DTIC ADA436090: Determination of Thiodiglycol in Groundwater Using Solid Phase Extraction Followed by Gas Chromatography with Mass Spectrometric Detection in the Selected Ion Mode PDF
Preview DTIC ADA436090: Determination of Thiodiglycol in Groundwater Using Solid Phase Extraction Followed by Gas Chromatography with Mass Spectrometric Detection in the Selected Ion Mode
DETERMINATION OF THIODIGLYCOL IN GROUNDWATER USING SOLID PHASE EXTRACTION FOLLOWED BY GAS CHROMATOGRAPHY WITH MASS SPECTROMETRIC DETECTION IN THE SELECTED ION MODE snikm o .TeAcurB 1 ag e.ySAr adGna noitc esSnoitarap edS nyartsime hcCinagrO n alacimehC noisivi Dsecneic Slacitylan Ad yrotaro blaaLnoi teagN dkiaRO 2 , 3 P. O. Box 2008 , e 1kgN3adT8Oi7R3 - 6120 :xa) F568( - 576 - 7956 fnooisreV enuJ 4 , 2001 h nCeocnerefn ocCifitnei c1S0 0e2 h otdtettimb unsoitubirtn olcanigi rnoA lacigoloi B&lacime hcraes eeRsnefeD 6 - ,8h1c0r0a2M D,Myell atVn u,Hn nyIell atVn usH’ttoirraM 1 .de s sde l reueEdbocdhnasednop se rmoroTohcw - :sserdd aliam vog.lnro@absnikmot 2 hcraeseR derosnops yb eht ykcoRoM niatnu ,lanesrA EOD .oN9891 - 770H - 1A htiw ehtS U t n .e yym frgtdoor retesa ga niplaryEean ob DnakbeomaagTiOLdUtiaRN - ,e l,lCeLt LtraoBf eht tne mS tU fr yoat gpcrreaeeDrdntnEEnuDoc - CA - 05 - 00OR22725. 3 ehT dettimbus tpircsunam sah neeb derohtua yb atnoc rotcar fo eht SU tnemnrevoGr ednu contract DE - 50CA - .52722RO00 ,ylgnidroccA eht SU tnemnrevoG sniater a, evisulcxenon ytlayor - eerf esnecil ot hsilbup ro ecudorper eht dehsilbup mrof fo siht ,noitubirtnoc row olla others to do so, for US Government purposes . 1 Report Documentation Page Form Approved OMB No. 0704-0188 Public reporting burden for the collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden, to Washington Headquarters Services, Directorate for Information Operations and Reports, 1215 Jefferson Davis Highway, Suite 1204, Arlington VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to a penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. 1. REPORT DATE 2. REPORT TYPE 3. DATES COVERED 00 JAN 2002 N/A - 4. TITLE AND SUBTITLE 5a. CONTRACT NUMBER Determination Of Thiodiglycol In Groundwater Using Solid Phase 5b. GRANT NUMBER Extraction Followed By Gas Chromatography With Mass Spectrometric Detection In The Selected Ion Mode 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION Organic Chemistry and Separations Section Chemical and Analytical REPORT NUMBER Sciences Division Oak Ridge National Laboratory2, 3 P. O. Box 2008 Oak Ridge, TN 37831-6120 9. SPONSORING/MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR’S ACRONYM(S) 11. SPONSOR/MONITOR’S REPORT NUMBER(S) 12. DISTRIBUTION/AVAILABILITY STATEMENT Approved for public release, distribution unlimited 13. SUPPLEMENTARY NOTES This article is from ADA409494 Proceedings of the 2001 ECBC Scientific Conference on Chemical and Biological Defense Research, 6-8 March , Marriott’s Hunt Valley Inn, Hunt Valley, MD., The original document contains color images. 14. ABSTRACT 15. SUBJECT TERMS 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF 18. NUMBER 19a. NAME OF ABSTRACT OF PAGES RESPONSIBLE PERSON a. REPORT b. ABSTRACT c. THIS PAGE UU 9 unclassified unclassified unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 DETERMINATION OF THIODIGLYCOL IN GROUNDWATER USING SOLID PHASE EXTRACTION FOLLOWED BY GAS CHROMATOGRAPHY WITH MASS SPECTROMETRIC DETECTION IN THE SELECTED ION MODE snikmo T. AecurB ag e.ySAr adGna egd ikR a,Onoisiv isDecnei clSacityla ndA nlaacime h,Cnoitc esSnoitarap edS nyartsime hcCinagrO ,y r.o P t,. , ae O1x8 krgN3o0laodT8B0aObi72naR3oLitaN - 6120 Aylhgih - evitisnes lacitylana erudecorpi s debircsed rof gninimr eltoecdylgidoiht ni. retawdnuorg selpmaS era yllait idneiifitrof htiw’3,3 - lo n,a)peotrapgiodroriuh stn(eht htob seiceps era detcartxeg nisu laitneuqes