Evidence-Based Hematology PDF
Preview Evidence-Based Hematology
BLFS004-Crowther April15,2008 8:22 Evidence-based Hematology Evidence-based Hematolog y . Edited by Mark A. Crowther, Jeff Ginsberg, Holger J. Schu¨nemann, Ralph M. Meyer, and Richard Lottenberg. © 2008 Blackwell Publishing, ISBN: 978-1-405-15747-6. BLFS004-Crowther April15,2008 8:22 Evidence-based Hematology EDITED BY MARK A. CROWTHER md, msc, frcpc ProfessorandDivisionDirector DivisionofHematology McMasterUniversity Hamilton,Canada JEFF GINSBERG md, frcpc Professor,DepartmentofMedicine McMasterUniversity Hamilton,Canada HOLGER J. SCHU¨ NEMANN md, phd, msc, facp, fccp Professor ItalianNationalCancerInstitute“ReginaElena” Rome,Italy,and McMasterUniversity Hamilton,Canada RALPH M. MEYER md, frcpc EdithEisenhauerChairinClinicalCancerResearch Professor,DepartmentsofOncologyandMedicine Queen’sUniversity Kingston,Canada RICHARD LOTTENBERG md, facp ProfessorofMedicine UniversityofFlorida Gainesville,USA BLFS004-Crowther April15,2008 8:22 Thiseditionfirstpublished2008,(cid:2)C 2008byBlackwellPublishingLtd BMJBooksisanimprintofBMJPublishingGroupLimited,usedunderlicence byBlackwellPublishingwhichwasacquiredbyJohnWiley&SonsinFebruary2007. Blackwell’spublishingprogrammehasbeenmergedwithWiley’s globalScientific,TechnicalandMedicalbusinesstoformWiley-Blackwell. Registeredoffice:JohnWiley&SonsLtd,TheAtrium,SouthernGate,Chichester,WestSussex,PO198SQ,UK Editorialoffices:9600GarsingtonRoad,Oxford,OX42DQ,UK TheAtrium,SouthernGate,Chichester,WestSussex,PO198SQ,UK 111RiverStreet,Hoboken,NJ07030-5774,USA Fordetailsofourglobaleditorialoffices,forcustomerservicesandforinformationabouthowtoapplyfor permissiontoreusethecopyrightmaterialinthisbookpleaseseeourwebsiteatwww.wiley.com/wiley-blackwell Therightoftheauthortobeidentifiedastheauthorofthisworkhasbeenassertedinaccordancewiththe Copyright,DesignsandPatentsAct1988. Allrightsreserved.Nopartofthispublicationmaybereproduced,storedinaretrievalsystem,ortransmitted,in anyformorbyanymeans,electronic,mechanical,photocopying,recordingorotherwise,exceptaspermittedby theUKCopyright,DesignsandPatentsAct1988,withoutthepriorpermissionofthepublisher. Wileyalsopublishesitsbooksinavarietyofelectronicformats.Somecontentthatappearsinprintmaynotbe availableinelectronicbooks. Designationsusedbycompaniestodistinguishtheirproductsareoftenclaimedastrademarks.Allbrandnames andproductnamesusedinthisbookaretradenames,servicemarks,trademarksorregisteredtrademarksoftheir respectiveowners.Thepublisherisnotassociatedwithanyproductorvendormentionedinthisbook.This publicationisdesignedtoprovideaccurateandauthoritativeinformationinregardtothesubjectmattercovered. Itissoldontheunderstandingthatthepublisherisnotengagedinrenderingprofessionalservices.Ifprofessional adviceorotherexpertassistanceisrequired,theservicesofacompetentprofessionalshouldbesought. Thecontentsofthisworkareintendedtofurthergeneralscientificresearch,understanding,anddiscussiononly