ENCYCLOPEDIA OF BIOCOLLOID AND BIOINTERFACE SCIENCE ENCYCLOPEDIA OF BIOCOLLOID AND BIOINTERFACE SCIENCE VOLUME 1 Editedby HIROYUKIOHSHIMA Copyright©2016byJohnWiley&Sons,Inc.Allrightsreserved PublishedbyJohnWiley&Sons,Inc.,Hoboken,NewJersey PublishedsimultaneouslyinCanada Nopartofthispublicationmaybereproduced,storedinaretrievalsystem,ortransmittedinanyformorbyanymeans,electronic,mechanical, photocopying,recording,scanning,orotherwise,exceptaspermittedunderSection107or108ofthe1976UnitedStatesCopyrightAct,without eitherthepriorwrittenpermissionofthePublisher,orauthorizationthroughpaymentoftheappropriateper-copyfeetotheCopyrightClearance Center,Inc.,222RosewoodDrive,Danvers,MA01923,(978)750-8400,fax(978)750-4470,oronthewebatwww.copyright.com.Requeststothe PublisherforpermissionshouldbeaddressedtothePermissionsDepartment,JohnWiley&Sons,Inc.,111RiverStreet,Hoboken,NJ07030, (201)748-6011,fax(201)748-6008,oronlineathttp://www.wiley.com/go/permission. 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Wileyalsopublishesitsbooksinavarietyofelectronicformats.Somecontentthatappearsinprintmaynotbeavailableinelectronicformats.For moreinformationaboutWileyproducts,visitourwebsiteatwww.wiley.com. LibraryofCongressCataloging-in-PublicationData Names:Ohshima,Hiroyuki,1944–editor. Title:Encyclopediaofbiocolloidandbiointerfacescience/editedbyHiroyukiOhshima. Description:Hoboken,NewJersey:JohnWiley&Sons,Inc.,2016–|Includesindex. Identifiers:LCCN2016004182|ISBN9781118542767(set)|ISBN9781118542682(cloth:v.1) Subjects:LCSH:Biocolloids–Encyclopedias.|Biologicalinterfaces–Encyclopedias.|Surfacechemistry–Encyclopedias. Classification:LCCQD549.E532016|DDC547/.134503–dc23LCrecordavailableathttp://lccn.loc.gov/2016004182 10 9 8 7 6 5 4 3 2 1 1 2016 CONTENTS ListofContributors xxiii Preface xxix A Aerogel 1 StudiesOnBiocompatibleSurface-ActiveSilicaAerogeland Polyurethane−SiloxaneCross-LinkedStructuresforVariousSurfaces 1 K.SeeniMeera,R.MuraliSankar,S.N.Jaisankar,andAsitBaranMandal 1.1 Introduction, 1 1.1.1 SilicaAerogel, 1 1.1.2 IonicLiquids, 2 1.1.3 Polyurethane–SiloxaneCross-LinkedStructures, 2 1.2 ExperimentalSection, 3 1.2.1 PreparationofSilicaAerogelUsingCholineFormate, 3 1.2.2 PreparationofPolyurethane–SiloxaneCross-LinkedFilms, 3 1.2.3 Characterization, 4 1.3 ResultsandDiscussion, 5 1.3.1 ResultsofSurface-ActiveSilicaAerogel, 5 1.3.2 ResultsofPolyurethane–SiloxaneCross-LinkedStructures, 8 1.4 Conclusions, 12 Acknowledgment, 14 References, 14 Anesthetics 2 InteractionofAnestheticswithGlobularProteins 17 MakotoNishimoto,MichioYamanaka,andHitoshiMatsuki 2.1 Introduction, 17 2.2 AnestheticEffectonFFL, 18 2.3 AnestheticEffectonMgb,Lys,andBSA, 22 2.4 IntrinsicInteractionModeofanAnestheticwithProteins, 29 v vi CONTENTS 2.5 Conclusions, 32 Acknowledgments, 33 References, 33 3 LipidMonolayerandInteractionwithAnesthetics 36 YasushiYamamotoandKeijiroTaga 3.1 Introduction, 36 3.2 MonolayerFormation, 36 3.2.1 DipalmitoylPhosphatidylCholine(DPPC), 37 3.2.2 DimyristoylPhosphatidylCholine(DMPC), 39 3.2.3 Cholesterol, 40 3.2.4 DPPCandCholesterolMixture, 41 3.2.5 UsefulnessofDroppingMethod, 