dilos esahp noitcartxe htiwC dna brosrebmA 275 snmuloc ni .mednat ehTC c ,nmulo 81 81 hcihw sevome rsuoen arrettxaew d,nsutonregnopmoc si ;dedracsid eht brosrebmA 275 nmuloc sid eird ylhguoroht erofeb gnitule ralop stnenopmoc htiw a llams emulov fo .enahtemorolhcid ehT tcartxes i nek a s ,tosgnten e ni ggdysynonrurira ddwteoihlntf A Fd gTed nSzneiB iausTgtdu Mnaisivsitielrruesder .enidiryp edheTz isttacvuidroerdp era detulid ot a lanif emulov hdteih wp,aern gegountliaosmtuorhca desuf - aycri al,linlsmiuplaoc cd ndaetce thetdiw eal ocp iurr rotsdtesacmaueomqtret dcneips stieles detc - noi .edom y lotlw naTde cedsisnetaersipuibedtndeaunct ioserrpew desu ot etaulave eh tnoitces tteidmil 6 1dn a4neewte bdegna rseula veh t;locylgidoih trof m Lg -1.retawdnuo rg NOITCUDORTNI rufluS dratsum ,DH( syn. sib - 2( - ,ediflus)lyhteorolhc SAC yrtsigeR .oN 505[ - 60 - )]2 si n a ruflusonagro retsilb tnega taht saw tsrif deyolped ni dlroW raW I dna sah neeb desuy llanoisacco ediwdlr orweve .ecnis tI dsearwutcafu nyabm lar esveeiscn eggnairud dlroW raW ,I Ignidulcn iehtS U ymrA ykcoR niatnuoManesrA l neewteb rebmeceD 2491 dna yaM3491 1 . setiS hcus sa ehty kcoR ni altannueosMr A eyrlatn edgrenrtiuaecibd e dmdneeartrevn ooctnon - yrat i.lsiemsu nI redro ot erusne taht eht lanif etis sniatnoc lios dna retawdnuorg htiw tnanimatno cslevel woleb esohtm mumixas level dewolla yb eht yrotal u,gseericnyelgsauorogir - detset lacitylan asdohtem tsum eb elbaliava taht lliw) a( etartsnomed eht ecneserp ro ecnesba fo DH ta yrotaluge rslevel ni lios ro retawdn u,osreglpmas )b(e b detn eyymlbei ldctparsmeeoirmmmoc lai l a,csietiyrloatnaarob a)lc( eb dipar dna tneinevnoc ot ,esud na )ed t(laar mes inelneiaigtnmiitfy nlfalouaqcimehc - suodraz a.hetsaw enhoTitanimret efdo secart foD H dna sti noitisopm osctecdudorp si laicurc ot troppus stroffe ni eht noitaidemer fo detanimatnoc setist a ynam yratilim snoitallatsni dna eht noitacifirev fo smra lortnoc stnemeerga ni ecnailpmoc htiwe ht .noitnevno Csnopae WlacimehC leaht Tnyer ma enmmtoisarrifipnvanhec efmo derots ro deirub DH ssiisylordyh 2 . hguoh tDlHA si yldiparh dezyl orfdlyah( - efil fo 5.8 nim ta52 (cid:176) C) 3 , sti etar sdietim iylb eht wol se.tnaori tfuol ossi dehT sisyl omrsdiynhahcem si xelpmoc ,dna gnidneped nopu eh tytilibaliava fo ,retaw srucco yb owt, setuor htob fo hcihw dael ot eht lai tnioniitamrof foidoiht locylg ,GDT( syn. 2,2’ - ,lonahteid oSiAhCty rtsigeR .oN111[ - 48 - )]8 dna cirolhcordyh .dica ,ecneH eht ecneserp fo GDT ni a retawdnuorg elpmas sin a 2 tn erlolteaccxiedni fo ycagel DeHrutcafun armo .egarots ehT tnerr utce ggrnaiTtro pteiRmiL )LRT( tes hytb retawdnuo r ngGi DrT olfanes rnAiatnu oyMkc oyRm r SAeU 4 s i5 m Lg -.1 ehT nepo erutaretil sebircsed a yteirav fo lacitylana serudecorp rof GDT ni suoeuqa ,secirtamt ub wef tibihxe htob eht deriuqer ytivitisnes dna ytivitceles deriuqer dna ydaerilibaliava yt nihtiwt som laicremmoc lacitylana .seirotarobal emoS fo ehthgih - erusserp diuqilyhpargotamorhc - desabs dohtem detrop errof si hetso pyroulp prmuef lc usiesrrmotatelcmfeotteodhp 5 ,6 , si shetriowh pV oUyrrtaclelliepac noitceted 7 , dna ssam cirtemortceps d srotcete gniyolpme rehtieyarpsortcele 8 ,9 ro c irehpsomta erusserp lacimehcnoitazinoi 10 ,11 . sdohteM desab no sag yhpargotamorhc era ylralucitrape vitcartta d nen on ehiiphttbewia mtwzhositc toa ab lv ogoietncrc iyeudlldd nigefaairo td eootvitiohsrtnpemsi ytivi dna .ytivitceles roF ,elpmaxe kcalB dnadaeR 21 detrevnoc eht yraniru setilobatem fo ruflus, dratsum gnidul cs),neeGivtDiaTto azrvnoieirb reoopdrtou lg fn oairttdinneeohppty(shsep irasbrraoggcotamorhc - mednat ssam yrtemortcepsCG( - MS - )SM ronortcele - erutpac evitagen noi lacimehc noitazinois sam yrtem onritc e dpee shtgtcn einlroeeoidstoimnom 31 . GDT tneserp ni eht eniru fo desopxe star roa eniug