andarenotintendedandshouldnotberelieduponasrecommendingorpromotingaspecificmethod,diagnosis, ortreatmentbyphysiciansforanyparticularpatient.Thepublisherandtheauthormakenorepresentationsor warrantieswithrespecttotheaccuracyorcompletenessofthecontentsofthisworkandspecificallydisclaimall warranties,includingwithoutlimitationanyimpliedwarrantiesoffitnessforaparticularpurpose.Inviewof ongoingresearch,equipmentmodifications,changesingovernmentalregulations,andtheconstantflowof informationrelatingtotheuseofmedicines,equipment,anddevices,thereaderisurgedtoreviewandevaluate theinformationprovidedinthepackageinsertorinstructionsforeachmedicine,equipment,ordevicefor,among otherthings,anychangesintheinstructionsorindicationofusageandforaddedwarningsandprecautions. Readersshouldconsultwithaspecialistwhereappropriate.ThefactthatanorganizationorWebsiteisreferredto inthisworkasacitationand/orapotentialsourceoffurtherinformationdoesnotmeanthattheauthororthe publisherendorsestheinformationtheorganizationorWebsitemayprovideorrecommendationsitmaymake. Further,readersshouldbeawarethatInternetWebsiteslistedinthisworkmayhavechangedordisappeared betweenwhenthisworkwaswrittenandwhenitisread.Nowarrantymaybecreatedorextendedbyany promotionalstatementsforthiswork.Neitherthepublishernortheauthorshallbeliableforanydamagesarising herefrom. LibraryofCongressCataloging-in-PublicationData Evidence-basedhematology/editedbyMarkA.Crowther...[etal.]. p. ; cm. Includesbibliographicalreferencesandindex. ISBN978-1-4051-5747-6(alk.paper) 1.Blood—Diseases. 2.Hematology. 3.Evidence-basedmedicine. I.Crowther,Mark,1966- [DNLM:1. HematologicDiseases–therapy. 2.Evidence-BasedMedicine. 3.Hematologic Diseases–diagnosis.WH120E932008] RC636.E942008 616.1(cid:3)5—dc22 2007047284 ISBN:978-1-4051-5747-6 AcataloguerecordforthisbookisavailablefromtheBritishLibrary. Setin9.25/12byAptara,Inc. PrintedinSingaporebyFabulousPrintersPteLtd 1 2008 BLFS004-Crowther April15,2008 8:22 Contents ListofContributors,vii 10 Long-TermAnticoagulationinVenous Thromboembolism,73 Preface,xi CliveKearon Part1 AGuidetotheEvidence 11 ThrombolyticTherapyforDeepVeinThrombosisand PulmonaryEmbolism,88 Editor:HolgerJ.Schu¨nemann SimonJ.McRae,JohnW.Eikelboom 1 RatingtheQualityofEvidenceandMaking 12 InferiorVenaCavaInterruption,99 Recommendations:AGuidetotheSpectrumof MichaelB.Streiff,ChristineL.Hann ClinicalResearch,3 HolgerJ.Schu¨nemann,MartinStanulla, 13 ManagementofVenousThromboembolismin JanL.Brozek,GordonG.Guyatt Pregnancy,110 2 AnOverviewofSystematicReviews,10 Wee-ShianChan MartinPrins,ArinatenCate-Hoek,PieterLeffers 14 PediatricThrombosis,120 3 InterpretingResultsinClinicalResearch:Overviewof AnthonyK.C.Chan,PaulMonagle measuresofeffect,measuresofprecision,and 15 BridgingAnticoagulationinPatientsWhoRequire measuresofdiagnosticaccuracyforcliniciansand TemporaryInterruptionofWarfarinforSurgery,124 researchers,15 JamesD.Douketis,ScottKaatz MarcelloDiNisio,HarryR.Bu¨ller,PatrickM.M.Bossuyt 