Ciba Foundation Symposium - Peripheral Circulation in Man

251 Pages·1954·4.188 MB·English

PERIPHERAL CIRCULATION
IN MAN
Ciba Foundation Symposia
General Volumes:
Toxemias of Pregnancy . . . . . . . 21s.
Isotopes in Biochemistry . . . . . . 27s. 6d.
Visceral Circulation . . . . . . . . . 30s.
The Spinal Cord . . . . . . . . . . 30s.
The.Chemica1 Structure of Proteins . . . 25s.
PrTesisesruveast ion. an. d .T ra. ns.p la.n ta.t io.n o.f N.o rm. a.l 25s.
The Kidney . . . . . . . .
Hypertension: Neurogenic and
. . . . . . In preparation
Humoral Factors
Leukremia Research . . . . . .
A CIBA FOUNDATION SYMPOSIUM
PERIPHERAL
CIRCULATION IN MAN
Editors for the Ciba Foundation
G. E. W. WOLSTENHOLME, O.B.E.,M.A.,M.B., B.Ch.
and
JESSIE S. FREEMAN, M.B., B.S., D.P.H.
Assisted by
JOAN ETHERINGTON
With 72 Illustrations
LONDON
J. & -A.C HURCHILL Ltd.
104 GLOUCESTER PLACE, W.l
1954
THE CIBA FOUNDATION
for the Promotion of International Co-operation in Medical
and Chemical Research
41 PORTLANDPL ACEL, ONDONW, .1
Trustees:
DR. E. D. ADRIANO, .M., P.R.S.
THER IGHTH ON.L ORDB EVERIDGKE.,C .B., F.B.A
THE RIGHTH ON. LORDH ORDERG, .C.V.O.
MR. RAYMONNDE EDHAMQ, .C.
Director:
DR. G. E. W. WOLSTENHOLMO.EB,. E.
Seeretaty :
MISS N. BLAND
Scientific Assistant and Librarian:
MISS M. P. CAMERON>L, A.
Editorial Assistant:
MISS JOANE THERINGTON
ALL RIGHTSR ESERVED
This book may not be reproduced by
any means, in whole or in part, with-
out the permi.ssion of the Publishers
Printed in Great Britain
PREFACE
THEC iba Foundation is an international centre, establiShed
as an educational and scientific charity under the laws of
England. It owes its inception and support to its founder,
Ciba Limited of Switzerland, but is administered exclusively
by its distinguished Trustees.
As one part of the Foundation’s activities, informal
symposia or colloquia, strictly limited in membership, are
arranged, to which leading research workers from different
countries and different disciplines are invited. As the small-
ness of the group necessarily excludes many others active and
interested in the subjects discussed, the proceedings are being
published and made available throughout the world.
“Peripheral Circulation in Man” was the subject of a
symposium arranged in succession to one held and published
earlier on Vi’isceral Circulation”. It was largely initiated by
LL
Prof. A. C. Burton, Prof. J. H. Dible, and Dr. 0. G. Edholm,
to whom the Director of the Foundation is greatly indebted
for support and advice in its organisation.
The book covers the methods for studying blood flow, the
changes in circulation due to exposure to cold or heat,
the actions of adrenaline and noradrenaline on blood flow, the
neurohistology and reflex control of the circulation and the
effects of sympathectomy, the significance of cold agglutinins,
and the influence of visceral activity on the peripheral cir-
culation.
To an understanding of these problems, important workers
in this field, whether anatomist, physiologist, biophysicist,
pathologist, physician, surgeon, or in aviation medicine,
have contributed.
It is hoped that the papers and discussions presented here
will prove mt only informative and stimulating, but will also
give a sense of participation in this informal and friendly
occasion.
Y

CONTENTS
PAGE
Chairman’s Opening Remarks
DR. 0. G. EDHOLNBSIC.,, MB, BS (M.R.C. Laboratories,
Hampstead, London) . 1
A critical survev of methods available for the measurement
of human peripheral blood flow
A. c. BURTONM, A., PhD (Dept. of Biophysics, univ. of
Western Ontario) 3
Discussion
A. C. BURTONK, . E. COOPERG, . S. DAWES,A . C. DORN-
HORST, P. GASKELLA, . D. M. GREENFIE.L D,A . B. HERTZ-
MAN, R. B. LYNN,R . J. WHITNEY 20
The venous occlusive technique for measurement of finger
blood flow
G. E. BURCH,J r., MD, (Dept. of Medicine, Tulane Univ.,
.