sgip sah neeb dezitavired htiw cirytuboroulfatpeh edirdyhna roirp ot sag yhpargotamorhc htiws sam mortceps stluse rtnellecx ehti w,noitcete dcirte 41 ,51 . ehT tnes edroph tsedmnapxe eht krow fo gnoeL te.la 61 ot edivorp a elba idvohtemg nriotfatitnauq GDT dna ’3,3 - lonaporpidoiht ,PDT( SAC yrtsigeR .oN 59501[ - 09 - ]20 ,) a desoporp ,etagorrus n i retawdnuorg ta wol m /g L .s n)obiptpa(rtnec noc ehT noitce tsetdimil dn aseirevoce rrof htd oebzitavired seiceps erew ylsuoro gdiernimreted gnisu slocotorp detadnam yb htob eht SU ymrA ykcoRn iatnuoM lanesrA dna eht SU latnemnor invoniEtcetorP .ycnegA ehT lanif lacimehc etsawp decudorg niriuqer .elpma sre pL m1deecx eto ndi dlasopsid NOITATN E,MS UUDRTNT AAS,RNSAITPNPEAGAER locylgidoihT( syn. 2,2’ - ,lonahteidoiht SAC yrtsigeR .oN 111[ - 48 - 8]), 3,3’ - lonaporpidoihtS AC( yrtsigeR .oN 59501[ - 09 - ,)]20 dna N - tret( -lylislyhtemidlytub ) - N - edimatecaoroulfirtlyhtem, AFTSBTM( SAC yrtsigeR .oN77377[ - 52 - )]7 htiw %1 t - enalisoroSlMhDcBlTy(htemidlytub - ,lC SAC yrtsigeR. oN 26181[ - 48 - ) ]d6 ees ramehowcr rf luehaphcctii rm.deolhCAC ta %.+y9t9irup n o e ientdiaadlriygrlyipS SAC( yrtsigeR .oN[ 110 - 86 - )]1 saw deniatbo morf .amgiS eneuloT SAC( yrtsigeR .oN801[ - 88 - ,)]3 HPLC - edarg ,retaw elirtinoteca SAC( yrtsigeR .oN57[ - 05 - ,)]8 ena hdtneam oSrAoCl (hycritdsigeR. oN 57[ - 09 - de s na ) eCihe] y dLcr2mtr aPreoierrHuw rrtogp.futJpe br.eT kraioBllA kci d,r .u,cBlnaI ndgeiS & .noskcaJ tnegaeR - edarg muidos edirolhc dna suordyhn amuidos etaflus erew derucorp morfr ehsiF .noitacifir urpehtr utfuoht idwe seur eswlacime h lc. lcAifitnei c MSdE n,a.c n,IcifitneicS brosrebmA 365 dna brosrebmA 275 02( - 05 m )hse erew desahcrup morf ,oclepuS .cnI e sehT st n eedrbeerkwo csd aesp raoi tuynqtieprme6 - sennm eu.llJyo(pc o l r .a)pyTc rytiLeligmkocrapauBpsac htiw yramotsuc 02 m m ytisoropnolfeT (cid:210) .stirf snmuloC6( - )Lm gniniatnoc 005 gmivnE - braCe rew deniatbomorf .oclepuS elbasopsiD6 - Lm snm udleokcca phtiw 005 gdmnobrekeapBs (cid:212) lycedatcoC 81 5d7na .rek a .B .TmJo rdfesahcr uepr eswri-ovres eerlpm aesnelyporpyl olpacigr uystp mLem llA retawdnuorg selpmas erew detcartxe gnisu a21 - noitisop dilos esahp noitcartxe dlofinamh tiw nolfeT (cid:210) sevlav dna seldeen dna muu cdaevilpp amorf e hstseln ilaetests ,pot rehtar naht eht ,edis foe ht ssalg rebmahc kcidruB( & ,noskcaJ trap .on .)0049 enahtemorolhciD stcartxe erew detcellocd na dd)eewz boisilt arean(cbvisierded8 - Lms l lselha idd vnegalnaiessu51 - c5 i2kt4cs aasllpbp ahct inwepo spot dnaEFTP - deen corace fib.lbaiutsrpe sde zit ad vnd ia eerdtueeudD rliyris ledesef ratsowantmairttlu 2 - Lm rebma dezin acliitsamot uraelpmas slaiv gniraeb eloh spac htiwnolfeT (cid:210) - enocilisr rebbu -nolfeT (cid:210) .atpes 3 owTitluM - kcolB sretaeH erew desu gnirud elpm a.snoitaraperp ,enO hcihw saw desu yltcirtsr of tcartxe ,noitartnecnoc saw denoitisop htaenrednu aenin - tropitcaeR - paV (cid:212) rotaropavE dehcatta ota negortin rednilyc %999.99( .)ytirup ehT lausu tsac munimula gnitaeh kcolb saw denrut ,revog nilbane lleh sslaiv ot dnat srednu eht senav fo reohttarop anvie lluf weiv fo e h.ttsylana ehTe rkuctoalrbepmet den is aattwaniam54 (cid:176) , nsoaiiwtaam z.iC ty a lhv ,r tci dos cirdnfaeiheeowhrwdscTtuess de ntiaa5t0n1 (cid:176) C dna deyolpme a gnitaeh kcolb dellird rof 31/21 mm retemaid slessev ,.e.i( 8 Lm llehs )slaiv dnaa .retemomreht ttelwe HA ttelw- eoadHtecafret nhipargotamor hsc a IgsIeir e0S9 8l5ed odMrakcaP - led odMrakcaP elw edH nraelpm acsitamot u3a767 tt r- odfe ssu arwetemortce psss aemlopurda uAq98 9l5ed odMrakcaP elbuo dahti wdeppiuq esa wrotcejn ie h .Tstnemerusae mlla desu fe h .-Teveel srotcejn ikcenesoog - acilis P nHsa anwmul occihpargotamor hscag -lynehpi d%5 (deel Bwo Lartl USM5 -xolislyhtemi d%59 ,0)3ena 52 .,0.d .m5 im2 m.x0 m )ytir u%p99. 