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Challenges in Pediatric Kidney Transplantation A Practical Guide Katherine E. Twombley Editor 123 Challenges in Pediatric Kidney Transplantation Katherine E. Twombley Editor Challenges in Pediatric Kidney Transplantation A Practical Guide Editor Katherine E. Twombley Department of Pediatrics, Division of Pediatric Nephrology MUSC Shawn Jenkins Children’s Hospital/Medical University of South Carolina Charleston, SC USA ISBN 978-3-030-74782-4 ISBN 978-3-030-74783-1 (eBook) https://doi.org/10.1007/978-3-030-74783-1 © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2021 This work is subject to copyright. All rights are solely and exclusively licensed by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and trans- mission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publica- tion does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland Contents Part I Immunologic Challenges 1 Immunologic Challenges Pre-transplant . . . . . . . . . . . . . . . . . . . . . . . . 3 Roshan George and Howard M. Gebel 2 Challenges in Post-transplant Immunologic Monitoring . . . . . . . . . . . 25 Rouba Garro and Pamela D. Winterberg 3 Rejection Challenges: Diagnosis and Management . . . . . . . . . . . . . . . . 41 Samantha Lang, Maziar Riazy, and Tom D. Blydt-Hansen Part II I nfectious Challenges 4 Pretransplant Donor and Recipient Infectious Challenges . . . . . . . . . . 121 Sarah Kizilbash and Jodi M. Smith 5 Post-transplant Recipient Infectious Challenges . . . . . . . . . . . . . . . . . . 145 Isa F. Ashoor and Sonia Solomon Part III D isease Challenges 6 Urological Considerations for Pediatric Renal Transplantation: CAKUT Challenges . . . . . . . . . . . . . . . . . . . . . . . . . . . 179 Oana Nicoara, Hailey Silverii, and Shumyle Alam 7 Rheumatologic Challenges . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 193 Sonia I. Savani and Mileka Gilbert 8 Recurrent Disease Challenges in Pediatric Kidney Transplantation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 223 Lyndsay A. Harshman and Sharon M. Bartosh 9 Nephrotic Syndrome Challenges: An Old Recurring Problem. . . . . . . 245 German Lozano Guzman and Joshua J. Zaritsky v vi Contents 10 Challenges of Maintaining Adequate Health and Well-Being, Growth, Nutrition, and Development in Pediatric Transplant Recipients . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 261 Kristen Sgambat, Kaushalendra Amatya, and Asha Moudgil Part IV M edication Challenges 11 Challenges Surrounding Induction Protocols in Children . . . . . . . . . . 289 Raphael H. Parrado and Satish N. Nadig 12 Post-transplant Medication Challenges . . . . . . . . . . . . . . . . . . . . . . . . . 305 Nida Siddiqi and Alesa Campbell Part V S urgical Challenges 13 Challenges in Surgical Approach and Complications in Pediatric Renal Transplant . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 359 Aleah L. Brubaker and Beau Kelly 14 Multiorgan Transplantation Challenges . . . . . . . . . . . . . . . . . . . . . . . . . 371 Rachel M. Engen and Priya Verghese Part VI Ethical Challenges 15 Ethical Challenges in Pediatric Kidney Transplantation . . . . . . . . . . . 397 James Johnston and Aviva Goldberg Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 423 Contributors Shumyle Alam, MD Department of Urology, MUSC Shawn Jenkins Children’s Hospital/Medical University of South Carolina, Charleston, SC, USA Kaushalendra  Amatya, PhD Children’s National Hospital Washington DC, Division of Nephrology, Washington, DC, USA Isa F. Ashoor, MD Department of Pediatrics, LSU Health and Children’s Hospital New Orleans, New Orleans, LA, USA Sharon  M.  Bartosh, MD University of Wisconsin, Division of Pediatric Nephrology, Pediatric Kidney Transplantation, Madison, WI, USA Tom D. Blydt-Hansen, MDCM, FRCPC Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada Aleah L. Brubaker, MD, PhD Division Abdominal Transplantation, Department of Surgery, Stanford University, Stanford, CA, USA Alesa Campbell, PharmD Department of Pharmacy, Montefiore Medical Center, Bronx, NY, USA Rachel M. Engen, MD, MS Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA Rouba Garro, MD Pediatric Nephrology, Emory University School of Medicine Department of Pediatrics, Atlanta, GA, USA Children’s Health Care of Atlanta, Atlanta, GA, USA Howard M. Gebel, PhD Histocompatibility & Immunogenetics Labs, Emory Medical Laboratory, Emory University School of Medicine, Atlanta, GA, USA Roshan  George, MD, PhD Department of Pediatrics; Division of Pediatric Nephrology, Emory University and Children’s Healthcare of Atlanta, Atlanta, GA, USA Mileka  Gilbert, MD, PhD Department of Pediatrics, Division of Pediatric Rheumatology, MUSC Shawn Jenkins Children’s Hospital/Medical University of South Carolina, Charleston, SC, USA vii viii Contributors Aviva Goldberg, MD Department of Pediatrics and Child Health, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada German Lozano Guzman, MD Section of Nephrology St Christopher Hospital, Philadelphia, PA, USA Lyndsay A. Harshman, MD University of Iowa Organ Transplant Center, Iowa City, IA, USA James Johnston, MD Department of Pediatrics and Child Health, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada Beau Kelly, MD, MBA, FACS DCI Donor Services, West Sacramento, CA, USA Sarah Kizilbash, MBBS, MS Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA Samantha Lang, MBBS, BSc Department of Experimental Medicine, University of British Columbia, Vancouver, BC, Canada Asha Moudgil, MD Children’s National Hospital Washington DC, Division of Nephrology, Washington, DC, USA Satish  N.  