GLOBAL ATLAS OF ALLERGY - EAACI

406 Pages·2014·26.29 MB·English

Global
atlas
oF
allERGY
Published by the European Academy of Allergy and Clinical Immunology
www.eaaci.org
Allergy - Mechanisms

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Epidemiology and risk factors
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a
G
l Allergy diagnosis
t
R
a
Major Allergic Diseases
E

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Other hypersensitivity diseases
l
a
a
b
Special considerations

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o
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Management of allergic
diseases
G
Towards a comprehensive
global strategy for the
management of allergic diseases
Global atlas
oF allERGY
Editors
Cezmi A. Akdis
Ioana Agache
Editorial Board
Pascal Demoly
Peter Hellings
Antonella Muraro
Nikolaos G.Papadopoulos
Ronald van Ree
Published by the European Academy of Allergy and Clinical Immunology
2014
Global atlas of allERGY
EAACI ExECUTIVE COMMITTEE
BOARD OF OFFICERS
Nikos Papadopoulos, President
Antonella Muraro, Secretary General
Peter Hellings, Treasurer
Ioana Agache, Vice-President Communication and Membership
Pascal Demoly, Vice-President Education and Specialty
Ronald Van Ree, Vice-President Congresses
Cezmi A. Akdis, Past President
SECTION CHAIRPERSONS
Leif Bjermer, Asthma
Carsten Bindslev-Jensen, Dermatology
Cemal Cingi, ENT
Carsten Schmidt-Weber, Immunology
Susanne Lau, Pediatrics
Alexandra Santos, Junior Members and Affiliates
INTEREST GROUP REPRESENTATIVES
Moises Calderon
Karin Hoffmann-Sommergruber
MEMBERS AT LARGE
Lars K. Poulsen
Tomas Chivato
Thomas Werfel
Beatrice M. Bilo
Graham Roberts
Musa Khaitov
CHAIR EAACI PATIENT ORGANIZATION COMMITTEE
Frans Timmermans
ADJUNCT MEMBERS
Fulvio Braido, CME Committee Chairperson
Jan de Monchy, Specialty Committee Chairperson
Jacques Gayraud, Ethics Committee Secretary
Peter Schmid-Grendelmeier, Exam Committee Chairperson
Marek Jutel, SPC Co-ordinator
Angel Mazon, Web Editor
Olympia Tsilochristou, Web Editor
Michael Walker, Executive Director
II EAACI Executive Committee
Global atlas of allERGY
CONTRIBUTORS
Azza Abdel-Gadir, PhD Zürich, Switzerland Montpellier, France
Division of Immunology, Boston Mark Ballow, MD Onur Boyman, MD
Children’s Hospital. Department Division of Allergy and Immunology, Department of Clinical Immunology,
of Pediatrics, Harvard Medical University of South Florida University Hospital Zurich, Zurich,
School. Morsani School of Medicine, All Switzerland.
Ioana Agache, MD Children’s Hospital, St Petersburg Gert Jan Braunstahl, MD
Dept, of Allergy and Clinical USA St. Franciscus Gasthuis Rotterdam,
Immunology, Transylvania
Nuray Bayar Muluk, MD The Netherlands
University of Brasov, Faculty of
Dept Otorhinolaryngology,-Kırıkkale Heimo Breiteneder, PhD
Medicine
University, Turkey Department of Pathophysiology
Cezmi A. Akdis, MD
Thomas Bieber, MD, PhD, MDRA and Allergy Research, Medical
Swiss Institute of Allergy and Asthma
Department of Dermatology and University of Vienna, Austria
Research (SIAF), University of
Allergy, University Medical Center, Knut Brockow, MD
Zurich, Davos, Switzerland
Friedrich-Wilhelms University of Department of Dermatology
Christine Kühne – Center for Allergy
Bonn, Germany and AllergologyBiederstein,
Research and Education (CK-
M. Beatrice Bilò, MD TechnischeUniversitätMünchen,
CARE), Davos, Switzerland
Allergy Unit - Department of Internal Germany.
