Cannabinoids in Neurologic and Mental Disease PDF
Preview Cannabinoids in Neurologic and Mental Disease
Cannabinoids in Neurologic and Mental Disease http://store.elsevier.com/product.jsp?&isbn=9780124170414 Cannabinoids in Neurologic and Mental Disease Edited by Liana Fattore Resources for Professors: All figures from the book available as Powerpoint slides All tables from the book available as PDFs Links to web sites carefully chosen to supplement the content of the volume Abstracts of all chapters plus a full Table of Contents Cannabinoids in Neurologic and Mental Disease Edited by Liana Fattore CNR Neuroscience Institute (cid:1) Cagliari National Research Council of Italy Department of Biomedical Sciences Division of Neuroscience and Clinical Pharmacology University of Cagliari, Cagliari, Italy AMSTERDAM(cid:129)BOSTON(cid:129)HEIDELBERG(cid:129)LONDON NEWYORK(cid:129)OXFORD(cid:129)PARIS(cid:129)SANDIEGO SANFRANCISCO(cid:129)SINGAPORE(cid:129)SYDNEY(cid:129)TOKYO AcademicPressisanimprintofElsevier AcademicPressisanimprintofElsevier 32JamestownRoad,LondonNW17BY,UK 525BStreet,Suite1800,SanDiego,CA92101-4495,USA 225WymanStreet,Waltham,MA02451,USA TheBoulevard,LangfordLane,Kidlington,OxfordOX51GB,UK Copyright©2015ElsevierInc.Allrightsreserved. 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Practitionersandresearchersmustalwaysrelyontheirownexperienceandknowledgeinevaluatingand usinganyinformation,methods,compounds,orexperimentsdescribedherein.Inusingsuchinformationor methodstheyshouldbemindfuloftheirownsafetyandthesafetyofothers,includingpartiesforwhomthey haveaprofessionalresponsibility. Tothefullestextentofthelaw,neitherthePublishernortheauthors,contributors,oreditors,assumeany liabilityforanyinjuryand/ordamagetopersonsorpropertyasamatterofproductsliability,negligenceor otherwise,orfromanyuseoroperationofanymethods,products,instructions,orideascontainedinthe materialherein. ISBN:978-0-12-417041-4 BritishLibraryCataloguing-in-PublicationData AcataloguerecordforthisbookisavailablefromtheBritishLibrary LibraryofCongressCataloging-in-PublicationData AcatalogrecordforthisbookisavailablefromtheLibraryofCongress ForinformationonallAcademicPresspublications visitourwebsiteathttp://store.elsevier.com/ CoverImage(topleft):[18F]MK-9470andHDCross-sectional,partial-volumecorrected,modified standardizeduptakevalue(mSUV)parametricimages,averagedforallcontrols(n514),early-HDpatients (n57),andtotalgroupofHDpatients(n519). TypesetbyMPSLimited,Chennai,India www.adi-mps.com PrintedandboundintheUnitedStatesofAmerica In memory of Sabrina, a faithful friend, a precious colleague, a generous heart Preface Cannabis sativa has a very long history of use for medical purposes, however this use declined early in the twentieth century due to the growing evidence of marijuana’s addictive potential. Recent progress in cannabinoid pharmacology, together with the discovery of the body’s endogenous cannabinoid system as a neuromodulatory system comprised of receptors, endogenous ligands (endo- cannabinoids), and enzymes responsible for the synthesis and degradation of endocannabinoids, has renewed interest in cannabis-based medicines. This allowed novel cannabinoid-based medicines development for treatment of dif- ® ® ferent human pathologies, like Cesamet (nabilone), Marinol (synthetic THC), ® and Sativex (an equimolecular combination of THC and cannabidiol enriched botanical extracts). This book is intended to provide a fascinating exploration into the latest evi- dence of therapeutic potentials of Cannabis derivatives, and to analyze the pros and cons for cannabis-based medications in mental diseases in a systematic and balanced manner. Leading academics and clinicians in the fields of medicine, neuroscience, pharmacology, and psychology illustrate and discuss the most recent findings on involvement of endocannabinoid system in 16 different brain diseases, ranging from rodent studies to clinical trials, from behavioral pharma- cologyto brain neurotransmission. By illustrating opinions of prominent experts on current advances in each mental disorder in a clear and readable form, this book provides a balanced syn- opsis of the role of the endogenous cannabinoid