Edited by Wayne B. Jonas Department of Family Practice, Uniformed Services University of the Health Sciences, Bethesda, Maryland; Director (1995–1998), Office of Alternative Medicine, National Institutes of Health, Bethesda, Maryland Jeffrey S. Levin Senior Research Fellow National Institute for Healthcare Research, Rockville, Maryland; President (1997–1998), International Society for the Study of Subtle Energies and Energy Medicine (ISSSEEM), Golden, Colorado ASSOCIATE EDITORS Brian Berman M.D. Associate Professor of Family Medicine and Director The Center for Complementary Medicine, University of Maryland, Complementary Medicine Program, Baltimore, Maryland George T. Lewith M.A., D.M., M.R.C.P., M.R.C.G.P. The Centre for the Study of Complementary Medicine; Senior Research Fellow, University Medicine, University of Southampton School of Medicine, Southampton, Hampshire, UK MED Klaus Linde Dr. München Modell-Center for Complementary Medicine Research, Department of Internal Medicine II, Technische Universität, Munich, Germany Joseph E. Pizzorno Jr. N.D. President Bastyr University, Kenmore, Washington Kichiro Tsutani M.D., Ph.D. Associate Professor Department of Clinical Pharmacology, Division of Information Medicine, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan Jean Watson R.M., Ph.D., F.A.A.N. Distinguished Professor of Nursing; Founder Center for Human Caring; Endowed chair, Caring Science, University of Colorado Health Sciences Center, Denver, Colorado SECONDARY EDITORS Timothy Hiscock Editor Joyce Murphy Managing Editor Kathy Neely Marketing Manager Kathleen Gilbert Project Editor CONTRIBUTORS VLADIMIR BADMAEV M.D., PHD. Staten Island, New York MICHAEL J. BAIME M.D. Division Chief Department of General Internal Medicine, The Graduate Hospital; Assistant Professor, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania DANIEL J. BENOR M.D. Author of Healing Research Vols. I-IV, Vision Publications, Southfield, Michigan KEITH I. BLOCK M.D. Medical Director Institute of Integrative Cancer Care, Evanston, Illinois; Clinical Assistant Professor, College of Medicine, University of Illinois, Chicago, Illinois HOWARD BRODY M.D., PHD. Professor Departments of Family Practice and Philosophy, Michigan State University; Director, Center for Ethics and Humanities in the Life Sciences, East Lansing, Michigan EDWARD H. CHAPMAN M.D., PHD. Clinical Instructor Harvard University School of Medicine, Boston, Massachusetts RONALD A. CHEZ M.D. Professor of Obstetrics and Gynecology; Professor of Community and Family Health University of South Florida, Tampa, Florida KENNETH S. COHEN M.A., M.S.TH. Adjunct Professor Union Institute Graduate School, Cincinnati, Ohio PETER A.G.M. DE SMET PHD. Pharmaceutical Care Unit Scientific Institute of Dutch Pharmacists, The Hague, The Netherlands BARBARA DOSSEY, R.N. M.S., F.A.A.N. Director Holistic Nursing Consultants, Santa Fe, New Mexico DAVID EISENBERG M.D. Assistant Professor of Medicine Harvard Medical School; Director Center for Alternative, Medicine Research and Education, Beth Israel Deaconess Medical Center, Boston, Massachusetts EDZARD ERNST M.D., PHD., F.R.C.P. (EDIN) Professor and Director Department of Complementary Medicine University of Exeter, Exeter, England MICHAEL D. FETTERS M.D., M.P.H. Assistant Professor Department of Family Medicine, University of Michigan Health System; Director, Japanese Family Health Program, University of Michigan Health System, Ann Arbor, Michigan TIFFANY FIELD PHD. Director, Touch Research Institute Nova/Southeastern University, Fort Lauderdale, Florida ALAN R. GABY M.D. Professor of Nutrition Bastyr University, Kenmore, Washington HAROLD GOODMAN D.O. Private Practice Silver Spring, Maryland JUDITH A. GREEN PHD. Professor Department of Psychology, Aims Community College; Co-director, Health Psychology Services, LLC, Greeley, Colorado JOSEPH M. HELMS M.D. Private Practice Berkeley, California, Chairman of Physician Acupuncture Training Programs, UCLA School of Medicine, Los Angeles, California WAYNE B. JONAS M.D. Department of Family Practice, Uniformed Services University of the Health Sciences, Bethesda, Maryland; Director (1995–1998), Office of Alternative Medicine, National Institutes of Health, Bethesda, Maryland STANLEY KRIPPNER PHD. Professor of Psychology Saybrook Graduate School, San Francisco, California D. VASANT LAD B.A.M.S., M.A.SC. The Ayurvedic Institute, Albuquerque, New Mexic LIXING LAO PHD., L.AC Assistant Professor and Clinical Director Department of Complementary Medicine, University of Maryland School of Medicine, Baltimore, Maryland; Clinic Director, MD Institute of Traditional Chinese Medicine, Bethesda, Maryland DANA J. LAWRENCE