Medical Faculty, University of Zurich
Medicine – University Hospital A. Wesley Burks, MD
Mübeccel Akdis, MD, PhD
Ospedali Riuniti di Ancona - Italy Department of Pediatrics, University
Swiss Institute of Allergy and Asthma
Carsten Bindslev-Jensen, MD of North Carolina at Chapel Hill,
Research (SIAF), University of
Odense Research Center for Chapel Hill ,USA
Zurich, Davos, Switzerland
Anaphylaxis, Odense Denmark Robert K. Bush, MD
Walter J. Ammann, PhD
Odense University Hospital, Odense University of Wisconsin-Madison,
Global Risk Forum (GRF) Davos,
Denmark U.S.A
Switzerland
Leif Bjemer, MD Jeroen Buters, PhD
Abena S. Amoah, MD
Lund University, Department Center for Allergy & Environment
Department of Parasitology, Leiden
of Respiratory Medicine and (ZAUM), Technische Universität
University Medical Center, Leiden,
The Netherlands Allergology, Sweden München and Helmholtzzentrum
Department of Parasitology, Noguchi Barbara Bohle, PhD München, Germany
Memorial Institute for Medical Department of Pathophysiology EAACI Interest Group Aerobiology
Research, Accra, Ghana and Allergy Research and and Air Pollution
Evangelos Andreakos, PhD Christian Doppler Laboratory Moisés A. Calderón, MD
Biomedical Research Foundation, for Immunomodulation, Division Section of Allergy and Clinical
Academy of Athens, Greece of Cellular Allergology, Medical Immunology, Imperial College
University of Vienna, Vienna, London, NHLI, Royal Brompton
Isabella Annesi-Maesano, MD
Austria Hospital, London, UK.
French Institute of Health and
Medical Research, Epidemiology Matteo Bonini, MD Victòria Cardona, MD, PhD
of Allergic and Respiratory Department of Public Health and Allergy Section, Department of
Diseases (EPAR), France Infectious Diseases “Sapienza” Internal Medicine. Hospital
Claus Bachert, MD University of Rome, Italy UniversitariValld’Hebron,
Sergio Bonini, MD Barcelona, Spain
Upper Airways Research Laboratory,
University of Ghent, Ghent, Department of Internal Medicine, Kai-Håkon Carlsen, MD
Belgium; Second University of Naples, Italy (Paediatric respiratory medicine and
Division of ENT Diseases, CLINTEC, Jean Bousquet, MD allergology), University of Oslo,
Karolinska Institutet Stockholm, University of Montpellier,France Institute for Clinical Medicine
Sweden WHO Global Alliance Against and Oslo University Hospital,
Barbara Ballmer-Weber, MD Chronic Respiratory Diseases Department of Paediatrics, Oslo,
Department of Dermatology, (GARD) Norway
University Hospital Zürich, Director of the WHO Collaborating Jean-Christoph Caubet, MD
Switzerland University Hospital Centre for Asthma and Rhinitis in Department of Child and Adolescent,
Contributors III
Global atlas of allERGY
University Hospitals of Geneva Imperial College London, United Philippe Gevaert, MD, PhD
and Medical School of the Kingdom. Dept Otorhinolaryngology, Ghent
University of Geneva, Geneva, EAACI Patient Organisation University Hospital
Switzerland Committee, Stefanie Gilles, PhD
Yih-Chih Chan, MD Philippe Eigenmann, MD Institute for environmental medicine,
King’s College London, London, University Hospitals of Geneva, UNIKA-T, TechnischeUniversität
United Kingdom Geneva, Switzerland Munich, Germany
Talal Chatila, MD Veit Erpenbeck, PhD Christine Kühne Center for Allergy
Division of Immunology, Boston Novartis Institutes for Biomedical Research and Education (CK-
Children’s Hospital/ Department Research, Basel, Switzerland Care), Davos, Switzerland
of Pediatrics, Harvard Medical Claude Favrot, Dr .Vet. Hannah Gould, PhD
School.
