Computers in Biology and Medicine VOLUME 27 1997 LIST OF CONTENTS AND AUTHOR INDEX © PERGAMON Computers in Biology and Medicine An International Journal Editor-in-Chief: ROBERT S. LEDLEY National Biomedical Research Foundation, Georgetown University Medical Center, 3900 Reservoir Road, N.W., Washington, DC 20007, U.S.A. Managing Editor: BLAIRE V. MOSSMAN P.O. Box 13177, Scottsdale, AZ 85267-3177, U.S.A. European Deputy Editor: FRANCESCO PINCIROLI Dipartimento di Bioingegneria, Politecnico di Milano, Piazza Leonardo da Vinci, 32, 20133 Milano, Italy Associate Editors E. NEELY ATKINSON, U.S.A. H. K. Huanae, U.S.A. JAMES A. REGGIA, U.S.A. WILLIAM R. Ayers, U.S.A. ROGER JELLIFFE, U.S.A. R. P. CHANNING Ropers, U.S.A. Coin B. Bec, U.S.A. INGER KJAER, Denmark J. ROSING, The Netherlands MICHAEL Buas, U.S.A. CASIMIR A. KULIKOWSKI, U.S.A. FRANK H. RuDDLE, U.S.A. C. A. CACERES, U.S.A. CHAN F. Lam, U.S.A. PETER SANTAGO, U.S.A. ALDEN W. DUDLEY Jr, U.S.A. FRED D. LEDLEY, U.S.A. EUGENE S. SCHNELLER, U.S.A. Gary S. LEDLEY, U.S.A. ROBERT M. ELASHOFF, U.S.A. JOHN L. SEMMLOw, U.S.A. STEVEN L. LEHMAN, U.S.A. MARIO FERRARO, Italy WESLEY E. SNYDER, U.S.A. JAMES M. Lester, U.S.A. PAUL D. FISHER, Canada BENI SOLOW, Denmark CLIFF LIEBERMAN, U.S.A. DavipD H. Foster, U.K. THOMAS O. Stair, U.S.A. ZHI-QIANG Liv, Australia H. L. L. FRANK, The LAWRENCE STARK, U.S.A. Netherlands HERBERT A. Luss, Norway STANLEY TUHRIM, U.S.A. ROBERT S. GALEN, U.S.A. JOCHEN R. MoOEHR, Canada SHIRO UsulI, Japan Davip G. GEorGE, U.S.A. RICHARD Moore, U.S.A. RUSSELL E. WALKER, U.S.A. STEPHEN L. GEORGE, U.S.A. KENNETH L. MossMANn, U.S.A. EDMUND M. Giaser, U.S.A. Davip A. NaGey, U.S.A. RICHARD F. WALTERS, U.S.A. RICHARD L. WEBBER, U.S.A. F. P. Giick, Canada ANDERS NATTESTAD, Denmark H. C. HEMKER, The Netherlands BRUCE OrcUuTT, U.S.A. PAMELA H. Wotr, U.S.A. RoGER A. HorTon, U.S.A. YUN PENG, U.S.A. STUART ZIMMERMAN, U.S.A. GEORGE Hripcsak, U.S.A. DENIS J. PRoTTI, Canada A. E. ZUCKERMAN, U.S.A. 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Computers in Biology and Medicine (ISSN 0010-4825) is published in January, March, May, July, September and November in one volume, by Elsevier Science Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, U.K. The annual subscription in the U.S.A. is US$812. Computers in Biology and Medicine is distributed by Mercury Airfreight International Ltd, 2323 Randolph Avenue, Avenel, NJ 07001-2413. Postmaster: please send address corrections to Computers in Biology and Medicine, c/o Elsevier Science RSO, Customer Support Department, 655 Avenue of the Americas, New York, NY 10010, U.S.A. [Tel.: (+1) 212-633-3730/1 888 4ES-INFO. Fax: (+1) 212-633-3680. E-mail: [email protected]]. Cooperating Societies—American Institute of Nutrition; American Society of Biological Chemists; American Society for Pharmacology and Experimental Therapeutics Inc.; Association for Computing Machinery: Biophysical Society; Pattern Recognition Society; Federation of European Biochemical Societies; The Danish Biochemical Society; Societa Italiana di Biochimica; Nederllands Vereniging Voor Biochemie; Sveriges Biokemiska Forening. Listing as a cooperating society does not imply endorsement or sponsorship of Computers in Biology and Medicine by individual societies. © 1997 Elsevier Science Ltd. All rights reserved CONTENTS OF VOLUME 27 Number 1 H. C. Tuckwell and P. Lansky ] On the simulation of biological diffusion processes G. Zouridakis and D. C. Tam Multi-unit spike discrimination using wavelet transforms C. E. Kahn Jr, L. M. Roberts, Construction of a Bayesian network for mammo- K. A. Shaffer and P. Haddawy graphic diagnosis of breast cancer E. E. Westberg, N. H. Mann III Integrating and presenting clinical and treatment and D. M. Spengler outcome data for cost-effective case management J. Sun, E. Shibata, M. Kamijima, An efficient SAS program for exact stratification of M. Toida and Y. Takeuch person-years L. Ohno-Machado A comparison of Cox proportional hazards and artificial neural network models for medical prognosis H. Ogura, H. Agata, M. Xie, T. Odaka A study of learning splice sites of DNA sequence by and H. Furutani neural networks Number 2 F. J. Sanchez-Marin 77 The curvature function evolved in scale-space as a representation of biological shapes Y. Eshel and S. Abboud Correlation between source asymmetry and scalp potential