Generation and Effector Functions of Regulatory Lymphocytes: Novartis Foundation Symposium 252

325 Pages·3.375 MB·English

by  Novartis Foundation(eds.)

GenerationandEffectorFunctionsofRegulatoryLymphocytes:NovartisFoundationSymposium
252.Volume252
EditedbyGregoryBockandJamieGoode
CopyrightNovartisFoundation2003.ISBN:0-470-85074-4
GENERATION AND
EFFECTOR FUNCTIONS
OF REGULATORY
LYMPHOCYTES
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Novartis Foundation Symposium 252
GENERATION AND
EFFECTOR FUNCTIONS
OF REGULATORY
LYMPHOCYTES
2003
Copyright&NovartisFoundation2003
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NovartisFoundationSymposium252
x+315pages,42¢gures,19tables
LibraryofCongressCataloging-in-PublicationData
Generationande¡ectorfunctionsofregulatorylymphocytes/[editors,GregoryBockand
JamieGoode].
p.cm.^(NovartisFoundationsymposium;252)
Includesbibliographicalreferencesandindex.
ISBN0-470-85074-4(alk.paper)
1.Lymphocytes.2.Tcells.3.Immuneresponse^Regulation. I.Bock,Gregory. II.
Goode,Jamie. III.Series.
QR185.8.L9G462003
571.9’6^dc22 2003057598
BritishLibraryCataloguinginPublicationData
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ISBN0470850744
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Contents
SymposiumonGenerationande¡ectorfunctionsofregulatorylymphocytes,heldattheNovartis
Foundation,London,9^11July2002
Editors:GregoryBock(Organizer)andJamieGoode
ThissymposiumwasbasedonaproposalmadebyMatthiasvonHerrathandJe¡reyBluestone
Jean-Francc(cid:1)oisBach Chair’sintroduction 1
ShimonSakaguchi,ShoheiHori,YoshinoriFukui,TakehikoSasazuki,
NorikoSakaguchiandTakeshiTakahashi Thymicgenerationandselectionof
CD25+CD4+regulatoryTcells:implicationsoftheirbroadrepertoireandhigh
self-reactivityforthemaintenanceofimmunologicalself-tolerance 6
Discussion 16
EthanM.Shevach,CiriacoA.Piccirillo,AngelaM.Thorntonand
RebeccaS.McHugh ControlofTcellactivationbyCD4+CD25+suppressor
Tcells 24
Discussion 36
AdamP.Kohm,PamelaA.CarpentierandStephenD.Miller Regulationof
experimentalautoimmuneencephalomyelitis(EAE)byCD4+CD25+regulatory
Tcells 45
Discussion 52
ElisaBoden,QizhiTang,HeleneBour-JordanandJe¡reyA.Bluestone The
roleofCD28andCTLA4inthefunctionandhomeostasisofCD4+CD25+
regulatoryTcells 55
Discussion 63
ClareBaecher-Allan,JuliaA.Brown,GordonJ.FreemanandDavidA.Ha£er
CD4+CD25+regulatorycellsfromhumanperipheralbloodexpressveryhighlevels
ofCD25exvivo 67
Discussion 88
v
vi CONTENTS
FionaPowrie,SimonRead,ChristianMottet,HolmUhligandKevinMaloy
ControlofimmunepathologybyregulatoryTcells 92
Discussion 98
GeneraldiscussionI TGFb 106
MariaGraziaRoncarolo,SilviaGregoriandMeganLevings Type1T
regulatorycellsandtheirrelationshipwithCD4+CD25+Tregulatorycells 115
Discussion 127
LeonardC.Harrison,NatashaR.SollyandNathanR.Martinez (PRO)insulin-
speci¢cregulatoryTcells 132
Discussion 141
Qing-ShengMi,CraigMeagherandTerryL.Delovitch CD1d-restrictedNKT
regulatorycells:functionalgenomicanalysesprovidenewinsightsintothe
mechanismsofprotectionagainstType1diabetes 146
Discussion 160
EliSercarz,EmanualMaverakis,PetervandenElzen,LouiMadakamutiland
VipinKumar SevensurprisesintheTCR-centredregulationofimmune
responsivenessinanautoimmunesystem 165
Discussion 171
KathrynJ.Wood,HidetakeUshigome,MahzuzKarim,AndrewBushell,
ShoheiHoriandShimonSakaguchi Regulatorycellsintransplantation 177
Discussion 188
KimJ.Hasenkrug CD4+regulatoryTcellsinchronicviralinfection 194
Discussion 199
GeneraldiscussionII 203
MarcaH.M.Wauben,EstherN.M.’tHoenandLeonieS.Taams Modulationof
Tcellresponsesaftercross-talkbetweenantigenpresentingcellsandTcells:agive-
and-takerelationship 211
Discussion 220
JacquesBanchereau,JosephFay,VirginiaPascualandA.KarolinaPalucka
Dendriticcells:controllersoftheimmunesystemandanewpromisefor
immunotherapy 226
