Embryology at a Glance Companion website This book is accompanied by a website containing a link to Dr Webster’s website and podcasts: www.wiley.com/go/embryology Embryology at a Glance Samuel Webster Lecturer in Anatomy & Embryology College of Medicine Swansea University Swansea, UK Rhiannon de Wreede Honorary Lecturer College of Medicine Swansea University Swansea, UK A John Wiley & Sons, Ltd., Publication This edition first published 2012 © 2012 by John Wiley & Sons, Ltd. Wiley-Blackwell is an imprint of John Wiley & Sons, formed by the merger of Wiley’s global Scientific, Technical and Medical business with Blackwell Publishing. 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Designations used by companies to distinguish their products are often claimed as trademarks. All brand names and product names used in this book are trade names, service marks, trademarks or registered trademarks of their respective owners. The publisher is not associated with any product or vendor mentioned in this book. This publication is designed to provide accurate and authoritative information in regard to the subject matter covered. It is sold on the understanding that the publisher is not engaged in rendering professional services. If professional advice or other expert assistance is required, the services of a competent professional should be sought. Library of Congress Cataloging-in-Publication Data Webster, Samuel, 1974- Embryology at a glance / Samuel Webster, Rhiannon de Wreede. p. ; cm. – (At a glance series) Includes bibliographical references and index. ISBN 978-0-470-65453-8 (pbk. : alk. paper) I. De Wreede, Rhiannon. II. Title. III. Series: At a glance series (Oxford, England). [DNLM: 1. Embryonic Development. QS 604] 612.6'4–dc23 2011049102 A catalogue record for this book is available from the British Library. Wiley also publishes its books in a variety of electronic formats. Some content that appears in print may not be available in electronic books. Cover image: © Joseph Mercier | Dreamstime.com Cover design by Meaden Creative Set in 9/11.5pt Times by Toppan Best-set Premedia Limited 1 2012 Contents Preface 6 24 Musculoskeletal system: limbs 56 Acknowledgements 7 25 Circulatory system: heart tube 58 List of abbreviations 8 26 Circulatory system: heart chambers 60 Timeline 9 27 Circulatory system: blood vessels 62 28 Circulatory system: embryonic veins 64 Part 1 Early development 29 Circulatory system: changes at birth 66 1 Embryology in medicine 10 30 Respiratory system 68 2 Language of embryology 12 31 Digestive system: gastrointestinal tract 70 3 Introduction to development 14 32 Digestive system: associated organs 72 4 Embyonic and foetal periods 16 33 Digestive system: congenital anomalies 74 5 Mitosis 18 34 Urinary system 76 6 Meiosis 20 35 Reproductive system: ducts and genitalia 78 7 Spermatogenesis 22 36 Reproductive system: gonads 80 8 Oogenesis 24 37 Endocrine system 82 9 Fertilisation 26 38 Head and neck: arch I 84 10 From zygote to blastocyst 28 39 Head and neck: arch II 86 11 Implantation 30 40 Head and neck: arch III 88 12 Placenta 32 41 Head and neck: arches IV–VI 90 13 Gastrulation 34 42 Central nervous system 92 14 Germ layers 36 43 Peripheral nervous system 94 15 Neurulation 38 44 The ear 96 16 Neural crest cells 40 45 The eye 98 17 Body cavities (embryonic) 42 18 Folding of the embryo 44 Part 3 Self-assessment 19 Segmentation 46 MCQs 101 20 Somites 48 MCQ answers 106 EMQs 107 Part 2 Systems development EMQ answers 108 21 Skeletal system (ossification) 50 Glossary 109 22 Skeletal system 52 23 Muscular system 54 Index 114 Companion website This book is accompanied by a website containing a link to Dr Webster’s website and podcasts: www.wiley.com/go/embryology Contents 5 Preface We wrote this book for our students; those studying medicine with books cover development in detail, but students struggle to get us, those listening to the podcasts wherever they may be, and those started, and to get to grips with early concepts. Hopefully we have studying the other forms that biology takes on their paths to addressed these difficulties with this book. whatever goals they may have in life. We have introduced many We hope that you will use this book to begin your studies of students to the fascinating and often surprising processes of embryology and development, but also that you will return to it embryological development, and we hope to do the same in this when preparing for assessments or checking your understanding. book. It is written for anyone wondering, “where did I come You will find example assessment questions in Chapters 46 and from?” 47, and a glossary in Chapter 48. The content of this book extends beyond the curricula of most Let this be the start of your integration of embryonic develop- medicine, health and bioscience teaching programmes in terms of ment with anatomy, to the ends of improved understanding and breadth, but we have limited its depth. Many embryology text- better patient care or scientific insight. 6 Preface Acknowledgements Thank you to Kim and Robin for being so encouraging and putting up with the time demands of completing this book. We would also like to thank the editors at Wiley-Blackwell for leading us through this process and for their support and encouragement, and Jane Fallows for all her work with the illustrations. Acknowledgements 7 List of abbreviations AER Apical ectodermal ridge IVC Inferior vena cava CAM Cell adhesion molecule IVD Intervertebral disc CN Cranial nerve IVF In vitro fertilisation CSF Cerebrospinal fluid LH Luteinising hormone ECMO Extracorporeal membrane oxygenation LMP Last menstrual period FGF Fibroblast growth factor PDA Patent ductus arteriosus FSH Follicle stimulating hormone PFO Patent foramen ovale GnRH Gonadotrophin releasing hormone PTH Parathyroid hormone HbF Foetal haemoglobin PZ Proliferating zone hCG Human chorionic gonadotrophin Rh Rhesus hCS Human chorionic somatomammotrophin SVC Superior vena cava IUD Intrauterine device – contraceptive device TGF Transforming growth factor IUGR Intrauterine growth restriction ZPA Zone of polarising activity 8 List of abbreviations
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