Practice (AMTCP) Book Series brings together the most recent research on the latest technology used in areas of nursing informatics, clinical technology, biomedicine, diagnostic technologies, and more. Researchers, students, and practitioners in this field will benefit from this fundamental coverage on the use of technology in clinical practices. Coverage • Nutrition IGI Global is currently accepting • Patient-Centered Care manuscripts for publication within this • Clinical Studies series. To submit a proposal for a volume in • Biometrics this series, please contact our Acquisition • Medical informatics Editors at [email protected] or • Medical Imaging visit: http://www.igi-global.com/publish/. • Nursing Informatics • Telemedicine • Neural Engineering • Clinical Data Mining The Advances in Medical Technologies and Clinical Practice (AMTCP) Book Series (ISSN 2327-9354) is published by IGI Global, 701 E. Chocolate Avenue, Hershey, PA 17033-1240, USA, www.igi-global.com. This series is composed of titles available for purchase individually; each title is edited to be contextually exclusive from any other title within the series. For pricing and ordering information please visit http://www.igi-global.com/book-series/advances-medical-tech- nologies-clinical-practice/73682. Postmaster: Send all address changes to above address. ©© 2019 IGI Global. All rights, including translation in other languages reserved by the publisher. No part of this series may be reproduced or used in any form or by any means – graphics, electronic, or mechanical, including photocopying, recording, taping, or information and retrieval systems – without written permission from the publisher, except for non commercial, educational use, including classroom teaching purposes. The views expressed in this series are those of the authors, but not necessarily of IGI Global. Titles in this Series For a list of additional titles in this series, please visit: https://www.igi-global.com/book-series/advances-medical-technologies-clinical-practice/73682 Research Advancements in Pharmaceutical, Nutritional, and Industrial nzymology Shashi Lata Bharati (North Eastern Regional Institute of Science and Technology, India) and Pankaj Kumar Chaurasia (Babasaheb Bhimrao Ambedkar Bihar University, India) Medical Information Science Reference • ©2018 • 549pp • H/C (ISBN: 9781522552376) • US $255.00 Microbial Cultures and Enzymes in Dairy Technology Şebnem Öztürkoğlu Budak (Ankara University, Turkey) and H. Ceren Akal (Ankara University, Turkey) Medical Information Science Reference • ©2018 • 413pp • H/C (ISBN: 9781522553632) • US $265.00 Multifunctional Nanocarriers for Contemporary Healthcare Applications Md. Abul Barkat (K.R. Mangalam University, India) Harshita A.B. (K.R. Mangalam University, India) Sarwar Beg (Jubilant Generics, India) and Farhan J. Ahmad (Jamia Hamdard, India) Medical Information Science Reference • ©2018 • 602pp • H/C (ISBN: 9781522547815) • US $265.00 Biomedical Signal and Image Processing in Patient Care Maheshkumar H. Kolekar (Indian Institute of Technology Patna, India) and Vinod Kumar (Indian Institute of Technology Roorkee, India) Medical Information Science Reference • ©2018 • 312pp • H/C (ISBN: 9781522528296) • US $265.00 Next-Generation Mobile and Pervasive Healthcare Solutions Jose Machado (University of Minho, Portugal) António Abelha (University of Minho, Portugal) Manuel Filipe Santos (University of Minho, Portugal) and Filipe Portela (University of Minho, Portugal) Medical Information Science Reference • ©2018 • 286pp • H/C (ISBN: 9781522528517) • US $245.00 For an entire list of titles in this series, please visit: https://www.igi-global.com/book-series/advances-medical-technologies-clinical-practice/73682 701 East Chocolate Avenue, Hershey, PA 17033, USA Tel: 717-533-8845 x100 • Fax: 717-533-8661 E-Mail: [email protected] • www.igi-global.com Table of Contents Preface..................................................................................................................xv Acknowledgment.................................................................................................xx Chapter 1 A.Study.on.Segmentation.of.Leukocyte.Image.With.Shannon’s.Entropy..............1 N. Sri Madhava Raja, St. Joseph’s College of Engineering, India S. Arunmozhi, Manakula Vinayagar Institute