16 Evidence-basedApproachtotheDiagnosisand 4 FindingtheEvidenceinHematology,23 ManagementofThromboticThrombocytopenic K.AnnMcKibbon,CynthiaJ.Walker-Dilks,R.BrianHaynes Purpura,131 5 ApplyingEBMinClinicalPractice,32 BrianBoulmay,CraigS.Kitchens AlessandroSquizzato,WalterAgeno,DavideImberti 17 DiagnosisandManagementofDisseminated 6 UsingEvidencetoGuidetheDiagnosisofDisease,37 IntravascularCoagulation,138 LucasM.Bachmann,HolgerJ.Schu¨nemann JuliaA.M.Anderson Part2 HemostasisandThrombosis 18 DiagnosisandManagementofHereditaryBleeding Disorders:IncludingCongenital/AcquiredPlatelet Editor:JeffGinsberg FunctionDisorders,145 NigelS.Key,AliceD.Ma 7 DiagnosisofDeepVeinThrombosis,49 Lori-AnnLinkins 19 DiagnosisandManagementofAcquiredBleeding 8 TheDiagnosisofAcutePulmonaryEmbolism,56 Disorders:VitaminKAntagonists,152 VictorF.Tapson MiguelA.Escobar 9 InitialTherapyofDeepVeinThrombosisand 20 DiagnosisandManagementofHeparin-Induced PulmonaryEmbolism,65 Thrombocytopenia,158 SamSchulman TheodoreE.Warkentin,AndreasGreinacher v BLFS004-Crowther April15,2008 8:22 Contents 21 ManagementofAntiphospholipidAntibody 37 ChronicMyeloidLeukemia,300 Syndrome,168 IrwinWalker WendyLim,MarkA.Crowther 38 SelectedManagementofPatientswithMyelodysplastic Syndromes,305 Part3 BenignHematologicDisorders JohnM.Storring,KarenW.L.Yee Editor:RichardLottenberg 39 Evidence-basedTreatmentofBurkittLymphomain Adults,311 22 ClinicalQuestionsinIronOverload,179 JohnGerecitano,DavidJ.Straus AntonelloPietrangelo,NicolaMagrini 23 AplasticAnemia,ParoxysmalNocturnal 40 PrimaryCentralNervousSystemLymphoma,317 Hemoglobinuria,andPureRedCellAplasia,189 TamaraShenkier ShivaniSrivastava,RichardW.Childs 41 DiffuseLargeB-cellLymphoma,327 24 AcquiredAnemias:IronDeficiency,Cobalamin MichaelCrump Deficiency,andAutoimmuneHemolyticAnemia,197 42 FollicularLymphoma,334 MarcS.Zumberg,MarcJ.Kahn KevinImrie,MatthewCheung 25 ImmuneThrombocytopenicPurpura,206 43 LymphoblasticLymphoma,342 JamesN.George,SaraK.Vesely,GeorgeR.Buchanan TylerY.Kang,JohnW.Sweetenham 26 Neutropenia,215 44 MantleCellLymphoma,347 DavidC.Dale C.TomKouroukis 27 Hypereosinophilia:PrimaryandSecondary,221 45 ManagementofPatientswithPeripheralT-cell FlorenceRoufosse,MichelGoldman,ElieCogan Lymphoma,352 28 Porphyrias,229 KerryJ.Savage GaganSood,KarlE.Anderson 46 SelectedManagementIssuesofPatientswithHodgkin 29 MembraneandEnzymeAbnormalitiesofthe Lymphoma,365 Erythrocyte,238 RalphM.Meyer PatrickG.Gallagher,ErnestBeutler 47 LymphocytePredominantHodgkinLymphoma,372 30 SickleCellDisease,244 BrandonMcMahon,JonathanW.Friedberg RichardLottenberg,SallyC.Davies 48 ManagementofPatientswithEssential 31 Evidence-basedTreatmentofThalassemiaMajor,251 Thrombocythemia,378 IssacOdame,DeborahRund GuidoFinazzi,GiovanniBarosi,TizianoBarbui 49 ManagementofPatientswithPolycythemia Part4 MalignantHematologicDisorders Vera,385 Editor:RalphM.Meyer GuidoFinazzi,RobertoMarchioli,TizianoBarbui 32 AcuteLymphoblasticLeukemiainAdults,263 