Cancer: Principles and Practice of Oncology Primer of the Molecular Biology of Cancer 3rd ed (Eds) Vincent T. DeVita Jr., Theodore S. Lawrence, Steven A. Rosenberg with 71 contributing authors PDF
Preview Cancer: Principles and Practice of Oncology Primer of the Molecular Biology of Cancer 3rd ed (Eds) Vincent T. DeVita Jr., Theodore S. Lawrence, Steven A. Rosenberg with 71 contributing authors
Editors Vincent T. DeVita Jr., MD Amy and Joseph Perella Professor of Medicine Yale Comprehensive Cancer Center and Smilow Cancer Hospital at Yale-New Haven Professor of Epidemiology and Public Health Yale University School of Public Health New Haven, Connecticut Theodore S. Lawrence, MD, PhD Isadore Lampe Professor and Chair Department of Radiation Oncology University of Michigan Ann Arbor, Michigan Steven A. Rosenberg, MD, PhD Chief, Surgery Branch, National Cancer Institute, National Institutes of Health Professor of Surgery, Uniformed Services University of the Health Sciences School of Medicine Bethesda, Maryland Professor of Surgery George Washington University School of Medicine Washington, District of Columbia With 71 Contributing Authors Senior Acquisitions Editor: Sharon Zinner Development Editor: Sean McGuire Editorial Coordinator: John Larkin Marketing Manager: Hunter Phyllis Production Project Manager: Bridgett Dougherty Design Coordinator: Holly McLaughlin Manufacturing Coordinator: Beth Welsh Prepress Vendor: Absolute Service, Inc. Third edition Copyright © 2021 Wolters Kluwer Copyright © 2015 Wolters Kluwer Health. Copyright © 2011 Wolters Kluwer Health / Lippincott Williams & Wilkins. All rights reserved. This book is protected by copyright. No part of this book may be reproduced or transmitted in any form or by any means, including as photocopies or scanned- in or other electronic copies, or utilized by any information storage and retrieval system without written permission from the copyright owner, except for brief quotations embodied in critical articles and reviews. Materials appearing in this book prepared by individuals as part of their official duties as U.S. government employees are not covered by the above-mentioned copyright. To request permission, please contact Wolters Kluwer at Two Commerce Square, 2001 Market Street, Philadelphia, PA 19103, via email at [email protected], or via our website at shop.lww.com (products and services). 9 8 7 6 5 4 3 2 1 Printed in China Library of Congress Cataloging-in-Publication Data Names: DeVita, Vincent T., Jr., 1935‐ , editor. | Lawrence, Theodore S., editor. | Rosenberg, Steven A., editor. Title: Cancer : principles & practice of oncology. Primer of the molecular biology of cancer / editors, Vincent T. DeVita, Jr., Theodore S. Lawrence, Steven A. Rosenberg ; with 71 contributing authors. Other titles: Primer of the molecular biology of cancer | Devita, Hellman, and Rosenberg’s cancer. 11th edition. Description: Third edition. | [Philadelphia] : Wolters Kluwer, [2021] | Abridgement of: Devita, Hellman, and Rosenberg’s cancer. 11th edition. [2019]. | Includes bibliographical references and index. Identifiers: LCCN 2019055156 | ISBN 9781975149116 | ISBN 9781975149130 (epub) Subjects: MESH: Neoplasms—etiology | Neoplasms—genetics | Neoplasms—physiopathology | Molecular Biology—methods Classification: LCC RC263 | NLM QZ 202 | DDC 616.99/4—dc23 LC record available at https://lccn.loc.gov/2019055156 This work is provided “as is,” and the publisher disclaims any and all warranties, express or implied, including any warranties as to accuracy, comprehensiveness, or currency of the content of this work. This work is no substitute for individual patient assessment based on health-care professionals’ examination of each patient and consideration of, among other things, age, weight, gender, current or prior medical conditions, medication history, laboratory data, and other factors unique to the patient. The publisher does not provide medical advice or guidance, and this work is merely a reference tool. Health-care professionals, and not the publisher, are solely responsible for the use of this work including all medical judgments and for any resulting diagnosis and treatments. Given continuous, rapid advances in medical science and health information, independent professional verification of medical diagnoses, indications, appropriate pharmaceutical selections and dosages, and treatment options should be made, and health-care professionals should consult a variety of sources. When prescribing medication, health-care professionals are advised to consult the product information sheet (the manufacturer’s package insert) accompanying each drug to verify, among other things, conditions of use, warnings, and side effects and identify any changes in dosage schedule or contraindications, particularly if the medication to be administered is new, infrequently used, or has a narrow therapeutic range. To the maximum extent permitted under applicable law, no responsibility is assumed by the publisher for any injury and/or damage to persons or property, as a matter of products liability, negligence law or otherwise, or from any reference to or use by any person of this work. shop.lww.com C O N T R I B U T O R S Gregory P. Adams, PhD Chief Scientific Officer Eleven Biotherapeutics Cambridge, Massachusetts Anupriya Agarwal, PhD Hematology and Medical Oncology, Knight Cancer Institute Oregon Health & Science University Cristina R. Antonescu, MD Director, Bone and Soft Tissue Pathology Department of Pathology Memorial Sloan Kettering Cancer Center New York, New York Brittany A. Avin, PhD Candidate Biochemistry, Cellular, and Molecular Biology Program Johns Hopkins University School of Medicine Baltimore, Maryland Alberto Bardelli, PhD Full Professor Director, Molecular Oncology Department of Oncology University of Torino Candiolo Cancer Institute Candiolo, Italy Alice Hawley Berger, PhD Assistant Member Human Biology and Public Health Sciences Divisions Fred Hutchinson Cancer Research Center Seattle, Washington Tara Berman, MD, MS Medical Oncologist National Cancer Institute National Institutes of Health Bethesda, Maryland Bryan L. Betz, PhD Associate Professor Department of Pathology University of Michigan Technical Director Molecular Diagnostics Laboratory University of Michigan Health System Ann Arbor, Michigan James S. Blachly, MD Assistant Professor of Internal Medicine Division of Hematology Assistant Professor of Biomedical Informatics The Ohio State University Comprehensive Cancer Center—Arthur G. James Cancer Hospital and Richard J. Solove Research Institute Columbus, Ohio Danielle C. Bonadies, MS, CGC Director My Gene Counsel Branford, Connecticut
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