Cardiovascular Physiology in the Genetically Engineered Mouse PDF
Preview Cardiovascular Physiology in the Genetically Engineered Mouse
CARDIOVASCULAR PHYSIOLOGY IN THE GENETICALLY ENGINEERED MOUSE SECOND EDITION Developments in Cardiovascular Medicine 213. Juan Carlos Kaski (ed.): Chest Pain with Normal Coronary Angiograms: Pathogenesis, Diagnosis and Management. 1999. ISBN: 0-7923-8421-0 214. P.A. Doevendans, R.S. Reneman and M . Van Bilsen (eds): Cardiovascular Specific Gene Expresion. 19 ISBN:0-7923-563-0 215. G. Pons-Lladö, F. Carreras, X . Borräs, Subirana and L . J . Jimenez-Borreguero (eds.): Atlas of Practical Cardiac Applications ofMRI. 1999 ISBN: 0-7923-5636-5 216. L . W . Klein, J.E. Calvin, Resource Utilization in Cardiac Disease. 1999. ISBN:0-7923-8509-8 217. R. Gorlin, G. Dangas, P. K . Toutouzas, M . M Konstadoulakis, Contemporary Concepts in Cardiology, Pathophysiology and Clinical Management. 1999 ISBN.0-7923-8514-4 218. S. Gupta, J. Camm (eds.): Chronic Infection, Chlamydia and Coronary Heart Disease. 19. ISBN:0-7923-5797-3 219. M . Raj skina: Ventricular Fibrillation in Sudden Coronary Death. 1999. ISBN:0-7923-8570-5 220. Z. Abedin, R. Conner: Interpretation of Cardiac Arrhythmias: Self Assessment Aproach. 19. ISBN:0-7923-8576-4 221. J. E. Lock, J.F. Keane, S. B. Perry: Diagnostic and Interventional Catheterization In Congenital Heart Disease. 2000. ISBN: 0-7923-8597-7 222. J.S. Steinberg: Atrial Fibrillation after Cardiac Surgery. 2000. ISBN: 0-7923-8655-8 223. E.E . van der Wall, A . van der Laarse, B . M . Pluim, A . V . G . Bruschke: Left Ventricular Hypertrophy: Physiology versus Pathology. 2000 ISBN: 0-7923-6038-9 224. J.F. Keaney, Jr. (ed.): Oxidative Stress and Vascular Disease. 2000. ISBN: 0-7923-8678-7 228. B.E. Jaski: Basics of Heart Failure. 2000 ISBN: 0-7923-7786-9 229. H . H . Osterhues, V . Hombach, A . J . Moss (eds.): Advances in Non-Invasive Electrocardiographic Monitoring Techniques. 2000. ISBN: 0-7923-6214-4 230. K. Robinson (ed.): Homocysteine and Vascular Disease. 2000 ISBN: 0-7923-6248-9 231. C.I. Berul, J .A. Towbin (eds.): Molecular Genetics of Cardiac Electrophysiology. 2000. ISBN: 0-7923-7829-6 232. A . Bay es de Luna, F. Furlanello, B.J. Maron and D.P. Zipes (eds.): Arrhythmias and Sudden Death in Athletes. 2000 ISBN: 0-7923-6337-X 233. J-C. Tardif and M . G . Bourassa (eds): Antioxidants and Cardiovascular Disease. 2000. ISBN: 0-7923-7829-6 234. J. Candell-Riera, J. Castell-Conesa, S. Aguade Bruiz (eds): Myocardium at Risk and Viable Myocardium Evaluation by SPET. 2000.ISBN: 0-7923-6724-3 235. M . H . Ellestad and E. Amsterdam (eds): Exercise Testing: New Concepts for the New Century. 2001. ISBN: 0-7923-7378-2 236. Douglas L . Mann (ed.): The Role of Inflammatory Mediators in the Failing Heart. 2001 ISBN: 0-7923-7381-2 237. Donald M . Bers (ed.): Excitation-Contraction Coupling and Cardiac Contractile Force, Second Edition. 2001 ISBN: 0-7923-7157-7 238. Brian D. Hoit, Richard A . Walsh (eds.): Cardiovascular Physiology in the Genetically Engineered Mouse, Second Edition. 2001 ISBN 0-7923-7536-X Previous volumes are still available CARDIOVASCULAR PHYSIOLOGY IN THE GENETICALLY ENGINEERED MOUSE SECOND EDITION edited by Brian D. Hoit Case Western Reserve University and University Hospitals of Cleveland And Richard A . Walsh Case Western Reserve University and University Hospitals of Cleveland SPRI N G E R SCIENCE+BUSINESS M E D I A , L L C Library of Congress Cataloging-in-Publication Data Cardiovascular physiology in the genetically engineered mouse / edited by Brian D. Hoit n d and Richard A . W a l s h . — 2 ed. p.; cm. — (Developments in cardiovascular medicine; 238) Includes bibliographical references and index. ISBN 978-1-4613-5661-5 ISBN 978-1-4615-1653-8 (eBook) DOI 10.1007/978-1-4615-1653-8 1. Heart—Physiology. 