Dermatology Service, Clinic for Division of Cell and Molecular
R. Sharon Chinthrajah, MD Small Animal Internal Medicine, Biophysics and Division of Allergy,
Division of Immunology and Allergy, Vetsuisse Faculty, University of Asthma and Lung Biology, Allergy
Department of Pediatrics, Zurich, Zurich, Switzerland and Asthma Group in the Division
Stanford University, Stanford, Fatima Ferreira, PhD of Cell and Molecular Biophysics
USA King’s College London, London,
Department of Molecular Biology,
Tomás Chivato Pérez, MD Christian Doppler Laboratory for United Kingdom
University CEU San Pablo, Madrid, Allergy Diagnosis and Therapy, Clive E. Grattan, MD
Spain Saltzburg, Austria Norfolk and Norwich University
Cemal Cingi, MD Michael B. Foggs, MD Hospital, UK
Dept Otorhinolaryngology, Eskisehir President American College of Hans Grönlund, PhD
Osmangazi University, Turkey Allergy, Asthma & Immunology Karolinska Institutet, Therapeutic
Linda Cox, MD Dept of Allergy and Immunology, Immune Design Unit, Department
Allergy and Asthma Center, Fort Advocate Health Care, Chicago, of Clinical Neuroscience, Center
Lauderdale, Florida, USA United States for Molecular Medicine
Reto Crameri, PhD Remo Frei, PhD Karolinska University Hospital
Swiss Institute of Allergy and Asthma Swiss Institute of Allergy and Asthma Tari Haahtela, MD
Research (SIAF), University of Research (SIAF), University of Skin and Allergy Hospital, Helsinki
Zürich, Davos, Switzerland Zurich, Davos, Switzerland University Hospital, Finland
Adnan Custovic, MD, PhD Christine Kühne-Center for Allergy Viktor Hafner, PhD
University of Manchester, UK Research and Education, Davos Landesgeschäftsstelle Wien, Öster-
Janet Davies, PhD Anthony J. Frew, MD reichische Apothekerkammer,
Lung and Allergy Research Department of Respiratory Medicine, Austria
Centre, School of Medicine, Royal Sussex County Hospital, Susanne Halken, MD, DMSci
The University of Queensland, Brighton, UK Hans Christian Andersen Children’s
Translational Research Institute, Gabriele Gadermaier, MD Hospital, Odense University
Woolloongabba, Queensland, Department of Molecular Biology, Hospital, Denmark
Australia Christian Doppler Laboratory for Firdaus Hamid, MD
Jan G. R. de Monchy, MD Allergy Diagnosis and Therapy, Department of Parasitology, Leiden
University of Groningen, University University of Salzburg, Austria University Medical Center, Leiden,
Medical Center Groningen, The Stephen J. Galli, MD The Netherlands
Netherlands Stanford Center for Genomics and Department of Microbiology,
Pascal Demoly, MD Personalized Medicine Faculty of Medicine, Hasanuddin
University Hospital of Montpellier, Professor Stanford University, USA, University, Makassar, Indonesia
France Chair, Department of Pathology Catherine M. Hawrylowicz, PhD
Günnur Deniz, PhD James Gardner, RN Dip MRC and Asthma UK Centre for
Istanbul University, Experimental Department of Child Health, Royal Allergic Mechanisms in Asthma,
Asthma Research Institute, Free Hospital, London, UK Division of Asthma, Allergy and Lung
Istanbul, Turkey Jacques Gayraud, MD Biology, Guy’s Hospital, King’s
Anthony E.J. Dubois, MD Polyclinique de l’Ormeau, Tarbes, College London, London, United
Dept. of Pediatric Allergy, University France Kingdom
of Groningen, The Netherlands Julia Katharina Genser, MD Enrico Heffler, MD, PhD
Stephen R. Durham, MD Allergy Unit, Dept of Dermatology, Department of Medical Sciences,
Allergy and Clinical Immunology, University Hospital of Zürich, Allergy and Clinical Immunology,
National Heart and Lung Institute, Switzerland University of Torino, Italy
IV Contributors
Global atlas of allERGY
Peter W. Hellings, MD Marek Jutel, MD Medicine, McMaster University,
