Cancer Nanotechnology: Methods and Protocols

407 Pages·2017·10.853 MB·English

by  Reema Zeineldin (eds.)

Methods in
Molecular Biology 1530
Reema Zeineldin Editor
Cancer Nano-
technology
Methods and Protocols
M M B
ETHODS IN OLECULAR IO LO GY
SeriesEditor
JohnM.Walker
University ofHertfordshire
School of Lifeand MedicalSciences
Hatfield, Hertfordshire, UK
Forfurther volumes:
http://www.springer.com/series/7651
Cancer Nanotechnology
Methods and Protocols
Edited by
Reema Zeineldin
School of Applied Sciences
Mount Ida College
Newton, MA, USA
Editor
ReemaZeineldin
SchoolofAppliedSciences
MountIdaCollege
Newton,MA,USA
ISSN1064-3745 ISSN1940-6029 (electronic)
MethodsinMolecularBiology
ISBN978-1-4939-6644-8 ISBN978-1-4939-6646-2 (eBook)
DOI10.1007/978-1-4939-6646-2
LibraryofCongressControlNumber:2017932075
©SpringerScience+BusinessMediaNewYork2017
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Preface
This volume presents protocols for advancing the utility of nanotechnology in cancer
research toward improving our understanding of cancer biology, prevention, diagnosis,
and therapy. There are continuously new discoveries in the field of nanotechnology, thus
creating new imaging systems or therapies. This volume does not aim at covering those
expansivediscoveries; instead,itfocusesonhowtoemploy certaindiscoveriesforstudying
cancerbypresentingprinciplesalongwithtechniquestoallowforthetransformationofany
new discoveries in the field into cancer-studying tools. The audience for the field of
nanotechnologyincancerisdiverseandincludesphysicalscientists,engineers,andbiomed-
icalscientists.Amajordeficiencyinthefieldofcancernanotechnologyhasbeenthelimited
involvementofbiomedicalscientistswhocanenhancethespeedofdiscoveriestowardcancer
diagnosis and therapy. This volume of the Methods in Molecular Biology series in cancer
nanotechnology may help focus the biomedical scientists on the potential in this field and
improve their understanding of the utility of this field for conquering cancer. This volume
also serves as a resource for physical scientists and engineers interested in employing
nanotechnologyincancerdiagnosisandtherapy.
Newton,MA ReemaZeineldin
v
Contents
Preface ..................................................................... v
Contributors................................................................. xi
PART I OVERVIEWS
1 CancerNanotechnology:OpportunitiesforPrevention,
Diagnosis,andTherapy.................................................. 3
ReemaZeineldinandJoanSyoufjy
2 ImprovedTargetingofCancerswithNanotherapeutics...................... 13
ChristianFoster,AndreWatson,JosephKaplinsky,andNazilaKamaly
PART II NANOTECHNOLOGY-BASED PLATFORMS
3 MultifunctionalLiposomes............................................... 41
BhawaniAryasomayajula,GiuseppinaSalzano,
andVladimirP.Torchilin
4 MultifunctionalConcentricFRET-QuantumDotProbesforTracking
andImagingofProteolyticActivity ....................................... 63
MelissaMassey,JiaJunLi,andW.RussAlgar
5 PreparationandCharacterizationofMagneticNano-in-Microparticles
forPulmonaryDelivery.................................................. 99
AmberA.McBride,DominiqueN.Price,andPavanMuttil
6 MultifunctionalizationofGoldNanoshells................................. 109
SandraW.BishnoiandYujenLin
7 FabricationofPhotothermal StableGoldNanosphere/MesoporousSilica
HybridNanoparticleResponsivetoNear-InfraredLight..................... 117
BeiChengandPeishengXu
8 EngineeringWell-CharacterizedPEG-CoatedNanoparticles
forElucidatingBiologicalBarrierstoDrugDelivery......................... 125
QiYangandSamuelK.Lai
9 PilotingYourNanovehicletoOvercomeBiologicalBarriers.................. 139
StevenM.RichardsandRobertB.Campbell
10 DetectingSonolysisofPolyethyleneGlycolUponFunctionalizing
CarbonNanotubes...................................................... 147
RuhungWang,VasanthS.Murali,andRockfordDraper
11 MethodsforGenerationandDetectionofNonstationaryVapor
NanobubblesAroundPlasmonicNanoparticles............................. 165
