Circulating Nucleic Acids in Early Diagnosis, Prognosis and Treatment Monitoring: An Introduction PDF
Preview Circulating Nucleic Acids in Early Diagnosis, Prognosis and Treatment Monitoring: An Introduction
Advances in Predictive, Preventive and Personalised Medicine Series Editor: Olga Golubnitschaja Peter B. Gahan Editor Circulating Nucleic Acids in Early Diagnosis, Prognosis and Treatment Monitoring An Introduction Circulating Nucleic Acids in Early Diagnosis, Prognosis and Treatment Monitoring Advances in Predictive, Preventive and Personalised Medicine Volume 5 Series Editor: Olga Golubnitschaja Managing Editor: Kristina Yeghiazaryan Forfurthervolumes: http://www.springer.com/series/10051 Peter B. Gahan Editor Circulating Nucleic Acids in Early Diagnosis, Prognosis and Treatment Monitoring An Introduction Editor PeterB.Gahan Anatomy&HumanSciences King’sCollegeLondon London UnitedKingdom ISSN2211-3495 ISSN2211-3509(electronic) ISBN978-94-017-9167-0 ISBN978-94-017-9168-7(eBook) DOI10.1007/978-94-017-9168-7 SpringerDordrechtHeidelbergNewYorkLondon LibraryofCongressControlNumber:2014954083 ©SpringerScience+BusinessMediaDordrecht2015 Thisworkissubjecttocopyright.AllrightsarereservedbythePublisher,whetherthewholeorpart of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation,broadcasting,reproductiononmicrofilmsorinanyotherphysicalway,andtransmissionor informationstorageandretrieval,electronicadaptation,computersoftware,orbysimilarordissimilar methodologynowknownorhereafterdeveloped.Exemptedfromthislegalreservationarebriefexcerpts inconnectionwithreviewsorscholarlyanalysisormaterialsuppliedspecificallyforthepurposeofbeing enteredandexecutedonacomputersystem,forexclusiveusebythepurchaserofthework.Duplication ofthispublicationorpartsthereofispermittedonlyundertheprovisionsoftheCopyrightLawofthe Publisher’s location, in its current version, and permission for use must always be obtained from Springer.PermissionsforusemaybeobtainedthroughRightsLinkattheCopyrightClearanceCenter. ViolationsareliabletoprosecutionundertherespectiveCopyrightLaw. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publicationdoesnotimply,evenintheabsenceofaspecificstatement,thatsuchnamesareexempt fromtherelevantprotectivelawsandregulationsandthereforefreeforgeneraluse. While the advice and information in this book are believed to be true and accurate at the date of publication,neithertheauthorsnortheeditorsnorthepublishercanacceptanylegalresponsibilityfor anyerrorsoromissionsthatmaybemade.Thepublishermakesnowarranty,expressorimplied,with respecttothematerialcontainedherein. Printedonacid-freepaper SpringerispartofSpringerScience+BusinessMedia(www.springer.com) TO MAURICE STROUN who overcame scientific and political resistance to lay the foundations leading to the current studies on circulating nucleic acids. ThiSisaFMBlankPage What This Book Series Is About… Current Healthcare: What Is Behind the Issue? Formanyacuteandchronicdisorders,thecurrenthealthcareoutcomesareconsid- ered as being inadequate: global figures cry for preventive measures and personalisedtreatments.Infact,severechronicpathologiessuchascardiovascular disorders, diabetes and cancer are treated after onset of the disease, frequently at near end-stages. Pessimistic prognosis considers pandemic scenario for type 2 diabetes mellitus, neurodegenerative disorders and some types of cancer over the next 10–20 years followed by the economic disaster of healthcare systems in a globalscale. Advanced Healthcare Tailored to the Person: What Is Beyond the Issue? Advancedhealthcarepromotestheparadigmchangefromdelayedinterventionalto predictivemedicinetailoredtotheperson,fromreactivetopreventivemedicineand from disease to wellness. The innovative predictive, preventive and personalised medicine (PPPM) is emerging as the focal point of efforts in healthcare aimed at curbing the prevalence of both communicable and non-communicable diseases such asdiabetes, cardiovascular diseases,chronicrespiratory diseases, cancer and dentalpathologies.Thecost-effectivemanagementofdiseasesandthecriticalrole of PPPM in modernisation of healthcare have been acknowledged as priorities by global andregionalorganisations