Louisiana) 23
Discussion
H. BARCROFGT. , E. BURCH,J r., A. C. BURTON,G . S.
DAWES,A . C. DORNHORST0,. G. EDROLMA. , B. HERTZ-
.
MAN, J. T. SHEPHERAD. , Y. WERNER 42
The electrical strain gauge method for measurement of
peripheral circulation in man
R. J. WHITNEY, PhD . (M.R.C. Climate and Working
Efficiency Unit, Oxford) 45
Discussion
H. BARCROFTA, . C. BURTON,G . S. DAWES, A. C.
DORNHORST0, . G. EDHOLMA., D. M. GREENFIEL.D ,
D. McK. KERSLAKEJ, . T. SHEPHERDR, . J. WHITNEY 53
The transparent chamber technique for observation of
the peripheral circulation, as studied in mice
G. H. ALGIRE( Nat. Cancer Institute, Bethesda, Maryland) 58
Discussion
G. H. ALGIRE,A . C. BURTON,J . H. DIBLE, U. S. VON
EULERP, . GASKELL,R . T. GRANT, A. B. HERTZMAN,
.
G. WEDDELL 63
vii
CONTENTS
Viil
PAGE
Differential secretion of noradrenaline and adrenaline
from the suprarenal gland
U. S. VON EU.L ERM, D (Fysiologiska Inst., Karolinska Inst.,
Stockholm) 68
Discussion
A. C. BURTONH, . DALE, .0 . G. EDHOLMU,. S. VON
EULERA,. B. HERTZMAN 73
The effect of adrenaline and noradrenaline on the blood
flow through human skeletal muscle
R. F. WKELANM, D, BCh (Dept. of Physiology, Queen’s Univ.,
Belfast) 75
Discussion
A. AHMADE, . ASMUSSENH,. BARCROFTG,. E. BURCHJ,r .,
A. C. BURTONK,. E. COOPER, H. DALE,G . S. DAWESA, . C.
DORNHORS0T., G. EDHOLMU., S. VON EULERA, . D. M.
GREENFIELD,A . B. €€ERTZMAN, P. HOW. ARDJ,. T.
SHEPHERDG, . WEDDELLR, . F. WHELAN 81
Changes in peripheral circulation with exposure to cold
L. D. CARLSON( Dept. of Physiology and Biophysics, Univ.
.
of Washington, Seattle) 92
The response to cold in the range 0-10°C.
A. D. M. GREENFIELDD., SC,M B, BS (Dept. of Physiology,
Queen’s Univ., Belfast) 105
Discussion
G. E. BURCHJ, R.,A . C. BURTONL, . D. CARLSON,A . C.
DORNHORS0T., G. EDHOLMU., S. VON EULERA,. D. M.
GREENFIELD,A . B. HERTZMANM,. NIELSEN, J. T.
SHEPHERDR,. F. WHELANR, . J. WHITNEY : 109
Factors concerned in the regulation of skin blood flow
D. McK. KERSLAKEP,h D, MB, BS (R.A.F. Inst. of Aviation
Medicine, Farnborough, Hants) and K. . E. COOPER,M SCM, B,
BS (M.R.C. Labs., Hampstead) 115
Blood flow response to temperature and other factors
H. BARCROFMTA, , MD,F RS (Sherrington School of Physiology,
St. Thomas’s Hospital), and A. C. DORNHORSMTD, , . MRCP.
