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Essentials of Modern Neuroscience This page intentionally left blank A LANGE medical book Essentials o f Modern Neuroscience Editors Franklin R. Amthor, PhD David G. Standaert, MD, PhD Professor ofP sychology John N. Whitaker Professor and Chair University ofA labama at Birmingham Department ofN eurology Birmingham, Alabama University ofA labama at Birmingham Birmingham, Alabama Anne B. Theibert, PhD Erik D. Roberson, MD, PhD Professor ofN eurobiology University ofA labama at Birmingham Rebecca Gale Endowed Professor Birmingham, Alabama Department ofN eurology University ofA labama at Birmingham Birmingham, Alabama New York Chicago San Francisco Athens London Madrid Mexico City Milan New Delhi Singapore Sydney Toronto Copyright © 2020 by McGraw Hill. All rights reserved. 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This limitation of liability shall apply to any claim or cause whatsoever whether such claim or cause arises in contract, tort or otherwise. Contents About the Authors ix Contributors xi Preface xiii 6 Resting Membrane Potential & Action Potential 109 PART I Franklin R. Amthor ANATOMY & FUNCTION OF THE 7 Mechanisms of Synaptic Transmission 123 NERVOUS SYSTEM Anne B. Theibert 8 Neurotransmitter Systems I: SECTION Acetylcholine & the Amino Acids 141 Organization Bi Structure of I Anne B. Theibert the Nervous System 1 9 Neurotransmitter Systems II: Monoamines, Purines, Neuropeptides, &U nconventional 1 Organization & Cells of the Nervous Neurotransmitters 159 System 3 Anne B. Theibert Anne B. Theibert 10 Synaptic Plasticity 177 2 Development of the Nervous System 27 Cristin F. Gavin & Anne B. Theibert Lucas Pozzo-Miller & Anne B. Theibert 3 Functional Anatomy of the Nervous System I: Cerebrum & Subcortical SECTION Systems Neuroscience: Structures 45 Ill Sensory Bi Motor Anne B. Theibert Systems 197 4 Functional Anatomy of the Nervous System II: The Brainstem, Cerebellum, 11 Visual System I: The Eye 199 Spinal Cord, Peripheral Nervous Franklin R. Amthor System, & Supporting Systems 67 12 Visual System II: Central Visual Pathways 217 Anne B. Theibert Franklin R. Amthor 13 Auditory & Vestibular Systems 227 Cellular Bi Molecular SECTION Franklin R. Amthor Neuroscience: Eledrical II Signaling Bi Synaptic 14 Chemical Senses: Olfactory & Transmission 93 Gustatory Systems 243 Franklin R. Amthor 5 Movement of Ions Across Biological Membranes: Ion Transporters & 15 Somatosensory System 257 Channels 95 Franklin R. Amthor, Stacie K. Totsch, & Robin AJ. Lester Robert E. Sorge y vi CONTIHl'S 16 Pyramidal Motor System 273 25 Neurooncology 393 Franklin R. Amthor Paula Warren 17 Extrapyramidal Motor Systems: Basal 26 Headache Disorders & Neurologic Ganglia & Cerebellum 281 Pain Syndromes 409 Franklin R. Amthor Cristina Woh/gehagen 18 Autonomic Nervous System: Sympathetic, 27 Epilepsy 425 Parasympathetic, & Enteric 297 Ashley Thomas Franklin R. Amthor 28 Movement Disorders 437 Victor W. Sung SECTION 29 Age-Associated Cognitive Disorders Cognitive IV & Dementia 449 Neuroscience 313 Marissa C. Nate/son love & RabiaJamy 19 Consciousness 315 30 Neuroimmunology & Neuroinflammatory Franklin R. Amthor Disorders 461 20 Learning & Memory 329 William Meador Cristin F. Gavin & Anne B. Theibert 31 Neuromuscular Disorders 475 21 Language 341 Mohamed Kazamel Daniel Mirman 32 Neurologic Infections 489 22 Emotion 351 Shruti P. Agnihotri Franklin R. Amthor 33 Neurotrauma 507 23 Circadian Rhythms & Sleep 359 Angela Hays Shapshak Christopher M. Ciar/eg/io, Rachel C. Besing, 34 Sleep Disorders 523 & Karen L. Gamble Joseph T. Daley 35 Pediatric Neurology 537 Lydia Marcus PART II NERVOUS SYSTEM DISORDERS &T HERAPEUTICS SECTION VI Ear&EyeDisorders 551 SECTION v Neurologlc & Neurosurglcal Disorders 377 36 Neurotology & Ear Disorders 553 Yoon-Hee Cha 24 Stroke & Neurovascular Disorders 379 37 Ocular Disorders 567 Michael Lyerly Brion Samuels CONTENTS Vii G Personality Disorders 635 SECTION Merida Grant VII Psychiatric Disorders 591 43 Substance Use Disorders 641 Stephen Brackett, Samantha Schiavon, 38 Thought Disorders 593 Michelle Sisson, &K aren Cropsey Nina Kraguljac 44 Child & Adolescent Psychiatry 651 39 Mood Disorders 605 YesieYoon Lili Answers 659 40 Anxiety Disorders 619 Index 675 Jesse Tobias C. Martinez, Jr. 41 Somatic Symptom Disorder & Related Disorders 627 Aaron D. Fabian & Lindsey Elliott This page intentionally left blank