2. Transgenic mice. 3. Heart—Diseases—Animal models. I. Hoit, Brian D. II. Walsh, Richard A. , 1946- III. Developments in cardiovascular medicine; v. 238. [ D N L M : 1. Cardiovascular Physiology. 2. Genetic Engineering. 3. Mice, Transgenic—physiology. W G 102 C267152 2001] QP112.5.A55 C37 2001 573.T9353—dc21 2001038763 Copyright © 2002 Springer Science+Business Media New York Originally published by Kluwer Academic Publishers in 2002 Softcover reprint of the hardcover 2nd edition 2002 A l l rights reserved. N o part o f this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means, mechanical, photo- copying, recording, or otherwise, without the prior written permission o f the publisher, Springer Science+Business Media, L L C . Printed on acid-free paper. DEDICATION To our wives, Valerie Hoit and Donna Walsh. TABLE OF CONTENTS Preface xiii PART ONE 1. The Hierarchical Approach to Analysis of Cardiovascular 1 Function in Mice:An Overview Richard A. Walsh, M.D. 2. Genetic Alterations and Modeling of Cardiovascular 17 Physiology Albrecht Schmidt, M.D., Vivek J. Kadambi, Ph.D., Karen B. Young, Evangelia G. Kranias, Ph.D. 3. Conditional Transgenesis 39 Tetsuo Minamino, M.D., Ph.D., Michael D. Schneider, M.D. 4. Array Transcription Profiling: Molecular Phenotyping 53 Of Rodent Cardiovascular Models Susan Acton, Ph.D., Raju Jeyaseelan, Ph.D., Vivek 1. Kadambi, Ph.D.,Roger E. Breitbart, M.D. 5. Murine Cardiovascular Development 63 Steven A. Fisher, M.D. PART TWO 6. Isolated Myocyte Mechanics and Calcium Transients 71 Zhi Su, M.D., Ph.D., William H. Barry, M.D. 7. Single Cell Patch-Clamp Analysis of Mouse Cardiac Myocytes 91 Nipavan Chiamvinonvat, M.D., M. Jane Lalli Ph.D., Atsuko Yatani, Ph.D. 8. The Isolated Isovolumic (Langendorff) Heart Preparation 113 Martin LeWinter, M.D. 9. The Isolated Work-Performing and Ejecting Mouse Heart 129 Preparation, Comparison and Quantification of Cardiac Performance inTransgenic and Wild-type Mice Ingrid L. Grupp, M.D., Jo El Schultz, Ph.D., George Sfyris, Gunter Grupp, M.D., Ph.D. 10. 31 p NMR Spectroscopy of the Mouse Heart 151 Joanne S. Ingwall, Ph.D., Maryan M. Javadpour, Ph.D. Wenfeng Miao, M.D., Ph.D. viii 11. Electrophysiological Characterization of the Mouse Heart 165 Using Voltage-Sensitive Dyes Benjamin C. Eloff, M.S., David Rosenbaum, MD. 12. Echocardiographic Assessment of the Mouse Heart 177 and Aorta Brian D. Hoit, M.D. 13. In Vivo Invasive Hemodynamic Studies in Mice 191 Brian D. Hoit, MD. 14. Pressure-Volume Relations 207 Dimitrios Georgakopoulos, Ph.D., David A. Kass, M.D. 15. Assessment of Left Ventricular Diastolic Function in Mice 223 Michael R. Zile, M.D., Anne Hauef, M.D., Elizabeth Hapke, B.S., Janet Simsic, MD. 16. In Vivo Electrophysiologic Studies in Mice 237 Charles 1. Beml, M.D., Paul J. Yang, M.D. 17. Cardiovascular Physiology in Mice: Conscious 257 Function Measurements and Effects of Anesthesia Stephen Vatner, M.D., Gen. Takagi M.D., Kuniya Asai, M.D., Richard P. Shannon, M.D. 18. Exercise and Oxygen Consumption in the Mouse 277 Kavin H. Desai, M.D., Daniel Bernstein, M.D. 19, Clinical Laboratory Analysis of the Genetically 303 Manipulated Mouse William Lewis, M.D. PART THREE 20. Smooth Muscle Studies Using Gene-Altered 319 Mouse Models: A Users' Guide Roy L. Sutliff, Ph.D., Richard J. Paul, Ph.D. 21. Models of Cardiac Disease in the Mouse, 335 Cardiac Hypertrophy and Heart Failure Yasuhiro Ikeda, M.D., Ph.D., John Ross, Jr., M.D. 22. Analysis of Murine Embryonic Cardiovascular Phenotype 