50 Evidence-basedReviewofTherapiesinMultiple StephenCouban,AndreaKew Myeloma,390 33 AcuteMyeloidLeukemiainAdults:Remission MichaelSebag,A.KeithStewart InductionTherapy,268 51 ManagementofWaldenstrom’s CaraA.Rosenbaum,RichardA.Larson Macroglobulinemia,396 34 AcuteMyeloidLeukemiainAdults:Postremission ChristineI.Chen Therapy,278 52 TheRoleofHematopoieticGrowthFactorsin CaraA.Rosenbaum,RichardA.Larson ManagingPatientswithHematologicMalignancies, 35 CurrentAreasofControversyintheTreatmentof 402 PatientsWithNewlyDiagnosedAcutePromyelocytic HeloisaP.Soares,AmbujKumar,CharlesBennett, Leukemia,287 BenjaminDjulbegovic MartinS.Tallman,SyedA.Abutalib 36 ChronicLymphocyticLeukemia,294 Index,413 BruceD.Cheson Companionwebsite:www.blackwellpublishing.com/medicine/bmj/hematology vi BLFS004-Crowther April15,2008 8:22 List of contributors SyedA.Abutalib MD GiovanniBarosi MD JanL.Brozek MD,PhD NorthwesternUniversityFeinbergSchoolof Director,UnitofEpidemiologyCenterforthe ItalianNationalCancerInstitute“ReginaElena” Medicine StudyofMyelofibrosis Rome,Italy RobertH.LurieComprehensiveCancerCenter IRCCSPoliclinicoS.MatteoFoundation PolishInstituteforEBM Chicago Pavia,Italy Krakow,Poland Illinois,USA CharlesBennett MDPhD GeorgeR.Buchanan MD WalterAgeno MD DivisionofHematology-Oncology DivisionofHematology/Oncology DepartmentofClinicalMedicine DepartmentofPediatrics DepartmentofMedicine UniversityofInsubria UniversityofTexas FeinbergSchoolofMedicine Varese,Italy SouthwesternMedicalCenteratDallas Mid-WestCenterforHealthServicesPolicy Dallas Research Texas,USA JuliaA.M.Anderson MBChB, ChicagoVA/LakesideDivision NorthwesternUniversityMedicalSchool BSc(Hons),MDFRCP(Edin),FRCPath,FACP DepartmentofMedicine Chicago HarryR.Bu¨ller MD McMasterUniversity Illinois,USA DepartmentofVascularMedicine Hamilton AcademicMedicalCenter Ontario,Canada UniversityofAmsterdam ErnestBeutler MD Amsterdam,TheNetherlands DepartmentofMolecularandExperimental KarlE.Anderson MD Medicine DepartmentsofPreventiveMedicineand TheScrippsResearchInstitute ArinatenCate-Hoek MD CommunityHealth LaJolla DepartmentofEpidemiology InternalMedicineandPharmacologyand California,USA CareandPublicHealthResearchInstitute Toxicology UniversityofMaastricht UniversityofTexasMedicalBranch Maastricht,TheNetherlands Galveston PatrickM.M.Bossuyt PhD Texas,USA DepartmentofClinicalEpidemiologyand AnthonyK.C.Chan MBBS,FRCPC Biostatistics DepartmentofPediatrics AcademicMedicalCenter LucasM.Bachmann MD,PhD McMasterUniversity UniversityofAmsterdam ReaderinClinicalEpidemiology Hamilton Amsterdam DeputyDirector,HortenCentreforPatient Ontario,Canada TheNetherlands OrientedResearch UniversityofZu¨rich Wee-ShianChan MD,FRCPC,MSc Zu¨rich,Switzerland BrianBoulmay MD DepartmentofMedicine DepartmentofMedicine Women’sCollegeHospital TizianoBarbui MD HealthScienceCenter DepartmentofObstetricsandGynecology DepartmentofHematology-Oncology UniversityofFlorida SunnybrookHealthSciencesCentre