of Technology, India Hong Lin, University of Houston – Downtown, USA Nilanjan Dey, Techno India College of Technology, India V. Rajinikanth, St. Joseph’s College of Engineering, India Chapter 2 Microscopic.Image.Processing.for.the.Analysis.of.Nosema.Disease...................28 Soumaya Dghim, Universidad de Las Palmas de Gran Canaria, Spain Carlos M. Travieso-Gonzalez, Universidad de Las Palmas de Gran Canaria, Spain Mohamed Salah Gouider, Université de Tunis, Tunisia Melvin Ramírez Bogantes, Costa Rica Institute of Technology, Costa Rica Rafael A. Calderon, National University of Costa Rica, Costa Rica Juan Pablo Prendas-Rojas, Costa Rica Institute of Technology, Costa Rica Geovanni Figueroa-Mata, Costa Rica Institute of Technology, Costa Rica Chapter 3 Medical.Image.Lossy.Compression.With.LSTM.Networks.................................47 Nithin Prabhu G., JSS Science and Technology University, India Trisiladevi C. Nagavi, JSS Science and Technology University, India Mahesha P., JSS Science and Technology University, India  Chapter 4 Digital.Image.Analysis.for.Early.Diagnosis.of.Cancer:.Identification.of.Pre- Cancerous.State.....................................................................................................69 Durjoy Majumder, West Bengal State University, India Madhumita Das, West Bengal State University, India Chapter 5 Multi-Criteria.Decision-Making.Techniques.for.Histopathological.Image. Classification.......................................................................................................103 Revathi T., Mepco Schlenk Engineering College, India Saroja S., Mepco Schlenk Engineering College, India Haseena S., Mepco Schlenk Engineering College, India Blessa Binolin Pepsi M., Mepco Schlenk Engineering College, India Chapter 6 Histopathological.Image.Analysis.in.Medical.Decision.Making:. Classification.of.Histopathological.Images.Based.on.Deep.Learning.. Model..................................................................................................................139 R. Meena Prakash, Sethu Institute of Technology, India Shantha Selva Kumari R., Mepco Schlenk Engineering College, India Chapter 7 A.Novel.Approach.of.K-SVD-Based.Algorithm.for.Image.Denoising..............154 Madhu Golla, VNR Vignana Jyothi Institute and Engineering and Technology, India Sudipta Rudra, VNR Vignana Jyothi Institute and Engineering and Technology, India Chapter 8 Analysis.of.Medical.Images.Using.Fractal.Geometry........................................181 Soumya Ranjan Nayak, KL University, India Jibitesh Mishra, College of Engineering and Technology, India Chapter 9 Analysis.of.Color.Image.Encryption.Using.Multidimensional.Bogdanov.. Map.....................................................................................................................202 R. N. Ramakant Parida, Kalinga Institute of Industrial Technology, India Swapnil Singh, Kalinga Institute of Industrial Technology, India Chittaranjan Pradhan, Kalinga Institute of Industrial Technology, India  Chapter 10 Automatic.Computerized.Diagnostic.Tool.for.Down.Syndrome.Detection.in. Fetus....................................................................................................................226 Michael Dinesh Simon, Anna University, India Kavitha A. R., Anna University, India Chapter 11 Adaptive.Prediction.Methods.for.Medical.Image/Video.compression.for. Telemedicine.Application...................................................................................244 Ketki C. Pathak, Sarvajanik College of Engineering and Technology, India Jignesh N. Sarvaiya, Sardar Vallabhbhai National Institute of Technology Suart, India Anand D. Darji, Sardar Vallabhbhai National Institute of Technology Suart, India Chapter 12 HE.Stain.Image.Segmentation.Using.an.Innovative.Type-2.Fuzzy.Set-Based. Approach.............................................................................................................276 Dibya Jyoti Bora, Kaziranga University, India Compilation of References...............................................................................300 About the Contributors....................................................................................330 Index...................................................................................................................338 