system in: 1) neuroinflamma- tory and neurodegenerative diseases (Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, multiple sclerosis, epilepsy, migraine); 2) neurological and psychiatric disorders (schizophrenia, bipolar disorder, Tourette syndrome, post-traumatic stress disorder, drug addiction, appetite dysregulation); and 3) impulsive and compulsive disorders (impulsive behavior, obsessive-compul- sive disorder, binge eating disorder, trichotillomania). An introductory chapter on Endocannabinoids in the nervous system health and disease paves the way for the following dedicated chapters, while a comprehensive overview on canna- binoid CB ligands and their therapeutic potential in mental diseases concludes 2 this volume. Thisbookwilllikelyhelpunravelwhysomepatientsvoluntarilyconsumecanna- binoids to relieve symptoms (e.g. multiple sclerosis) while others (e.g. schizophrenic patients) are particularly vulnerable to cannabis exposure, and will shed (scientific) lightoncommonmythsconcerningthemedicinalusesofcannabis. LianaFattore xvii List of Contributors SherifAbdelmessih Center for Treatment and Research ofBipolarDisorder,The ZuckerHillside Hospital, North Shore-LIJ Health System, Glen Oaks, NY,USA; Department of Psychiatry Research,The ZuckerHillside Hospital, North Shore-LIJ Health System, GlenOaks, NY,USA; Fordham University,Bronx, NY,USA Rawaha Ahmad Division ofNuclear Medicine and MolecularImaging, University Hospitals Leuven,Leuven, Belgium Robert E. Blair Department ofNeurology,VirginiaCommonwealth University School of Medicine, Richmond,VA,USA RaphaelJ. Braga Center for Treatment and Research ofBipolarDisorder,The ZuckerHillside Hospital, North Shore-LIJ Health System, Glen Oaks, NY,USA; Department of Psychiatry Research,The ZuckerHillside Hospital, North Shore-LIJ Health System, GlenOaks, NY,USA; Department ofPsychiatry,HofstraNorth Shore-LIJ School ofMedicine atHofstraUniversity,Hempstead,NY,USA VeronicaA. Campbell Trinity College Instituteof Neuroscience, Department ofPhysiology,Schoolof Medicine, University ofDublin, Trinity College, Dublin, Ireland Plinio C.Casarotto Department ofPharmacology,Medical School ofRibeira˜o Pretoand Center for Interdisciplinary Research on Applied Neurosciences, University ofSa˜oPaulo, Ribeira˜oPreto,SP, Brazil Cindy Casteels Division ofNuclear Medicine and MolecularImaging, University Hospitals Leuven,Leuven, Belgium; Molecular Small AnimalImaging Centre, KU Leuven, Leuven,Belgium SamuelR. Chamberlain DepartmentofPsychiatry,UniversityofCambridge,Cambridge,UKand CambridgeandPeterboroughNHSFoundationTrust,Fulbourn,Cambridge,UK Kwang H.Choi Center for theStudy ofTraumatic Stress, Department of Psychiatry,Bethesda, MD, USA Ruth Concannon Pharmacology& Therapeutics and NCBES Galway Neuroscience Centre, NationalUniversity ofIreland, Galway,Ireland xix xx List of Contributors MariaL. de Ceballos NeurodegenerationGroup,DepartmentofCellular,MolecularandDevelopmental NeurobiologyandCIBERNED,CajalInstitute,CSIC,Madrid,Spain Eva de Lago Departamento de Bioquı´micay Biologı´a Molecular,Instituto Universitariode Investigacio´n enNeuroquı´mica, Facultad de Medicina,Universidad Complutense,Madrid, Spain; Centro de Investigacio´n Biome´dica en Red sobre Enfermedades Neurodegenerativas; InstitutoRamo´ny Cajal de Investigacio´n Sanitaria, Madrid, Spain MariaAntoniettaDe Luca Department ofBiomedicalScience, Neuropsychopharmacology Section, University ofCagliari,Italy; National Instituteof Neuroscience,University of Cagliari, Italy Robert J. DeLorenzo Department ofNeurology,Virginia Commonwealth University School of Medicine, Richmond,VA,USA Laxmikant S.Deshpande Department ofNeurology,Virginia Commonwealth University School of Medicine, Richmond,VA,USA Eilı´s Dowd Pharmacology & Therapeutics and NCBES GalwayNeuroscience Centre, National University ofIreland, Galway,Ireland Francisco Espejo-Porras Departamento de Bioquı´micay Biologı´a Molecular,Instituto Universitariode Investigacio´n enNeuroquı´mica, Facultad de Medicina,Universidad Complutense,Madrid, Spain; Centro de Investigacio´n Biome´dica en Red sobre Enfermedades Neurodegenerativas; InstitutoRamo´ny Cajal de Investigacio´n Sanitaria, Madrid, Spain