Cellular Peptidases in Immune Functions and Diseases 2 PDF
Preview Cellular Peptidases in Immune Functions and Diseases 2
CELLULAR PEPTIDASES IN IMMUNE FUNCTIONS AND DISEASES 2 ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY Editorial Board: NATHAN BACK, State University of New York at Buffalo IRUN R. COHEN, The Weizmann Institute of Science DAVID KRITCHEVSKY, Wistar Institute ABEL LAJTHA, N. S. Kline Institute for Psychiatric Research RODOLFO PAOLETTI, University of Milan Recent Volumes in this Series Volume 468 THE FUNCTIONAL ROLES OF GLIAL CELLS IN HEALTH AND DISEASE: Dialogue between Glia and Neurons Edited by Rebecca Matsas and Marco Tsacopoulos Volume 469 EICOSANOIDS AND OTHER BIOACTIVE LIPIDS IN CANCER, INFLAMMATION, AND RADIATION INJURY, 4 Edited by Kenneth V. Honn, Lawrence J. Marnett, and Santosh Nigam Volume 470 COLON CANCER PREVENTION: Dietary Modulation of Cellular and Molecular Mechanisms Edited under the auspices of the American Institute for Cancer Research Volume 471 OXYGEN TRANSPORT TO TISSUE XXI Edited by Andras Eke and David T. Delpy Volume 472 ADVANCES IN NUTRITION AND CANCER 2 Edited by Vincenzo Zappia, Fulvio Delia Ragione, Alfonso Barbarisi, Gian Luigi Russo, and Rossano Dello lacovo Volume 473 MECHANISMS IN THE PATHOGENESIS OF ENTERIC DISEASES 2 Edited by Prem S. Paul and David H. Francis Volume 474 HYPOXIA: Into the Next Millennium Edited by Robert C. Roach, Peter D. Wagner, and Peter H. Hackett Volume 475 OXYGEN SENSING: Molecule to Man Edited by Sukhamay Lahiri, Naduri R. Prabhakar, and Robert E. Forster, II Volume 476 ANGIOGENESIS: From the Molecular to Integrative Pharmacology Edited by Michael E. Maragoudakis Volume 477 CELLULAR PEPTIDASES IN IMMUNE FUNCTIONS AND DISEASES 2 Edited by Jürgen Langner and Siegfried Ansorge A Continuation Order Plan is available for this series. A continuation order will bring delivery of each new volume immediately upon publication. Volumes are billed only upon actual shipment. For further information please contact the publisher. CELLULAR PEPTIDASES IN IMMUNE FUNCTIONS AND DISEASES 2 Edited by Jürgen Langner Martin Luther University Halle, Germany and Siegfried Ansorge Otto von Guericke University Magdeburg, Germany Kluwer Academic Publishers New York, Boston, Dordrecht, London, Moscow eBookISBN: 0-306-46826-3 Print ISBN: 0-306-46383-0 ©2002 Kluwer Academic Publishers New York, Boston, Dordrecht, London, Moscow All rights reserved No part of this eBook may be reproduced or transmitted in any form or by any means, electronic, mechanical, recording, or otherwise, without written consent from the Publisher Created in the United States of America Visit Kluwer Online at: http://www.kluweronline.com and Kluwer's eBookstore at: http://www.ebooks.kluweronline.com PREFACE The good response and high scientific output of the first meeting in 1996 encouraged us tocontinuewithasecondone, “CellularpeptidasesinImmuneFunctionsandDiseases (II)” which was held September 12–14th, 1999 again at Magdeburg-Herrenkrug, Germany. This meeting again was organised by the Sonderforschungsbereich 387 of the Deutsche Forschungsgemeinschaft “Zelluläre Proteasen, Bedeutung für Immun- mechanismen undentzündliche Erkrankungen”.Thisfieldhasexpandedcontinuously and has become anestablishedandhighlyeffectiveareaduring thelastyears.Sincethe first meeting in 1996 new proteases have been detected and new topics