Healthcare 4.0 The main aim of Healthcare 4.0: Health Informatics and Precision Data Management is to improve the services given by the healthcare industry and to bring meaningful patient outcomes by applying the data, information and knowledge in the healthcare domain. Features: • Improves the quality of health data of a patient • Presents a wide range of opportunities and renewed possibilities for healthcare systems • Gives a way for carefully and meticulously tracking the provenance of medical records • Accelerates the process of disease-oriented data and medical data arbitration • Brings meaningful patient health outcomes • Eradicates delayed clinical communications • Helps the research intellectuals to step down further toward the disease and clinical data storage • Creates more patient-centered services The precise focus of this handbook is on the potential applications and use of data informatics in healthcare, including clinical trials, tailored ailment data, patient and ail- ment record characterization and health records management. Healthcare 4.0 Health Informatics and Precision Data Management Edited by Lalitha Krishnasamy Rajesh Kumar Dhanaraj Balamurugan Balusamy Munish Sabharwal Poongodi Chinnasamy First edition published 2023 by CRC Press 6000 Broken Sound Parkway NW, Suite 300, Boca Raton, FL 33487-2742 and by CRC Press 4 Park Square, Milton Park, Abingdon, Oxon, OX14 4RN CRC Press is an imprint of Taylor & Francis Group, LLC © 2023 selection and editorial matter, Lalitha Krishnasamy, Rajesh Kumar Dhanaraj, Balamurugan Balusamy, Munish Sabharwal and Poongodi Chinnasamy; individual chapters, the contributors Reasonable efforts have been made to publish reliable data and information, but the author and publisher cannot assume responsibility for the validity of all materials or the consequences of their use. 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For works that are not available on CCC please contact [email protected] Trademark notice: Product or corporate names may be trademarks or registered trademarks and are used only for identification and explanation without intent to infringe. ISBN: 978-1-032-10860-5 (hbk) ISBN: 978-1-032-42262-6 (pbk) ISBN: 978-1-003-21743-5 (ebk) DOI: 10.1201/9781003217435 Typeset in Palatino by SPi Technologies India Pvt Ltd (Straive) Contents Preface ............................................................................................................................................vii Editor Biography ............................................................................................................................xi List of Contributors .....................................................................................................................xiii 1. Privacy-preserving Healthcare Informatics Using Federated Learning and Blockchain .......................................................................................................1 K. Tamil Selvi and R. Thamilselvan 2. Applications, Opportunities, and Current Challenges in the Healthcare Industry ..............................................................................................................27 A. Veena and S. Gowrishankar 3. Harnessing Big Data and Artificial Intelligence for Data Acquisition, Storage, and Retrieval of Healthcare Informatics in Precision Medicine .................51 S. Mohana Saranya, K. Tamilselvi, and S. Mohanapriya 4. Analogous Healthcare Product Identification in Online Shopping ...........................77 N. Archana, R. Menaka, S. M. J. Blessy Regina, and P. M. Lakshmi Prabha 5. Segmentation-based Comparative Analysis for Detection of Bone Tumour Using Healthcare Data ..........................................................................................97 J. Eric Clapten, A. Tamilselvi, K. Oviya, and M. Swetha 6. Challenges, Progress and Opportunities of Blockchain in Healthcare Data ..............111 Dinesh Komarasamy, M. K. Dharani, R. Thamilselvan, and J. Jenita Hermina 7. SepSense: A Novel Sepsis Detection System Using Machine Learning Techniques ...........................................................................................................................131 V. Aruna Devi, Sakthi Jaya Sundar Rajasekar, and Varalakshmi Perumal 8. Oral Cancer Detection at Early Stage Using Convolutional Neural Network in Healthcare Informatics ................................................................................151 S. Bhuvaneswari, R. Pandimeena, M. Sridhar, and S. Vignesh 9. Lung Diseases Identification ............................................................................................173 A. Sivabalan, Jai Jaganath Babu Jayachandran, D. Sandhiya, and M. B. Sharada 10. Brain–Computer Interface-based Real-Time Movement of Upper Limb Prostheses ..................................................................................................................185 K. Kalpana, B. Hakkem, J. Teresa Dhanasekar, and S. Ramya v vi Contents 11. A Robust Image-Driven CNN Algorithm to Detect Skin Disease in Healthcare Systems ............................................................................................................207 S. Suganyadevi, V. Seethalakshmi, N. Vidhya, and K. Balasamy 12. Patient Identity Ailments and Maintenance Using Blockchain and Health Informatics ..............................................................................................................229 K. S. Suganya, R. Nedunchezian, and K. S. Arvind 13. An Innovative Outcome of Internet of Things and Artificial Intelligence in Remote Centered Healthcare Application Schemes ...............................................245 Lalitha Krishnasamy, A. Tamilselvi, and Rajesh Kumar Dhanaraj 14. Electronic Health Records Storing and Sharing System Using Blockchain ...........267 Shailendra S. Aote, Amit Khaparde, Balamurugan Balusamy, Aayush Muley, Adesh Kotgirwar, Atharva Uplanchiwar, and Lalita Sharma Index ......................................................................................................................................279 Preface Health records in the electronic format are increasing day by day and to analyze these massive records with heterogeneous data sets, informatics and data analysis are obliga- tory. This book reveals an enigmatic assembly of diverse biomedical data types which comprise clinical data, data from electrocardiogram, genomic data, etc. Biomedical data are notorious for their diversified scales, dimensions, and volumes and requires interdisci- plinary technologies for visual illustration and digital characterization. Various computer programs and servers have been developed for these purposes by both theoreticians and engineers. The healthcare industry today is notorious to feel pain from heterogeneous and uneven data, delayed clinical communications, and disparate workflow tools due to the lack of identification of proper disease, lack of interoperability caused by vendor-locked healthcare systems, and security/privacy concerns regarding data storage, sharing, and usage. Apart from data informatics, which is of paramount importance for improving quality of health data of a patient, there is also a wide range of opportunities and renewed possi- bilities for healthcare systems to influence the categories of health data. This powerful and breakthrough information system paves a way for