Chapter 16 - The University of Adelaide PDF
Preview Chapter 16 - The University of Adelaide
16 Mechanisms of Vascular Disease Mechanisms of Vascular Disease: A Reference Book for Vascular Specialists Robert Fitridge The University of Adelaide, The Queen Elizabeth Hospital, Woodville, Australia Matthew Thompson St George’s Hospital Medical School, London, UK Published in Adelaide by The University of Adelaide, Barr Smith Press Barr Smith Library The University of Adelaide South Australia 5005 [email protected] www.adelaide.edu.au/press The University of Adelaide Press publishes peer-reviewed scholarly works by staff via Open Access online editions and print editions. The Barr Smith Press is an imprint of the University of Adelaide Press, reserved for scholarly works which are not available in Open Access, as well as titles of interest to the University and its associates. The Barr Smith Press logo features a woodcut of the original Barr Smith Library entrance. © The Contributors 2011 This book is copyright. Apart from any fair dealing for the purposes of private study, research, criticism or review as permitted under the Copyright Act, no part may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording or otherwise without the prior written permission. Address all inquiries to the Director at the above address. This CIP cataloguing for this work is as follows; Mechanisms of vascular disease : a reference book for vascular surgeons / Robert Fitridge, Matthew Thompson, [editors]. 1. Blood vessels, Diseases. 2. Blood vessels‚ Surgery. I. Fitridge, Robert II. Thompson, M. M. For the full Cataloguing-in-Publication data please contact National Library of Australia: [email protected] ISBN (paperback) 978-0-9871718-2-5 Book design: Midland Typesetters Cover design: Emma Spoehr, based on a diagram by Dave Heinrich of the Medical Illustration and Media Unit, Flinders Medical Centre Paperback edition printed by Griffin Press, South Australia Table of Contents Contributors vii target 201 Detailed Contents xi Sandeep Prabhu, Rahul Sharma, Karlheinz Peter (Melbourne, Australia) 1. Endothelium 1 12. Pathogenesis of aortic aneurysms 227 Paul Kerr, Raymond Tam, Jonathan Golledge, Guo-Ping Shi, Frances Plane (Calgary, Canada) Paul Norman (Townsville & Perth, 2. Vascular smooth muscle structure and Australia; Boston, USA) function 13 13. Pharmacological treatment of David Wilson (Adelaide, Australia) aneurysms 247 3. Atherosclerosis 25 Matthew Thompson, Janet Powell Gillian Cockerill, Qingbo Xu (London, UK) (London, UK) 14. Aortic dissection and connective tissue 4. Mechanisms of plaque rupture 43 disorders 255 Ian Loftus (London, UK) Mark Hamilton (Adelaide, Australia) 5. Current and emerging therapies in 15. Biomarkers in vascular disease 277 atheroprotection 79 Ian Nordon, Robert Hinchliffe Stephen Nicholls, Rishi Puri (London, UK) (Cleveland, USA) 16. Pathophysiology and principles 6. Molecular approaches to of management of vasculitis and revascularisation in peripheral vascular Raynaud’s phenomenon 295 disease 103 Martin Veller (Johannesburg, Greg McMahon, Mark McCarthy South Africa) (Leicester, UK) 17. SIRS, sepsis and multiorgan 7. Biology of restenosis and targets for failure 315 intervention 115 Vishwanath Biradar, John Moran Richard Kenagy (Seattle, USA) (Adelaide, Australia) 8. Vascular arterial haemodynamics 153 18. Pathophysiology of reperfusion Michael Lawrence-Brown, Kurt injury 331 Liffman, James Semmens, Ilija Prue Cowled, Robert Fitridge Sutalo (Melbourne & Perth, Australia) (Adelaide, Australia) 9. Physiological haemostasis 177 19. Compartment syndrome 351 Simon McRae (Adelaide, Australia) Edward Choke, Robert Sayers, 10. Hypercoagulable states 189 Matthew Bown (Leicester, UK) Simon McRae (Adelaide, Australia) 20. Pathophysiology of pain 375 11. Platelets in the pathogenesis of vascular Stephan Schug, Helen Daly, disease and their role as a therapeutic Kathryn Stannard (Perth, Australia) v vi Mechanisms of Vascular Disease 21. Postamputation pain 389 26. Pathophysiology and principles of Stephan Schug, Gail Gillespie management of the diabetic foot 475 (Perth, Australia) David Armstrong, Timothy Fisher, 22. Treatment of neuropathic pain 401 Brian Lepow, Matthew White, Stephan Schug, Kathryn Stannard Joseph Mills (Tucson, USA) (Perth, Australia) 27. Lymphoedema – Principles, genetics 23. Principles of wound healing 423 and pathophysiology 497 Gregory