Essentials of Anatomic Pathology

907 Pages·2002·3.32 MB·English

by  Liang Cheng

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Edited by
Liang Cheng,
MD
David G. Bostwick,
MD
Humana Press
E A P
SSENTIALS OF NATOMIC ATHOLOGY

E
SSENTIALS OF
A P
NATOMIC ATHOLOGY
Edited By
L C ,
IANG HENG MD
Department of Pathology
Indiana University School of Medicine, Indianapolis, IN
and
D G. B , , ,
AVID OSTWICK MD MBA FCAP
University of Virginia School of Medicine, Charlottesville, VA
and Bostwick Laboratories, Richmond, VA
H P
UMANA RESS
T , N J
OTOWA EW ERSEY
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Library of Congress Cataloging-in-Publication Data
Essentials of anatomic pathology / Liang Cheng and David G. Bostwick.
p.;cm.
Includes bibliographical references and index.
ISBN 1-58829-132-4 (HB); 1-58829-118-9 (PB) (alk. paper)
1. Anatomy, Pathological. 2, Pathology, Surgical. 3. Diagnosis, Differential. 4. Physiology, Pathological. I, Cheng, Liang. II. Bostwick,
David G.
[DNLM: 1. Pathology, Surgical–methods. 2. Diagnosis, Differential. WO 142 E78 2002]
RB25.E775 2002
617’.07–dc21 2001039717
P
REFACE
The past decade has witnessed remarkable progress in surgical pathology. The ability of contem-
porary surgical pathologists to reach a definite diagnosis has been greatly enhanced by innovative
immunohistochemical techniques and markers. Information useful in the practice of pathology may
not be readily accessible in the daily sign-out. An up-to-date handbook that contains information
relevant to the establishment of accurate diagnoses would be of immense practical value. Therefore,
we have concentrated on setting forth basic diagnostic criteria and differential diagnoses that will help
our readers ensure accurate diagnoses.
Essentials of Anatomic Pathology is intended to provide a concise review of anatomic pathology for
all pathologists in training as well as practicing pathologists, integrating the many recent advances in
diagnostic surgical pathology. The book is organized to allow easy reference for daily practice, and is
intended to aid residents who are preparing for Anatomic Pathology Boards and in-service examinations.
It will prove a useful resource not only for medical students, but also for anyone interested in pathology.
Part I covers general anatomic pathology, including diagnostic molecular pathology, human genetic
disorders, microbiology for surgical pathologists, diagnostic electron microscopy, forensic pathology,
and cytopathology. Part II is classified by organ system, and covers all the important diagnostic features
of common medical diseases and tumors. The pertinent clinical information, salient diagnostic features,
relevant ancillary data (for example, immunohistochemical profiles), main differential diagnoses, and
most recent tumor-staging information are presented for each disease, in a consistently user-friendly
format. We believe that this approach will provide easy access to information essential for sign-out. It
is not meant as a substitute for lavishly illustrated, comprehensive textbooks, but to complement them
as a practical aid. We hope that this text will materially aid in continuing efforts to recognize, understand,
and accurately interpret the gross and light microscopic findings in anatomic pathology specimens.
We thank the staff at Humana Press, Thomas H. Moore, James Geronimo, Mary Jo Casey, Wendy
Kopf, and Humana Press’ composition department, for their assistance in the preparation of this work.
We earnestly solicit constructive criticism from colleagues so that the utility of our book can be
expanded and improved to its maximum potential in future editions.
Liang Cheng, MD
David G. Bostwick, MD
v