9,9muile hs( argeirr aec h fteorusse rdpa e eh. hsTsenkci hmtl imf eneul odt nlaonaht ehmt ihwc aeeci wdtehsu lsf aewgnir yrselpm acsitamot u ea. h)Ti s8p. 7a( P 4ks5aw 1gnitcejn ierofeb m sa geh totn ielpma sL .hpargotamor hc , r, oretoh ctTdecnteae j dsnrseiesrfau sm tenranaorirfeltp mheephtat reg roseta wag,m0o5r 2h,c082 dna082 (cid:176) ,.Cylevitcepser ehT nmuloc ne veorutarepme tsaw desae ryclnriaenil morf001 (cid:176) C dloh( rof3 )nim ot072 (cid:176) C dloh( rof 1 )nim ta01 (cid:176) C .nim/ ehT r e stdseeamtmoarrtecpeo ptsa ecruos denlaopurdauq seruta rfeopmet002 (cid:176) dna001 (cid:176) ,y l deen vr asiud sts l necs,oeaaleeCfchprirtspnu eao8rms x01 -6 .rrot ehT noitazinoi edom saw nortcele tcapmi 07( ,)Ve htiw na nortcele reilpitlum egatlov fo05 V evobae ht ”enut“ .egatlov ehT tnevlos“ ,”yaled ro eht emit retfa eht trats fo a nevig sisylana litnu ehts sam retemortceps saw denrut ,no saw 41 .nim ehT SM/CG metsys saw detarepo ni sti detceles“n oi ”gniroti n)oMmIS( ,edom ni hcihw ehtssam - ot - grahc e oitar )z/m( derotinom rof GDT saw ,392e lihw es odhetrotino mrof PDT erew 123 dna .363 ehT detcele ssnoi rof GDT erew denn ancesewteb 41d na 5.6 1,n ieml iehswoh trof PDT ednreeenew nw5at.ce6sb1 dna 91 .nim e hl Tl,e”wedm“i tro em ittneps gnirotinom a nevig z/m ,eulav rof ,392 ,123 ro 363 saw ,004 ,004 ro 001 ,c e.symlevitcepser ehTw ol“ ssa m”noitul oesreurtaef saw ,”no“ gniwolla a ssam kaep htdiw fo 9.0 .uma ehT desaercni kaeph tdiw cep sn isso leltti lhti wytivitisne sdesaercn i)um a5. 0yllamron( .yticifi LATNEMISREERPUXDEECORP n Ato u yqgnlinoll iiaafttmoaur rlo0bon1is(lac ot 001 m d he) tn L0iis0wba1mwoc m enid i hrLcyape d nAaFTS BhtTtsMiywlat anci a2 - de t dda.en el parha lspeieaaalvhiwc pTvcmiatsam odteuzain aLlmis ot501 (cid:176) C rof 1 ,rhht n edel o.o ecortu tmaor oerpm e stethnTet nfooc eht lai vedreetwul iodt 1 Lm htiw ,eneulot neht dezylana rof GDT dna PDT ybCG - MS - MIS gnidrocca ot eht sretemar adpeton .evoba f I sisyl afnoaer sethctar tsx iedreethctei pe,rxdoeer ieshe tdslai vyam ebr depp ad cndeaerot sta4 (cid:176) C for at .dednemmoc e srsidradna tdsezitavir ehdt irwetemortce psss aem h ftnooitarbil aycl i. asDy andev etssael 001 sLnmoi t rrfeootp al0we0dd1n o(uLmo/rg gmhcae endiir o dlenhtacafl ussa r imeuh itsdtolsas ni MTSA epyT IItaw )re 71 erew deifitrof ot a der insoeidtartnecnoc fo GDT2( - 001 gn .)Lm/GDT n I 5,2etagorru sP( DhTt idweifitr osf aewlpm arsetawdnuo rhgc a,enoitidda m g TDP/L). ehT dilos esahp noitcartxe nmuloc niart saw deraperp sa :swollof ehTC ”draug“ nmulocs aw 81 oc denoitidn htiw owt nmuloc semulov hcae fo lonahtem dnaCLPH - edarg ,retaw elihw ehtn oitcartxe“ ”nmuloc 001( gm brosreb m)A275 sdaewnoiti dhntoicw a elgni snmulo cemulov fo lonahtem dnao wt C LsfPeoHmu lnomvuloc - .erdeatrag w ecnO eht nmuloc gninoitidnoc ssecorp sah ,nugeb rehtien ehtC 18 ron eht brosrebmA 275 nmuloc dluohs eb dewolla ot og.yrd ehT dilos es anhopitca rntmxuelocn iart stsisnoc fo )a( 57 Lm ,riovreser )b(C ”draug“ nmuloc dellif htiw ,retaw dna )c( brosrebmA2 75 81 4 noit cnamrutlx oedcellif htiw ,retaw lla detcenn ogcnisu eht eraw ddreaihlppus htiw e h.tsriovreser e hT detelpmoc niart si neht detnuom no eht dilos esahp noitcartxe .dlofinam ehT deifitrofr etawdnuorg elpmas si dedda ot eht ,riovreser dna diuqil wolf si detsujda ot a wolf fo2 - 3 ,nim/Lm htiwm uucav dei l.p dpseaariuq er et o rsNtee(atlh ap tewmynmdaaio nsma syuteton vironitg casn esafleuoccqixterap senif taht lliw golc eht draug“ ”nmul o.cyldipar nI taht ,esacffo“ - n”oeintialrt lfiof edhetife iltprmoafs yam edberiuqierrp ro ot )d.inl ooeisstacha prtx eretfA eh teritn e001 Lm elpma ssa hd ehsgsuaopr hetht brosrebmA 275 ,nmuloc eht niart si delbmessasid dna eht brosrebmA 275 nmuloc si deird rednul luf .ru oeh ntosa e tlra omfuucav sla