EkaterinaY.Lukianova-HlebandDmitriO.Lapotko
vii
viii Contents
PART III NANOTECHNOLOGY TO STUDY CANCER
12 ForceMeasurementsforCancerCells ..................................... 195
VivekRajasekharan,VarunK.A.Sreenivasan,andBrendaFarrell
13 FractalAnalysisofCancerCellSurface..................................... 229
IgorSokolovandMaximE.Dokukin
14 QuantitativeEvaluationoftheEnhancedPermeability
andRetention(EPR)Effect.............................................. 247
LuisaM.Russell,CharleneM.Dawidczyk,andPeterC.Searson
PART IV NANOTECHNOLOGY FOR PREVENTION AND DETECTION/IMAGING
OF CANCER
15 Nanotechnology-BasedCancerVaccine.................................... 257
AwsAlshamsan
16 DesigningMulticomponentNanosystemsforRapidDetection
ofCirculatingTumorCells............................................... 271
ShashwatS.Banerjee,VrushaliKhobragade,andJayantKhandare
17 FluorescenceandBioluminescenceImagingofOrthotopic
BrainTumorsinMice................................................... 283
EmilieMcKinnon,AlfredMoore,SurajDixit,YunZhu,
andAnn-MarieBroome
18 AnUltrasensitiveBiosensingPlatformEmployingAcetylcholinesterase
andGoldNanoparticles ................................................. 307
DingbinLiuandXiaoyuanChen
PART V NANOTECHNOLOGY-BASED THERAPIES
19 GeneSilencingUsingMultifunctionalizedGoldNanoparticles
forCancerTherapy ..................................................... 319
AlexandraR.FernandesandPedroV.Baptista
20 GenerationofDose–ResponseCurvesandImprovedIC50s
forPARPInhibitorNanoformulations..................................... 337
PaigeBaldwin,ShifalikaTangutoori,andSrinivasSridhar
21 ArtificialAntigen-PresentingCellsforImmunotherapies..................... 343
AlyssaL.Siefert,TarekM.Fahmy,andDonginKim
22 ExploitingUptakeofNanoparticlesbyPhagocytes
forCancerTreatment ................................................... 355
MeeRieSheenandStevenFiering
23 PulmonaryDeliveryofMagneticallyTargetedNano-in-Microparticles ........ 369
AmberA.McBride,DominiqueN.Price,andPavanMuttil
Contents ix
24 Neutron-ActivatableNanoparticlesforIntraperitoneal
RadiationTherapy ...................................................... 379
DerekHargroveandXiulingLu
25 Nanoparticle-MediatedX-RayRadiationEnhancement
forCancerTherapy ..................................................... 391
AutumnD.Paro,IlanchezhianShanmugam,andAnneL.vandeVen
26 RadiosensitizingSilicaNanoparticlesEncapsulatingDocetaxel
forTreatmentofProstateCancer ......................................... 403
JodiBelz,NoelleCastilla-Ojo,SrinivasSridhar,andRajivKumar
Index ...................................................................... 411
Contributors
W.RUSSALGAR (cid:1) DepartmentofChemistry,UniversityofBritishColumbia,
Vancouver,BC,Canada
AWSALSHAMSAN (cid:1) NanomedicineResearchUnit,DepartmentofPharmaceutics,College
ofPharmacy,KingSaudUniversity,Riyadh,SaudiArabia;KingAbdullahInstitute
forNanotechnology,KingSaudUniversity,Riyadh,SaudiArabia
BHAWANIARYASOMAYAJULA (cid:1) Center forPharmaceuticalBiotechnologyandNanomedicine,
NortheasternUniversity,Boston,MA,USA
PAIGE BALDWIN (cid:1) DepartmentofBioengineering,NortheasternUniversity,Boston,MA,
USA;NanomedicineScienceandTechnologyCenter,NortheasternUniversity,
Boston,MA,USA
SHASHWATS.BANERJEE (cid:1) MaharashtraInstituteofMedicalEducationandResearchMedical
College,TalegaonDabhade,Pune,India
PEDRO V.BAPTISTA (cid:1) UCIBIO,DepartamentodeCieˆnciasdaVida,Faculdade
deCieˆnciaseTecnologia,UniversidadeNOVAdeLisboa,Caparica,Portugal
JODI BELZ (cid:1) DepartmentofBioengineering,NortheasternUniversity,Boston,MA,USA;
NanomedicineScienceandTechnologyCenter,NortheasternUniversity,Boston,MA,USA
SANDRAW.BISHNOI (cid:1) Rice360InstituteforGlobalHealth,RiceUniversity,
Houston,TX,USA
ANN-MARIEBROOME (cid:1) DepartmentofRadiologyandRadiologicalScience,Medical
UniversityofSouthCarolina,Charleston,SC,USA;CenterofBiomedicalImaging,
MedicalUniversityofSouthCarolina,Charleston,SC,USA;DepartmentofCelland
MolecularPharmacology&ExperimentalTherapeutics,MedicalUniversityofSouth