Department of Otorhinolaryngology, Department of Clinical Immunology, Hamilton, ON, Canada
Head and Neck Surgery, University Wroclaw Medical University Désirée Larenas Linnemann, MD
Hospitals Leuven, Belgium ALL-MED Medical Research Institute, Hospital Médica Sur, Mexico city,
Department of Otorhinolaryngology, Wroclaw , Poland Mexico
Academic Medical Center, Ömer Kalayci, MD Susanne Lau , MD
Amsterdam, The Netherlands
Pediatric Allergy and Asthma Unit, Charité Medical University Berlin,
Christoph Heusser, PhD Hacettepe University School of Germany
Novartis Institutes for Biomedical Medicine, Ankara, Turkey Roger Lauener, MD
Research, Basel, Switzerland Hajime Karasuyama, MD, PhD Children’s Hospital of Eastern
Hans Jürgen Hoffmann, PhD Department of Immune Regulation, Switzerland, St. Gallen,
Department of Respiratory Medicine Graduate School of Medical and Switzerland
and Allergology, Aarhus University Dental Sciences, Tokyo Medical Christine Kühne-Center for Allergy
Hospital and Dental University (TMDU), Research and Education, Davos
Department of Clinical Medicine, Tokyo, Japan Dennis K. Ledford, MD
Aarhus University, Denmark Constance H. Katelaris, MB BS Morsani College of Medicine,
Karin Hoffmann-Sommergruber, PhD FRACP University of South Florida and
MD, PhD Immunology & Allergy, University James A. Haley V.A. Hospital, Tampa,
Dept. of Pathophysiology and Allergy of Western Sydney and Florida, USA
Research, Medical University of Campbelltown Hospital, Sydney, Robert F. Lemanske Jr., MD
Vienna,Vienna, Austria Australia. University of Wisconsin, Madison,
Stephen T Holgate, MD, DSc, Musa R. Khaitov, MD Wisconsin
FMedSci NRC Institute of Immunology FMBA Donald Y. M. Leung, MD, PhD
Russia
Clinical and Experimental Sciences, Department of Pediatrics, National
Faculty of Medicine, University of Rakhim M. Khaitov, MD Jewish Health, Denver, USA
Southampton,UK. NRC Institute of Immunology FMBA James T. Li, MD PhD
Patrick G. Holt, MD, PhD Russia Mayo Clinic, Rochester, Minnesota,
Division of Cell Biology, Telethon Jörg Kleine-Tebbe, MD USA
Institute for Child Health Allergy & Asthma Center Westend, Maximin Liebl, PhD
Research, The University Outpatient Clinic Hanf, Ackermann
Pharmaceutical Group of the
of Western Australia and & Kleine-Tebbe, Berlin, Germany
European Union, Bolzano, Bozen,
Queensland Children’s Medical Edward F. Knol, PhD Italy
Research Institute, The University
Dept. Immunology and Dermatology/ Richard F. Lockey, MD
of Queensland, Australia
Allergology; University Medical Joy McCann Culverhouse Airway
Friedrich Horak, PhD Center Utrecht, Utrecht, The Disease Research Center, Division
Research Consult GmbH, Dpt. Netherlands of Allergy and Immunology,
Vienna Challenge Chamber (VCC), Marek L. Kowalski, MD Department of Internal Medicine,
Vienna, Austria Medical University of Lodz, Poland University of South Florida
Arne Høst, MD Thomas M. Kündig, MD Morsani College of Medicine;
Head of Hans Christian Andersen Department of Dermatology, James A. Haley Veterans’ Hospital,
Children’s Hospital, Odense University Hospital Zurich, Zurich, Tampa, FL, USA
University Hospital Denmark
Switzerland Karin C. Lødrup Carlsen, MD
Natalia I. Ilyna, MD Gideon Lack, MD Head of Research, University of Oslo,
NRC Institute of Immunology FMBA MRC Asthma UK Centre in Allergic Institute for Clinical Medicine
Russia Mechanisms of Asthma, King’s and Oslo University Hospital,
Kenji Izuhara, MD, PhD College London, Guy’s and St Department of Paediatrics, Oslo,
Saga Medical School, Saga, Japan Thomas’ NHS Foundation Trust, Norway
Jan Lötval, MD Children’s Allergies Department, Lyudmila V. Luss, MD
Krefting Research Center, University St Thomas’ Hospital, London, UK NRC Institute of Immunology FMBA