D.C. Professor of Chiropractic Practice; Director of Publications and Editorial Review National College of Chiropractic, Lombard, Illinois CHING-TSE LEE PHD. Professor Department of Psychology, Brooklyn College of the City, University of New York, Brooklyn, New York; Visiting Scholar, Institute of Ethnology, Academia Sinica, Taipei, Taiwan TING LEI PHD. Assistant Professor Department of Social Science, Borough of Manhattan Community, College of the City University of New York, New York, New York JEFFREY S. LEVIN PHD., M.P.H. Senior Research Fellow National Institute for Healthcare Research, Rockville, Maryland; President (1997–1998), International Society for the Study of Subtle Energies and Energy Medicine (ISSSEEM), Golden, Colorado GEORGE T. LEWITH M.A., D.M., M.R.C.P., M.R.C.G.P. Partner The Centre for the Study of Complementary Medicine and Senior Research Fellow, University Medicine, University of Southampton School of Medicine, Southampton, Hampshire, United Kingdom KLAUS LINDE M.D. Muenchener Modell-Research Center for Complementary Medicine, Department of Internal Medicine II, Technische Universitaet, Munich, Germany TIERAONA LOW DOG M.D., A.H.G. Medical Director Treehouse Center of Integrative Medicine, Medical Advisor, Quality Control & Standards, Materia Medica Group; Physician, Private Practice, Albuquerque, New Mexico MICHAEL T. MURRAY N.D. Member, Board of Trustees and Faculty Bastyr University, Kenmore, Washington JOSEPH E. PIZZORNO JR., N.D. President Bastyr University, Kenmore, Washington JANIS M. RYGWELSKI M.D. Assistant Professor Department of Family Practice, Michigan State University, East Lansing, Michigan G. RANDOLPH SCHRODT Jr., M.D. Associate Professor Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine; Medical Director, Behavioral Medicine Program, Norton Psychiatric Clinic, Louisville, Kentucky ROBERT SHELLENBERGER PHD. Licensed Psychologist; Chair of Psychology Aims Community College, Co-Director, Health Psychology Service LLC, Greeley, Colorado ALLAN TASMAN M.D. Professor and Chairman Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, Kentucky HARALD WALACH PHD., Dipl. Psych. Department of Psychology University of Freiburg, Freiburg, Germany JAMES C. WHORTON PHD. Professor Department of Medical History and Ethics, University of Washington School of Medicine, Seattle, Washington IAN WICKRAMASEKERA PHD., A.B.P.P., A.B.P.H. Consulting Professor of Psychiatry Stanford Medical School, Stanford, California; Professor of Family Medicine, Eastern Virginia Medical School, Norfolk, Virginia DEDICATION THIS BOOK IS DEDICATED TO MY WIFE, SUSAN CUNNINGHAM JONAS, WHOSE LOVE, WISDOM, AND SERVICE TO OTHERS IS AN EXAMPLE FOR US ALL. W B J FOR LEA STEELE LEVIN, MY BELOVED WIFE AND PARTNER. J S L FOREWORD The publication of Essentials of Complementary and Alternative Medicine, the first comprehensive textbook for physicians about these increasingly popular forms of medical treatment, is very timely. For the first time, information about the foundations of complementary and alternative medicine (CAM), the safety of CAM products and practices, and overviews of nearly two dozen CAM systems are available in one place. The purpose of this textbook is to provide mainstream medical professionals useful and balanced information about CAM. The development of this type of book is an ambitious and difficult goal for several reasons. Many CAM systems are claimed to have special patient benefits not met by either conventional medicine or other CAM approaches. There are few unifying themes across these systems (other than the belief that there are unmet patient benefits outside of conventional medicine). Faced with these problems, the editors have sought the best individuals in these diverse areas and worked with them to produce a balanced and useful book developed specifically for physicians. In many areas of CAM, there is a history of long-term and vigorous antagonism with conventional medicine, as well as different educational standards, training, and practices. Also, the basic concepts of what constitutes sufficient evidence of safety and efficacy vary among CAM systems. Ultimately, the usefulness of this book will depend on its success in addressing these issues in an objective, pragmatic, and convincing way. Why is it important to publish this textbook? The main reason is the compelling evidence that medicine has been changing both scientifically and culturally for several decades. Let us start with the changes in conventional medicine since World War II. The medicine of my childhood in a small rural town in Virginia was very different from the conventional medicine of today. For example, my 80-year-old sister