353 Kimimasa Tobita, Joseph P. Tinney, Bradley B. Keller, M.D. 23. Newer In Vivo Imaging Modalities 377 Roee S. Lazebnik, David L. Wilson, Ph.D. Index 397 CONTRIBUTING AUTHORS Susan Acton, Ph.D. Benjamin C. Eloff, M.S. Senior Scientist The Heart & Vascular Research Center Millennium Pharmaceuticals, Inc. MetroHealth Campus and 75 Sydney St. Case Western Reserve University Cambridge, Mass 02139 2500 MetroHealth Drive Cleveland,OH 44109 Kuniya Asai, M.D. Steven Fisher, M.D. Assistant Professor of Medicine Assistant Professor of Medicine Cardiovascular Research Institute Case Western University and University of Medicine & Dentistry University Hospitals of Cleveland of New Jersey 11100 Euclid Avenue 185 South Orange Street Cleveland,OH 44109 Newark, New Jersey 07103 Dimitrios Georgakopoulos, Ph.D. William Barry, M.D. Johns Hopkins Medical Institution Professor of Medicine Johns Hopkins University University of Utah Medical Center 725 N Wolfe St 50 North Medical Drive Baltimore, MD 21205-2100 Salt Lake City, UT 84132-0001 Ingrid L. Grupp, M.D. Daniel Bernstein, M.D. Professor of Pharmacol and Cell Biophysics Chief, Division of Pediatric Cardiology University of Cincinnati Stanford University Medical Center P. O. Box 670575 750 Welch Road, Suite 305 Cincinnati,OH 45267-0575 Palo Alto, CA 94304 Gunter L. Grupp, M.D. Ph.D. C.1. Berul, M.D. Professor Emeritus Associate Professor of Pediatrics Molecular and Cell Physiology Department of Cardiology University of Cincinnati Children's Hospital P.O. Box 670576 300 Longwood A venue Cincinnati, OH 452670576 Boston, MA 02115 Elizabeth Hapke, B.S. Roger E. Breitbart, M.D. Medical University of South Carolina Research Scientist Gazes Cardiac Research Center Millennium Pharmaceuticals, Inc. Two Richland Medical Park 75 Sydney St. Columbia, SC 29203 Cambridge, Ma. 02139 Anne Hauet, M.D. Nipavan Chiamvimonvat, M.D. Fellow in Cardiology Assistant Professor of Medicine Medical University of South Carolina University of California, Davis Gazes Cardiac Research Center 808 Kestrel Place Two Richland Medical Park Davis, CA 94616 Columbia, SC 29203 Kavin H. Desai, M.D. Brian D. Hoit, M.D. Assistant Professor of Medicine Professor of Medicine Department of Pediatric Cardiology Case Western Reserve University and Stanford University Medical Center University Hospitals of Cleveland 750 Welch Road, Suite 305 11100 Euclid Ave Palo Alto, CA 94304 Cleveland, OH 44106-5038 x Yasuhiro Ikeda, M.D. Ph.D. Roee S. Lazebnik Department of Medicine Department of Biomedical Eng. University of California San Diego Case Western Reserve University 200 W. Arbor Street 11100 Euclid Avenue San Diego, CA 92103-9000 Cleveland, Ohio 44109 Martin LeWinter, M.D. Joanne S. Ingwall, Ph.D. Director, NMR Lab Physiology Chemistry Professor of Medicine and Director, Cardiology Unit Brigham and Women's Hospital 221 Longwood A venue, Room 209 University of Vermont Boston, MA 02115-5817 Fletcher Allen Health Care, MCHVCampus III Colchester Ave. Maryam M. Javadpour, Ph.D. Burlington, Vt. 05401-1473 Brigham and Women's Hospital 221 Longwood Avenue, Room 209 William Lewis, M.D. Boston, MA 02115-5817 Professor of Pathology Emory University Raju Jeyaseelan, Ph.D. 1364 Clifton Road NE Senior Scientist Atlanta, GA 30303-3033 Millennium Pharmaceuticals, Inc. 75 Sydney St. Wenfeng Miao, M.D. Ph.D. Cambridge, MA. 02139 Brigham and Women's Hospital 221 Longwood Avenue, Room 209 Vivek J. Kadambi, Ph.D. Boston, MA 02115-5817 Scientist Millennium Pharmaceuticals, Inc. 75 Sydney Street Tetsuo Minamino, M.D. PhD. Cambridge, MA 02139 Associate Professor Center for Cardiovascular Development David Kass, M.D. Baylor College of Medicine