Schultz, Gloria Chin, Matt Waltham (London, UK) Lyle Moldawer, Robert Diegelmann 28. Graft materials past and future 511 (Florida, USA) Mital Desai, George Hamilton 24. Pathophysiology and principles of (London, UK) varicose veins 451 29. Pathophysiology of vascular graft Andrew Bradbury (Birmingham, UK) infections 537 25. Chronic venous insufficiency and leg Mauro Vicaretti (Sydney, Australia) ulceration: Principles and vascular biology 459 Index 549 Michael Stacey (Perth, Australia) List of Contributors David G Armstrong Prue Cowled The University of Arizona Department of Surgery Southern Arizona Limb Salvage Alliance University of Adelaide Tucson, AZ The Queen Elizabeth Hospital USA Woodville, SA Australia Vishwanath Biradar Intensive Care Unit Helen Daly Royal Perth Hospital The Queen Elizabeth Hospital Perth, WA Woodville, SA Australia Australia Mital Desai Matthew Bown University Department of Vascular Surgery Department of Vascular Surgery Royal Free Hospital University of Leicester University College Leicester London UK UK Andrew W Bradbury Robert F Diegelmann University Department of Vascular Surgery Department of Biochemistry Birmingham Heartlands Hospital Medical College of Virginia Birmingham Richmond, VA UK USA Edward Choke Timothy K Fisher Department of Vascular Surgery Rashid Centre for Diabetes and Research University of Leicester Sheikh Khalifa Hospital Leicester Ajmon UK UAE Gillian Cockerill Robert A Fitridge Department of Clinical Sciences Department of Surgery St George’s Hospital Medical School University of Adelaide London The Queen Elizabeth Hospital UK Woodville, SA Australia vii viii Mechanisms of Vascular Disease Gail Gillespie Michael MD Lawrence-Brown Royal Perth Hospital Curtin Health Innovation Research Perth, WA Institute Australia Curtin University Perth, WA Jonathan Golledge Australia Vascular Biology Unit School of Medicine & Dentistry Brian Lepow The University of Arizona James Cook University Department of Surgery Townsville, QLD Southern Arizona Limb Salvage Alliance Australia Tucson, AZ USA George Hamilton University Department of Vascular Surgery Kurt Liffman Royal Free Hospital CSIRO Material Science & Engineering University College and School of Mathematical Sciences London Monash University UK Melbourne, Vic Australia Mark Hamilton Department of Surgery Ian Loftus University of Adelaide Department of Vascular Surgery The Queen Elizabeth Hospital St George’s Hospital Woodville, SA London Australia UK Robert J Hinchliffe Mark J McCarthy St George’s Vascular Institiute Department of Surgery and Cardiovascular St George’s Hospital Sciences London University of Leicester UK Leicester UK Richard D Kenagy Department of Surgery Greg S McMahon University of Washington Department of Surgery and Cardiovascular Seattle, WA Sciences USA University of Leicester Leicester Paul Kerr UK Department of Pharmacology University of Alberta Simon McRae Alberta Adult Haemophilia Treatment Centre Canada SA Pathology Adelaide, SA Australia List of Contributors ix Joseph L Mills Janet T Powell The University of Arizona Imperial College Southern Arizona Limb Salvage Alliance London Tucson, AZ UK USA Sandeep Prabhu Lyle Moldawer Baker IDI Heart & Diabetes Institute Department of Surgery Alfred Hospital University of Florida Melbourne, Vic Gainesville, FL Australia USA Rishi Puri John L Moran The Heart and Vascular Institute Faculty of Health Sciences Cleveland Clinic University of Adelaide Cleveland, OH The Queen Elizabeth Hospital USA Woodville, SA Australia Stephan A Schug Royal Perth Hospital Stephen Nicholls Perth, WA The Heart and Vascular Institute Australia Cleveland Clinic Cleveland, OH USA Gregory S Schultz Department of Obstetrics and Gynaecology Ian M Nordon University of Florida St George’s Vascular Institiute Gainesville, FL St George’s Hospital USA London UK Rahul Sharma Baker IDI Heart & Diabetes Institute Paul E Norman Alfred Hospital School of Surgery Melbourne, Vic University of WA Australia Fremantle, WA Australia Guo-Ping Shi Department of Cardiovascular Medicine Karlheinz Peter Brigham & Women’s Hospital Baker IDI Heart & Diabetes Institute Harvard Medical School Melbourne, Vic Boston, MA Australia USA Frances Plane Michael Stacey Department of Pharmacology University Department of Surgery University of Alberta Fremantle Hospital Alberta Fremantle, WA Canada Australia
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