carefully and meticulously tracking the provenance of medical records, accelerating the process of disease-oriented data and medi- cal data arbitration, connecting alike patient populations to clinical trials, and creating more patient-centered services. The precise focus of this handbook will be on the potential applications and use of data informatics in area of healthcare, including clinical trials, tailored ailment data, patient and ailment record characterization, and health records management. Organization of this Book Chapter 1 presents the big data era; the healthcare informatics need exploration of the health records to identify the hidden patterns. Machine learning and deep learning tech- niques provide classification, clustering, and prediction tasks. Healthcare data processed in the centralized architecture pose single point of failure and it is difficult to collaborate with different distribution of data to design a robust system. This chapter identifies the current challenges in the healthcare informatics and addresses those issues with enabling technologies that explore the healthcare informatics with application of artificial learning and security mechanisms. Chapter 2 investigates the state-of-the-art research solutions for the complete range of healthcare data, analyzes the data, and provides guidance for future progress in healthcare practice. It highlights the developments in using blockchain technology in healthcare domain, emphasizing the need for healthcare data to be shared among various healthcare entities. It then summarizes modern and emerging technologies such as cloud and fog vii viii Preface computing in healthcare industry for classifying illness and segmentation, with an empha- sis on deep learning and AI and machine learning architectures that have already been established as the standard methodology. Chapter 3 presents the recent advances in computer storage systems, processing power, and data-analysis algorithms in the modern Clinical Information Systems that made the above task easier. Bioinformatics addresses these problems and aims to create integrated storage systems and analysis tools to convert the biological data into meaningful informa- tion. This helps to predict the disease and paves the way for drug discovery in precision medicine. Chapter 4 discusses how to purchase medicines online that are rarely available in the market. In the COVID period, people suffered a lot to get the recommended medicine from an authorized agency through online. Many fake images were posted and patients received different medicines than expected. Clinical information system analysis is explored with image processing techniques to predict the disease and the correct drug identification and discovery. Chapter 5 focuses primarily on two strategies for using MATLAB software simulations to segment bone tissues and then adopting the most effective segmentation approach based on iImage pre-processing, edge and boundary detection, and other related tasks. The graph cut technique, which is known for its smoothness and energy economy, has been more popular in the image processing and analysis disciplines in recent years. Chapter 6 presents that the hospital has planned to maintain the patient history in the form of electronic data. The patients do not prefer to maintain the patient history in the distributed network due to security concerns. Therefore, blockchain technique is evolved to securely maintain the patient’s history in the distributed networks. Chapter 7 briefly introduces sepsis, a life-threatening emergency medical condition and is one of the leading causes of death in patients who are being treated at the intensive care unit (ICU) of hospitals. It is the extreme response shown by the body in response to infec- tion. Sepsis arises due to the excessive quantity of infective microbes in the blood which are in a state of active replication. Here, a novel sepsis detection system using machine learning techniques has been presented. The system would predict if the patient would develop sepsis using a range of clinical parameters like blood pressure, temperature, oxy- gen saturation, heart rate, and other biochemical investigations. Chapter 8 discusses oral sickness. Two-thirds of the population has been suffering from oral sickness in Asia for the past three decades, and the ailment is particularly prevalent in low- and middle-income nations, according to the World Health Organization. A neural network-based oral cancer detection system that makes use of a range of image processing methodologies is presented here. Chapter 9 explores deep learning and is used to identify lungs illness. According to the Globe Health Organization, lung illnesses would be the third most important cause of demise in the world by 2030. Lung infection is a common occurrence all around the globe. The foundation of lung infection diagnosis is the ease with which it may be accomplished. Chapter 10 proposes that brain–computer interfaces (BCI) circumvent the body’s nor- mal neuromuscular controls and are intended to act as a backup mechanism for com- munication and control in the case of a neuronal or muscle failure. The chapter discusses the effects of BCI on cognition, sensors, machine learning, neurophysiology, psychology, signal detection and processing, source localization, pattern recognition, clustering, and classification of signals, as well as signal detection and processing in general. Chapter 11 highlights segmentation and feature extractions to diagnose the skin condi- tion at an early stage. Text-based features are extracted with the help of CNN and an image Preface ix processing technique that incorporates symmetry detection, border detection, and color. A major development in healthcare 4.0 is also occurring in the treatment of aging skin. Chapter 12 presents the technology and or approach utilized to precisely identify patients, thorough design of the care processes using blockchain will ensure effective patient identification prior to any medical intervention and result in safer care with fewer errors. In healthcare, patient information is shared with healthcare experts using electronic health record (EHR) where patient’s information is shared among the healthcare experts with the help of patient/healthcare expert’s identity. Chapter 13 discusses that IoT is a significant improvement in intelligence to the current societal issues. There is no way to classify the subjective pain associated with such an active communication network as something that is outside of artificial intelligence, and we are certainly not outside of artificial intelligence. It is possible to analyze, combine, and prioritize the data collected in this way if it is required. When physicians work with algo- rithms, they may change therapy while also delivering more cost-effective healthcare, which has a more positive result for patients. Chapter 14 focuses on developing a secure and privacy-preserving health chain system based on blockchain technology. The system ensures data security and patient privacy by giving full authority of the data to the patient. It also regulates that the data are updated by the skilled healthcare professional, only with the permission of the patient. It will automate the process throughout the chain and contribute toward robustness of the healthcare infor- mation sharing environment.