Ciba Foundation Symposium 164 - Interactions Among Cell Signalling Systems

282 Pages·16.347 MB·English

INTERACTIONS AMONG CELL
SIGNALLING SYSTEMS
The Ciba Foundation is an international scientific and educational
charity. It was established in 1947 by the Swiss chemical and
pharmaceutical company of ClBA Limited-now CIBA-GEIGY
Limited. The Foundation operates independently in London under
English trust law.
The Ciba Foundation exists to promote international cooperation
in biological, medical and chemical research. It organizes about
eight international multidisciplinary symposia each year on topics
that seem ready for discussion by a small group of research
workers. The papers and discussions are published in the Ciba
Foundation symposium series. The Foundation also holds many
shorter meetings (not published), organized by the Foundation
itself or outside scientific organizations. The staff always
by
welcome suggestions for future meetings.
The Foundation’s house at 41 Portland Place, London W1N 4BN,
provides facilities for meetings of all kinds. Its Media Resource
Service supplies information to journalists on all scientific and
technological topics. The library, open five days a week to any
graduate in science or medicine, also provides information on
scientific meetings throughout the world and answers general
enquiries on biomedical and chemical subjects. Scientists from
any part of the world may stay in the house during working visits
to London.
Ciba Foundation Symposium 164
INTERACTIONS
AMONG CELL
SIGNALLING
SYSTEMS
A Wiley-lnterscience Publication
1992
JOHN WILEY & SONS
Chichester . New York . Brisbane . Toronto . Singapore
OCiba Foundation 1992
Published in 1992 by John Wiley & Sons Ltd.
Baffins Lane, Chichester
West Sussex PO19 IUD, England
All rights reserved.
No part of this book may be reproduced by any means,
or transmitted, or translated into a machine language
without the written permission of the publisher.
Other Wiley Editorial Offices
John Wiley & Sons, Inc., 605 Third Avenue,
New York, NY 10158-0012, USA
Jacaranda Wiley Ltd, G.P.O. Box 859, Brisbane,
Queensland 4001, Australia
John Wiley & Sons (Canada) Ltd, 22 Worcester Road,
Rexdale, Ontario M9W 1L1, Canada
John Wiley & Sons (SEA) Pte Ltd, 37 Jalan Pemimpin #05-04,
Block B, Union Industrial Building, Singapore 2057
Suggested series entry for library catalogues:
Ciba Foundation Symposia
Ciba Foundation Symposium 164
xi+268 pages, 49 figures, 5 tables
Library of Congress Cataloging-in-Publication Data
Interactions among cell signalling systems.
p. cm.-(Ciba Foundation symposium ; 164)
Editors, Ryo Sato, Gregory R. Bock (organizers), and Kate Widdows.
A Wiley-Interscience publication.
Includes bibliographical references and index.
ISBN 0 471 93073 3
1. Cellular signal transduction-Congresses. 2. Cell interaction-
Congresses I. SatB, RyB, 1923- . 11. Bock, Gregory.
111. Widdows, Kate. IV. Series.
[ DNLM: 1. Cell Communication-physiology-congresses. 2. Signal
Transduction-physiology-congresses. W3 C161F v. 1641
QP517.C45155 1992
574.87-dc20
DNLM/DLC
for Library of Congress 92-95
CIP
British Library Cataloguing in Publication Data
A catalogue record for this book is available
from the British Library
ISBN 0 471 93073 3
Phototypeset by Dobbie Typesetting Limited, Tavistock, Devon.
Printed and bound in Great Britain by Biddles Ltd., Guildford.
Contents
Symposium on Interactions among cell signalling systems, held in
collaboration with the CIBA-GEIG Y Foundation (Japan) for the
Promotion of Science, at the Portopia Hotel on Port Island, Kobe,
Japan, 23-25 April 1991
Editors: Ryo Sato, Gregory R. Bock (Organizers) and Kate Widdows
Y. Nishizuka Introduction 1
R. H. Michell, L. A. Conroy, M. Finney, J. French, C. M. Bunce,
P.
K. Anderson, M. A. Baxter, G. Brown, J. Gordon, E. J. Jenkinson,
J. M. Lord, C. J. Kirk and J. J. T. Owen Inositol lipids and
phosphates in the proliferation and differentiation of lymphocytes and
myeloid cells 2
Discussion 12
K. Mikoshiba, T. Furuichi, A. Miyawaki, S. Yoshikawa, N. Maeda,
M. Niinobe, S. Nakade, T. Nakagawa, H. Okano and J. Aruga
The inositol 1,4,5-trisphosphate receptor 17
Discussion 29
J. H. Exton, S. J. Taylor, J. S. Blank and S. B. Bocckino Regulation of
phosphoinositide and phosphatidylcholine phospholipases by G
proteins 36
Discussion 43
Y. Asaoka, K. Yoshida, M. Oka, T. Shinomura, H. Mishima,
S. Matsushima and Y. Nishizuka The signal-induced phospholipid
degradation cascade and protein kinase C activation 50
Discussion 59
J.-P. Changeux, A. Devillers-ThiCry, J.-L. Galzi and F. Revah The
acetylcholine receptor: a model of an allosteric membrane protein
mediating intercellular communication 66
Discussion 89
V
vi Contents
H. Rasmussen, C. Isales, Ganesan, R. Calle and W. Zawalich Ca2+-
S.
