Disruptive Developments in Biomedical Applications This book covers advancements and future challenges in biomedical application development using disruptive technologies like artifcial intelligence (AI), the Internet of Things (IoT), and signal processing. The book is divided into four main sections, namely, medical image processing using AI; IoT and biomedical devices; biomedical signal processing; and electronic health records, including advances in biomedical systems. It includes different case studies of biomedical applications using different AI algorithms related to diabetes, skin cancer, breast cancer, cervical cancer, and osteoarthritis. Features: • Covers different technologies like AI, IoT, and signal processing in the context of biomedical applications. • Reviews medical image analysis, disease detection, and prediction. • Comprehends the advantage of recent technologies for medical record keeping through electronic health records (EHRs). • Presents state-of-the-art research in the feld of biomedical engineering using various physiological signals. • Explores different bio sensors used in healthcare applications using IOT. This book is aimed at graduate students and researchers in AI, medical imaging, biomedical engineering, and IoT. Disruptive Developments in Biomedical Applications Edited by Swati V. Shinde, Parikshit N. Mahalle, Varsha Bendre and Oscar Castillo Boca Raton London New York CRC Press is an imprint of the Taylor & Francis Group, an informa business First edition published 2023 by CRC Press 6000 Broken Sound Parkway NW, Suite 300, Boca Raton, FL 33487–2742 and by CRC Press 4 Park Square, Milton Park, Abingdon, Oxon, OX14 4RN CRC Press is an imprint of Taylor & Francis Group, LLC © 2023 selection and editorial matter, Swati V. Shinde, Parikshit N. Mahalle, Varsha Bendre and Oscar Castillo; individual chapters, the contributors Reasonable efforts have been made to publish reliable data and information, but the author and publisher cannot assume responsibility for the validity of all materials or the consequences of their use. The authors and publishers have attempted to trace the copyright holders of all material reproduced in this publication and apologize to copyright holders if permission to publish in this form has not been obtained. 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ISBN: 978-1-032-22470-1 (hbk) ISBN: 978-1-032-22471-8 (pbk) ISBN: 978-1-003-27269-4 (ebk) DOI: 10.1201/9781003272694 Typeset in Times by Apex CoVantage, LLC Contents Editor Biographies ............................................................................................................................ix List of Contributors ...........................................................................................................................xi Preface..............................................................................................................................................xv PART I AI/ML for Biomedical Applications Chapter 1 Recent Advances of Artifcial Intelligence (AI) for Nanobiomedical Applications: Trends, Challenges, and Future Prospects .............................................3 J. G. Gujar, Sonali Kadam, and Ujwal D. Patil Chapter 2 Medical Imaging Modalities and Different Image Processing Techniques: State of the Art Review .............................................................................................. 17 S. Lalitha, T. Sanjana, H. T. Bhavana, Ishan Bhan, and G. Harshith Chapter 3 Prognosis and Diagnosis of Disease Using AI/ML Techniques ................................ 37 K. V. Sandhya and Jithu Jerin James Chapter 4 AI-Based Approach for Brain Tumor Detection and Classifcation .......................... 53 Shweta Pandav and Dr. Lenina SVB Chapter 5 Prediction and Classifcation of Alzheimer’s Disease Using Machine Learning Models ........................................................................................................ 67 Santrupti M. Bagali, S. Sanjana, Priyanka. R, Sara Sadiya, and Deepa N. Reddy Chapter 6 Classifcation of Histopathology Images of Lung Cancer Using Convolutional Neural Network (CNN) ...................................................................... 75 Neha Baranwal, Preethi Doravari, and Renu Kachhoria Chapter 7 Case Study on Oropharyngeal Cancer Prediction and Diagnosis and Management Based Upon MRI, CT Scan Imaging Techniques ................................ 91 Pallavi Bhosle, Hujeb Pathan, Ganesh Tapadiya, and Md. Irshad Alam PART II IOT and Smart Healthcare Chapter 8 Introduction to Smart Healthcare Using IoMT ........................................................ 109 Varsha Bendre and Deepti Khurge v vi Contents Chapter 9 A Webcam-Based Belt-System for Respiratory and Chest-Expansion Measurements ........................................................................................................... 127 Niveditha, Rohan Gupta, Anup Bhat, Kalyana Chakravarthy Bairapareddy, Rahul Magazine, and Ramesh R. Galigekere Chapter 10 Novel Data Analysis Framework in Smart City Healthcare .................................... 147 Swapnaja Hiray and Bhramaramba Ravi PART III Bio-Signal Processing Chapter 11 Evolution of Automatic Epilepsy Detection and Classifcation Techniques: A Survey............................................................................................... 161 Neeta Hemant Chapatwala and Dr. Chirag N. Paunwala Chapter 12 Evaluation of Boosting Algorithms for P300 Detection in EEG Signals ................ 173 Priyanka Jain, Subhash Tatale, Dr. Nivedita Bhirud, Rutuja Pote, Vinaya Kumar, Purvi Sampat, and N. K. Jain Chapter 13 Comprehensive Study of Brain–Computer Interface (BCI) with Emphasis on Strategies Used for Processing the Signals ......................................... 