Discussion 235
vii CONTENTS
ChrystelleAssemanandMatthiasvonHerrath Regulationofviraland
autoimmuneresponses 239
Discussion 253
GeneraldiscussionIII Activeimmuneregulation 257
MargaretJ.Dallman,BrianChampionandJonathanR.Lamb Notchsignalling
intheperipheralimmunesystem 268
Discussion 276
LucienneChatenoud CD3antibodytreatmentstimulatesthefunctionalcapability
ofregulatoryTcells 279
Discussion 286
AllanMcIMowat,AnneM.Donachie,LucyA.Parker,NeilC.Robson,
HelenBeacock-Sharp,LindsayJ.McIntyre,OwainMillingtonand
FernandoChirdo Theroleofdendriticcellsinregulatingmucosalimmunity
andtolerance 291
Discussion 302
Indexofcontributors 306
Subjectindex 308
Participants
AbulK.Abbas DepartmentofPathology,UniversityofCaliforniaSan
Francisco,RoomM590,513ParnassusAvenue,SanFrancisco,CA94143,USA
ChrystelleAsseman(NovartisFoundationBursar) LaJollaInstituteforAllergy
andImmunology,10355ScienceCenterDrive,SanDiego,CA92121,USA
Jean-Francc(cid:1)oisBach(Chair) Laboratoired’Immunologie,Ho“pitalNecker,
161ruedeSe'vres,75743ParisCedex15,France
JacquesBanchereau BaylorInstituteforImmunologyResearch,3434Live
Oak,Suite205,Dallas,TX75204,USA
Je¡reyBluestone UCSFDiabetesCenter,513ParnassusAveBox0540,
SanFrancisco,CA94143-0540,USA
LucienneChatenoud Laboratoired’Immunologie,Ho“pitalNecker,161ruede
Se'vres,F-75743ParisCedex15,France
CristinaCuturi INSERMU437,CHUdeNantes,30solJ.Monnet,44093,
Nantes,France
MargaretDallman DepartmentofBiology,SirAlexanderFlemingBuilding,
ImperialCollegeofScience,TechnologyandMedicine,SouthKensington,
LondonSW72AZ,UK
TerryDelovitch TheJohnP.RobartsResearchInstitute,1400WesternRoad,
London,Ontario,CanadaN6G2V4
RichardFlavell DepartmentofImmunobiology,YaleUniversitySchoolof
Medicine,HHMI,310CedarStreet,FMB412,Box208011,NewHaven,
CT06520-8011,USA
DavidHa£er CenterforNeurologicDiseases,HarvardMedicalSchool,77
AvenueLouisPasteur,Boston,MA02115,USA
viii
ix PARTICIPANTS
LeonardHarrison AutoimmunityandTransplantationDivision,TheWalter
andElizaHallInstituteofMedicalResearch,TheRoyalMelbourneHospital
PO,Parkville,3050Victoria,Australia
KimHasenkrug LaboratoryofPersistentViralDiseases,RockyMountain
Laboratories,NationalInstituteofAllergyandInfectiousDiseases,Hamilton,
MT59840,USA
StephenMiller ImmunobiologyCenter,NorthwesternUniversitySchoolof
Medicine,303E.ChicagoAvenue,Chicago,IL60611-3072,USA
AvMitchison DepartmentofImmunology,WindeyerInstituteofMedical
Science,UniversityCollegeLondonMedicalSchool,46ClevelandStreet,
LondonW1P6DB,UK
AllanMowat DepartmentofImmunologyandBacteriology,WesternIn¢rmary,
GlasgowG116NT,UK
VirginiaPascual BaylorInstituteforImmunologyResearch,3434LiveOak,
Suite205,Dallas,TX75204,USA
FionaPowrie UniversityofOxford,SirWilliamDunnSchoolofPathology,
SouthParksRoad,OxfordOX13RE,UK
MariaGraziaRoncarolo SanRa¡aeleTelethonInstituteforGeneTherapy
(HSR-TIGET),ViaOlgettina58,I-20132Milano,Italy
ShimonSakaguchi DepartmentofExperimentalPathology,Institutefor
FrontierMedicalSciences,KyotoUniversity,53ShogoinKawahara-cho,
Sakyo-ku,Kyoto606-8507,Japan
EliSercarz TheLaJollaInstituteforAllergyandImmunology,10355Science
CenterDrive,SanDiego,CA92121,USA
EthanShevach CellularImmunologySection,NIAIDLaboratoryof
Immunology,Building10,Room11N315,10CenterDrive,MSC1892,Bethesda,
MD20892-1892,USA
MatthiasvonHerrath DepartmentofImmuneRegulation,LaJollaInstitute
forAllergyandImmunology,10355ScienceCenterDrive,SanDiego,CA92121,
USA
x PARTICIPANTS
MarcaWauben DepartmentofInfectiousDiseasesandImmunology,Facultyof
VeterinaryMedicine,UtrechtUniversity,POBox80.165,NL-3508TDUtrecht,
TheNetherlands
ChristophWalker NovartisPharmaUK,NovartisHorshamResearchCentre,
WimblehurstRoad,HorshamRH125AB,UK
KathrynWood TheNu⁄eldDepartmentofSurgery,UniversityofOxford,
JohnRadcli¡eHospital,HeadleyWay,Headington,OxfordOX39DU,UK