Dept. of Medicine, St. Thomas’s Hospital, London) 122
CONTENTS ix
PAGE
Discussion
E. ASMUSSENH, . BARCROFTG, . E. BURCH,J R.,A . C.
BURTON,L . D. CARLSON, G. S. DAWES,J . H. DIBLE,
A. C. DORNHORST0,. G. EDHOLMR,. T. GRANT,
A. D. M. GREENFIELD,A . B. ~RTZMAN. , D. McK..
KERSLAKEJ,. T. SHEPHERDR, . J. WHITNEY 126
Observations on the neurohistology of cutaneous blood
vessels
G. WEDDELLD, SC, MD, and W. PALLIE,M B, BS (Dept. of.
Human Anatomy, Univ. of Oxford) 132
Discussion
L. D. CARLSON, A. C. DORNHORSTU,. S. VON EULER,
R. T. GRANT,A . D. M. GREENFIELDA, . B. HERTZMAN,
. .
G. WEDDELL 141
Reflex control of the cutaneous circulation
K. %. COOPER, MSC,M B, BS (M.R.C. Labs., Hampstead),
and D. MCK. KERSLAKE, RLD, MB, BS .( R.A.F. hst. of.
Aviation Medicine, Farnborough, Hants) 143
Discussion
A. C. BURTONK, . E. COOPER, H. DALE, A. C. DORN-
HORST, 0. G. EDHOLMP. , FITZGERALDA,. D. M. GREEN-
FIELD, A. B. HERTZMADN. . , McK. KERSLAKEJ, . T..
SHEPHERDG,. WEDDELL 149
The problem of vasomotor denervation
A. B. HERTZMANPh,D , .e t az. (Dept. of Physiology, St..
Louis Univ., Missouri) 153
Vascular reactivity following sympathectomy
RG.u yT’s. HGoRsApiNtaTl,,O LBoEn, dMoDn, ) F.R CP, FRS (M.R.C. Clin. Res. Unit., 167
Discussion
H. BARCROFTA,. C. BURTONA, . C. DORNHORST0,. G.
EDHOLMU,. S. VON EULER, R. T. GRANT,A . B..
HERTZMARN. ,B . LYNN,P . MARTING, . WEDDELL 169
Some anatomical observations on peripheral ischaemia
in man
gJr. adHu.a tDe IMBLedEic, aMlB S, chCo~oBl ,oF f RLCPo nd(oDne,p Ht. amof mPerastmhoiltohg) y,. Post.- 173
x CONTENTS
PAGE
Discussion
G. H. ALGIRE,G . E. BURCH,J R., A. C. BURTON,G . S.
DAWES,J . H. DIBLE, A. C. DORNHORST0, . G. EDHOLM,
U. S. VON EULER,P . FITZGERALDR, . T. GRANT,L .
GUTTMANNP,. HOWARDP,. MARTIN, J. L. NICKERSON,
. .
G. WEDDELL 180
The mechanism of the Raynaud's phenomenon in patients
with high serum titres of cold agglutinins
J. T. SHEPHERD,M D, M C ~(D ept. of Physiology, Queen's
. .
Univ., Belfast) 185
Discussion
E. ASMUSSEN,H . BARCROFTA, . C. BURTON,L . D.
CARLSONK, . E. COOPER, G. S. DAWES, A. C. DORN-
HORST, 0. G. EDHOLMU., S. VON EULERP,. FITZGERALD,
R. T. GRANT,A . D. M. GREENFIELD,A . B. HERTZMAN,
. .
D. McK. KERSLAKEP, . MARTIN,J . T. SHEPHERD 187
Visceral activity and peripheral circulation in the spinal
man
L. GUTTMANNO, BE, MD, MRCP (Spinal Injuries Centre,
. .
Aylesbury, Bucks) 192
Discussion
H. BARCROFTA, . C. BURTONG, . S. DAWES,A . C. DORN-
HORST, 0. G. EDHOLMU., S. VON EULERR, . T. GRANT,
A. D. M. GREENFIELDL, . GUTTMANNA,. B. HERTZMAN,
G. WEDDELL . . 199
Some aspects of functional disorders of the circulation
P. MARTIN, VRD, MA, MChir (Dept. of Surgery, Postgrad.
. .
Medical School of London, Hammersmith) 204!
Discussion
P. FITZGERALDL, . GUTTMANNA, . B. HERTZMAPN. ,
. .
MARTIN 207
. .
Chairman's Closing Remarks 209