C
ONTENTS
Preface........................................................................................................................................................ v
Contributors............................................................................................................................................... ix
P I G P
ART ENERAL ATHOLOGY
1 Molecular Diagnostic Pathology ......................................................................................................1-1
Richard Press and Charli Nesbitt
2 Human Genetic Disorders.................................................................................................................2-1
Teresa M. Kruisselbrink, Noralane M. Lindor, and John O’Brien
3 Microbiology for the Surgical Pathologist .......................................................................................3-1
Melanie Triffet-Treviño
4 Diagnostic Electron Microscopy ......................................................................................................4-1
Moo-Nahm Yum and Michael P. Goheen
5 Forensic Pathology............................................................................................................................5-1
Jeffrey J. Barnard and Frank P. Miller, III
6 Cytopathology...................................................................................................................................6-1
Fadi W. Abdul-Karim, Claire W. Michael, Robert L. Koscick, and Liang Cheng
P II O S
ART RGAN YSTEMS
7 Lymph Node and Spleen...................................................................................................................7-1
Ellen D. Remstein and Paul J. Kurtin
8 Bone Marrow.....................................................................................................................................8-1
William G. Morice and Paul J. Kurtin
9 Dermatopathology.............................................................................................................................9-1
Daniel P. Vandersteen and Melanie Triffet-Treviño
10 Neuropathology...............................................................................................................................10-1
Arie Perry and Bernd W. Scheithauer
11 Endocrine Pathology.......................................................................................................................11-1
Brian J. Bock and J. Aidan Carney
12 Bone and Joints ...............................................................................................................................12-1
Geza Acs and Jasvir S. Khurana
13 Soft Tissue Tumors .........................................................................................................................13-1
David Schembri-Wismayer and Antonio Nascimento
14 Tumor of the Salivary Glands.........................................................................................................14-1
Adel K. El-Naggar and John G. Batsakis
15 Mediastinum....................................................................................................................................15-1
Chung Che (Jeff) Chang and Joseph F. Tomashefski, Jr.
16 Cardiovascular Pathology ...............................................................................................................16-1
Eric A. Pfeifer and Liang Cheng
17 Lung.................................................................................................................................................17-1
Carol F. Farver and Henry D. Tazelaar
vii
viii Contents
18 Breast...............................................................................................................................................18-1
Eoghan E. Mooney, Zhengping Zhuang, and Fattaneh A. Tavassoli
19 Vulva, Vagina, Uterus, and Fallopian Tube ...................................................................................19-1
Kristen Hobday and Gary Keeney
20 Ovary and Peritoneum.....................................................................................................................20-1
Kevin Wu and Gary Keeney
21 Placenta and Gestational Trophoblastic Disease............................................................................21-1
Raymond W. Redline
22 Prostate............................................................................................................................................22-1
David G. Bostwick and Liang Cheng
23 Non-Neoplastic Renal Diseases......................................................................................................23-1
Donna J. Lager
24 Tumors of the Kidney .....................................................................................................................24-1
