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Dolutegravir in contributing the 90:90:90 ambition Tuna LUKIANA MD, PhD Head, Medical Affairs Middle East & Africa ViiV Healthcare Yaoundé, 04th May 20161 DISCLOSURE • Employee of ViiV Healthcare working with GlaxoSmithKline 2 UNAIDS 90-90-90 target for 2020 to end AIDS by 2030 3 3 Fund 90:90:90: The Spectrum Research PMTCT Others…. High risk Population Testing Supply Chain ARV Human rights Healthcare Goverments Care and Policies Capacities Management and of co capabilities Community morbidities Social conditions s Children Prevention 4 90:90:90: The Spectrum ARV 5 2016: ARV HISTORY Genvoya, TAF ? Dolutegravir, Elvitegravir ARV Classes Rilpivirine NRTIs Etravirine NNRTIs Maraviroc, raltegravir, darunavir PIs Tipranavir Fusion inhibitor Enfuvirtide, fosamprenavir, atazanavir CCR5 inhibitor Emtricitabine Integrase inhibitor Tenofovir Lopinavir/r Efavirenz, abacavir, amprenavir Nevirapine, nelfinavir Delavirdine Stavudine, Lamivudine, saquinavir, ritonavir, indinavir Zidovudine AIDS, Zalcitabine LAV 1st case (HIV) Didanosine e 1 3 7 1 2 6 7 8 9 1 2 3 4 5 7 8 23 ru 8 8 8 9 9 9 9 9 9 0 0 0 0 0 0 0 11 t 9 9 9 9 9 9 9 9 9 0 0 0 0 0 0 0 00 u 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 2 22 F 1981 1990 2000 2010 6 Confidential and proprietary –internal use only Job code: VIIV/DGR/0007/15 Date of preparation: June 2015 2003–2010: CORE AGENTS DRIVE ADVANCEMENTS IN HIV THERAPY Meta-analysis shows that from 1995 to 2010 the overall mean efficacy of initial therapy for HIV-1 improved 7 Lee FJ et al. PLoS One 2014;9:e97482 HIV: FIGHT IS NOT OVER… 8 UNAIDS 90-90-90 target for 2020 to end AIDS by 2030 9 9 ARVs: REACH & MAINTAIN UNDETECTABILITY ? Efficacy 10

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Pregnancy. Cost effectiveness VIKING-3. DTG bid. +optimised regimen. VIKING-4. DTG bid vs. placebo for .. No ectopic pregnancy. A study is

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Pregnancy. Cost effectiveness VIKING-3. DTG bid. +optimised regimen. VIKING-4. DTG bid vs. placebo for .. No ectopic pregnancy. A study is

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Author:	Unknown
Publication Year:	2016
Pages:	47
Language:	English
File Size:	3.68
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