OspedaliRiunitidiBergamo Gainesville Toronto Bergamo(Bg),Italy Florida,USA Ontario,Canada vii BLFS004-Crowther April15,2008 8:22 Listofcontributors ChristineI.Chen MD,MMED,FRCP MarcelloDiNisio MD,PhD JohnGerecitano MD,PhD DepartmentofMedicalOncologyandHematology DepartmentofMedicineandAging DepartmentofMedicine PrincessMargaretHospital SchoolofMedicine,andAgingResearchCenter, LymphomaService UniversityofToronto Ce.S.I. MemorialSloan-KetteringCancerCenter Toronto “GabrieleD’Annunzio” NewYork,USA Ontario,Canada UniversityFoundation Chieti-Pescara,Italy BruceD.Cheson MD MichelGoldman MD,PhD DivisionofHematology/Oncology InstituteforMedicalImmunology GeorgetownUniversityHospital BenjaminDjulbegovic MD,PhD Universite´LibredeBruxelles Washington,DC,USA DepartmentofInterdisciplinaryOncology Charleroi-Gosselies,Belgium H.LeeMoffittCancerCenterandResearch Institute MatthewCheung MD,SM,FRCP(C) UniversityofSouthFlorida AndreasGreinacher DivisionofHematology/Oncology Tampa DepartmentofImmunologyandTransfusion DepartmentofMedicine Florida,USA MedicineandTransfusionMedicine UniversityofTorontoSunnybrookHealthSciences ThrombosisandHemostasisService Centre Universita¨tsklinikumGreifswald Toronto,Ontario JamesD.Douketis MD,FRCP(C) Ernst-Moritz-ArndtUniversityGreifswald Canada DepartmentofMedicine Greifswald,Germany McMasterUniversityandStJoseph’sHealthcare RichardW.Childs MD Hamilton HematologyBranch Ontario,Canada GordonG.Guyatt MD,MSc NationalHeart,Lung,andBloodInstitute CLARITYResearchGroup NationalInstitutesofHealth JohnW.Eikelboom MBBS,MSc,FRACP, DepartmentofClinicalEpidemiologyand Bethesda Biostatistics FRCPA Maryland,USA McMasterUniversity DepartmentofMedicine Hamilton ElieCogan MD,PhD McMasterUniversity Ontario,Canada DepartmentofInternalMedicine Hamilton ErasmeHospital,Brussels Ontario,Canada Universite´LibredeBruxelles(ULB) ChristineL.Hann MD,PhD Belgium MiguelA.Escobar MD DepartmentofOncology JohnsHopkinsUniversitySchoolofMedicine DepartmentofPediatricsandInternalMedicine StephenCouban MD,FRCPC DivisionofHematology Baltimore QueenElizabethIIHealthSciencesCentre UniversityofTexasHealthScienceCenterat Maryland,USA Halifax Houston NovaScotia,Canada Houston R.BrianHaynes MD,PhD Texas,USA HealthInformationResearchUnit MarkA.Crowther MD,MSc,FRCPC DepartmentofClinicalEpidemiologyand ProfessorandDivisionDirector GuidoFinazzi MD Biostatistics DivisionofHematology McMasterUniversity,and Director,TransfusionMedicineandHaemostasis McMasterUniversityFacultyofHealthSciences St.Joseph’sHospital andThrombosisServices Hamilton Hamilton OspedaliRiuniti Ontario,Canada Ontario,Canada Bergamo,Italy DavideImberti MD MichaelCrump MD,FRCPC JonathanW.Friedberg MD HeadofThrombosisCenter PrincessMargaretHospital JamesP.WilmotCancerCenter EmergencyDepartment DivisionofMedicalOncologyandHematology UniversityofRochester HospitalofPiacenza DepartmentofMedicine Rochester Piacenza,Italy UniversityofToronto NewYork,USA Toronto Ontario,Canada