189 Vrushali Ganesh Raut, Pranoti P. Mane, and Supriya O. Rajankar Chapter 14 Fetal Electrocardiogram Extraction Using Adaptive Filters Approach ...................203 Manjiri A. Ranjanikar, Sagar V. Joshi, Jaishri M. Waghmare, Swati V. Shinde, and Rachana Y. Patil Chapter 15 Detection of Heart Functioning Abnormalities (Arrhythmia) Using ECG Signals: A Systematic Review ..................................................................................229 Ketan Sanjay Desale, Swati V. Shinde, Vaishnavi Patil, and Parth Shrivastava Chapter 16 Heart Rate Variability Analysis in Healthy Male Subjects with Comprehensive Age Groups ............................................................................. 241 Anjali C. Birajdar and Vijaya R. Thool PART IV Electronic Health Records Chapter 17 Electronic Health Records: Need, Challenges, and Future Scope ...........................259 Priya M. Shelke and J. V. Bagade Contents vii Chapter 18 Role of EHR in Cancer Detection: Need, Challenges, and Future Scope of EHR........................................................................................................... 275 Pratiksha R. Deshmukh and Rashmi Phalnikar PART V Recent Devlopement in Biomedical Applications Chapter 19 Implantable Pacemaker Low Power Telemetry Unit................................................285 Santosh D. Chede Chapter 20 Recent Advances in Drug Delivery Systems: MEMS Perspective..........................299 H. T. Bhavana, M. Anantha Sunil, T. Sanjana, and B. Harshitha Chapter 21 Estimating the Blood-Vessel Response to Vaso-Active Agents by Microscope Video Image Processing.................................................................. 311 Rohit Nayak, Mikkel Brydegaard, and Ramesh R. Galigekere Chapter 22 Organ Donation and Transplantation Challenges, Opportunities, and the Role of Blockchain ......................................................................................325 Rachana Y. Patil, Yogesh H. Patil, Sujeet Kumar Gupta, and Aparna Bannore Index .............................................................................................................................................. 341 Editor Biographies Swati V. Shinde holds a PhD in computer science and engineering from Swami Ramanand Teerth Marathwada University, Nanded. She has a total of 22 years of teaching experience and currently is Professor of Computer Engineering and Dean—Research & Developments in Pimpri Chinchwad College of Engineering (PCCoE), Pune. She worked as a HOD-IT for seven years in PCCoE. Her research interests include machine learning, deep learning, soft computing, artifcial neural network, and fuzzy logic. She has published 95+ research papers in reputed conferences and journals. Five of these are published in the prestigious SCI indexed journals. She has received the fve Best Paper Awards at different IEEE Conferences. She has fled fve research patents and received the DST grant of almost Rs. 36 lakhs for the research project. She also has received a research grant from SPPU University, Pune, the International FDP grant from SPPU, and also the conference grant from AICTE. She is a certifed trainer and ambassador of NVDIA’s Deep Learning Institute. She was conferred the “Dr. APJ Abdul Kalam Women Achievers Award” by IItechBanglore. She was awarded the Indo Global Engineering Excellence Award by Indo Global Chamber of Commerce Industries and agriculture. She has delivered 20+ research talks in various workshops, STTPs, etc. Currently she is a SPPU-approved PhD supervisor and is guiding four PhD research scholars. Dr. Parikshit N. Mahalle is a senior member of IEEE and Professor and Head of the Department of Artifcial Intelligence and Data Science at Vishwakarma Institute of Information Technology, Pune, India. He completed his PhD at Aalborg University, Denmark, and continued as Post-Doc Researcher at CMI, Copenhagen, Denmark. He has 22+ years of teaching and research experi- ence. He is a member of the Board of Studies in Computer Engineering, Ex-Chairman Information Technology, SPPU, and various universities and autonomous colleges across India. He has nine patents, 200+ research publi- cations (Google Scholar citations-2020 plus, H index-21, and Scopus Citations are 986 with H index -14) and has authored/edited 40+ books with Springer, CRC Press, Cambridge University Press, etc. He is editor in chief for IGI Global—International Journal of Rough Sets and Data Analysis; Associate Editor for IGI Global—International Journal of Synthetic Emotions and Inter-science International Journal of Grid and Utility Computing; member of the Editorial Review Board for IGI Global—International Journal of Ambient Computing and Intelligence. His research interests are machine learning, data science, algorithms, Internet of Things, identity management and secu- rity. He is a recognized PhD guide of SSPU, Pune, and s guiding seven PhD students in the area of IoT and machine learning. Recently, four students successfully defended their PhDs. He is also the recipient of “Best Faculty Award” from Sinhgad Institutes and Cognizant Technologies Solutions. He has delivered 200+ lectures at the national and international level. Varsha Bendre received her bachelor’s degree in electronics and telecommu- nication engineering from Saint Gadge Baba Amravati University, Amravati, and her ME degree from Savitribai Phule Pune University in 2000 and 2010 respectively. After her ME, she completed her PhD in the area of nanotech- nology and low power VLSI at Savitribai Phule Pune University, Pune, and Maharashtra, India, in Jan 2020. The area of her research work is analog circuit design at a very deep submicron technology using carbon nanotube feld effect transistors. She has published fve research papers in various SCI/Scopus indexed journals and 30 research papers in peer-reviewed international conferences. ix