idreettcaeMlloc no eht brosrebmA 275c nmulo er a,de tyullweols f,ielbi sostonpi na8 - l lLemhs laiv gnisu eerht 3 - Lm snoitrop fo enahtemorolhcid ,yllacipyt( 8 Lm enahtemorolhcid tcartxe e ra .)derev ocer A 001 m Ltouqi lefanoidi rsyip dedda ot ethctart xsea , ”are pdeneak “g neihtttulluosser noi si nekat ot ssenyrd htob yb gnimraw eht mottob fo eht llehs laiv ot(54 (cid:176) )C dna yb gnisu yrdg niwolf .negorti n g enehiuTtdl iudssee ezrsriita vniired eht8 - Lm llehs laiv ta501 (cid:176) C rof 1 rh htiw 001 m Lhcae elnaind o idiArntFyai.Tp dtShdsBtayTilMwatac , d e edrts leui a dott ohseouxtizcliiimt d ar veeithrfteAd a leamnuil fofvo 1 Lm hti w008 m L ,deenreruelfostna rott a2 - cr ie Ltl,maplmma oai dtsvdeunzaaylana rof GDT dna PDT ybCG - MS - .deevbo ibss r ari cM esgs Irtynes SeelidiefhmashItanutiraeaepr detcepxe t4daero tds ndaeppac e eryb asmla iev h,tderis erdo (cid:176) .sy andev etssa etrl aoCf ehT derusaem detargetni kaep aera rof rehtie GDT ro PDT si detaluclac gnisu eht” etargetni“ noitcnuf fo PH A9895 ssam retemortceps atad .metsys ehT kaep saera morf eht dezitavis rderdadnats erew tif ot a cit anrodiatuaqrbil aecvruc fo eht mrof C =Aa 2 + Ab + ,c erehw C snioit aer htftnoecnoc etylan ani e httcartx eni m ,Lm/g A si edhetru skaaeem p,aera dna ,a ,b dna c , sn toeniras atslselnraogcer fo hc idhlwuohseb der eydlilsan co.icttnsaictiaftisngis ehT tca rntoxietartnecnoc saw retal detcerrocn i . L0m 0,1emul oevlpm arsetawdnuo reg hrt orfenn almau seuht NO ISST SLDUUNCSASEIRD nI ,elpicnirp GDT dluoc eb devomer dna detartnecnoc morf suoeuqa selpmas gnisutie rehdiuqil - diuqil rodilos - esahp .noitcartxe htoB sehcaorppa detibihxe seicneicifed dna .segnellahc GDT sio s elbulos ni retaw taht gninoititrap htiw a yteirav fo cinagro ,stnevlos ,.g.e lyhte etateca d na , ed ne saclehulitdareoremrev opvotrocooenlrhcid retaerg na hytletamixorpp a%02 ta a tsen toitartnecnoc egna rfo02 - 120 m d eott s eus lj a npdneswde maehuehHavt otwp sefeseouih qstnaro ei.ptLam u/stgiihsT 1< dna tlas %52~( )v/w saw .dedda oT dnuopmoc eht ,melborpdiuqil - diuqil noitcartxe detarenega .edi sta ess ahwcaorp psai h,tsnosa eerse h ftlo lr.a oeFts atwnevl ocsinag r foyotitna ueqlbaredisnoc nA evitanretla hcaorppa devlovni eht noitprosda fo GDT otno a suoecanobrac ,)s(tnebrosh tiw tneu qneosibtuusle dn a.sisylana lar esvtenSebro serewave ,detaul ,.e.i brosrebmA ,365 brosrebmA ,275 dnaivnE - .braC brosrebmA 275 saw na evitcartta eciohc esuaceb ti sah neeb desu yllufsseccus rofe ht noitanimreted fo rehto llamsretaw - elbicsim ,setylana hcusN - ,enimalyhtemidosor tniinretawdnuorg 81 . ivnE - Carb si el byallliaaivcaremmoc ni llams dekcape rspnmuloc dna dluow eb tneinevnoc rofe nituor .sesylana llamS snmuloc dekcap htiw 005 gm fo hcae tnebros erew degnellahc htiw 001 Lml edom retawdn usoerlgpm adseifitrof ot2 - 50 m g .Lm/GDT ehT etylana saw detule htiw a yteirav fo, stnevlos gni d,uelncanhitemorolhc ildyhte ,etateca ,lonahtem dna .enoteca ehT lanimon gnitule noitidnocs aw eerht3 - s nLomi tf ro,o tphhncc e ai.veehdlrweoelswoo p tgcn ai ertsht laTxnuweeskear tsoste ndynrad FTSB ThMt idwezitavired .wol edbebircs e sd,aA tI emaceb raelc taht gnissap eht elpmas hguorht brosrebmA 275 dna gnitule GDT h tiw enahtemorolhcid saw eht derreferp eciohc fo tnebros dna gnitule .tnevlos brosrebmA 365 saws sel lufsseccus naht brosrebmA ,275 elihw ehtivnE - Carb s tnebro reven deniater GDT ta .lla nevE htiwn a 5 dezimitpo tnebros dna gnibrosed ,tnevlos eht seirevocer fo GDT erew htob wol dna. tnetsisnocni tdsnetetnuaeqrmetissr bnetuopaSmxheetd eht n oyihtt agsrndteonliercen pogcnisu yrd gni, wnoelgfortin netfroom e naht s1gen ii,etzrc ii ua ytlforeln iohtrbayt eiula,wcqwlGuoo DdlvdTosnr ap deanruroipmoc y.l ”ldeaelmriretodanilsonvonco n“ yB gnidda a llam sytitnauq 001( m )L fo enidiryp sa a ”repeek“d na gnimraw