KevinImrie MD,FRCPC PatrickG.Gallagher MD,FAAP Chair,CancerCareOntarioHematologyDisease DavidC.Dale MD,FACP DepartmentofPediatrics SiteGroup,and DepartmentofMedicine YaleSchoolofMedicine Toronto-SunnybrookRegionalCancerCentre UniversityofWashington NewHaven Toronto Seattle Connecticut,USA Ontario,Canada Washington,USA JamesN.George MD ScottKaatz DO,MSc,FACP SallyC.Davies MB,FRCP,FRCPath Hematology–OncologySection HenryFordHealthSystem FacultyofMedicine UniversityofOklahomaHealthSciencesCenter Detroit ImperialCollegeatCentralMiddlesexHospital OklahomaCity Michigan,USA London,UK Oklahoma,USA viii BLFS004-Crowther April15,2008 8:22 Listofcontributors MarcJ.Kahn MD PieterLeffers BrandonMcMahon MD SchoolofMedicine DepartmentofEpidemiology NorthwesternUniversity TulaneUniversitySchoolofMedicine CareandPublicHealthResearchInstitute FeinbergSchoolofMedicine NewOrleans MaastrichtUniversity RobertH.LurieComprehensiveCancerCenter Louisiana,USA Maastricht,TheNetherlands Chicago Illinois,USA TylerY.Kang MD Hematology/OncologyFellow WendyLim MD,MSc SimonJ.McRae MBBS,FRACP,FRCPA TaussigCancerCenter St.Joseph’sHospital TheQueenElizabethHospital ClevelandClinic DepartmentofMedicine Woodville Cleveland McMasterUniversity SouthAustralia Ohio,USA Hamilton Australia Ontario,Canada CliveKearon MB,MRCPI,FRCPC,PhD RalphM.Meyer MD,FRCP(C) McMasterUniversity Lori-AnnLinkins MD,MSc,FRCPC Director,NationalCancerInstituteofCanada ClinicalTrialsGroup Hamilton HendersonResearchCentre EdithEisenhauerChairinClinicalCancer Ontario,Canada HamiltonHealthSciencesCorporation Research Hamilton Professor,DepartmentsofOncologyandMedicine AndreaKew MD,FRCPC Ontario,Canada Queen’sUniversity QueenElizabethIIHealthSciencesCentre Kingston,Ontario Halifax RichardLottenberg MD,FACP Canada NovaScotia,Canada DivisionofHematology/Oncology DepartmentofMedicine PaulMonagle MBBS,MSc,MD,FRACP, NigelS.Key MB,ChB,FRCP(UK) UniversityofFloridaCollegeofMedicine FRCPA,FCCP DepartmentofMedicine Gainesville DepartmentofHaematology UniversityofNorthCarolinaatChapelHill Florida,USA RoyalChildren’sHospital ChapelHill DepartmentofPathology NorthCarolina,USA UniversityofMelbourne AliceD.Ma MD Melbourne CraigS.Kitchens MD,MACP UniversityofNorthCarolinaSchool Victoria,Australia ofMedicine VeteransAffairsMedicalCenter UniversityofFlorida DivisionofHematology/Oncology IsaacOdame MB,ChB,FRCPCH,FRCPath, HaroldR.RobertsComprehensiveHemophilia Gainesville FRCPC CenterCB Florida,USA DivisionofHematology/Oncology ChapelHill TheHospitalforSickChildren NorthCarolina,USA C.TomKouroukis MD,MSc,FRCPC Toronto Hematology-Oncology Ontario,Canada JuravinskiCancerCentre NicolaMagrini MD DepartmentofOncology CeVEASNHSCentrefortheEvaluationofthe AntonelloPietrangelo MD.PhD McMasterUniversity EffectivenessofHealthCare DepartmentofMedicine Hamilton ModenaLocalHealthAuthority CenterforHemochromatosis Ontario,Canada Modena,Italy UniversityofModenaandReggioEmilia Modena,Italy AmbujKumar MD,MPH