Ciba Foundation Symposium 80 - Adhesion and Microorganism Pathogenicity

356 Pages·1981·7.55 MB·English

Adhesion and microorganism pathogenicity
The Ciba Foundation is an international scientific and educational charity. It was established in
1947 by the Swiss Chemical and Pharmaceutical company of CIBA Limited - now CIBA-GEIGY
Limited. The foundation operates independently in London under English trust law.
The Ciba Foundation exists to promote international cooperation in medical and chemical
research. It organizes international multidisciplinary meetings on topics that seem ready for
discussion by a small group of research workers. The papers and discussions are published in
the Ciba Foundation series.
The Foundation organizes many other meetings, maintains a library which is open to graduates
in science or medicine who are visiting or working in London, and provides an information
service for scientists. The Ciba Foundation also functions as a centre where scientists from
any part of the world may stay during working visits to London.
Adhesion and
microorganism
pathogenicity
Ciba Foundation symposium 80
1981
Pitman Medical
0 Ciba Foundation 1981
ISBN 0-272-79615-8
Published in February 1981 by Pitman Medical Ltd, London. Distributed in North America by
CIBA Pharmaceutical Company (Medical Education Administration), Summit, NJ 07901,U SA.
Suggested series entry for library catalogues:
Ciba Foundation symposia.
Ciba Foundation symposium 80
x + 346 pages, 59 figures, 58 tables
British Library Cataloguing in publication data:
Adhesion and microorganism pathogenicity. -
(Ciba Foundation. Symposia; 80).
