Copper Amine Oxidases: Structures, Catalytic Mechanisms and Role in Pathophysiology

376 Pages·2009·7.97 MB·English

by  Giovanni Floris

C o p p e r A m i n e
O x i d a s e s
Structures, Catalytic Mechanisms,
and Role in Pathophysiology

C o p p e r A m i n e
O x i d a s e s
Structures, Catalytic Mechanisms,
and Role in Pathophysiology
Edited by
Giovanni Floris
Bruno Mondovì
Boca Raton London New York
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Library of Congress Cataloging-in-Publication Data
Copper amine oxidases : structures, catalytic mechanisms, and role in
pathophysiology / edited by Giovanni Floris and Bruno Mondovì.
p. ; cm.
Includes bibliographical references and index.
ISBN-13: 978-1-4200-7680-6 (hardcover : alk. paper)
ISBN-10: 1-4200-7680-9 (hardcover : alk. paper)
1. Amine oxidase. 2. Copper enzymes. I. Floris, Giovanni, 1945- II. Mondovì,
Bruno.
[DNLM: 1. Amine Oxidase (Copper-Containing)--metabolism. 2. Amine
Oxidase (Copper-Containing)--pharmacology. QU 140 C785 2009]
QP603.M6C67 2009
572’.548--dc22 2008038892
Visit the Taylor & Francis Web site at
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Contents
Acknowledgments .....................................................................................................ix
Introduction: The Dawn of Pink Enzymes ...............................................................xi
Editors ......................................................................................................................xv
Contributors ...........................................................................................................xvii
Abbreviations ..........................................................................................................xxi
Chapter 1 History ..................................................................................................1
Franca Buffoni
Chapter 2 Nomenclature and Potential Functions of Copper Amine
Oxidases................................................................................................5
Sinéad Boyce, Keith F. Tipton, Michael I. O’Sullivan, Gavin P. Davey,
Martha Motherway Gildea, Andrew G. McDonald, Aldo Olivieri, and Jeff
O’Sullivan
Chapter 3 Cofactors of Amine Oxidases: Copper Ion and Its
Substitution and the 2,4,5-Trihydroxylphenylalanine
Quinone ..............................................................................................19
Shinnichiro Suzuki, Toshihide Okajima, Katsuyuki Tanizawa, and Minae Mure
Chapter 4 Copper Amine Oxidases from Plants.................................................39
Rosaria Medda, Andrea Bellelli, Pavel Pecˇ, Rodolfo Federico, Alessandra
Cona, and Giovanni Floris
Chapter 5 Soluble Copper Amine Oxidases from Mammals..............................51
Paola Pietrangeli, Laura Morpurgo, Bruno Mondovì, Maria Luisa Di Paolo,
and Adelio Rigo
Chapter 6 Membrane-Bound Copper Amine Oxidases ......................................69
Andrew Holt
Chapter 7 Copper Amine Oxidase Genes ...........................................................87
Ivo Frébort and Hubert G. Schwelberger
v
vi Contents
Chapter 8 Mechanism of TPQ Biogenesis in Prokaryotic
Copper Amine Oxidase ....................................................................103
Toshihide Okajima and Katsuyuki Tanizawa
Chapter 9 Copper Amine Oxidase Crystal Structures ......................................119
J. Mitchell Guss, Giuseppe Zanotti, and Tiina A. Salminen
Chapter 10 Plasma Amine Oxidases in Various Clinical Conditions
and in Apoptosis .............................................................................143
Frans Boomsma, Anton H. van den Meiracker, and Antonio Toninello
Chapter 11 Copper Amine Oxidases in Intestinal Diseases .............................159
Wieslawa Agnieszka Fogel, Ewa Toporowska-Kowalska, and Anna Stasiak
Chapter 12 Copper Amine Oxidases in Adipose Tissue-Related
Disorders .........................................................................................177
Christian Carpéné
Chapter 13 Copper Amine Oxidases in Adhesion Molecules in Renal
Pathology and in Alzheimer’s Disease and VAP-1 in
Leukocyte Migration ......................................................................195
Peter Boor, Mercedes Unzeta, Marko Salmi, and Sirpa Jalkanen
Chapter 14 Inhibitors of Copper Amine Oxidases: Past,
Present, and Future .........................................................................219
Marek Šebela and Lawrence M. Sayre
Chapter 15 Pharmacological Applications of Copper Amine
Oxidases..........................................................................................239
Emanuela Masini and Laura Raimondi
Chapter 16 Copper Amine Oxidases as Antioxidant and
Cardioprotective Agents .................................................................253
Mircea Alexandru Mateescu and Réginald Nadeau
Contents vii
Chapter 17 Biotechnological Aspects of Copper Amine Oxidases ..................261
Roberto Stevanato
Chapter 18 Concluding Remarks ......................................................................275
David M. Dooley
References ..............................................................................................................279
Index ......................................................................................................................325

Acknowledgments
The editors wish to thank Drs. Francesca Pintus and Delia Spanò of the Department
of Applied Sciences in Biosystems, Cagliari University, Italy, for their valuable help
in the preparation of this book.
ix