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GENETICS A PERIODICAL RECORD OF INVESTIGATIONS BEARING ON HEREDITY AND VARIATION FOUNDED IN 1916 and pul lished b THE GENETICS SOCIETY OF AMERICA VOLUME 168, SEPTEMBER-DECEMBER 2004 GENETICS VOLUME 168, SEPTEMBER-DECEMBER 2004 EDITORIAL 3OARD ELIZABETH W. JONES, Editor- n-Chief Carnegie Mellon University, Pi } MONTSERRAT AGUADE (2005) STEVEN HENIKOFI OOD Outi SAVOLAINEN (2005) Universitat de Barcelona Fred Hutchinson Cance1 Universit Oulu KATHRYN \ ANDERSON (2005) NANCY A. JENKINS STEPHEN W. SCHAEFFER 2006) Sloan-Kettering Institute National Cancer In The Pennsylvania State University FCRD¢ 3RENDA J. ANDREWS (2006) TRUDI SCHUPBACH (2005 University of Toronto MARK JOHNSTON Princeton University Washington Uni NORMAN ARNHEIM (2005) Medicine MICHAEL | SIMMONS (2006) University of Southern L'nI iversit Minnesota California Monica J. JusTict rH (2004) Bavlor College BONNII 3ARTEL (2005) n Cancer Cente Rice University ITnHdiOaMnAa S UCn.i veKrAsuiFt) ENSHEIN 2004) Davip BEGUN (2005) School of Medicine KENNETH J]. KEMPHt University of California, Davis Cornell Universit SPENCER (20060 JoY BERGELSON (2005) CHRISTINE KOZAK (2005 Universitv of Chicago National Institute of He JAMES A. BIRCHLER (2005) MICHAEL LICHTEN COVE University of Missouri National Cancer Ins DARESAN (2006 Davip BorsTEIN (2006) \. JAVIER Lopez lial \grobiology Princeton University Carnegie Mellon | NGTON (2005 KARL W BROMAN (2006) JENNIFER |. LOROS rsitv Colle ve of t Surgeons Johns Hopkins University Dartmouth Medi ATA (2005 ANTHONY H. D. Brown (2006) SUSAN LOVET! 4 Grad rsitv, Kanagawa CSIRO Division of Plant Industry Brandeis Universit Vicki L. CHANDLER (2004) SUSAN R McCoo University of Arizona Cornell I Hive Sil Santa Cruz DEBORAH CHARLESWORTH 29005 BARBARA J. Mey! University of Edinburgh University of Calif 1 California REBECCA DOERGE (2005) AARON P. Mircut MDuAkReC Y K. | | \ 2004 t Purdue University Columbia Univers LL 2006) ALAIN NICOLAS UTnHiOveMrAsSit y A. of EiRcokcsheusstHe r (2005) Institut Curie les Hautes Etudes, Paris Howarp OcHM EUVI 2006 LUnAiUvReErsNiTt y EoXf COFBeFrInE R (2005) University of Ai sitv Schoolo f Medicine PETER J. OFFNI IOO5 Marcus W. Fe_pMAN (2006) Stanford | Stanford University . \ | ip YUN-XIN Ft (2004) University of Briti University of Texas, Houston ANDREW PATERSOD GREGORY C. GIBSON (2006) University of Geo North Carolina State University LORRAINE PILLUS Kent Gonic (2005) University of Calif University of Utah PATRICIA |. PUKKII DAVID JONAH GRUNWALD (2004) University of University of Utah Davip RAND ,00IH 2006 Curis Hatey (2006) Brown University 1 School Roslin Institute (Edinburgh) MarK D Ros! N04 2005 MicHAaent Hampsey (2004) Princeton Universi lege London Robert Wood Johnson Medical PAUL Russet (2005 10 (2006) School-U MDN] The Scripps Resea son Cancer Research Cente1 LAWRENCE HARSHMAN (2005) MATTHEW S. SACHS 4 2005) University of Nebraska Oregon Health and Scien ersit\ R. Scorr Haw ey (2006) SUZANNE SANDMEYER ZOLAN (2004 Stowers Institute for Medical Research University of California Managing