who had a heart attack was treated by removal of the clot and insertion of a stent; both she and her husband viewed the procedure on television, and she was up and walking the next day. In contrast, when my 59-year-old father suffered a heart attack over 50 years ago, medicine really had little to offer. Although there are many reasons for these dramatic changes in medicine, the dominant force has been the emergence of exact sciences underlying medicine (whereas once they were viewed as “soft sciences”). The rewarding results have been an ever-increasing understanding of basic life processes. This understanding, in turn, has allowed novel and successful approaches to disease control. However, the advancement of science-based medicine has a downside: science-based specialty medicine has become less personal and more costly. And, cost-containment efforts pay for procedures done, rather than time spent with patients. For these and other reasons, patients seek to augment the benefits of modern conventional medicine with CAM. The initial striking evidence of the widespread use of CAM in the United States was reported by David Eisenberg and colleagues in the New England Journal of Medicine in 1993. According to Eisenberg's report, one in three Americans saw an alternative health care practitioner in 1990 (constituting more visits than to conventional primary care physicians), and they paid more than 10 billion dollars in out-of-pocket expenses for this care. In addition, patients did not tell their physicians of their use of CAM because they assumed the physicians would not be interested or would not approve. In a follow-up study now completed, the evidence of even greater use of CAM has been confirmed and is most striking: more than 40% of Americans currently use CAM (approaching European and Australian rates), and as much out-of-pocket money is spent for CAM care as is out-of-pocket money spent for all of conventional medicine. These facts confirm the need for readily available information to help physicians understand, evaluate, and address CAM treatments that their patients are receiving. This textbook will help them do that. A significant change occurred when the United States Congress mandated the opening of the Office of Alternative Medicine (OAM) at the National Institutes of Health (NIH). Medical schools are now seeking research support from this source. Research findings supported by the OAM can be expected to meet the familiar standards of NIH. In addition to research, more than 70 medical schools have (or are planning) courses in CAM for their medical student curriculum. And, although future physicians and other conventional health care workers will be versed in the advantages and disadvantages of CAM, most of those now in practice need accurate information. Both conventional medicine and CAM share similar concerns in several important areas. Both systems need always to be committed to eliminating fraudulent practice or practitioners who severely misguide desperately ill patients. Therefore, a complete section on safety is provided in this book. However, information about efficacy is likely the most needed. Over the last few decades, conventional medicine has relied increasing on highly disciplined experimental methods to arrive at the most reasonable conclusions about effective treatments. Even with complex, large-scale, double-blind, controlled clinical trials, the goal always is both to increase our understanding of life processes and to demonstrate a difference in health outcomes. NIH-supported studies of CAM share this approach. Yet, there is also interest in developing other methods for testing effectiveness. For example, in Germany and elsewhere, efforts are being made to collect and use carefully evidence of symptomatic and clinical improvement in patients with long-term problems. Demonstrating well-documented alleviation of troublesome chronic symptoms, improved function, and better quality of life in satisfied patients using CAM would interest both the CAM and conventional medical communities. In summary, CAM is being used by large numbers of people who derive benefits they have not received from conventional medicine. NIH-sponsored research is exploring the underlying scientific mechanisms of these approaches as well as their clinical efficacy. Medical students are being educated in the advantages and disadvantages of CAM systems and modalities. This textbook has been crafted to serve the growing communities of professionals who need thorough and accurate information about CAM. A majority of the authors are MDs or PhDs who have taught in medical schools. Only time will tell how useful any new textbook will