andhealth-related institutionssuch astheOrga- nisation of United Nations, the European Union and the National Institutes of Health. vii viii WhatThisBookSeriesIsAbout… Why Integrative Medical Approach by PPPM as the Medicine of the Future? PPPM is the new integrative concept in healthcare sector that enables to predict individualpredispositionbeforeonsetofthedisease,toprovidetargetedpreventive measuresandcreatepersonalisedtreatmentalgorithmstailored tothe person. The expectedoutcomesareconducivetomoreeffectivepopulationscreening,preven- tionearlyinchildhood,identificationofpersonsatrisk,stratificationofpatientsfor theoptimaltherapyplanning,andpredictionandreductionofadversedrug-drugor drug-disease interactions relying on emerging technologies, such as pharmaco- genetics, pathology-specific molecular patterns, sub-cellular imaging, disease modelling, individual patient profiles, etc. Integrative approach by PPPM is con- sideredasthemedicineofthefuture.Beingattheforefrontoftheglobalefforts,the European Association for Predictive, Preventive and Personalised Medicine (EPMA, http://www.epmanet.eu/) promotes the integrative concept of PPPM amonghealthcarestakeholders,governmentalinstitutions,educators,fundingbod- ies,patientorganisationsandinthepublicdomain. CurrentBookSeries,publishedbySpringerincollaborationwithEPMA,over- viewmultidisciplinaryaspectsofadvancedbio-medicalapproachesandinnovative technologies.Integrationofindividualprofessionalgroupsintotheoverallconcept of PPPM is a particular advantage of this book series. Expert recommendations focusonthecost-effectivemanagementtailoredtothepersoninhealthanddisease. Innovativestrategiesareconsideredforstandardisationofhealthcareservices.New guidelines are proposed for medical ethics, treatment of rare diseases, innovative approaches to early and predictive diagnostics, patient stratification and targeted prevention in healthy individuals, persons at risk, individual patient groups, sub- populations,institutions,healthcareeconomyandmarketing. WhatThisBookSeriesIsAbout… ix Prof.Dr.OlgaGolubnitschaja BookSeriesEditor Dr.Golubnitschaja,DepartmentofRadiology,MedicalFacultyoftheUniversity in Bonn, Germany, has studied journalism, biotechnology and medicine and has beenawardedfellowshipsforbiomedicalresearchinPaediatricsandNeurosciences (MedicalCentresinAustria,Russia,UK,Germany,theNetherlands,andSwitzer- land). She is well-cited in the research fields of “gene hunting” and “subtractive hybridisation”appliedtopredictiveprenatalandpostnataldiagnosticspublishedas O. Labudova in years 1990–2000. Dr. Golubnitschaja is an expert in molecular diagnosticsactivelypublishinginthefieldsofophthalmicdiseases,neurodegener- ative pathologies, cancer, cardiovascular disease, Diabetes mellitus, hyperhomo- cysteinemia, etc. She is the cofounder of the theory of individual patient profiles, author of fundamental works in systems medicine (holistic approach considering molecularpatternsatepi/genomic,transcriptionalandpost/translationallevels).Dr. Golubnitschaja holds appointments, at the rank of Professor, at several European Universities and in International Programmes for Personalised Medicine, and is authorofmorethan300internationalpublicationsinthefield.Herawardsinclude: NationalandInternationalFellowshipoftheAlexandervonHumboldt-Foundation, Highest Prize in Medicine and Eiselsberg-Prize in Austria. She is Secretary-Gen- eral of the “European Association for Predictive, Preventive and Personalised Medicine”(EPMAinBrussels,www.epmanet.eu),Editor-in-ChiefofTheEPMA- Journal (BioMed Central, London); Book Editor of Predictive Diagnostics and Personalized Treatment: Dream or Reality, Nova Science Publishers, New York 2009; Book Co-editor Personalisierte Medizin, Health Academy, Dresden 2010; Book Series Editor of Advances in Predictive, Preventive and Personalised Med- icine, Springer 2012; European Representative in the EDR-Network at the NIH/ NCI, http://edrn.nci.nih.gov/; Advisor and Evaluator of projects dedicated to personalisedmedicineattheEU-CommissioninBrussels,NIH/NCI,Washington, DC,USA,andFoundationsandNationalMinistriesofHealthinseveral countries worldwide.
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