Detailed Table of Contents Preface..................................................................................................................xv Acknowledgment.................................................................................................xx Chapter 1 A.Study.on.Segmentation.of.Leukocyte.Image.With.Shannon’s.Entropy..............1 N. Sri Madhava Raja, St. Joseph’s College of Engineering, India S. Arunmozhi, Manakula Vinayagar Institute of Technology, India Hong Lin, University of Houston – Downtown, USA Nilanjan Dey, Techno India College of Technology, India V. Rajinikanth, St. Joseph’s College of Engineering, India In.recent.years,.a.considerable.number.of.approaches.have.been.proposed.by. the.researchers.to.evaluate.infectious.diseases.by.examining.the.digital.images. of.peripheral.blood.cell.(PBC).recorded.using.microscopes..In.this.chapter,.a. semi-automated.approach.is.proposed.by.integrating.the.Shannon’s.entropy.(SE). thresholding.and.DRLS-based.segmentation.procedure.to.extract.the.stained.blood. cell.from.digital.PBC.pictures..This.work.implements.a.two-step.practice.with. cuckoo.search.(CS).and.SE-based.pre-processing.and.DRLS-based.post-processing. procedure.to.examine.the.PBC.pictures..During.the.experimentation,.the.PBC.pictures. are.adopted.from.the.database.leukocyte.images.for.segmentation.and.classification. (LISC)..The.proposed.approach.is.implemented.by.considering.the.RGB.scale.and. gray.scale.version.of.the.PBC.pictures,.and.the.performance.of.the.proposed.approach. is.confirmed.by.computing.the.picture.similarity.and.statistical.measures.computed. with.the.extracted.stained.blood.cell.with.the.ground.truth.image.  Chapter 2 Microscopic.Image.Processing.for.the.Analysis.of.Nosema.Disease...................28 Soumaya Dghim, Universidad de Las Palmas de Gran Canaria, Spain Carlos M. Travieso-Gonzalez, Universidad de Las Palmas de Gran Canaria, Spain Mohamed Salah Gouider, Université de Tunis, Tunisia Melvin Ramírez Bogantes, Costa Rica Institute of Technology, Costa Rica Rafael A. Calderon, National University of Costa Rica, Costa Rica Juan Pablo Prendas-Rojas, Costa Rica Institute of Technology, Costa Rica Geovanni Figueroa-Mata, Costa Rica Institute of Technology, Costa Rica In.this.chapter,.the.authors.tried.to.develop.a.tool.to.automatize.and.facilitate.the. detection.of.Nosema.disease..This.work.develops.new.technologies.in.order.to.solve. one.of.the.bottlenecks.found.on.the.analysis.bee.population..The.images.contain. various.objects;.moreover,.this.work.will.be.structured.on.three.main.steps..The. first.step.is.focused.on.the.detection.and.study.of.the.objects.of.interest,.which.are. Nosema.cells..The.second.step.is.to.study.others’.objects.in.the.images:.extract. characteristics..The.last.step.is.to.compare.the.other.objects.with.Nosema..The.authors. can.recognize.their.object.of.interest,.determining.where.the.edges.of.an.object.are,. counting.similar.objects..Finally,.the.authors.have.images.that.contain.only.their. objects.of.interest..The.selection.of.an.appropriate.set.of.features.is.a.fundamental. challenge.in.pattern.recognition.problems,.so.the.method.makes.use.of.segmentation. techniques.and.computer.vision..The.authors.believe.that.the.attainment.of.this.work. will.facilitate.the.diary.work.in.many.laboratories.and.provide.measures.that.are. more.precise.for.biologists. Chapter 3 Medical.Image.Lossy.Compression.With.LSTM.Networks.................................47 Nithin Prabhu G., JSS Science and Technology University, India Trisiladevi C. Nagavi, JSS Science and Technology University, India Mahesha P., JSS Science and Technology University, India Medical.images.have.a.larger.size.when.compared.to.normal.images..There.arises.a. problem.in.the.storage.as.well.as.in.the.transmission.of.a.large.number.of.medical. images..Hence,.there.exists.a.need.for.compressing.these.images.to.reduce.the.size. as.much.as.possible.and.also.to.maintain.a.better.quality..The.authors.propose.a. method.for.lossy.image.compression.of.a.set.of.medical.images.which.is.based.on. Recurrent.Neural.Network.(RNN)..So,.the.proposed.method.produces.images.of. variable.compression.rates.to.maintain.the.quality.aspect.and.to.preserve.some.of. the.important.contents.present.in.these.images.

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