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Trans.#: 1081135 Title Finding the balance report : Author National Institute of Mental Health (U.S.). Call# RC337 .N375 1997 CIRC Loaned To: HNI - N.I.H. Library- Interlibrary Loan Unit Due 3/7/2016 ILL# 162688624 ILL Office Hours: Monday-Friday 8:00am-5:00pm Contact: [email protected] Finding the Balance Report ofthe National Institute of Mental Health Intramural Research Program (IRP) Planning Committee RC 337 N375 . 1997 NATIONAL. INSTITUTES OF HEALT H National Institute of Menial Health Finding the Balance Report ofthe National Institute ofMental Health Intramural Research Program (IRP) Planning Committee LIBRARY U.S.F. Steven Hyman, M.D. Chairman National Advisory Mental Health Council National Institute ofMental Health Bethesda, Maryland 20892 January 29, 1997 Dear Dr. Hyman: The Intramural Research Program Planning Committee (IRPPC) is pleased to transmit its report to the National Advisory Mental Health Council oftheNational Institute ofMental Health (NIMH). The Fiscal Year 1994 House Appropriations Committee Reportmandatedthatthe DirectoroftheNational Institutes ofHealth (NIH) reviewtherole, size, andcostoftheoverallNIH Intramural Research Program. In turn, the External Advisory Committee oftheNIH Director’s Advisory Committeerecommendedthat each ofthe individual IRPs at NIH undergo separatereview. AtthebehestoftheNational Advisory Mental Health Council, Dr. Rex Cowdry, formerActingDirector oftheNIMH, formedthe IRPPC withthe charge ofreviewing therationale forcontinued investment in theNIMH IRP and evaluating its strengths andweaknesses. Afterextensive deliberations between March andDecember of 1996, our Committee determined that continued investment intheNIMH IRP is stronglyjustified, providedtheresearch is ofthehighest quality. TheNIMH IRP is a uniquenational resource inmental healthresearch, with ahistory ofillustrious contributions. Ithas the capacity to leadtheNationbyvirtue ofits concentrationofexpertise, special facilities, and far-reaching ability to conduct basic, clinical, andtranslationalresearch. Nevertheless, thenature ofscience andthe environment inwhich it is conducted arechangingradically. The organizational structures thatprovedeffective inthe pastdonot equip the IRP to meetthe opportunities and challenges ofthe future. Inresponse, our Committee focusedonbroad structural, organizational, and leadership changes that laythe foundationfor scientific renewal. Ourreport contains 77 recommendations designedto stimulaterenewal byprovidingunderlying goals andmanagementtools forhowrenewal may be accomplished. We are grateful forthe opportunityto develop this report. Respectfully, The Members ofthe Intramural Research Program Planning Committee Co-Chair, IRPPC Executive Secretary Patricia Goldman-Rakic, Ph.D. NormanAnderson, Ph.D. Floyd Bloom, M.D. A fv-\ t^d enjamm StephensonB Kenneth S. Kendler, M.D. M3 RobertE. Burke, M.D. William T. Carpenter, M.D. The Intramural Research Program Planning Committee Chairman: HERBERT PARDES, M.D. JOSEPH DEVEAUGH-GEISS, M.D. Vice President for Health Sciences, Dean ofthe Faculty Director, International CNS Clinical Research, Glaxo ofMedicine and Chairman ofthe Department of Wellcome, Research Triangle Park, North Carolina, Psychiatry, College ofPhysicians and Surgeons, Clinical ProfessorofPsychiatry, University ofNorth Columbia University. Carolina at Chapel Hill and Associate Consulting ProfessorofPsychiatry, Duke University Medical Co-Chairman: BRUCE McEWEN, Ph D. Center. Professor, The RockefellerUniversity and Head ofthe Harold & Margaret Milliken Hatch Laboratory of PATRICIA GOLDMAN-RAKIC, Ph D. Neuroendocrinology. ProfessorofNeuroscience, Department ofNeurobiology, Yale University School ofMedicine. Executive Secretary: HAROLD A. SACKEIM, Ph D., Chief, Department ofBiological Psychiatry, New York RAQUELE. GUR, M.D., Ph.D. State Psychiatric Institute and ProfessorofClinical Professor ofPsychiatry andNeurology, and Director of Psychology in Psychiatry and Radiology, College of Neuropsychiatry, Department ofPsychiatry, University Physicians and Surgeons, Columbia University. ofPennsylvania. NANCY E. ADLER, Ph D. LILY JAN, Ph D. ProfessorofMedical Psychology and Director, Health ProfessorofPhysiology and Biochemistry, University of Psychology Program and Vice-Chair, Department of California at San Francisco and Howard Hughes Psychiatry and Program Director, NIMH Training Medical Institute Investigator. Program in "Psychology and Medicine," University of California at San Francisco. KENNETH S. KENDLER, M.D. Rachel Brown Banks Distinguished Professorof NORMAN ANDERSON, Ph D. Psychiatry, Virginia Institute ofPsychiatric and Associate Director for Behavioral and Social Sciences Behavioral Genetics, Departments ofPsychiatry and Research, National Institutes ofHealth. Human Genetics, Medical College ofVirginia/Virginia Commonwealth University. FLOYD BLOOM, M.D. Chairman, Department ofNeuropharmacology, The DAVID KUPFER, M.D. Scnpps Research Institute, La Jolla and Editor-in-Chief, Thomas Detre Professor and Chairman, Department of Science. Psychiatry, University ofPittsburgh and Director, Mental Health Clinical Research Center forAffective BENJAMIN STEPHENSON BUNNEY, M.D. Disorders and Professor, Neuroscience, Western Charles B.G. Murphy Professor and Chairman, Psychiatric Institute and Clinic. Department ofPsychiatry and Professor of Pharmacology, Yale University School ofMedicine. JOHN C. MAZZIOTTA, M.D., Ph.D. Professor, Department ofNeurology and Director, Brain ROBERT E. BURKE, M.D. Mapping Division, ReedNeurology Research Center, UCLA Chief, Laboratory ofNeural Control, National Institute School ofMedicine. ofNeurological Disorders and Stroke,National Institutes ofHealth. Science Writer: MIRIAM DAVIS, Ph D. Science and Health Policy Consultant, Silver Spring, WILLIAM T. CARPENTER, M.D. Maryland, and Adjunct Assistant Professor, George Director, Maryland Psychiatric Research Center and Washington University School ofPublic Health. Professor ofPsychiatry and Pharmacology, Universityof Maryland School ofMedicine. NIMH StaffLiaisons: NANCY OSTROWSKI, Ph D. and RICHARD NAKAMURA, Ph.D., Office ofScience JOSEPH COYLE, M.D. Policy and Program Planning. Chairman, Consolidated Department ofPsychiatry, Harvard Medical School. Finding the Balance Report ofthe NIMH Intramural Research Program Planning Committee Executive Summary i Introduction 1 Leadership 13 Quality ofScience 27 Recruitment, Retention, andRetirement 39 Training and Mentoring 47 Clinical Research 55 Appendices 67 A. Meeting Dates 67 B. Associations Invitedto Send Comments AbouttheNIMH IRP 68 C. Presentations to the IRPPC 69