of Gothenburg, Göteborg, Sweden Bart N. Lambrecht, MD, PhD Russia
S.G.O. Johansson, MD, PhD VIB Inflammation Research Center, Adriano Mari, MD
Department of Medicine, Allergy Gent University, Belgium Associated Centers for Molecular
and Clinical Immunology Unit, Mark Larché, PhD Allergology, Rome, Italy
Karolinska Institute, Stockholm, Division of Allergy & Clinical Gianni Marone, MD, PhD
Sweden Immunology, Department of Department of Translational Medical
Contributors V
Global atlas of allERGY
Sciences and Center for Basic and Allergy and Immunology, Johannes Ring, MD, PhD
Clinical Immunology Research Jaffe Food Allergy Institute, Department Dermatology and
(CISI), University of Naples Department of Pediatrics, Division Allergology Biederstein,
Federico II, School of Medicine, of Allergy and Immunology, Kravis Technische Universität München
Naples, Italy Children’s Hospital, Icahn School Christine Kühne-Center for Allergy
Paolo Maria Matricardi, MD of Medicine at Mount Sinai, New Research and Education (CK-
Dept. of Paediatric Pneumology and York, NY, USA CARE) Davos
Immunology, Charité Medical Liam O’Mahony, PhD Graham Roberts, MD
University, Berlin, Germany Swiss Institute of Allergy and Asthma David Hide Asthma and Allergy
Marcus Maurer, MD Research (SIAF), University of Research Centre, St Mary’s
Department of Dermatology Zurich, Davos, Switzerland Hospital, Newport, Isle of Wight
and Allergy, Charité – Christine Kühne-Center for Allergy NIHR Southampton Respiratory
Universitätsmedizin Berlin Research and Education, Davos Biomedical Research Unit,
Angel Mazon, MD Markus Ollert, MD University Hospital Southampton
Children’s Hospital La Fe, Valencia, Technische Universität München NHS Foundation Trust
Spain (TUM), Munich, Germany Faculty of Medicine, Human
Shanthi Mendis, MD, PhD Nikolaos G. Papadopoulos, MD Development and Health and
Clinical Experimental Sciences
WHO Dept of Allergy & Pediatric Allergy,
Academic Units, University of
University of Manchester, UK,
Department of Management of
Southampton, Southampton, UK
Noncommunicable Diseases, University of Athens, Greece,
Caroline Roduit, MD
World Health Organisation, EAACI President
Zurich University Children’s Hospital,
Geneva, Switzerland Ruby Pawankar, MD, PhD
Zurich, Switzerland
Dean D. Metcalfe, MD Past President, World Allergy
Children’s Hospital of Eastern
National Institute of Allergy and Organization
Switzerland, St. Gallen,
Infectious Diseases, National Dept. of Pediatrics, Nippon Medical
Switzerland
Institutes of Health, Bethesda, School,Tokyo, Japan.
Lanny J. Rosenwasser, MD
Maryland, United States Oliver Pfaar, MD
President, World Allergy
Antonella Muraro, MD, PhD Center for Rhinology and Allergology
Organization
Food Allergy Referral Centre Veneto Wiesbaden, Department of
Allergy-Immunology Division,
Region Department of Women Otorhinolaryngology, Head and
Children’s Mercy Hospital, Kansas
and Child Health , Padua General Neck Surgery, University Hospital,
City
University Hospital Mannheim, Mannheim, Germany
University of Missouri-Kansas City
Dept of Pediatric Allergology, Werner J Pichler, MD
School of Medicine
University of Padua, Italy Clinic for Rheumatology and
Frederick J. Rubner, MD
Erika von Mutius, MD Clinical Immunology/Allergology,
University of Wisconsin, Madison,
Dr. von Hauner Children’s Hospital, University Hospital of Bern, Bern,
Wisconsin
Ludwig-Maximilians-University Switzerland
Franziska Ruëff, MD
Munich, Germany Thomas A.E Platts-Mills, MD,
Department of Dermatology and
Kari C Nadeau, MD, PhD PhD, FRS
Allergology, Ludwig-Maximilian
Division of Immunology and Allergy, Asthma and Allergic Disease
University, Munich, Germany
Department of Pediatrics, Center, University of Virginia,
Dermot Ryan, Dr.