have been explored whereproteolysisplays animportantrole. Increasingly itis becomingclear thatmany—if notall—pathomechanisms ofinfectious and inflammatory diseases and malignancies are closely associated with dysregulation of proteolytic enzymes. The activeparticipation ofcolleagues from abouttwenty laboratoriesinGermany andfrom other European countries—in addition to the invited speakers—provides telling evi- dence of the attraction of this field, also outside the SFB. The present volume contains most of the presentations of the invited speakers. The three parts of the contents each are introduced by a review of the topic of the respective section. Weunderstand this asahelpfulintroduction forthose readerswho are not so close to the special topics of proteolysis in relation to immune functions covered by the meeting. In addition, short communications are included from the members of the SFB showing the variety of projects as well as their development. Included are also some contribution from participants of groups outside the SFB, originally presented as posters. We are glad to have again the opportunity to publish this volume in the series “Advances in Experimental Medicine and Biology” of Kluwer Academic/Plenum Publishers, and we are especially grateful to Joanna Lawrence, London, for her invaluable help and all cooperation in the production of this book. Financial support of the meeting was provided by the Deutsche Forschungs- gemeinschaft, the Ministerium für Kultur des Landes Sachsen-Anhalt, Otto-von- Guericke-Universität Magdeburg, Martin-Luther-Universität Halle-Wittenberg and the companies: Becton Dickinson GmbH Heidelberg, Biochrom Beteiligungs GmbH & Co, Centeon/Liederbach, Karl Roth GmbH & Co KG, NEN Life Science Products GmbH, R & D Systems, Röche Diagnostics GmbH. v vi Preface The organization of the meeting was greatly managed by Gudrun Plexnies and Barbara Schotte. The editorial work was excellently performed by Christi Walcker. Invaluable help with all editorial computer problems was provided by Cornelius Hempel. Our deep gratitude goes to all of them. Jürgen Langner Siegfried Ansorge CONTENTS Part I: Membrane Ectopeptidases with Influence on Immune Functions 1. Review: The Role ofMembrane Peptidases in Immune Functions ..... 1 Uwe Lendeckel, Thilo Kähne, Dagmar Riemann, Klaus Neubert, Marco Arndt, and Dirk Reinhold 2. Structure and Function of Aminopeptidase N .................. 25 Hans Sjöström, Ove Norén, and Olsen 3. Modulation of WNT-5a Expression by Actinonin: Linkage of APN to the WNT-Pathway? ......................................... 35 Uwe Lendeckel, Marco Arndt, Karin Frank, Antje Spiess, Dirk Reinhold, and Siegfried Ansorge 4. Enzymatic Activity is not a Precondition for the Intracellular Calcium Increase Mediated by mAbs Specific for Aminopeptidase N/CD13 ..... 43 Alexander Navarrete Santos, Jürgen Langner, and Dagmar Riemann 5. Transforming Growth Factor- Increases the Expression of Aminopeptidase N/CD13 mRNA and Protein in Monocytes and Monocytic Cell Lines ...................................... 49 Astrid Kehlen, Jürgen Langner, and Dagmar Riemann 6. Cell-Cell Contact Between Lymphocytes and Fibroblast-like Synoviocytes Induces Lymphocytic Expression of Aminopeptidase N/CD13 and Results in Lymphocytic Activation ................... 57 Dagmar Riemann, Jana Röntsch, Bettina Hause, Jürgen Langner, and Astrid Kehlen 7. Natural Substrates of Dipeptidyl Peptidase IV ..................... 