eht mottob fo eht llehs laiv ylthgils ot(54 (cid:176) ,)Cht e neoliptmaarstn eecmniotc saw decudero t yletamixorppa03 - 54 ,nim elihw eht etylana yrevocer saw desaercni ot yletamixorppa %04 ta t set sgnnneoieigw5tnt2aae.rrb0tnecnoc - 2 m .gLm/GD T , e ev s Wetst,iueoe lbnnvteenoabvarh icptethcteffe b rfoosre7b5mA 2 ni s idhothte m sdietal eort cseitcfiai fcareeu prs,sataht ta 0011m 2 t, s gfe s/oheighith detaula vsetnebr oeser hetht . ehT esu fo a suoecanobrac tnebrosda detneserp lareves lanoitidda segnellahc dna. s noitaredisnoc ,tsriF hcus a tnebros sicelesnon evit dna lli wniater yna non - cin oliar teuteyn ltanneaserp ni nac itnehtua detanimatnoc retawdnuorg .elpmas gnivaH lla fo eseht slairetam tneserp ni eht lanif tcartxed luow ediv oe rvnpias sddee nc t,axlnseeaev wcennnleue vrfeeo frroeftn ieht tstocmeles e v.isrotceted roF taht e c. inl oma b hui2 rclt7 eo oi5dh s mc naTdrd e fi eeen e dnonhcbash,nmi aamatnaudlA wotlrpasoaacuegr rof eht draug nmuloc saw a 005 gmC lycedatco EPS ,nmuloc hcihw dluow eb elbapac fog niniater 81 stesietdiotmn af uorqalopnonni .secnere fre treh td Orsanum gutlhogcim ge,nbeitd aneierrpopemodrppa noi t.as zeficorn eenr tro ee cephh,afuttdrrrnaeuohtfccn eitSi s it lyurcei vfoft iedtul esedehettryilsaenda ylevitatitnauq morf na noitprosda nmuloc htiw a llams emulov fo cinagros ,tnevlo hguohtla tahts i ylno memnoocd htiw adesrever - esahp .nmuloc roF ,elpmaxe nehw ew detpmetta ot etule GDT morfa 005 b, r sgoenms g o5r2dti2e7ist.b5rei0mttdAr(naocc - 2 m , Lg m0/0G 1 D) gTeLenlmeiprsmhuats3 - Lm stouqila fo ,enahtemorolhcidifingis tnac seititnauq pu( ot %52 fo eht detcepxe )ssam fo GDTe rew .stouqil adrih tdn adnoce sdenibmo ceh tn idevresbo owT sehcaorppa ot evorpmi eht llarevo yrevocer dna ecneinevnoc erew .detagitsevni ,tsriFn a evitanr edtnlaa er olmuf rgenwi ottpunleevlossaw .deredisno c si hhTcaorp p yaslaewtaid etmemsie disa esuaceb ew dah dnuof on nommoc cinagro tnevlos taht saw erom evitceffe rof gnippirts GDTm orf brosrebmA 275 naht .enahtemorolhcid ,dnoceS gnicuder eht deb ssam dluow tneverp GDT m orf gni traerhgtirmuf otn ie h t gtkn n nlenoyiuboi lmbrptdboeouunicrslaseesbop - .debrosda roF taht ,nosaer noitprosda snmuloc gniniatnoc ,005 ,002 dna 001 gm brosrebmA 275 erew .detaulave nehW hcaef o gni.n0i adeh teltrngpie on mwteceaa as lsswe0ladh0a w nt1hlLucemodrogm 25 - 2 m g GDT dna ,Lm/PDT dseev irereh estnvbiooce relhatitini3 - etnc aa ,hrerttraexel mewid omndnLriaeemosgelnwhatcre5ib2d - ,% 0s4seldrager fo eht deb .ssam desaB no eseht ,atad e wezisehto ptyahht eh tnoitprosda fo GDTd na PDT no brosrebmA 275 sisab yllaci a ,e ncgoannfierrmurosuncech opno eht yrev pot fo en hotitprosda .nmuloc sA gnol sa eht detc enpoxietartnecnoc fo GDT siecart - level dna eht yticapac fo ehte cafrus tnebros si t,odnedee cexhet tser fo eht deb ssam ssuioen a,rdtnxae ni ,tcafihni y reevviotcae trsittinbauq fo .etylana roF taht ,nos areerhtruf krow desucof no brosrebm A275 sn mgunlioycolpme a 001 gmd eb .ssam eerhT3 - Lm nmu lesonecahhsta eweh mrtdoeierwwyoollhpcmi edot erusn etaht eh ttnebross aw ylhguo rdoehstopxe ot tnevloshw eyllisuoe ngantilwuomlilsa a hgih oitar fo gnitule tnevlos ott nebros deb .semulov tA eht emas ,emit re htt nrsautcfniefmienvgoirspm ini llare vyorevocer era tond etcepxe ssel nn uodietc angtannvie drmnauuotriattescfnairt xreednu de tearvuetlaerepmetdna erus snsoeirtpidnoc noitcart xtEnevl odSetareleccA( (cid:212) .deyolpm es i) esuaceB tsom laicremmoc ecivres lacitylana seirotarobal dluow ssessopCG - SM ,seitilibapace ht tnerruc dohte ms enzoiistaahzpimteavire dfo GDT htiw a tnegaer taht dluow trevnoc ehtetylana otnia elbats dna elitalov seiceps elbanema otylhgih - evitceles dna evi teivsintecseles n o.ignirotinom fOe ht stnega e,relbaliav aAFTSBTM saw ylral u,ceivtirtacpartta rof eht gniwollo f:snosaer )a( lartuene