Stanford University, Stanford, Charlottesville, USA
GP Woodbrook Medical Centre,
USA Lars K. Poulsen, PhD
Loughborough Honorary Clinical
Jennifer A. Namazy, MD National University Hospital, Allergy
Research Fellow Allergy and
Scripps Clinic, San Diego, California, Clinic, Copenhagen, Denmark
Respiratory Research Group,
USA Susan L. Prescott, MD Centre for Population Health
Andrew Nickels, MD School of Paediatrics and Child Sciences, University of Edinburgh,
Dept. of Allergy and Immunology Health (SPACH), University of Medical School
Fellow, Mayo Clinic, Rochester, Western Australia, Australia Hirohisa Saito, MD, PhD
Minnesota Santiago Quirce, MD, PhD National Research Institute for Child
Verena Niederberger, PhD Department of Allergy, Hospital La Health & Development, Tokyo,
Department of Otorhinolaryngology, Paz Institute for Health Research Japan
Medical University of Vienna, (IdiPAZ), Madrid, Spain. Boleslaw Samolinski, MD
Austria Harald Renz, MD Department of Prevention of
Anna Nowak-Węgrzyn, MD Philipps- University of Marburg, Environmental Hazards and
Associate Professor Pediatrics, Institute of Laboratory Medicine Allergology, Medical University of
VI Contributors
Global atlas of allERGY
Warsaw, Warsaw, Poland London, UK Research, Western Australia
Marek Sanak, MD Helen Smith, MD Claudia Traidl-Hoffmann, MD
Department of Medicine, Jagiellonian Brighton & Sussex Medical School, Institute of environmental medicine
University Medical College, UK UNIKA-T, Technische Universität,
Kraków, Poland Hermelijn H. Smits, PhD Munich, Germany
Alexandra Santos, MD Department of Parasitology, Leiden Christine Kühne Center for Allergy
King’s College, Paediatric Allergy, University Medical Center, Leiden, Research and Education (CK-
London, UK The Netherlands Care), Davos, Switzerland
Georg Schäppi, MD François Spertini, MD Massimo Triggiani, MD
aha! Swiss Allergy Centre Division of Immunology and Allergy, Division of Allergy and Clinical
Christine Kühne – Center for Allergy Centre Hospitalier Universitaire Immunology, University of
Research and Education (CK- Vaudois, Lausanne, Switzerland Salerno, Italy
CARE), Davos, Switzerland Otto Spranger, MD Rudolf Valenta, PhD
Department of Pathophysiology
Michael Schatz, MD, MS Österreichische Lungenunion, Wien,
and Allergy Research, Medical
Department of Allergy, Kaiser Austria
University of Vienna, Austria
Permanente Medical Center, San Cristiana Stellato, MD
Diego, California, USA Department of Medicine and Surgery, Willem van de Veen, PhD
Swiss Institute of Allergy and Asthma
Peter Schmid-Grendelmeier, MD University of Salerno, Italy,
Research (SIAF), University of
Head of the Allergy Unit, University Division of Allergy and Clinical
Zurich,Davos, Switzerland
Hospital Zurich, Dept of Immunology, Johns Hopkins
Dermatology, Zürich, Switzerland University, Baltimore, Ronald van Ree, PhD
Professor, Department of
Carsten B. Schmidt-Weber, PhD Alex Straumann, MD
Experimental Immunology,
Center for Allergy & Environment Chairman Swiss EoE Research
Academic Medical
(ZAUM), Technische Universität Network
Center, Amsterdam, The
München and Helmholtzzentrum Department of Gastroenterology,
Netherlands, Department of
München University Hospital Basel, Basel,
Otorhinolaryngology, Academic
Gabriela Senti, MD Switzerland Medical Center, Amsterdam, The
Clinical Trials Center, University Stanley J. Szefler, MD Netherlands
Hospital Zurich, Zurich, Pediatric Asthma Research Program,
Roy Gert van Wijk, MD
Switzerland Section of Pediatric Pulmonary