be, but this goal is timely and the effort is to be commended. Emotions and opinions range widely on the subject of CAM, yet at such times it is well to remember the words of Thomas Jefferson: “We are not afraid to follow the truth wherever it may lead, nor to tolerate any error so long as reason is left free to combat it.” Robert Marston M.D. Director, National Institutes of Health (1968–1973) PREFACE The publication of a medical textbook for a new or emerging field always signals a turning point—a shift toward greater awareness of theories, basic science research, and modes of clinical practice at the cutting edge of medicine. Essentials of Complementary and Alternative Medicine represents just such a coming of age for an important new clinical and scientific field. With this book and the forthcoming and comprehensive Textbook of Complementary and Alternative Medicine, information is available in one place on the social and scientific foundations of complementary and alternative medicine (CAM) and the safety of CAM products and practices, and providing detailed overviews of most CAM systems and modalities. The primary purpose of these books is to provide medical and health care professionals with useful and balanced information about CAM in general and about particular CAM systems and practices. This is an ambitious and difficult task for several reasons. For one, the CAM systems detailed here offer benefits to patients not entirely available from mainstream medicine and not easily described in conventional terms. Further, the unifying themes or concepts across these systems are still undifferentiated from the dominant perception that unmet patient needs can be addressed outside of conventional medicine. In addition, CAM is characterized by a long-term history of vigorous antagonism; differing standards of education, training, and practice; and lack of consensus as to what constitutes sufficient evidence of safety and efficacy. Faced with these challenges, we have sought the leading experts in these diverse areas to contribute to this textbook, and have worked with them to provide balanced information for the conventional practitioner. This book is designed to be a companion volume to the forthcoming Textbook of Complementary and Alternative Medicine and to serve as a clinical resource for practicing physicians and health care professionals and for medical and health professions students and postgraduates enrolled in courses on CAM. Although originally envisioned as a condensed version of the Textbook, it quickly became apparent that this objective would be served better by including profiles of only the most popular complementary therapies and by focusing the first two parts of the book on safety, patient management issues, and social and scientific foundations of CAM. With the clinical reader clearly in mind, this book provides an entire section detailing the safety information needed in addressing CAM products and practices. The book also includes an Indications and Precautions Chart (IPC), which provides information-at-a-glance along with chapter references on CAM systems or modalities most highly supported by empirical evidence and most likely to be efficacious in the treatment of the most common conditions presented to primary care providers. Part I, “The Social and Scientific Foundations of Complementary and Alternative Medicine,” includes five chapters outlining the history and utilization patterns of CAM, issues related to professional ethics and evaluation of efficacy claims, and how to practice in an evidence-based context. Part II, “The Safety of Complementary and Alternative Products and Practices,” includes five chapters reviewing the safety of herbal and animal products, dietary and nutrient products, and homeopathy, as well as the adverse effects of acupuncture and manipulative therapies. Part III, “Overviews of Complementary and Alternative Medicine Systems,” provides thorough summary overviews of key issues such as history, principal concepts, patient assessment and diagnostic procedures, therapeutic options and treatment evaluation, indications and contraindications, training, quality assurance, and future prospects for 20 major systems of CAM. These include osteopathy, naturopathy, homeopathy, chiropractic medicine, traditional Chinese medicine, biofeedback, behavioral medicine, medical acupuncture, and a dozen other systems of therapy. It is our hope that Essentials of Complementary and Alternative Medicine will provide a useful resource for clinicians and clinicians-in-training. We also hope that this book will serve to further the integration of
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