asymmetry in a prolate spheroid model of the head W. E. Higgins and R. D. Swift Distributed system for processing 3D medical images B. He, S. Bansal, A. Tsai A comparison of volume conductor effects on body and J. P. Saul surface Laplacian and potential ECGs: a model study R. Benlamri, M. Batouche, S. Rami An automated system for analysis and interpretation and C. Bouanaka of epileptiform activity in the EEG S.C. Cassidy and D. F. Teitel Left ventricular pressure and volume data acquisition and analysis using LabVIEW™ T. Lehmann, A. Sovakar, A comparison of similarity measures for digital W. Schmitt and R. Repges subtraction radiography G. van Bebber, W. Doeler, Applying local statistics to detect subtle G-bands in R. Greinert and D. Harder chromosomes Ill Contents of Volume 27 Number 3 R. Miiller, M. Sergl, U. Nauerth, 177 THEMPO: a knowledge-based system for therapy D. Schoppe, K. Pommerening planning in pediatric oncology and H.-M. Dittrich A. Brai and Ph. Garnerin AUDILAB: a_ knowledge-based quality audit simulator for testing laboratories L. Tang, M. Ohya, Y. Sato, H. Naito, Cancellation of motion artifact in MRI due to 2D K. Harada and S. Tamura rigid translational motion M. I. Osman Exploring a mixture of distributions using Minitab A. Redaelli, F. Boschetti and F. Inzoli The assignment of velocity profiles in finite element simulations of pulsatile flow in arteries R. L. Summers, J.-P. Montani, Theoretical analysis of the mechanisms of chronic L. H. Woodward, T. G. Coleman hyperinsulinemia and J. E. Hall Number 4 K. Sakai, P. Sajda, S.-C. Yen 257 Coarse-grain parallel computing for very large scale and L. H. Finkel neural simulations in the NEXUS _ simulation environment L. Ohno-Machado and M. A. Musen Sequential versus standard neural networks for pattern recognition: an example using the domain of coronary heart disease I. Hammel and D. Lagunoff Determination of mean particle volume, a Monte Carlo simulation A. F. Kohn Computer simulation of noise resulting from random synaptic activities C. A. Phillips, D. W. Repperger The acceleration—velocity relationship: identification and T. L. Chelette of normal and spastic upper extremity movement L. V. Philosophov and L. G. Ryabinina Medical diagnostic decision rules based on mutually dependent diagnostic factors Number 5 SPECIAL ISSUE: TIME-ORIENTED SYSTEMS IN MEDICINE C. Combi and Y. Shahar 349 Guest Editors’ Introduction to the special issue on Time-oriented Systems in Medicine C. Combi and Y. Shahar Temporal reasoning and temporal data maintenance in medicine: issues and challenges Contents of Volume 27 V I. A. Goralwalla, M. T. Ozsu 369 Modeling medical trials in pharmacoeconomics using and D. Szafron a temporal object model W. Horn, S. Miksch, G. Egghart, 389 Effective data validation of high-frequency data: C. Popow and F. Paky time-point-, time-interval-, and trend-based methods C. F. Aliferis, G. F. Cooper, 411 Representing and developing temporally abstracted M. E. Pollack, B. G. Buchanan knowledge as a means towards facilitating time and M. M. Wagner modeling in medical decision-support systems L. Chittaro and M. Dojat 435 Using a general theory of time and change in patient monitoring: experiment and evaluation L. Ngo, P. Haddawy, R. A. Krieger 453 Efficient temporal probabilistic reasoning via and J. Helwig context-sensitive model construction Number 6 J. K.-J. Li, J. Y. Zhu and M. Nanna 477 Computer modeling of the effects of aortic valve stenosis and arterial system afterload on left ventricular hypertrophy S. B. Jiang, Z.-M. Luo, T. Pawlicki 487 A fast numerical algorithm for electron mean energy and K. M. Ayyangar calculation in radiation therapy D. W. Repperger, C. C. Ho, 493 Microprocessor based spatial TENS (transcutaneous P. Aukuthota, C. A. Phillips, electric nerve stimulator) designed with waveform D.C. Johnson and S. R. Collins optimality for clinical evaluation in a pain study B.-Z. Liu, J. Peng, Y.-C. Sun 507 A comprehensive dynamical model of pulsatile and Y.-W. Liu secretion of the hypothalamo-pituitary-gonadal axis in man J.C. Barry, U. M. Pongs and W. Hillen 515 Algorithm for Purkinje images I and IV and limbus centre localization T. Lee, V. Ng, R. Gallagher, 533 DullRazor*: a software approach to hair removal A. Coldman and D. McLean from images I Volume Contents and Author Index to Volume 27, 1997