Dept of Internal Medicine, Erasmus
Saira Z Sheikh, MD Medicine, Breathing Institute, Medical Center Rotterdam,
Division of Rheumatology, Allergy Department of Pediatrics, Netherlands
& Immunology, Department of Children’s Hospital Colorado;
Gilda Varricchi, MD
Medicine and Thurston Arthritis University of Colorado Denver School
Department of Translational Medical
Research Center, University of of Medicine, Aurora, Colorado
Sciences and Center for Basic and
North Carolina at Chapel Hill, Morvarid Tavassoli, MD
Clinical Immunology Research
Chapel Hill ,USA Division of Immunology and Allergy, (CISI), University of Naples
Scott H. Sicherer, MD Department of Pediatrics, Federico II, School of Medicine,
The Elliot and Roslyn Jaffe Food Stanford University, Stanford, Naples, Italy
Allergy Institute, Kravis Children’s USA J. Christian Virchow, MD
Hospital, Division of Allergy Michael N. Teng, MD Universitätsmedizin Rostock,
and Immunology, Department Joy McCann Culverhouse Airway Germany
of Pediatrics, Icahn School of Disease Research Center, Division Department of Pneumology/
Medicine at Mount Sinai, New of Allergy and Immunology, Intensive Care Medicine, Clinic 1,
York, NY, USA Department of Internal Medicine, Center of Internal Medicine
Hans-Uwe Simon, University of South Florida
Berber Vlieg-Boerstra, PhD RD
Institute of Pharmacology, University Morsani College of Medicine
Department of Pediatric Respiratory
of Bern, Switzerland Ingrid Terreehorst, MD
Medicine and Allergy, Emma
F. Estelle R. Simons, MD Department of ENT & Pediatrics, Children’s Hospital, Academic
Department of Pediatrics & Academic Medical Center, Medical Center, University of
Child Health, Department of Amsterdam, The Netherlands Amsterdam, The Netherlands
Immunology , Faculty of Medicine Wayne R. Thomas, PhD Kimberly Vu, MD
University of Manitoba, Canada Centre for Child Health Research, Division of Immunology and Allergy,
Isabel Skypala, PhD University of Western Australia, Department of Pediatrics,
Royal Brompton&Harefield NHS Perth, Australia Stanford University, Stanford,
Foundation Trust, Sydney Street, Telethon Institute for Child Health USA
Contributors VII
Global atlas of allERGY
Ulrich Wahn, MD Stephan Weidinger, MD Maria Yazdanbakhsh, PhD
Department of Pediatric Pneumology Department of Dermatology and Department of Parasitology, Leiden
and Immunology, Charité, Berlin, Allergy, University Hospital University Medical Center, Leiden,
Germany Schleswig-Holstein, Kiel, Germany
The Netherlands
Michael Wallner, MD Thomas Werfel, MD
M Osman Yusuf, MD
University of Salzburg, Department Division of Immunodermatology and
The Allergy & Asthma Institute,
of Molecular Biology, Christian Allergy Research, Department of
Doppler Laboratory for Allergy Dermatology, Hannover Medical Pakistan.
Diagnosis and Therapy, Saltzburg, School, Hannover, Germany The International Primary Care
Austria Marsha Wills-Karp, PhD Respiratory Group
Canonica G. Walter, MD Department of Environmental Quaid e Azam University, Islamabad,
Dept of Allergy & Respiratory Health Sciences, Johns Hopkins Pakistan.
Diseases Clinic, University of Bloomberg School of Public
Torsten Zuberbier, MD
Genova, Genova- Italy Health, Baltomore, USA
Dept. of Dermatology and Allergy,
Richard Weber, MD Margitta Worm, MD
Charité, Berlin
Department of Medicine, National Charité-Universitätsmedizin, Klinik
Jewish Medical & Research für Dermatologie, Venerologie Global Allergy and Asthma European
Center, Denver, US und Allergologie, Berlin, Germany Network (GA2LEN)
VIII Contributors