Nadig, MD, PhD Division of Transplant Surgery, Department of Surgery, Medical University of South Carolina, Charleston, SC, USA Oana Nicoara, MD Department of Pediatrics, Division of Pediatric Nephrology, MUSC Shawn Jenkins Children’s Hospital/Medical University of South Carolina, Charleston, SC, USA Raphael H. Parrado, MD Department of General Surgery, Medical University of South Carolina, Charleston, SC, USA Maziar Riazy, MD, PhD, FRCPC Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada Sonia I. Savani, MD Department of Medicine and Department of Pediatrics, Medical University of South Carolina, Charleston, SC, USA Kristen  Sgambat, PhD, RD Children’s National Hospital Washington DC, Division of Nephrology, Washington, DC, USA Nida Siddiqi, PharmD Department of Pharmacy, Sidra Medicine, Doha, Qatar Hailey Silverii, MD Department of Urology, MUSC Shawn Jenkins Children’s Hospital/Medical University of South Carolina, Charleston, SC, USA Jodi M. Smith, MD, MPH Department of Pediatrics, Seattle Children’s Hospital/ University of Washington, Seattle, WA, USA Sonia Solomon, DO Department of Pediatric Nephrology, Maria Fareri Children’s Hospital/New York Medical College/Westchester Medical Center/Boston Children’s Health Physicians, Valhalla, NY, USA Contributors ix Priya Verghese, MBBS, MPH Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA Pamela D. Winterberg, MD Pediatric Nephrology, Emory University School of Medicine Department of Pediatrics, Atlanta, GA, USA Children’s Health Care of Atlanta, Atlanta, GA, USA Joshua  J.  Zaritsky, MD, PhD Division Chief Section of Nephrology St Christopher Hospital, Philadelphia, PA, USA Part I Immunologic Challenges

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Challenges in Pediatric Kidney Transplantation: A Practical Guide PDF

429 Pages·2021·7.885 MB·English
by  Katherine E. Twombley
#Medicine #Surgery, Orthopedics
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Challenges in Pediatric Kidney Transplantation A Practical Guide Katherine E. Twombley Editor 123 Challenges in Pediatric Kidney Transplantation Katherine E. Twombley Editor Challenges in Pediatric Kidney Transplantation A Practical Guide Editor Katherine E. Twombley Department of Pediatrics, Division of Pediatric Nephrology MUSC Shawn Jenkins Children’s Hospital/Medical University of South Carolina Charleston, SC USA ISBN 978-3-030-74782-4 ISBN 978-3-030-74783-1 (eBook) https://doi.org/10.1007/978-3-030-74783-1 © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2021 This work is subject to copyright. All rights are solely and exclusively licensed by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and trans- mission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publica- tion does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland Contents Part I Immunologic Challenges 1 Immunologic Challenges Pre-transplant . . . . . . . . . . . . . . . . . . . . . . . . 3 Roshan George and Howard M. Gebel 2 Challenges in Post-transplant Immunologic Monitoring . . . . . . . . . . . 25 Rouba Garro and Pamela D. Winterberg 3 Rejection Challenges: Diagnosis and Management . . . . . . . . . . . . . . . . 41 Samantha Lang, Maziar Riazy, and Tom D. Blydt-Hansen Part II I nfectious Challenges 4 Pretransplant Donor and Recipient Infectious Challenges . . . . . . . . . . 121 Sarah Kizilbash and Jodi M. Smith 5 Post-transplant Recipient Infectious Challenges . . . . . . . . . . . . . . . . . . 145 Isa F. Ashoor and Sonia Solomon Part III D isease Challenges 6 Urological Considerations for Pediatric Renal Transplantation: CAKUT Challenges . . . . . . . . . . . . . . . . . . . . . . . . . . . 179 Oana Nicoara, Hailey Silverii, and Shumyle Alam 7 Rheumatologic Challenges . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 193 Sonia I. Savani and Mileka Gilbert 8 Recurrent Disease Challenges in Pediatric Kidney Transplantation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 223 Lyndsay A. Harshman and Sharon M. Bartosh 9 Nephrotic Syndrome Challenges: An Old Recurring Problem. . . . . . . 245 German Lozano Guzman and Joshua J. Zaritsky v vi Contents 10 Challenges of Maintaining Adequate Health and Well-Being, Growth, Nutrition, and Development in Pediatric Transplant Recipients . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 261 Kristen Sgambat, Kaushalendra Amatya, and Asha Moudgil Part IV M edication Challenges 11 Challenges Surrounding Induction Protocols in Children . . . . . . . . . . 289 Raphael H. Parrado and Satish N. Nadig 12 Post-transplant Medication Challenges . . . . . . . . . . . . . . . . . . . . . . . . . 305 Nida Siddiqi and Alesa Campbell Part V S urgical Challenges 13 Challenges in Surgical Approach and Complications in Pediatric Renal Transplant . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 359 Aleah L. Brubaker and Beau Kelly 14 Multiorgan Transplantation Challenges . . . . . . . . . . . . . . . . . . . . . . . . . 371 Rachel M. Engen and Priya Verghese Part VI Ethical Challenges 15 Ethical Challenges in Pediatric Kidney Transplantation . . . . . . . . . . . 397 James Johnston and Aviva Goldberg Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 423 Contributors Shumyle Alam, MD Department of Urology, MUSC Shawn Jenkins Children’s Hospital/Medical University of South Carolina, Charleston, SC, USA Kaushalendra  Amatya, PhD Children’s National Hospital Washington DC, Division of Nephrology, Washington, DC, USA Isa F. Ashoor, MD Department of Pediatrics, LSU Health and Children’s Hospital New Orleans, New Orleans, LA, USA Sharon  M.  Bartosh, MD University of Wisconsin, Division of Pediatric Nephrology, Pediatric Kidney Transplantation, Madison, WI, USA Tom D. Blydt-Hansen, MDCM, FRCPC Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada Aleah L. Brubaker, MD, PhD Division Abdominal Transplantation, Department of Surgery, Stanford University, Stanford, CA, USA Alesa Campbell, PharmD Department of Pharmacy, Montefiore Medical Center, Bronx, NY, USA Rachel M. Engen, MD, MS Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA Rouba Garro, MD Pediatric Nephrology, Emory University School of Medicine Department of Pediatrics, Atlanta, GA, USA Children’s Health Care of Atlanta, Atlanta, GA, USA Howard M. Gebel, PhD Histocompatibility & Immunogenetics Labs, Emory Medical Laboratory, Emory University School of Medicine, Atlanta, GA, USA Roshan  George, MD, PhD Department of Pediatrics; Division of Pediatric Nephrology, Emory University and Children’s Healthcare of Atlanta, Atlanta, GA, USA Mileka  Gilbert, MD, PhD Department of Pediatrics, Division of Pediatric Rheumatology, MUSC Shawn Jenkins Children’s Hospital/Medical University of South Carolina, Charleston, SC, USA vii viii Contributors Aviva Goldberg, MD Department of Pediatrics and Child Health, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada German Lozano Guzman, MD Section of Nephrology St Christopher Hospital, Philadelphia, PA, USA Lyndsay A. Harshman, MD University of Iowa Organ Transplant Center, Iowa City, IA, USA James Johnston, MD Department of Pediatrics and Child Health, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada Beau Kelly, MD, MBA, FACS DCI Donor Services, West Sacramento, CA, USA Sarah Kizilbash, MBBS, MS Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA Samantha Lang, MBBS, BSc Department of Experimental Medicine, University of British Columbia, Vancouver, BC, Canada Asha Moudgil, MD Children’s National Hospital Washington DC, Division of Nephrology, Washington, DC, USA Satish  N.  Nadig, MD, PhD Division of Transplant Surgery, Department of Surgery, Medical University of South Carolina, Charleston, SC, USA Oana Nicoara, MD Department of Pediatrics, Division of Pediatric Nephrology, MUSC Shawn Jenkins Children’s Hospital/Medical University of South Carolina, Charleston, SC, USA Raphael H. Parrado, MD Department of General Surgery, Medical University of South Carolina, Charleston, SC, USA Maziar Riazy, MD, PhD, FRCPC Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada Sonia I. Savani, MD Department of Medicine and Department of Pediatrics, Medical University of South Carolina, Charleston, SC, USA Kristen  Sgambat, PhD, RD Children’s National Hospital Washington DC, Division of Nephrology, Washington, DC, USA Nida Siddiqi, PharmD Department of Pharmacy, Sidra Medicine, Doha, Qatar Hailey Silverii, MD Department of Urology, MUSC Shawn Jenkins Children’s Hospital/Medical University of South Carolina, Charleston, SC, USA Jodi M. Smith, MD, MPH Department of Pediatrics, Seattle Children’s Hospital/ University of Washington, Seattle, WA, USA Sonia Solomon, DO Department of Pediatric Nephrology, Maria Fareri Children’s Hospital/New York Medical College/Westchester Medical Center/Boston Children’s Health Physicians, Valhalla, NY, USA Contributors ix Priya Verghese, MBBS, MPH Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA Pamela D. Winterberg, MD Pediatric Nephrology, Emory University School of Medicine Department of Pediatrics, Atlanta, GA, USA Children’s Health Care of Atlanta, Atlanta, GA, USA Joshua  J.  Zaritsky, MD, PhD Division Chief Section of Nephrology St Christopher Hospital, Philadelphia, PA, USA Part I Immunologic Challenges

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