High-Risk Cutaneous Squamous Cell Carcinoma: A Practical Guide for Patient Management PDF
Preview High-Risk Cutaneous Squamous Cell Carcinoma: A Practical Guide for Patient Management
High-Risk Cutaneous Squamous Cell Carcinoma A Practical Guide for Patient Management Chrysalyne D. Schmults Editor 123 High-Risk Cutaneous Squamous Cell Carcinoma Chrysalyne D. Schmults Editor High-Risk Cutaneous Squamous Cell Carcinoma A Practical Guide for Patient Management Editor Chrysalyne D. Schmults, MD, MSCE Director, Mohs & Dermatologic Surgery Center Brigham & Women’s Hospital Department of Dermatology Boston , MA , USA ISBN 978-3-662-47080-0 ISBN 978-3-662-47081-7 (eBook) DOI 10.1007/978-3-662-47081-7 Library of Congress Control Number: 2015956335 © Springer-Verlag Berlin Heidelberg 2016 T his work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifi cally the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfi lms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. T he use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specifi c statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. T he publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer-Verlag GmbH Berlin Heidelberg To my husband and daughters who have shown great patience with my distraction while editing this book. Pref ace My coauthors and I are happy to bring you this inaugural textbook on high-risk cutaneous squamous cell carcinoma. We feel it is timely in that many advances in defi ning this entity have occurred in recent years and we’re witnessing the begin- ning of the serious study of this historically understudied disease. If any subsequent editions of this text are released, they will almost certainly contain important advances in prognostic stratifi cation, our understanding of the molecular and genetic underpinnings of aggressive tumor formation and progression, accurate disease staging, and even treatment. Although the study of high-risk cutaneous squamous cell carcinoma is in its infancy, it will not remain there for long. Many distinguished investigators, many of whom are authors of this book, are hard at work to bring new information to light that will ultimately benefi t patients who suffer from this diffi - cult disease. Meanwhile, we hope that you will fi nd this a useful compendium of current knowledge. Boston, MA, USA Chrysalyne D. Schmults, MD, MSCE vii Contents Part I Defi ning the Problem of High-Risk SCC 1 Epidemiology and Outcomes of Cutaneous Squamous Cell Carcinoma ........................................................................................ 3 Pritesh S. Karia 2 Tumor Staging Systems and Prognostic Stratifi cation ........................ 29 Anokhi Jambusaria-Pahlajani Part II The Science of SCC 3 Genomics of SCC: Tumor Formation, Progression, and Future Therapeutic Implications for High-Risk Cutaneous Squamous Cell Carcinoma .................................................. 67 Catherine Anne Harwood , Charlotte Mary Proby , and Sarah Tuttleton Arron 4 Molecular and Cellular Interplay in SCC Including Immunomodulation and Clinical Implications .................................... 103 Valerie Yanofsky , John A. Carucci , and Günther F. L. Hofbauer Part III Management of High-Risk SCC 5 Management of Patients with Multiple SCCs/Field Cancerization ........................................................................................... 127 Sasha Jenkins Haberle , Lauren Rimoin , Myrto Georgia Trakatelli , and Fiona Zwald 6 Management of High-Risk Primary Tumors Including Nodal Staging .......................................................................................... 149 ix
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