DepartmentofHealthOutcomesandBehavior RobertoMarchioli MD MartinPrins MD,PhD LaboratoryofClinicalEpidemiologyof andOncologicSciences DepartmentofEpidemiology CardiovascularDisease H.LeeMoffittCancerCenterandResearch CareandPublicHealthReseachInstitute DepartmentofClinicalPharmacologyand Institute UniversityofMaastrichtandDepartmentof Epidemiology UniversityofSouthFlorida EpidemiologyandMedicalTechnologyAssessment ConsorzioMarioNegriSud Tampa AcademicHospitalMaastricht SantaMariaImbaro,Italy Florida,USA Maastricht,TheNetherlands RichardA.Larson MD K.AnnMcKibbon MLS,PhD CaraA.Rosenbaum MD SectionofHematology/Oncology HealthInformationResearchUnit SectionofHematology/Oncology DepartmentofMedicineandCancerResearch DepartmentofClinicalEpidemiologyand DepartmentofMedicineandCancerResearch Center Biostatistics Center UniversityofChicago McMasterUniversityFacultyofHealthSciences UniversityofChicago Chicago Hamilton Chicago Illinois,USA Ontario,Canada Illinois,USA ix BLFS004-Crowther April15,2008 8:22 Listofcontributors FlorenceRoufosse MD,PhD GaganSood MD MartinS.Tallman MD DepartmentofInternalMedicine DivisionofGastroenterologyandHepatology NorthwesternUniversityFeinbergSchoolof HoˆpitalErasme DepartmentofInternalMedicine Medicine Universite´LibredeBruxelles(ULB) TheUniversityofTexasMedicalBranch RobertH.LurieComprehensiveCancerCenter InstituteforMedicalImmunology Galveston Chicago Universite´LibredeBruxelles(ULB) Texas,USA Illinois,USA Gosselies Brussels,Belgium AlessandroSquizzato MD VictorF.Tapson MD DepartmentofClinicalMedicine DivisionofPulmonaryandCriticalCareMedicine DeborahRund MD UniversityofInsubria DukeUniversityMedicalCenter HematologyDepartment Varese,Italy Durham NorthCarolina,USA HebrewUniversity HadassahUniversityHospital EinKerem ShivaniSrivastava MD SaraK.Vesely PhD BoneMarrowandStemCellTransplantation Jerusalem,Israel DepartmentofBiostatisticsandEpidemiology IUSimonCancerCenter UniversityofOklahomaHealthSciencesCenter IndianaUniversity OklahomaCity KerrySavage BSc,MD,MSc,FRCPC Indianapolis Oklahoma,USA UniversityofBritishColumbia Indiana,USA DivisionofMedicalOncology CynthiaJ.Walker-Dilks MLS BritishColumbiaCancerAgency MartinStanulla MD,MSc HealthInformationResearchUnit Vancouver,BritishColumbia DepartmentofPediatricHematologyand DepartmentofClinicalEpidemiologyand Canada Oncology Biostatistics Children’sHospital McMasterUniversityFacultyofHealthSciences SamSchulman MD,PhD,FRCPS HannoverMedicalSchool Hamilton ClinicalThromboembolismProgram Hannover,Germany Ontario,Canada McMasterUniversity Hamilton A.KeithStewart MBCHB,FRCPC,FACP IrwinWalker MBBS,FRACP,FRCPC Ontario,Canada CollegeofMedicine,MayoClinic HematologyandBoneMarrowTransplantation Scottsdale McMasterUniversityMedicalCentre HolgerJ.Schu¨nemann MD,PhD,MSc, Arizona,USA Hamilton Ontario,Canada FACP,FCCP CLARITYResearchGroup JohnM.Storring MD TheodoreE.Warkentin MD, DepartmentofEpidemiologyItalianNational McGillUniversityHealthCentre