Editor, TRAcEY DEPELLE« Published at Baltimore, Ma by the GENETICS SOCIETY O1 Dlication Services and VOLUME CONTENTS to Volume 168, September—December, 2004 ADAMS, ALISON M., AND RICHARD R. Hupson, Maximum-likelihood estimation of demo- graphic parameters using the frequency spectrum of unlinked single-nt otide polymor- phisms 1699-1712 ADAMS, KeirH L., RYAN PERCIFIELD AND JONATHAN F. WENDEL, O duplicated genes in a newly synthesized cotton allotetraploid 9917-9996 AN, XIN, MOLLY TEBO, SUNMI SONG, MARIANNE FROMMER AND cryptochrome (cry) gene and a mating isolation mechanism in te] 2025-2036 ANDERSON, JAMES B., CAROLINE SIRJUSINGH AND NICOLI evolution of antifungal drug resistance in Saccharon 1915-1923 \RGUESO, JUAN LUCAS, JENNIFER WANAT, ZEKERIYYA crossover pathways act during meiosis in Saccharom) 1805-1816 AUSTIN, JAMES D., STEPHEN C. LOUGHEED AND PETER of history and nonequilibrium conditions in gene flow « calesbeiana) populations 1491-1506 AYE, MICHAEL, BECKY IRWIN, NADEJDA BELIAKO\ AND SUZANNE SANDMEYER, Host factors that CETEVISLAE 1159-1176 BAGHERI, HOMAYOUN C., AND GUNTER VAGNER, Evolutio1 in metabolic pathways 1713-1735 BAINES, JOHN F., APARUP Das, SYLVAIN Mouss! natural selection in genetic differentiation of world 987-1998 BENNETT, E. ANDREW, LAURA E. COLEMAN, CIR DEVINE, Natural genetic variation caused by t 933-95] BENNEWITZ, JORN, NORBERT REINSCH, VOLKER GUIARI BASTI [AUKE THOMSEN, CHRISTIAN Loorr, CHRISTA KUHN, MANFRED SCHWERIN WEIMANN, GEORG ERHARDT, FRITZ REINHARDT, REINHARD REENTS, DIDIER Bot RI ERNST KALM, Multi- ple quantitatitvreai t loci mapping with cofactorasn d tio ternative variantso f the false discovery rate in an enlarged granddaugh 1019-1027 BESSLER, JESSICA B., AND VIRGINIA A. ZAKIAN, cerevisiae DNA helicase Rrm sp modulates protel SRI ONNUMIN cor cicnce avacue<octeoocksisnssZecaneeadtesee s 1205-1218 BETANCOURT, ANDREA J., YUSEOB KIM AND H. ALLEN R Si chhiking model of X vs. autosomal diversity 2261-2269 BHUIYAN, HASANUZZAMAN, AND KARIN SCHMEKEI meer DOD occur without Spol l-induced DNA double-strand 449—/05 BIRMINGHAM, ERIN C., SHAUNA A. LEE, RICHARD D. McCCULLo¢ ) VIARI BAKER, Testing predictions of the double-strand break repair model ° tO crossing over in mammalian cells 1539-1555 BooTtH, JOAN M., AND JINNIE M. GARRETT, Instructors’ practi ind attitudes toward teaching ethics in the genetics classroom 1111-1117 BOURGAIN, CATHERINE, MARK ABNEY, DANIEL SCHNEIDER, CAROLE OBER AND MARY ra McPEekrk, Testing for Hardy-Weinberg equilibrium in samples WV elated individuals 2349-2361 BRADSHAW, JOHN E., BARNALY PANDE, GLENN J]. BRYAN, CHRISTINE A. HACKETT, KAREN McLean, HELEN E. STEWART AND ROBBIE WAUGH, Interval mapping of quantitative trait loci for resistance to late blight [Phytophthora infestans (Mont.) de Bary], height and maturity in a tetraploid population of potato (Solanum tuberosum subsp. tuberosum) 983-995 Brisson, DusTIN, AND DANIEL E. DyKHUIZEN, ospC diversity in Borrelia burgdorferi: Different hosts are different niches BRISSON, JENNIFER A., ALAN R. 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