litalov yb - stcudorp era ;decudorp )b( ehttub lylislyhtemidly rehte stcudorp era elbats ot ;sisylordyh dna) c( elpmisylidaer - detciderp ssam artceps erutaef naM( - )75 + ,noi hcihw stneserper ssol fo a yraitretl ytub .ytisnetn ihgi ho tmuide mf odn acitsongai dhto bs idn a,puorg 6 nI etips fo ehtsuoivbo ,segatnavda ereht era lanoitidda snoitaredisnoc nehw gnisu. A FTSBTM esuaceB ,retaw ton eht ,setylana lliw yllaitnereferp tcaer htiw ,AFTSBTM ti si tnatropmi tahte ht brosre b2m7A5 deb yelbetel pymrodc r oei nr.apnhoti etomutolreo lhcid d eedhnTemmocder gniye rmit rof eht brosrebmA 275 deb si ta tsael eno .ruoh nI ,noitidda ti si tnatropmi taht both lyxordys hpuorg tneserp no rehtie GDT ro PDT . deebzitav itr n eendiociitfcfa ueesrmniIt err ousteacruedpo mrhepttob a ylgnis - dezitavired ,seiceps esohwerp ecnes secuder eht tnerappa yrevocer fo ,etylana sa llew sae ht ylbuod - dezitavired .ytitne roF taht ,nosaer htob a noitazitavired emit 1( )rh dna erutarepmet501( (cid:176) C) rehg inha hltamro nrof shnco ui.stdce adseniremm ocer sdde rzaidtna a vrtsiostrceaDrtxe yl bearnaosaer elbats ot .sisylordyh yehT yam eb derots ta4 (cid:176) C dnaer - d eyzlyb lanaiinlhaet rinweve s,syad sa. dedeen htoB eht sdradnats dna dezitavir esdtcartxe erew yletamit lduevlossid ni ,eneulot rehtar naht nac itorpa ralop tnevlos hcus sa rtinoteca ,eli ot eziminim kaep gnittilps no eht ralopnon PH - MS5 gas .nmul occihpargotamorhc 91 ehT ecnamrofrep fo eht desoporp dohtem saw detaulave gnisu owytllacitsitats - desaibnu, slocotorp , .ezsiovh tfo eht SU yln maiyrnakAetcsnoruRAoM 02 dant aneehmtn oSrUivnE ynconietg cAletorP 12 , ot .yle vi tec he, Tp)tns L i oe)Dtmgi rLMiint dR(mLicd nMite oeea(Lrtdh hnoeotetipDhehmetMtrReeMted remrof si tnelaviuqe ot gninimreted a ”dnuof“ noitartnecnoc os taht htob eht eslaf evitisop dnae slaf evitagen srorre era htob.%5 22 , 32 yB ,tsartnoc eht rettal si eht muminim noitartnecnoc taht nace b .or enza hrtetae r sgnioitartnecn oectyla nea htta hetcnedifn o%c 9h9t idwetrop edr ndaerusaem ehT LRM saw detaulave gnisu a erudecorp dehsilbatse yb eht SU ymrA dna dessucsid nil iated erehwesle 42 . ,ylf e0i0r1B sLnmoi t rrfe ootdp aelewierdfdeniow utmoortrogf5.2 - 100 m g TDG/L, or 0.5 ) tL giRfnmToii( tL5 ro tot s ep0eege2mhrRitatT m h 5td2iewifit ro osseflal awp .mt Lash /secgtaE m L/g ,PDT hcihw devres sa a etadidnac .etagorrus maS selp e,rd ee,,wzddieettk acidvapnirsd arteexzdeylana s adebi r,cesveodba dna e hgtn i stdnleo utirlsateeelatdr uraongctwmonlndiiaentsccuaunororbcga itlaadc deniatbo no hcae fo owt dnoohitteamcif i.tsryeacd ehT LRM seulav ere wdetalucl agcnisu ehtruc tner noisrev fo erawtfos dednemmocer yb eht margorP reganaM ykcoR niatnuoMlanesrA 52 . e tadidnaC l gasncdiioythoytllepCammGnea - MS - MIS deerraedis nootc ebfles“ - ,”gn inmir itfa nhy ottecihtt nfeodi a ndenvu iodgpem h ossgciinlibs auhttsoeb nsotiitneter emi td nm ausr stda ce mr et.ospcnnseiolhietsi w oN tned nyerpoetdanmirifn odcohtem saw .deriuqer ehT epols fo eht detaluclac raenil noissergere nil s) e ”)uy e”l adudadme rn vnkdetunnaieb “oee pzp(fke esyi“awshlh(ttatase nnbg aon aiietthantleesrerper erusaem fo etyla n.ayrevocer ehT detaluclac LRM eulav rof GDT saw 2.61 m ,L/ gh tginwidn oapserroc .% 8 f3yorevocer LDM seulav ere wdetaluclac rof htob GDT dna ,PDT eht deso peotrapg o.rdrnuusopmoc Ae lgnis tes fo enin001 - L mr e stleaelwdpdomnmausosr(g de iyf liotttn re)odd f ne5ener2repieveuwedqneir m L/g ni hcae fo GDT evif( semit eht )LRT dna ,PDT neht dessecorp sa debircsed .evoba ehTg nitluser snoitartnecnoc dna elpmas dradnats noitaived rof hcae etylana erew .detaluclac ehT rettal seulave rew lum deilpit yb eht etairporppa eulav fo ehts’tnedutS - t ,noitubirtsid ,698.2 gnitneserper %99e cnedifnoc dnan( - )1 seerged fo modeerf ,ereh( ,)8 erehw n si eht rebmun fo atad seul