44 3.3 InteractionbetweenLipidMonolayerandAnesthetics, 44 3.3.1 QuartzCrystalOscillator(QCO)Method, 45 3.3.2 ApparatusesandProcedure, 46 3.3.3 TimeCourseofFrequency(QCM)andResistance(QCI), 48 3.3.4 ConcentrationDependenceofFrequency(QCM)andResistance (QCI), 49 3.3.5 TrueAnesthesiaPhenomenon, 56 Acknowledgment, 56 References, 57 AtomicForceMicroscopy 4 AtomicForceMicroscopyforMeasuringInteractionForcesinBiological MaterialsandCells 59 NaoyukiIshida,YasuyukiKusaka,TomonoriFukasawa,andHiroyukiShinto 4.1 Introduction, 59 4.2 MeasurementofInteractionForcesUsingAFM, 60 4.3 InteractionofModelMembranes, 61 4.4 InteractionofProteins, 62 4.5 InteractionofCells, 63 4.6 ConcludingRemarks, 65 References, 65 B BacterialInteraction 5 BacterialInteractions 68 MasanoriToyofuku,YosukeTashiro,TomohiroInaba,andNobuhikoNomura 5.1 Introduction, 68 5.2 Gram-PositiveandGram-NegativeBacteria, 68 5.3 Cell–CellCommunicationinBacteria, 69 5.3.1 Cell–CellCommunicationinGram-NegativeBacteria, 69 5.3.2 Cell–CellCommunicationinGram-PositiveBacteria, 71 5.3.3 ACommonLanguageforGram-NegativeandGram-Positive Bacteria:AI-2, 71 5.4 MembraneVesicles, 72 5.4.1 ComponentsofMVs, 72 5.4.2 BiologicalRolesofMVs, 73 CONTENTS vii 5.4.3 SurfaceCharacteristicsofMVs, 73 5.4.4 FuturePerspectivesinMVResearch, 74 5.5 BiofilmFormation, 74 5.5.1 Surface-AttachedBiofilms, 75 5.5.2 BacterialAggregates, 76 5.6 ConcludingRemarks, 77 References, 77 BiocompatiblePolymer 6 2Dand3DBiocompatiblePolymersforBiomedicalDevices 82 MasaruTanaka 6.1 Introduction, 82 6.2 BiocompatiblePolymericBiomaterials, 82 6.3 ProteinAdsorptiononPolymericBiomaterials, 83 6.4 WaterStructureofPolymers, 84 6.5 3DPolymerSurfacesforTissueEngineering, 85 6.6 Methodsof3DPolymerFabrication, 86 6.6.1 Top–DownFabrication, 86 6.6.2 Bottom–UpFabrication, 86 6.7 ControlofCellAdhesionandFunctions, 88 6.8 ConclusionsandPerspectives, 90 Acknowledgments, 91 References, 91 Biofilm 7 Biofilm 94 HisaoMorisaki 7.1 Introduction, 94 7.2 FormationProcessofBiofilm, 94 7.3 BiofilmConstituents, 95 7.3.1 SubstratumSurface, 95 7.3.2 BiofilmMicrobes, 96 7.3.3 ExtracellularPolymericSubstances(EPSs), 97 7.3.4 InterstitialWateramongEPSs, 98 7.4 BiofilmandSurroundingEnvironment, 99 7.4.1 InfluenceofSurroundingEnvironmentonBiofilm, 99 7.4.2 InfluenceofBiofilmonSurroundingEnvironment, 99 7.5 PresentandProspectiveBiofilmResearch, 100 References, 101 Bioflotation 8 UseofMicroorganismsforComplexOREBeneficiation:Bioflotationas anExample 108 AkiraOtsuki 8.1 Introduction, 108 8.2 CharacterizationofComplexOres, 108 8.2.1 MineralAnalysisinDryState, 108 8.2.2 Mineral/ParticleAnalysisinWater, 109 8.2.3 MixtureofComplementaryAnalyses, 111 viii CONTENTS 8.2.4 RefractoryGoldOreBeneficiation, 111 8.2.5 SulfideFlotationUsingaMicroorganismasaFlotationReagent, 111 8.3 Summary, 116 References, 116 Biofouling 9 Biofouling 118 KazuhoNakamura 9.1 DefinitionofBiofouling, 118 9.2 FormationofBiofilms, 118 9.3 BiofoulinginIndustries, 118 9.3.1 BiofoulinginHeatExchangers, 119 9.3.2 BiofoulingofMedicalDevices, 119 9.3.3 BiofilmsinWastewaterTreatmentProcesses, 120 9.3.4 BiofoulinginMembraneProcesses, 