cyclic AMP interactions in sustained cellular responses 98
Discussion 108
G. Ahn, R. Seger, R. L. Bratlien and G. Krebs Growth factor-
N. E.
stimulated phosphorylation cascades: activation of growth factor-
stimulated MAP kinase 113
Discussion 126
E. H. Fischer, H. Charbonneau, D. E. Cool and N. K. Tonks Tyrosine
phosphatases and their possible interplay with tyrosine kinases 132
Discussion 140
A. C. Nairn and A. Aderem Calmodulin and protein kinase C cross-talk:
the MARCKS protein is an actin filament and plasma membrane cross-
linking protein regulated by protein kinase C phosphorylation and by
calmodulin 145
Discussion 154
G. L. Collingridge, A. D. Randall, C. H. Davies and S. Alford The
synaptic activation of NMDA receptors and Ca2+ signalling in
neurons 162
Discussion 172
A. Malgaroli, Malinow, H. Schulman and R. W. Tsien Persistent
R.
signalling and changes in presynaptic function in long-term
potentiation 176
Discussion 192
General discussion I The metabotropic glutamate receptor 197
Distribution of protein kinase C subspecies in the hippocampal
formation 199
Cross-talk between the phosphatidylinositol and adenylate cyclase
signalling systems 202
D. A. Cantrell, J. D. Graves, M. Izquierdo, Lucss and J. Downward
S.
T lymphocyte activation signals 208
Discussion 2 18
G. Carpenter, S. M. T. Hernandez-Sotomayor, S. Nishibe, G. Todderud,
M. Mumby and M. Wahl Growth factor phosphorylation of
phospholipase C-y, 223
Discussion 233
Contents vi i
K. Toyoshima, Y. Yamanashi, K. Inoue, K. Semba, T. Yamamoto and
T. Akiyama Protein tyrosine kinases belonging to the src family 240
Discussion 248
General discussion I1 254
Index of contributors 258
Subject index 260
Participants
N. Akaike Department of Neurophysiology, Tohoku University School of
Medicine, 1-1 Seiryo-machi Aoba-ku, Sendai 980, Japan
D. A. Cantrell Lymphocyte Activation Laboratory, Imperial Cancer
Research Fund, PO Box 123, 44 Lincoln’s Inn Fields, London WC2A
3PX, UK
G. Carpenter Department of Biochemistry, Vanderbilt University School
of Medicine, Nashville, TN 37232-0146, USA
J.-P. Changeux Institut Pasteur, Neurobiologie MolCculaire, BLtiment des
Biotechnologies, 25 rue du Dr ROUX7, 5015, Paris, France
G. L. Collingridge Department of Pharmacology, University of
Birmingham, The Medical School, Edgbaston, Birmingham B 15 2TT,
UK
J. W. Daly Laboratory Bioorganic Chemistry, NIDDK, Building 8 Room
1A15, National Institutes of Health, Bethesda, MD 20892, USA
J. Exton Department of Molecular Physiology & Biophysics, Room 802,
Light Hall, Vanderbilt University School of Medicine, Nashville, TN
37232, USA
E. H. Fischer Department of Biochemistry, SJ-70, University of
Washington, Seattle, WA 98195, USA
B. Fredholm Department of Pharmacology, Karolinska Institute, PO Box
60400, S-104 01 Stockholm, Sweden
T. Hunter Molecular Biology & Virology Laboratory, The Salk Institute,
PO Box 85800, San Diego, CA 92186-5800, USA
H. Kanoh Department of Biochemistry, Sapporo Medical College,
West-17 South-1, Sapporo 060, Japan
viii
Participants ix
M. Kasuga Department of Internal Medicine, Kobe University School of
Medicine, Kobe, Japan 650
M. Kato-Homma Department of Hygiene & Oncology, Faculty of
Medicine, Tokyo Medical & Dental University, 1-5-45 Yushima, Bunkyo-
ku, Tokyo 113, Japan
E. G. Krebs Department of Pharmacology, University of Washington
School of Medicine, Mail Stop SL-15, Seattle, WA 98195, USA
R. H. Michell School of Biochemistry, University of Birmingham, PO
Box 363, Birmingham B15 2TT
K. Mikoshiba Institute for Protein Research, Osaka University, 3-2
Yamadaoka, Suita, Osaka 565, Japan
A. C. Nairn Laboratory of Molecular & Cellular Neuroscience, The
Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
Y. Nishizuka Department of Biochemistry, Kobe University School of
Medicine, Kobe 650, Japan
P. Parker Protein Phosphorylation Laboratory, Imperial Cancer Research
Fund, PO Box 123, Lincoln’s Inn Fields, London WC2A 3PX, UK
44
H. Rasmussen Division of Endocrinology, Department of Internal
Medicine, Yale University School of Medicine, Fitkin 1, PO Box 3333,
New Haven, CT 06510-8056, USA
H-1. Su Department of Biochemistry, Institute of Endocrinology, Tianjin
Medical College, 22 Qi Xiang Tai Road, Heping District, Tianjin
300070, People’s Republic of China
C. Tanaka Department of Pharmacology, Kobe University School of
Medicine, Kobe 650, Japan
G. Thomas Friedrich Miescher Institute, PO Box 2543, CH-4002 Basle,
Switzerland
K. Toyoshima Department of Oncogene Research, Research Institute for
Microbial Diseases, Osaka University, 3- 1 Yamadaoka, Suita City,
Osaka 565, Japan
X Participants
R. W. Tsien Department of Molecular & Cellular Physiology, Arnold &
Mabel Beckman Center, Stanford University Medical Center, Stanford,
CA 94305-5425, USA
M. Ui Department of Physiological Chemistry, Faculty of Pharmaceutical
Sciences, University of Tokyo, Tokyo 113, Japan
J. Warner Department of Physiology & Pharmacology, University of
Southampton, Bassett Crescent East, Southampton SO9 3TU, UK
C-c. Yang Institute of Life Sciences, National Tsing Hua University,
Hsinchu, Taiwan 30043