a.velbaliava ehTg nitluser eulav si eht ;LDM ti si 5.3 dna 2.1 m L/g rof GDTdna ,P D.Tylevitcepser ehT egare vsaeirevocerr of GDT dna PDT era 32 dna ,,y%l7e1vitce pdsnear tcelfer eh tytluciffid ni gnitcar texseehtretaw - elbicsim seiceps morf a retawdnuorg .xirtam ,revewoH eht seirevocer era ylraelc tnetsisnoc dna. e l bicudorper S sreailriem vieo rcdeeewrtrop errof noi teahnti mfroetedN - ,en ihmcailhywh tseimi doossloartin a, llams ylhgih - ,ralop retaw elbicsim ,etylana morf suoeuqa selpmas gnisu brosrebmA 275 sa ehtn oitcartxe tnebros 62 ,72 . ehT noitcartxe dna noitazitavired roivaheb fo PDT skcart taht fo GDT ,ylesolc dna s i .dnuopm oectagorr ueslbatpec c naearofereht 7 SNOISULCNOC locylgidoihT ,)GDT( a rojam sisylordyh tcudorp fo ruflus ,dratsum yam eb detcartxe m orf retawdnuorg selpmas gnisu a llams nmuloc dekcap htiw brosrebmA275 , a citehtnyss uoecanobrac .tnebros ehT etylana syiletamit ldsueizita vhitr ie,wdAF TdSeBtTuMli dht i,weneulo tdn adezylanay b GC - MS - n e5 e.ddw 3ent egae6rnb1 ua sd r. terMnsicoIoimofSih irttlp ceehtTed m .re tawd n uL o/grGgDT lona p)oPrDpTi(dohixheT rn ootdni iie ovdtmt2iancii. thaelb1nceti(aaberdtxe m g )L/P DrTalimis ot taht fo ,GDT dna saw deredisnoc ot eb na elbatpe cectaagorr u.sdnuopmoc ehT dohtem yrevocer rofh tob setylana si ,tsedom gnignar neewteb02 - ,%04 dna stcelfer eht ytluciffid nitxe gnitcarretaw - elbicsim .elpm arsetawdnuo rmago rsfetylana ehT laci pgyntilpmas etar rof eht desopo rdpohtem yslietam iexvolrepwpta ot ner eettxaiwsdnuorg selpmas repthgie - ruoh gnikrow .yad noitarbilaC sdradnats yam eb deraperp yltnerrucnoc htiwe ht g retawdnuor ,stcartxe dna dluohs osla eb dezylana .yliad tI si ylgnorts dednemmocer taht llae lpmas noitara p eedbrepm rgonfirreupd nathgie - ruoh ,tfihs dna taht lla tneuqesbusCG - MS - snoitanim rMeItSed eppiuq etnemurtsn in agnis uyltnednepedn idemrofre peb .relpm adsetamot u nahat idw STNEMGDELWONKCA de bhi crnerci hass Teeirdsdheeetp rraso pasywnbo pesht ,S lU na y inEmyaeOrktsDAcnrouARoM .oN9891 - 770H - ,1A SU tnemtrapeD fo ygrenE rednu tcartnocED - 50CA - 52722RO00 htiw kaOe gdiR lanoitaN ,yrotarobaLnam dega ybTU - ,elletta B.CLL ehT de tttpiimrbcussuna msah neeb derohtua yba rotcartnoc fo eht SU tnemnrevoG rednu tcartnoc ED - 50CA - .52722RO00 ,ylgnidroccA eht S U y,sttennlvieaiamystnou errlarecvxoeGnon - ed seeehn hecse osruice tifdlihrlobltobruuppper m rsfoiofht .sesopr utpnemnrev o SGrU o,f o os odstreh twool l ra,onoitubirtnoc REFERENCES 1 .D ,skraP ehT sisylanA fo ymrA lacimehC ;stnegA ,BG ,XV ,dratsuM dna etisiweL ni lioS tay kcoR niatnuoM ,lanesrA detneserp ot eht51 ht launnA etsaW gnitseT dna ytilauQ ecnarussA, muisopmyS .99 9,1 A,VnotgnilrA 2 N. .B ,ornuM .S .S ,egamlaT .G .D ,niffirG .L .C ,sretaW .A .P ,nostaW .J .F ,gniK .V, dlihcsuaH .3 3)9999 17 (0s1evitcepsr ehPtla e.HnorivnE 3 .S .J nidnuL ,)de( noitacifireV folauD - esu lacimehC rednu eht lacimehC snopaeW :noitnevnoC e hT Case of Thiodiglyc ol, )4199 1s(se ryptisrevi ndUrof xO - 23. 4 nneoe iw.t traee Dccb ,i ulyn,ra rus Bn.omnd oAtminlksa okaaa rrecmnO.eog oorPbdeTiMaivtLReatNS .00 0e2n u,J O,Cyt ieCcremm o,Clanes rnAiatnu oyMkc oyRm r SA,UacaB 5 , z. , tU..r. nAhuC.eTuEihKc s. jE. iW.oJoH . 3)3949 9. 91rA4(g8otamo r,.fhnJoCamkn irB 6.9 9)1010 0.22m7 (e.hlC a,nnAamkn i ,..r.thUBA sT ,l..zuAGtH n ,e..riCEuKuhcsj i .o..EoWJH 7 .R , e.tLnac i.eJhC .R ,ffutS .H .D ,ts r.urDo hy.prJoarl tl2ciep la)EC5991.(751 8 8 ,..oLRnitsog A..’PAD .) .78 ,r798.g 190Ao,,18t k t(a.c.sm Jo Jo ofc.vronRoharCHP 9 ,.y G r. .uC,Rbu s W.,A,.W s )3 ..ma. 0 7.FmetH4 0,2liic0.0lahSA4H2lnC(iAH 01 .R .,Wda e.RR ,..krMc g a.o, lJtA )B a29.fm699oo896r11h(C 11 .R .W ,daeR .R .M ,kc a.lcBo rCPEDR E.icSnoC . 7,9 .8,dgE r,..e)DAB89 9.1 s(.e fR.elD o.imB e.hfC 21 .R k. cMdan l a.B.rR g .o,). 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