121 References, 121 Bio-inspiredMicroemulsion 10 BioinspiredMicroemulsionsandTheirStrategicPharmacological Perspectives 122 SoumikBardhan,KaushikKundu,GulmiChakraborty,BidyutK.Paul,SatyaP.Moulik, andSwapanK.Saha 10.1 Introduction, 122 10.2 ABriefOutlineofMicroemulsionSystems, 123 10.2.1 TypesofMicroemulsionSystems, 124 10.2.2 RoleofSurfactantinFormationofMicroemulsions, 124 10.2.3 RoleofCosurfactantinFormationofMicroemulsions, 124 10.2.4 RoleofOilinFormationofMicroemulsions, 125 10.2.5 SolubilizationinMicroemulsions, 125 10.2.6 CharacterizationofMicroemulsions, 125 10.2.7 StabilityofMicroemulsions, 125 10.3 DesignStrategyforBioinspiredMicroemulsionSystems, 126 10.3.1 SelectionofIngredients, 126 10.3.2 TypesofBioinspiredMicroemulsions, 127 10.3.3 DecisiveFactorsforPharmaceuticalApplications, 129 10.4 RecentAdvancesinBioinspiredMicroemulsionsinPharmaceutical Science, 129 10.4.1 MicroemulsionsasinVitroDrugDeliverySystems, 129 10.4.2 MicroemulsionsasinVivoDrugDeliverySystems, 131 10.4.3 MicroemulsionsinCancerTherapy, 132 10.4.4 MicroemulsionsinBiotechnology, 133 10.4.5 AntimicrobialActivityofMicroemulsions, 134 10.4.6 BiocompatibleIonicLiquidMicroemulsionsinDrugDelivery andBiotechnology, 135 10.4.7 PatentsinMicroemulsionDrugDeliverySystems, 136 10.5 BiocompatibilityandToxicityIssues, 137 10.6 FutureOutlook, 138 Acknowledgment, 138 References, 138 CONTENTS ix Biomaterial 11 DevelopmentofNonfoulingBiomaterials 145 Ruey-YugTsayandToyokoImae 11.1 Introduction, 145 11.2 WhyNonfoulingisRelevantinBiomaterials, 145 11.2.1 AntithrombogenesisandAnti-inflammatoryResponse, 145 11.2.2 HostResponsetoBiomaterials, 146 11.2.3 AntibacterialProperty, 147 11.3 ProteinAdsorptionandMaterialProperties, 148 11.3.1 AdsorptionMechanismofProtein, 148 11.3.2 Protein–SurfaceInteractions, 148 11.3.3 SurfaceHydration, 149 11.3.4 StrategiesforNonfoulingDesign, 149 11.4 NonfoulingBiomaterials, 150 11.4.1 SurfaceImmobilizationTechniques, 151 11.4.2 NonionicHydrophilicMaterials, 153 11.4.3 ZwitterionicMaterials, 154 11.4.4 AmphiphilicMaterials, 156 11.5 ConclusionsandFuturePerspectives, 157 References, 157 12 SurfaceCharacterizationofSilverandFe O NanoparticlesIncorporated 3 4 intoCollagen-basedScaffoldsasBiomaterialsforTissueRegeneration: State-of-the-ArtandFuturePerspectives 161 AbhishekMandal,N.Chandrasekaran,AmitavaMukherjee,andThothapalliP.Sastry 12.1 Introduction, 161 12.2 StructuralInformation, 163 12.2.1 SDS-PAGEAnalysis, 163 12.2.2 CircularDichroism(CD)Studies, 164 12.2.3 DifferentialScanningCalorimetry(DSC), 165 12.2.4 X-RayDiffraction(XRD), 166 12.3 ChemicalInformation, 167 12.3.1 FourierTransformInfrared(FT-IR)Spectroscopy, 167 12.3.2 X-RayPhotoelectronSpectroscopy(XPS), 168 12.4 MorphologicalInformation, 171 12.4.1 ScanningElectronMicroscopy(SEM), 171 12.4.2 AtomicForceMicroscopy(AFM), 173 12.5 ConclusionsandFuturePerspectives, 175 Acknowledgment, 175 References, 175 Biomimetics 13 BiomimeticPolymerAggregates:Self-AssemblyInducedbyChemical Reactions 181 EriYoshida 13.1 Introduction, 181 13.2 Self-AssemblyInducedbyElectronTransfer, 181 13.2.1 Oxidation-InducedSelf-Assembly, 