Professor of Medicine 6550 Fannin, Suite 6629 & Biomedical Engineering Houston, TX 77030 Johns Hopkins University 725 N Wolfe St Baltimore, MD 21205-2100 Richard J. Paul, Ph.D. Professor of Molecular and Bradley B. Keller, M.D. Cellular Physiology Jennifer Gill Associate Professor of Pediatrics University of Cincinnati Chief, Pediatric Cardiology P. O. Box 670576 Director, Ped. CV Research Program Cincinnati, OH 45267 0576 University of Kentucky, Chandler Medical Center 800 Rose Street, Room MN472 Lexington, KY 40536-0298 David S. Rosenbaum, M.D. Director, Heart & Vascular Research Center Associate Professor of Medicine, Biomedical Evangelia G. Kranias, Ph.D. Engineering, Physiology Professor of Pharmacology and MetroHealth Campus Cell Biophysics 2500 MetroHealth Drive University of Cincinnati Cleveland,OH 44106 P. O. Box 670575 Cincinnati,OH 452670575 John Ross, Jr., M.D. Professor of Medicine M. Jane Lalli, Ph.D. Assoc. Director for Scientific Affairs Research Associate University of California, San Diego Hackensack University Medical Center 9500 Gilman Drive 0613B 30 Prospect Street La Jolla, CA 92093-5003 Hackensack, NJ 07601 xi Albrecht G. Schmidt, M.D. Gen Takagi, M.D. Department of Pharmacology Post Doctorate Fellow and Cell Biophysics University of Medic ine & Dentistry University of Cincinnati 185 South Orange St College of Medicine Newark, NJ 07103-2714 P. O. Box 67075 Cincinnati,OH 45267-0575 Kimimasa Tobita, Ph.D. Cardiovascular Development Research Jo El Schultz, Ph.D. Program Assistant Professor of Pharmacology University of Kentucky University of Cincinnati 740 South Limestone Street P. O. Box 670575 Lexington, KY 40536-0284 Cincinnati,OH 45267 0575 Joseph P. Tinney Michael Schneider, M.D. Cardiovascular Research Program Professor of Medicine University of Kentucky Center for Cardiovascular Development 740 South Limestone Street 1206·A Farrot Hall Lexington, KY 40536·0284 Bellows Lane Houston, TX 77030 Stephen Vatner, M.D. Professor, Department of Medicine George Sfyris Cardiovascular Research Institute University of Medicine & Research Associate Dentistry of New Jersey Department of Molecular and New Jersey Medical School Cellular Physiology 185 S. Orange Street University of Cincinnati Newark, New Jersey 07103-2757 P. O. Box 670576 Cincinnati, OH 452670576 Richard A. Walsh, M.D. Professor of Medicine Richard P. Shannon, M.D. Case Western Reserve University & Chairman, Department of Medicine University Hospitals of Cleveland Allegheny University Hospital 11100 Euclid Avenue 320 East North A venue Cleveland.OH 44106 Pittsburgh. PA 152124772 Paul J. Wang, M.D. Janet Simsic, M.D. Associate Director of Cardiac Assistant Professor. Pediatric Cardiology Electrophysiology and Pacing Lab Medical University of South Carolina New England Medical Center Gazes Cardiac Research Institute Tufts University School of Medicine Ralph H. Johnson Department of Veteran 750 Washington Street Affairs Medical Center Boston. MA 02111-1526 Two Richland Medical Park Columbia. SC 29203 David Wilson, Ph.D. Associate Professor of Biomedical Engineering Zhi Su, M.D., Ph.D. Department of Biomedical Engineering and Research Associate. Radiology Cardiology Division Case Western Reserve University University of Utah Health Sciences Center 11100 Euclid Avenue 50 North Medical Drive Cleveland,OH 44106 Salt Lake City, UT 84132 Atsuko Yatani, Ph.D. Roy L. Sutliff, Ph.D. Professor. Department of Medicine Department of Pathology New Jersey Medical School Emory University Hackensack Medical Center 1639 Pierce Drive. Rm 7120 WMB 30 Prospect Street Atlanta. GA 30322 Hackensack. NJ 07601
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