PaolaFadda Centre ofExcellence “Neurobiology ofDependence,” University ofCagliari, Italy;Department ofBiomedical Sciences, Division ofNeuroscience and Clinical Pharmacology, University ofCagliari,Italy; National Instituteof Neuroscience,University of Cagliari, Italy Steven G.Fagan Trinity College Institute ofNeuroscience, Department ofPhysiology,School of Medicine, University of Dublin, TrinityCollege, Dublin, Ireland Liana Fattore CNR Neuroscience Institute(cid:1)Cagliari,NationalResearch CouncilofItaly, Department ofBiomedicalSciences, Division of Neuroscienceand Clinical Pharmacology,University ofCagliari, Cagliari, Italy List of Contributors xxi Javier Ferna´ndez-Ruiz Departamentode Bioquı´mica y Biologı´aMolecular, InstitutoUniversitario de Investigacio´n en Neuroquı´mica, Facultad de Medicina,Universidad Complutense,Madrid, Spain; Centrode Investigacio´n Biome´dica en Red sobre Enfermedades Neurodegenerativas; Instituto Ramo´n y Cajal de Investigacio´n Sanitaria, Madrid, Spain David P.Finn Pharmacology& Therapeutics and NCBES Galway Neuroscience Centre, NationalUniversity ofIreland, Galway,Ireland Walter Fratta Centre ofExcellence “Neurobiologyof Dependence,” University of Cagliari, Italy;Department ofBiomedical Sciences, Division ofNeuroscience and ClinicalPharmacology,University ofCagliari, Italy; NationalInstitute of Neuroscience, University ofCagliari, Italy FrancesH. Gabbay Center for theStudy ofTraumatic Stress, Department of Psychiatry,Bethesda, MD, USA Felipe V.Gomes Department ofPharmacology,Medical School ofRibeira˜o Pretoand Center for Interdisciplinary Research on Applied Neurosciences, University ofSa˜oPaulo, Ribeira˜oPreto,SP, Brazil Jon E.Grant Department ofPsychiatry and Behavioral Neuroscience, University ofChicago, Chicago,IL, USA Rosaria Greco Headache Science Centre, C.Mondino NationalNeurological Institute,Pavia, Italy Francisco S.Guimara˜es Department ofPharmacology,Medical School ofRibeira˜o Pretoand Center for Interdisciplinary Research on Applied Neurosciences, University ofSa˜oPaulo, Ribeira˜oPreto,SP, Brazil HirokiIshiguro Department ofNeuropsychiatryand Clinical Ethics, University ofYamanashi, Japan F. MarkusLeweke CentralInstituteofMentalHealth,DepartmentofPsychiatryandPsychotherapy, MedicalFacultyMannheim,HeidelbergUniversity,Mannheim,Germany Qing-Rong Liu Intramural Research Program, NationalInstituteon DrugAbuse/National Institutes ofHealth,Baltimore, MD, USA xxii List of Contributors AnilMalhotra Department ofPsychiatryResearch, The Zucker HillsideHospital, North Shore-LIJ HealthSystem, Glen Oaks, NY,USA; Department of Psychiatry, HofstraNorthShore-LIJ School ofMedicine atHofstraUniversity,Hempstead, NY,USA Vincenzo DiMarzo Endocannabinoid Research Group,Instituteof Biomolecular Chemistry, Consiglio Nazionale delle Ricerche,Pozzuoli, Italy Ciara McCabe School ofPsychology and Clinical Language Sciences, University ofReading, Whiteknights, Reading, UK Miguel Moreno-Martet Departamento de Bioquı´micay Biologı´a Molecular,Instituto Universitariode Investigacio´n enNeuroquı´mica, Facultad de Medicina,Universidad Complutense,Madrid, Spain; Centro de Investigacio´n Biome´dica en Red sobre Enfermedades Neurodegenerativas; InstitutoRamo´ny Cajal de Investigacio´n Sanitaria, Madrid, Spain KirstenR.Mu¨ller-Vahl Clinicfor Psychiatry,Socialpsychiatry and Psychotherapy,Hannover Medical School, Germany Brian L. Odlaug Department ofPublic Health,Facultyof Health and Medical Sciences, University ofCopenhagen, Copenhagen,Denmark Emmanuel S.Onaivi Department ofBiology, William Paterson University,Wayne,NJ, USA Tommy Pattij Department ofAnatomy and Neurosciences, Neuroscience Campus Amsterdam, VUUniversity Medical Center,Amsterdam, The Netherlands Fabiana Piscitelli Endocannabinoid Research Group,Instituteof Biomolecular Chemistry, Consiglio Nazionale delle Ricerche,Pozzuoli, Italy Cathrin Rohleder CentralInstituteofMentalHealth,Department ofPsychiatry and Psychotherapy, Medical FacultyMannheim, Heidelberg University,Mannheim, Germany Valentina Satta Department ofBiomedicalSciences, Division of Neuroscienceand Clinical Pharmacology,University ofCagliari, Italy
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