182 13.2.2 Reduction-InducedSelf-Assembly, 184 13.2.3 Disproportionation-InducedSelf-Assembly, 184 x CONTENTS 13.3 Self-AssemblyInducedbyIrreversiblePhotoreactions, 186 13.3.1 Photolysis-InducedSelf-Assembly, 188 13.3.2 Photo-ClaisenRearrangement-InducedSelf-Assembly, 189 13.3.3 PhotoelectronTransfer–InducedSelf-Assembly, 190 13.4 Conclusions, 191 References, 191 14 MolecularInteractioninBiomimeticsandBiosystems:Chiralityand ConfinementatNanodimension 195 NilashisNandiandSahebDutta 14.1 Introduction, 195 14.2 MethodsofTheoreticalCalculation, 198 14.3 ChiralDiscriminationinBiomimeticMonolayers, 198 14.4 ExperimentalStudiesonChiralDiscriminationinPeptideSynthesisand AminoacylationReaction, 199 14.5 ComputationalAnalysisofChiralDiscriminationinAminoacylation Reaction, 202 14.6 ComputationalStudiesoftheChiralDiscriminationinPeptideBond FormationReaction, 204 14.7 ConcludingRemarks, 206 Acknowledgments, 207 References, 207 Biosensing 15 SoftinterfaceonBiosensing 211 YukichiHoriguchiandYukioNagasaki 15.1 Introduction, 211 15.2 AdvantagesofSuppressingtheNonspecificAdsorptiononaSurfaceby PEGylation, 212 15.3 PegChainBehavioronSurfaces, 212 15.4 FunctionalizationofPEGEndforPEGylationonSurface, 214 15.5 HybridImmobilizationofPEGwithLigandMolecules, 215 15.6 Conclusion, 217 References, 217 Bioseparation 16 BioseparationUsingThermoresponsivePolymers 220 KenichiNagaseandTeruoOkano 16.1 Introduction, 220 16.2 ThermoresponsiveChromatographywithHydrophobicInteractions, 220 16.3 ThermoresponsiveChromatographywithElectrostaticInteractions, 222 16.4 ThermoresponsiveChromatographyUsingVolumeExclusionEffectof PIPAAm, 224 16.5 ThermoresponsiveChromatographyforHigh-SpeedSeparation, 226 16.6 ThermallyModulatedCellSeparationUsingPIPAAm, 227 16.7 Conclusions, 228 Acknowledgment, 229 References, 229 CONTENTS xi Biosurfactant 17 Biosurfactants 231 EtsuoKokufuta 17.1 Introduction, 231 17.2 Classification, 231 17.3 ChemicalandPhysicalProperties, 239 17.4 Applications, 242 References, 243 Blood-brainBarrier 18 StructureandRegulationoftheBlood–BrainBarrier 244 Yung-ChihKuo,Chin-LungLee,andJyh-PingHsu 18.1 Introduction, 244 18.2 CellularSystemoftheBBB, 244 18.2.1 TightJunctions, 244 18.2.2 NeurovascularUnit, 245 18.2.3 BMECs, 245 18.2.4 Astrocytes, 245 18.2.5 Pericytes, 246 18.3 InVitroBBBModel, 246 18.3.1 PrimaryCulture, 247 18.3.2 Coculture, 247 18.4 ABCTransportersintheBBB, 247 18.4.1 MechanismofABCTransporters, 247 18.5 SecretedFactorsforBBBRegulation:MechanismandInhibitor, 247 18.5.1 TGF𝛽1, 248 18.5.2 VEGF, 248 18.5.3 MMP-9, 248 18.6 NanoparticlesforDeliveringPharmaceuticalsAcrosstheBBB, 248 Acknowledgments, 250 Abbreviations, 250 References, 250 BoronTracedrug 19 BoronTracedrugsasTheranosticAgentsforNeutronDynamicTherapy 255 HitoshiHoriandHiroshiTerada 19.1 TheRealCrisisforTwenty-First-CenturyMedicinalChemistsin PharmaceuticalIndustriesandAcademia, 255 19.2 BoronTracedrugsasaChallengetoTraditionalDrugDesignMethodology, 255 19.3 BoronTracedrugsforNeutronDynamicTherapy(NDT),as Physician-FriendlyTools, 257 19.4 Conclusions, 258 Acknowledgment, 259 References, 259