Liang Cheng and David G. Bostwick
25 The Urinary Bladder .......................................................................................................................25-1
Liang Cheng, Brian J. Bock, and David G. Bostwick
26 Testis, Penis, and Paratesticular Region.........................................................................................26-1
Kenneth A. Iczkowski and John C. Cheville
27 Esophagus and Stomach..................................................................................................................27-1
Sandra M. Spevacek and David G. Bostwick
28 Small Intestine, Appendix, and Colon............................................................................................28-1
Shuan C. Li and Stanley R. Hamilton
29 Pancreas...........................................................................................................................................29-1
Rhett P. Ketterling and Lawrence J. Burgart
30 Non-Neoplastic Hepatobiliary Disease...........................................................................................30-1
Hagen Blaszyk and Kenneth P. Batts
31 Neoplasms of the Liver and Biliary System...................................................................................31-1
Hagen Blaszyk and Kenneth P. Batts
C
ONTRIBUTORS
FADI W. ABDUL-KARIM, MD • Professor of Pathology, Case Western Reserve University and Director of
Anatomic Pathology, University Hospitals of Cleveland, Cleveland, OH
GEZA ACS, MD, PhD • Assistant Professor of Pathology, University of Pennsylvania School of Medicine,
Philadelphia, PA
JEFFREY J. BARNARD, MD • Chief Medical Examiner, Dallas County, Dallas, TX, Director, Southwestern Institute
of Forensic Sciences, Dallas, TX, and Professor of Pathology, University of Texas Southwestern Medical
Center, Dallas, TX
JOHN G. BATSAKIS, MD • Emeritus Professor of Pathology, The University of Texas M. D. Anderson Cancer
Center, Houston, TX
KENNETH P. BATTS, MD • Staff Pathologist, Abbott Northwestern Hospital, Minneapolis, MN
HAGEN BLASZYK, MD • Assistant Professor of Pathology, Institute of Pathology, University of Regensburg,
Regensburg, Germany
BRIAN J. BOCK, MD • Staff Pathologist, Regional Medical Laboratory, Tulsa, OK
DAVID G. BOSTWICK, MD, MBA, FCAP • Clinical Professor of Pathology, University of Virginia, Charlottesville, VA,
and Medical Director, Bostwick Laboratories, Richmond, VA
LAWRENCE J. BURGART, MD • Assistant Professor of Pathology, Mayo Medical School, Rochester, MN
J. AIDAN CARNEY, MD • Emeritus Professor of Pathology, Mayo Medical School, Rochester, MN
CHUNG CHE (JEFF) CHANG, MD • Associate Professor of Pathology, Medical College of Wisconsin, Milwaukee, WI
LIANG CHENG, MD • Assistant Professor of Pathology and Urology, Indiana University School of Medicine,
Indianapolis, IN
JOHN C. CHEVILLE, MD • Associate Professor of Pathology, Mayo Medical School, Rochester, MN
ADEL K. EL-NAGGAR, MD, PhD • Professor of Pathology and Head and Neck Surgery, The University of Texas M.
D. Anderson Cancer Center, Houston, TX
CAROL F. FARVER, MD • Staff Pathologist, The Cleveland Clinic Foundation, Cleveland, OH
MICHAEL P. GOHEEN, BS • Indiana University School of Medicine, Indianapolis, IN
STANLEY R. HAMILTON, MD • Chairman and Professor, Division of Laboratory Medicine and Pathology, The
University of Texas M. D. Anderson Cancer Center, Houston, TX
KRISTEN HOBDAY, MD • Fellow, Mayo Clinic, Rochester, MN
KENNETH A. ICZKOWSKI, MD • Assistant Professor of Pathology, University of Florida College of Medicine,
Gainesville, FL
GARY KEENEY, MD • Associate Professor of Pathology, Mayo Medical School, Rochester, MN
RHETT P. KETTERLING, MD • Assistant Professor of Laboratory Medicine, Mayo Medical School, Rochester, MN
JASVIR S. KHURANA, MD • Assistant Professor of Pathology, University of Pennsylvania School of Medicine,
Philadelphia, PA
ROBERT L. KOSCICK, MD • Staff Pathologist, Pathology Group of Louisiana, Baton Rouge, LA
TERESA M. KRUISSELBRINK, MS • Genetic Counselor, Mayo Clinic, Rochester, MN
PAUL J. KURTIN, MD • Professor of Pathology, Mayo Medical School, Rochester, MN
DONNA J. LAGER, MD • Associate Professor of Pathology, Mayo Medical School, Rochester, MN
SHUAN C. LI, MD • Staff Pathologist, Orlando Regional Medical Center, Orlando, FL
NORALANE M. LINDOR, MD • Associate Professor of Medical Genetics, Mayo Medical School, Rochester, MN
CLAIRE W. MICHAEL, MD • Associate Professor of Pathology, Director of Cytopathology, University of Michigan,
Ann Arbor, MI
FRANK P. MILLER, III, MD • Forensic Pathologist, Deputy Coroner, Cuyahoga County, OH and Instructor of
Pathology, Case Western Reserve University, Cleveland, OH
ix