CancerInstituteReginaElena Montreal BSc(Med),FRCP(C),FACP Rome,Italy Quebec,Canada DepartmentofPathologyandMolecular Medicine,andDepartmentofMedicineMcMaster University MichaelSebag MD,PhD,FRCPC DavidJ.Straus MD TransfusionMedicine MayoClinicArizona LymphomaService HamiltonRegionalLaboratoryMedicineProgram Scottsdale DepartmentofMedicine ServiceofClinicalHematology Arizona,USA MemorialSloan–KetteringCancerCenter Hamilton,Ontario NewYork Canada NewYork,USA TamaraShenkier MDCM,FRCPC KarenW.L.Yee MD DepartmentofMedicalOncology UniversityofBritishColumbia MichaelB.Streiff MD DepartmentofMedicalOncologyandHematology UniversityHealthNetwork—PrincessMargaret BritishColumbiaCancerAgency DepartmentofMedicine Hospital Vancouver JohnsHopkinsMedicalInstitutions Toronto BritishColumbia,Canada Baltimore Ontario,Canada Maryland,USA HeloisaP.Soares MD MarcS.Zumberg MD DepartmentofInternalMedicine JohnW.Sweetenham MD,FRCP DepartmentofMedicine MountSinaiMedicalCenter TaussigCancerCenter DivisionofHematology/Oncology MiamiBeach ClevelandClinic UniversityofFlorida Florida,USA Cleveland Gainesville Ohio,USA Florida,USA x BLFS004-Crowther April15,2008 8:22 Preface Evidence-basedmedicineisdefinedvariably,howeverfundamen- Althoughmosttextssuchasthisareinevitablydelayedintheir taltoitspractice,itisthesystematicappraisalofavailableevidence productionand,asaresult,theevidencepresentedmaybealready andtheformulationoftherapeuticplans,whichtakeintoaccount out of date, we have made every effort to update the material, thisevidence.Evidence-basedmedicineisflexibleanduses“best makingEvidence-basedHematologyatimelyadditiontotheliter- practice”evidenceasbroadlyaspossibletoanswerclinicallyrele- ature.Wehopethatreaderswillusethetechniquesemployedin vantquestions. thistext(formulationofaclinicallyrelevantquestion,systematic Evidence-basedHematologyfocusesonclinicalquestionswithin literaturereview,andgradingofevidence)toupdatetheirknowl- alldomainsofhematology.Thequestionsaredesignedtoaddress edgeinspecificcontentareasusingtheirownpersonalcontinuous clinicalproblemsseeninday-to-daypractice.Wehavesystemati- learningtechniques.Ourhopeisthatyouwillfindthistextuseful callyreviewedtheliteratureavailableasitappliestoeachofthese inyourday-to-dayclinicalpractice.Additionally,wehopethatit questionsandhavemaderecommendationsthatreflectthisevi- spursyourinterestinevidence-basedhematology,thusassisting dence.Wehopethatthistextwillassistreadersinunderstanding youinprovidingthebestpossiblecaretoyourpatients. howtoformulateandanswertheirownclinicalquestionsusing MarkA.Crowther thebestavailableevidence. Hamilton,Ontario,April1,2008 CompanionWebsite AcompanionsiteforthisbookisavailableatthefollowingURL: www.blackwellpublishing.com/medicine/bmj/hematology Thesiteincludesthefollowing: (cid:2) web-onlytables(Tables22.5and22.6,Appendix22.1) (cid:2) updatessection (cid:2) moreabouttheWiley–Blackwellevidence-based products. xi
The list of books you might like
