Table Of ContentKazuo Emoto · Rachel Wong
Editors
Eric Huang · Casper Hoogenraad
Dendrites
Development and Disease
Dendrites
.
Kazuo Emoto • Rachel Wong • Eric Huang •
Casper Hoogenraad
Editors
Dendrites
Development and Disease
Editors
KazuoEmoto RachelWong
GraduateSchoolofScience DepartmentofBiologicalStructure
TheUniversityofTokyo UniversityofWashington
Tokyo,Japan Seattle,Washington
USA
EricHuang CasperHoogenraad
DepartmentofPathology FacultyofScience
UniversityofCaliforniaSanFrancisco UtrechtUniversity
SanFrancisco,California Utrecht,TheNetherlands
USA
ISBN978-4-431-56048-7 ISBN978-4-431-56050-0 (eBook)
DOI10.1007/978-4-431-56050-0
LibraryofCongressControlNumber:2016942328
©SpringerJapan2016
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Contents
PartI Introduction
1 Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3
KazuoEmoto,RachelWong,EricHuang,andCasperHoogenraad
PartII BasicBiologyofDendrites
2 CytoskeletalOrganization:Actin. . . . . . . . . . . . . . . . . . . . . . . . . . 9
AmrAbouElezz,RimanteMinkeviciene,andPirtaHotulainen
3 MicrotubuleOrganizationandMicrotubule-AssociatedProteins
(MAPs). . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 31
ElenaTortosa,LukasC.Kapitein,andCasperC.Hoogenraad
4 MembraneTraffickingMechanisms:ExocytosisandEndocytosis
inDendrites. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 77
BettinaWinckler
5 ActivityDependentProteinTransportfromtheSynapsetothe
Nucleus. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 111
SujoyBera,GoncaBayraktar,KatarzynaM.Grochowska,
MichelleMelgarejodaRosa,andMichaelR.Kreutz
6 UltrastructureMethods. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 125
NunoMac¸aricodaCosta
7 ImagingSignalTransductioninDendritesUsingGenetically
EncodedBiosensors.. . . .. . . .. . . .. . . .. . . .. . .. . . .. . . .. . . .. 139
HidejiMurakoshiandRyoheiYasuda
PartIII PatterningDendriticArchitectureofNeuronsandTheir
Populations
8 DendriticSelf-Avoidance. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 157
PeterSoba
v
vi Contents
9 TilingandMosaicSpacingofDendrites. . . . . . . . . . . . . . . . . . . . . 181
JayZ.Parrish
10 MosaicsandLaminationintheRetina. . . . . . . . . . . . . . . . . . . . . . 213
PeterG.Fuerst
11 ModifyingDendriticStructureAfterFunction. . . . . . . . . . . . . . . . 245
YuanWangandEdwinW.Rubel
PartIV CellularandMolecularControlofDendriteDevelopment
andMaintenance
12 MolecularControlofDendriticRemodeling. . . . . . . . . . . . . . . . . . 273
KazuyaTogashi,HiroyukiKoizumi,TakahiroKanamori,
andKazuoEmoto
13 Experience-DependentDendriticArborDevelopment. . . . . . . . . . 295
HollisT.Cline
14 DendriteMaintenance. .. . . . . . . .. . . . . . . .. . . . . . . .. . . . . . . .. 317
SaraMarieKatranchaandAnthonyJ.Koleske
PartV SynapseFormationOntoDendrites
15 MolecularAssemblyofExcitatorySynapses. . . . . . . . . . . . . . . . . . 359
HirohideIwasaki,ShinjiTanaka,andShigeoOkabe
16 LocalisingReceptorsandChannelsAcrosstheDendriticArbour. . . 387
ArthurBikbaev,Mae¨lDume´nieu,JeffreyLopez-Rojas,andMartinHeine
17 AdhesionMoleculesinSynapseAssemblyandFunction. . . . . . . . . 425
PeterChipmanandYukikoGoda
18 ExcitatoryandInhibitorySynapticPlacementandFunctional
Implications. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 467
KatherineL.VillaandEllyNedivi
19 DevelopmentofSynapticInputPatternsonDendritesofRetinal
Neurons. .. . . .. . . .. . . .. . . .. . . .. . .. . . .. . . .. . . .. . . .. . . .. 489
FlorenceD.D’OraziandTakeshiYoshimatsu
PartVI DendritesinDisease
20 DendritesinAutismSpectrumDisorders. . . . . . . . . . . . . . . . . . . . 525
Ver(cid:2)onicaMart´ınez-Cerde~no,IzumiMaezawa,andLee-WayJin
21 MechanismsofDendriteDegenerationinAmyotrophicLateral
Sclerosis. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 545
SebumLee,YuleiShang,andEricJ.Huang
Contents vii
22 DendriteDegenerationinGlaucoma. . . . . . . . . . . . . . . . . . . . . . . . 581
LucaDellaSantinaandYvonneOu
Index. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 599
Part I
Introduction
Chapter 1
Introduction
KazuoEmoto,RachelWong,EricHuang,andCasperHoogenraad
Abstract Dendritesarecellularstructuresessentialfortheintegrationofneuronal
information. The immense variety but stereotypic architecture of dendritic arbors
acrossthenervoussystem,havelongsuggestedthatdendriticstructureandfunction
are organized to meet the processing needs unique to each circuit. Technological
advanceshavegreatlypushedthefrontiersinresearchondendritesatmacroscopic
andmicroscopic levels.As such, there has been increasing effortsandknowledge
gained in elucidating the structural, functional and molecular mechanisms that
regulate the development of dendritic arbors, and that maintain their form and
function throughout life. Moreover, as we seek to repair the damaged nervous
system, it is clear that a better understanding of how dendrites are perturbed in
neurodegenerativediseaseisneeded.Inthisbook,weintroducethebasicbiologyof
dendrites, and discuss current knowledge of the mechanisms that control cellular,
molecular and functional aspects of dendritic development and maintenance in
healthandindisease.
Dendritesaretheessentialsubstrateforreceivingandintegratingneuronalinforma-
tion.Theseelegantbutcomplexstructureshavebeenstudiedformorethanacentury
sincetheirvisualizationusingcellularstainingmethodsdevisedinthelatenineteenth
centurybyCamilloGolgi(Fig.1.1a;Golgi1873).SantiagoRamonyCajal’s(1899–
1904)initialandinsightfuldefinitionoftheroleofdendritesinneuronalprocessing
was borne out by electrophysiological investigations that became feasible in the
mid-1900s.Sincethen,anentirefieldhasevolved–thestudyofdendriticstructure
K.Emoto(*)
DepartmentofBiologicalSciences,GraduateSchoolofScience,TheUniversityofTokyo,
Tokyo,Japan
e-mail:[email protected]
R.Wong
DepartmentofBiologicalStructure,UniversityofWashington,Seattle,WA,USA
E.Huang
DepartmentofPathology,UniversityofCaliforniaSanFrancisco,SanFrancisco,CA,USA
C.Hoogenraad
CellBiology,FacultyofScience,UtrechtUniversity,Utrecht,TheNetherlands
©SpringerJapan2016 3
K.Emotoetal.(eds.),Dendrites,DOI10.1007/978-4-431-56050-0_1