Carolina,Charleston,SC,USA
ROBERTB.CAMPBELL (cid:1) DepartmentofPharmaceuticalSciences,MCPHSUniversity,
Worcester,MA,USA
NOELLECASTILLA-OJO (cid:1) NanomedicineScienceandTechnologyCenter,Northeastern
University,Boston,MA,USA
XIAOYUANCHEN (cid:1) LaboratoryofMolecularImagingandNanomedicine(LOMIN),
NationalInstituteofBiomedicalImagingandBioengineering(NIBIB),National
InstitutesofHealth(NIH),Bethesda,MD,USA
BEICHENG (cid:1) DepartmentofDrugDiscoveryandBiomedicalSciences,UniversityofSouth
Carolina,Columbia,SC,USA
CHARLENEM.DAWIDCZYK (cid:1) DepartmentofMaterialsScienceandEngineering,Johns
HopkinsUniversity,Baltimore,MD,USA;InstituteforNanoBioTechnology,JohnsHopkins
University,Baltimore,MD,USA
SURAJDIXIT (cid:1) DepartmentofRadiologyandRadiologicalScience,MedicalUniversity
ofSouthCarolina,Charleston,SC,USA
MAXIME.DOKUKIN (cid:1) DepartmentofMechanicalEngineering,TuftsUniversity,Medford,
MA,USA
ROCKFORD DRAPER (cid:1) DepartmentofBiologicalSciences,TheUniversityofTexasatDallas,
Richardson,TX,USA;DepartmentofChemistryandBiochemistry,TheUniversityofTexas
atDallas,Richardson,TX,USA
xi
xii Contributors
TAREK M.FAHMY (cid:1) DepartmentofBiomedicalEngineering,YaleUniversity,NewHaven,
CT,USA
BRENDA FARRELL (cid:1) DepartmentofOtolaryngology–HeadandNeckSurgery,BaylorCollege
ofMedicine,Houston,TX,USA
ALEXANDRAR.FERNANDES (cid:1) UCIBIO,DepartamentodeCieˆnciasdaVida,Faculdadede
CieˆnciaseTecnologia,UniversidadeNOVAdeLisboa,Caparica,Portugal
STEVENFIERING (cid:1) DepartmentofMicrobiologyandImmunology,GeiselSchoolofMedicine
atDartmouthUniversity,Hanover,NH,USA;DepartmentofGenetics,GeiselSchool
ofMedicineatDartmouthUniversity,Hanover,NH,USA;NorrisCottonCancerCenter,
DartmouthHitchcockMedicalCenter,Lebanon,NH,USA
CHRISTIAN FOSTER (cid:1) LigandalInc.,Berkeley,CA,USA
DEREKHARGROVE (cid:1) DepartmentofPharmaceuticalSciences,UniversityofConnecticut,
Storrs,CT,USA
NAZILA KAMALY (cid:1) DepartmentofMicroandNanotechnology,DTUNanotech,Technical
UniversityofDenmark,KongensLyngby,Denmark
JOSEPH KAPLINSKY (cid:1) DepartmentofMicroandNanotechnology,DTUNanotech,Technical
UniversityofDenmark,KongensLyngby,Denmark
JAYANTKHANDARE (cid:1) MAEER’sMaharashtraInstituteofPharmacy,Pune,India
VRUSHALIKHOBRAGADE (cid:1) ActoriusInnovationsandResearch,Pune,India
DONGINKIM (cid:1) DepartmentofBiomedicalEngineering,YaleUniversity,NewHaven,CT,
USA;DepartmentofPharmaceuticalSciences,IrmaLermaRangelCollegeofPharmacy,
TexasA&MHSC,CollegeStation,TX,USA
RAJIVKUMAR (cid:1) DepartmentofPhysics,NortheasternUniversity,Boston,MA,USA;
NanomedicineScienceandTechnologyCenter,NortheasternUniversity,Boston,MA,USA
SAMUELK.LAI (cid:1) DivisionofMolecularPharmaceutics,UniversityofNorthCarolinaat
ChapelHill,ChapelHill,NC,USA
DMITRIO.LAPOTKO (cid:1) DepartmentofBioSciences,RiceUniversity,Houston,TX,USA
JIAJUNLI (cid:1) DepartmentofChemistry,UniversityofBritishColumbia,Vancouver,BC,
Canada
YUJENLIN (cid:1) InstituteofChemistry,AcademiaSinica,Taipei,Taiwan,China
DINGBIN LIU (cid:1) CollegeofChemistry,ResearchCenter forAnalyticalSciences,StateKey
LaboratoryofMedicinalChemicalBiology,TianjinKeyLaboratoryofMolecular
RecognitionandBiosensing,andCollaborativeInnovationCenterofChemicalScience
andEngineering,NankaiUniversity,Tianjin,China
XIULINGLU (cid:1) DepartmentofPharmaceuticalSciences,UniversityofConnecticut,
Storrs,CT,USA
EKATERINAY.LUKIANOVA-HLEB (cid:1) DepartmentofBioSciences,RiceUniversity,Houston,TX,
USA
MELISSAMASSEY (cid:1) DepartmentofChemistry,UniversityofBritishColumbia,Vancouver,BC,
Canada
AMBERA.MCBRIDE (cid:1) SandiaNationalLaboratories,Albuquerque,NM,USA
EMILIEMCKINNON (cid:1) DepartmentofRadiologyandRadiologicalScience,MedicalUniversity
ofSouthCarolina,Charleston,SC,USA
ALFREDMOORE (cid:1) DepartmentofRadiologyandRadiologicalScience,MedicalUniversity
ofSouthCarolina,Charleston,SC,USA;CenterofBiomedicalImaging,Medical
UniversityofSouthCarolina,Charleston,SC,USA
VASANTHS.MURALI (cid:1) DepartmentofBiologicalSciences,TheUniversityofTexasatDallas,
Richardson,TX,USA