Diffusion Weighted and Diffusion Tensor Imaging A Clinical Guide ClaudiadaCostaLeite,MD,PhD AssociateProfessor DepartmentofRadiology UniversityofSãoPaulo SãoPaulo,Brazil AssociateProfessor DepartmentofRadiology SchoolofMedicine UniversityofNorthCarolinaatChapelHill ChapelHill,NorthCarolina MauricioCastillo,MD,FACR ProfessorofRadiology Chief,DivisionofNeuroradiology SchoolofMedicine UniversityofNorthCarolinaatChapelHill ChapelHill,NorthCarolina Thieme NewYork•Stuttgart•Delhi•RiodeJaneiro ExecutiveEditor:WilliamLamsback Important note: Medicine is an ever-changing science ManagingEditor:ElizabethPalumbo undergoingcontinualdevelopment.Researchandclinical Director,EditorialServices:MaryJoCasey experience are continuallyexpandingourknowledge, in EditorialAssistant:HaleyPaskalides particular our knowledge of proper treatment and drug ProductionEditor:SeanWoznicki therapy.Insofarasthisbookmentionsanydosageorappli- InternationalProductionDirector:AndreasSchabert cation,readersmayrestassuredthattheauthors,editors, VicePresident,EditorialandE-ProductDevelopment:Vera andpublishershavemadeeveryefforttoensurethatsuch Spillner referencesareinaccordancewiththestateofknowledgeat InternationalMarketingDirector:FionaHenderson thetimeofproductionofthebook. 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Formymother,mydaughterAnaBeatriz,mysonGabriel,andmyhusbandRicardo CCL ToHortensia MC Contents Foreword.............................................................................................. ix Preface................................................................................................. xi Contributors ........................................................................................ xiii 1 PhysicsofDiffusionWeightedandDiffusionTensorImaging....................... 1 MariaConcepciónGarciaOtaduy 2 BrainEdema:Pathophysiology .......................................................... 19 FalgunH.ChokshiandAmitM.Saindane 3 SupratentorialWhiteMatterTractsandTheirOrganization....................... 36 ChristopherP.HessandJasonM.Johnson 4 DiffusionWeightedImagingandDiffusionTensorImagingoftheBrain duringEarlyBrainDevelopment:TheFirstTwoYearsofLife ...................... 50 WeiGao,JohnHGilmore,andWeiliLin 5 DiffusionWeightedandDiffusionTensorImaginginAging ....................... 63 AndrewJosephDegnanandLucienM.Levy 6 DiffusionWeightedImaginginVascularPathology ................................. 79 SangamKanekarandChandanMisra 7 DiffusionWeightedImagingintheEvaluationofBrainTumors................... 99 FernandaC.Rueda-Lopes,CelsoHyginodaCruzJr.,andEmersonLeandroGasparetto 8 DiffusionWeightedandDiffusionTensorImaginginInfectiousDiseases...... 112 ClaudiadaCostaLeite,MariadaGraçaMoraisMartinandMauricioCastillo 9 DiffusionWeightedImagingandDiffusionTensorImaginginDemyelination andToxicDiseases......................................................................... 132 CeliSantosAndrade,CarolinadeMedeirosRimkus,ClaudiadaCostaLeite,AlexanderM.McKinney, andLeandroT.Lucato 10 DiffusionWeightedImagingandDiffusionTensorImagingofWhiteMatter DiseasesInChildren....................................................................... 154 JulieH.HarreldandZoltanPatay 11 DiffusionImagingfortheAssessmentofTraumaticBrainInjury................. 170 MichaelL.Lipton 12 DiffusionWeightedImaginginHemorrhage ........................................ 189 JoanaRamalhoandMauricioCastillo vii Contents 13 DiffusionWeightedImagingandDiffusionTensorImaginginSpineand SpinalCordDiseases...................................................................... 203 MajdaM.Thurnher 14 DiffusionWeightedImagingandDiffusionTensorImaginginHeadandNeck Diseases..................................................................................... 215 EloisaMSantiagoGebrim,ReginaLuciaEliaGomes,FlaviaK.IssaCevasco,andMarcioRicardoTaveiraGarcia 15 FutureApplicationsofDiffusionWeightedImaging:DiffusionalKurtosisand OtherNongaussianDiffusionTechniques............................................. 239 MariaGiseleMatheus Index.................................................................................................. 248 viii