67 Ingrid De Meester, Christine Durinx, Günther Bal, Paul Proost, Sofie Struyf, Filip Goossens, Koen Augustyns, and Simon Schärpe vii viii Contents 8. Relating Structure to Function in the Beta-Propeller Domain of Dipeptidyl Peptidase IV: Point Mutations that Influence Adenosine Deaminase Binding, Antibody Binding and Enzyme Activity ......... 89 Mark D. Gorrell, Catherine A. Abbott, Thilo Kähne, Miriam T. Levy, W. Bret Church, and Geoffrey W. McCaughan 9. Development of a Tertiary-Structure Model of the C-Terminal Domain of DPP IV .................................................. 97 Wolfgang Brandt 10. Post Proline Cleaving Peptidases Having DP IV Like Enzyme Activity: Post-Proline Peptidases ........................................ 103 Catherine A. Abbott, Denise Yu, Geoffrey W. McCaughan, and Mark D. Gorrell 11. A New Type of Fluorogenic Substrates for Determination of Cellular Dipeptidyl Peptidase IV (DP IV/CD26) Activity . . . . . . . . . . . . . . . . . . 111 Susan Lorey, Jürgen Faust, Frank Bühling, Siegfried Ansorge, and Klaus Neubert 12. Potent Inhibitors of Dipeptidyl Peptidase IV and their Mechanisms of Inhibition ................................................. 117 Angela Stöckel-Maschek, Beate Stiebitz, Ilona Born, Jürgen Faust, Werner Mögelin, and Klaus Neubert 13. N-terminal HIV-1 TAT Nonapeptides as Inhibitors of Dipeptidyl Peptidase IV. Conformational Characterization ..................... 125 Carmen Mrestani-Klaus, Annett Fengler, Jürgen Faust, Wolfgang Brandt, Sabine Wrenger, Dirk Reinhold, Siegfried Ansorge, and Klaus Neubert 14. Signal Transduction Events Induced or Affected by Inhibition of the Catalytic Activity of Dipeptidyl Peptidase IV (DP IV, CD26) ...... 131 Thilo Kähne, Dirk Reinhold, Klaus Neubert, Ilona Born, Jürgen Faust, and Siegfried Ansorge 15. Specific Inhibitors of Dipeptidyl Peptidase IV Suppress mRNA Expression of DP IV/CD26 and Cytokines ........................ 139 Marco Arndt, Dirk Reinhold, Uwe Lendeckel, Antje Spiess, Jürgen Faust, Klaus Neubert, and Siegfried Ansorge 16. Dipeptidyl Peptidase IV in Inflammatory CNS Disease .............. 145 Andreas Steinbrecher, Dirk Reinhold, Laura Quigley, Ameer Gado, Nancy Tresser, Leonid Izikson, Ilona Born, Jürgen Faust, Klaus Neubert, Roland Martin, Siegfried Ansorge, and Stefan Brocke Contents ix 17. Dipeptidyl PeptidaseIV (CD26): Role in T CellActivation and Autoimmune Disease ......................................... 155 Dirk Reinhold, Bernhard Hemmer, Bruno Gran, Andreas Steinbrecher, Stefan Brocke, Thilo Kähne, Sabine Wrenger, Ilona Born, Jürgen Faust, Klaus Neubert, Roland Martin, and Siegfried Ansorge 18. Effects of Nonapeptides Derived from the N-Terminal Structure of Human Immunodeficiency Virus-1 (HIV-1) TAT on Suppression of CD26-Dependent T Cell Growth .............................. 161 Sabine Wrenger, Dirk Reinhold, Jürgen Faust, Carmen Mrestani-Klaus, Wolfgang Brandt, Annen Fengler, Klaus Neubert, and Siegfried Ansorge 19. DNA Synthesis in Cultured Human Keratinocytes and HACAT Keratinocytes is Reduced by Specific Inhibition of Dipeptidyl Peptidase IV (CD26) Enzymatic Activity .................................. 167 Robert Vetter, Dirk Reinhold, Frank Bühling, Uwe Lendeckel, Ilona Born, Jürgen Faust, Klaus Neubert, Siegfried Ansorge, and Harald Gollnick 20. Attractin: A CUB-Family Protease Involved in T Cell-Monocyte/ Macrophage Interactions ....................................... 