1. Micro-organisms - Physiology - Congresses
2. Adhesion - Congresses
3. Medical microbiology - Congresses
I. O’Connor, Maeve
11. Whelan, Julie 111. Elliott, Katherine
IV. Series
576’.11’8 QR84
Set in lOpt Press Roman by Freeman Graphic, Tonbridge
Printed and bound in Great Britain at the Pitman Press, Bath
Contents
Symposium on Adhesion and microorganism pathogenicity held at the Ciba Founda-
tion, London, 13-15May 1980
Editors: Katherine Elliott (Organizer),M aeve 0 %onnor and Julie Whelan
D. TAYLOR-ROBINSON (Chairman): Introduction I
W. BREDT, J. FELDNER and I. KAHANE Attachment of mycoplasmas to inert
surfaces 3
Discussion 11
DAVID MIRELMAN and DAVID KOBILER Adhesion properties of Enfamoeba
histolytica 17
Discussion 30
ROLF FRETER Mechanisms of association of bacteria with mucosal surfaces 36
Discussion 47
J. W. WATTS, J. R. 0. DAWSON and JANET M. KING The mechanism of entry
of viruses into plant protoplasts 56
Discussion 65
D. C. A. CANDY, T. S. M. LEUNG, A. D. PHILLIPS, J. T. HARRIES and W. C.
MARSHALL Models for studying the adhesion of enterobacteria to the
mucosa of the human intestinal tract 72
Discussion 88
Short communication
SHMUEL KATZ, MORDEHAI IZHAR and DAVID MIRELMAN An in vivo
model for studying adherence of intestinal pathogens 94
Discussion 96
V
S. RAZIN, I. KAHNE, M. BANAI and W. BREDT Adhesion of rnycoplasrnas to
eukaryotic cells 98
Discussion 1 13
NATHAN SHARON, YUVAL ESHDAT, FREDRIC J. SILVERBLATT and ITZHAK
OFEK Bacterial adherence to cell surface sugars 119
Discussion 136
MYRON M. LEVINE Adhesion of enterotoxigenic Escherichia coli in humans and
animals 142
Discussion 154
C. SVANBORG EDEN, L. HAGBERG, L. A. HANSON, T. KORHONEN, H.
LEFFLER and S. OLLING Adhesion of Escherichia coli in urinary tract
infection 161
Discussion 178
EDMUND C. TRAMONT Adhesion of Neisseria gonorrhoeae and disease 188
Discussion 197
RUSSELL J. HOWARD and LOUIS H. MILLER Invasion of erythrocytes by
malaria rnerozoites: evidence for specific receptors involved in attachment and
entry 202
Discussion 2 14
DONALD F. H. WALLACH, ROSS B. MIKKELSEN and RUPERT SCHMIDT-
ULLRICH Plasrnodial modifications of erythrocyte surfaces 220
Discussion 230
J. H. PEARCE, I. ALLAN and S. AINSWORTH Interaction of chlamydiae with
host cells and mucous surfaces 234
Discussion 244
General Discussion Glycolipids in receptor assays 250
PURNELL W. CHOPPIN, CHRISTOPHER D. RICHARDSON, DAVID C. MERZ
and ANDREAS SCHEID Functions of surface glycoproteins of myxoviruses
and pararnyxoviruses and their inhibition 252
Discussion 264
ALAN D. ELBEIN, BARBARA A. SANFORD, MARY A. RAMSAY and Y. T. PAN
effect of inhibitors on glycoprotein biosynthesis and bacterial adhesion 270
Discussion 283
vi
EDWIN H. BEACHEY, BARRY I. EISENSTEIN and ITZHAK OFEK Sublethal
concentrations of antibiotics and bacterial adhesion 288
Discussion 300
Final general discussion Streptococcal adherence 306
Terminology 308
Receptors 3 11
Other factors affecting adhesion 3 19
Models 320
Clinical implications 323
D. TAYLOR-ROBINSON Closing remarks 328
Index of contributors 335
Subject index 337
vii
Participants
E. H. BEACHEY Veterans’ Administration Medical Center, 1030 Jefferson
Avenue, Memphis, Tennessee 38104, USA
W. BREDT Institut fur Allgemeine Hygiene und Bakteriologie, Zentrum fur
Hygiene, Universitat Freiburg, Hermann-Herder-Strasse 1 1, D-7800 Freiburg,
FRG
D. C. A. CANDY Institute of Child Health, The Nuffeld Building, Birmingham
Children’s Hospital, Ladywood, Birmingham B 16 8ET, UK
P. W. CHOPPIN Department ofvirology and Medicine, The Rockefeller University,
1230 York Avenue, New York, NY 1002 1, USA
A. D. ELBEIN Department of Biochemistry, The University of Texas Health
Science Center, 7703 Floyd Curl Drive, San Antonio, Texas 78284, USA
T. FEIZI Division of Communicable Diseases, MRC Clinical Research Centre,
Northwick Park, Watford Road, Harrow, Middlesex HA1 3UJ, UK
R. FRETER Department of Microbiology and Immunology, 6643 Medical
Science Building 11, The University of Michigan Medical School, Ann Arbor,
Michigan 48 109, USA
J. FRIEND Department of Plant Biology, University of Hull, Hull HU6 7RX, UK
A. HELENIUS European Molecular Biology Laboratory, Postfach 10.2209,
Meyerhofstrasse 1, D-6900 Heidelberg, FRG
R. J. HOWARD Malaria Section, Laboratory of Parasitic Diseases, National
Institute of Allergy and Infectious Diseases, National Institutes of Health,
Bethesda, Maryland 20205, USA
R. C. HUGHES Department of Biochemistry, MRC National Institute for Medical
Research, The Ridgeway, Mill Hill, London NW7 IAA, UK
...
Vlll
C. LEBEN Department of Plant Pathology, Ohio Agricultural Research and
Development Center, Wooster, Ohio 4469 1, USA
M. M. LEVINE Center for Vaccine Development, Division of Infectious Diseases,
University of Maryland School of Medicine, 29 South Greene Street, Baltimore,
Maryland 2 1201, USA
D. MIRELMAN Department of Biophysics, The Weizmann Institute of Science,
Rehovot, Israel
P. C. NEWELL Department of Biochemistry, University of Oxford, South Parks
Road, Oxford OX1 3QU, UK
J. H. PEARCE Department of Microbiology, South West Campus, University of
Birmingham, PO Box 363, Birmingham B15 2TT, UK
S. RAZIN Department of Membranes and Ultrastructure, The Hebrew University-
Hadassah Medical School, PO Box 1172, Jerusalem, Israel
M. H. RICHMOND Department of Bacteriology, University of Bristol Medical
School, University Walk, Bristol BS8 lTD, UK
J. M. RUTTER ARC Institute for Research on Animal Diseases, Compton, Near
Newbury, Berkshire, RG16 ONN, UK
N. SHARON Department of Biophysics, The Weizmann Institute of Science,
Rehovot, Israel
F. J. SILVERBLATT Veterans Administration Medical Center, Sepulveda,
California 9 1343, USA
M. SUSSMAN Department of Microbiology, University of Newcastle upon
Tyne Medical School, Newcastle upon Tyne NE1 7RU, UK
C. SVANBORG EDEN Department of Clinical Immunology, Institute of Medical
Microbiology, University of Goteborg, Guldhedsgatan 10, S-413 46 Goteborg,
Sweden
D. TAYLOR-ROBINSON Division of Communicable Diseases, MRC Clinical
Research Centre, Northwick Park, Watford Road, Harrow, Middlesex HA1 3UJ
UK
ix
E. C. TRAMONT Division of Infectious Diseases, Department of Bacterial Diseases,
Walter Reed Army Institute of Research, Walter Reed Army Medical Center,
Washington, DC 20012, USA
K. VOSBECK K-l25/2 12, CIBA-GEIGY Limited, CH-4002 Bade, Switzerland
D. F. H. WALLACH Radiobiology Division, Tufts University School of Medicine
-New England Medical Center, 171 Harrison Avenue, Boston, Massachusetts
021 1 1, USA
J. W. WATTS Department of Ultrastructural Studies, The John Innes Institute,
Colney Lane, Norwich NR4 7UH, UK
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