173 Jonathan S. Duke-Cohan, Wen Tang, and Stuart F. Schlossman 21. Analogs of Glucose-Dependent Insulinotropic Polypeptide with Increased Dipeptidyl Peptidase IV Resistance ...................... 187 Kerstin Kühn-Wache, Susanne Manhart, Torsten Hoffmann, Simon A. Hinke, R. Gelling, Raymond A. Pederson, Christopher H.S. McIntosh, and Hans-Ullrich Demuth 22. Dipeptidyl Peptidase IV (DPP IV, CD26) in Patients with Mental Eating Disorders ................................................... 197 Martin Hildebrandt, Matthias Rose, Christine May r, Petra Arck, Cora Schüler, Werner Reutter, Abdulgabar Salama, and Burghard F. Klapp 23. The Membrane-Bound Ectopeptidase CPM as a Marker of Macrophage Maturation in Vitro and in Vivo ................................. 205 Michael Rehli, Stefan W. Krause, and Reinhard Andreesen 24. Matrix Metalloproteinases (MMP-8, -13, and -14) Interact with the Clotting System and Degrade Fibrinogen and Factor XII (Hagemann Factor) ..................................................... 217 Harald Tschesche, Andrea Lichte, Oliver Hiller, André Oberpichler, Frank H. Büttner, and Eckart Bartnik x Contents 25. The Neprilysin Family in Health and Disease ...................... 229 Anthony J. Turner, Carolyn D. Brown, Julie A. Carson, and Kay Barnes Part II: Cellular Endopeptidases: New Cathepsins; Results from Knock-out-mice; Regulatory Aspects 26. Review: Novel Cysteine Proteases of the Papain Family ............. 241 Frank Bühling, Annen Fengler, Wolfgang Brandt, Tobias Welte, Siegfried Ansorge, and Dorit K. Nägler 27. Development and Validation of Homology Models of Human Cathepsins K, S, H, and F ..................................... 255 Annett Fengler and Wolfgang Brandt 28. The Function of Propeptide Domains ofCysteine Proteinases ......... 261 Bernd Wiederanders 29. Human Cathepsins W and F Form a New Subgroup of Cathepsins that is Evolutionarily Separated from the Cathepsin B- and L-like Cysteine Proteases ................................................... 271 Thomas Wex, Brynn Levy, Heike Wex, and Dieter Brömme 30. Cathepsin K Expression in Human Lung .......................... 281 Frank Bühling, Nadine Waldburg, Annegret Gerber, Carsten Häckel, Sabine Krüger, Dirk Reinhold, Dieter Brömme, Ekkehard Weber, Siegfried Ansorge, and Tobias Weite 31. Expression of Cathepsins B and L in Human Lung Epithelial Cells is Regulated by Cytokines ..................................... 287 Annegret Gerber, Tobias Weite, Siegfried Ansorge, and Frank Bühling 32. Functions of Cathepsin K in Bone Resorption: Lessons from Cathepsin K Deficient Mice .............................................. 293 Paul Saftig, Ernst Hunziker, Vincent Everts, Sheila Jones, Alan Boyde, Olaf Wehmeyer, Anke Sute r, and Kurt von Figura 33. Ceramide as an Activator Lipid of Cathepsin D .................... 305 Michael Heinrich, Marc Wickel, Supandi Winoto-Morbach, Wulf Schneider-Brachen, Thomas Weber, Josef Brunner, Paul Saftig, Christoph Peters, Martin Krönke, and Stefan Schütze 34. Human Cathepsin X: A Novel Cysteine Protease with Unique Specificity ................................................... 317 Robert Ménard, Dorit K. Nägler, Rulin Zhang, Wendy Tam, Traian Sulea, andEnrico O. Purisima
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