Cancer, Incorporated

253 Pages·2020·4.028 MB·English

by  Ralph W. Moss

%"’()*+,*-.//
!"#!$%&
22
$$
11
""
..%%
((
..%%
!!
##
00
!"#$%&’%(#$’!)*+
),$!"#$-)**./!%)&0
1*##($2$3%#’$),$
4%1$/"5*65
CANCER, INCORPORATED
Ralph W. Moss, PhD
© 2020 by Ralph W. Moss, PhD
All Rights Reserved
Equinox Press
Blue Hill, ME 04614
Advance Comments
“ At first I was appalled. Then I cried. Now I am angry and want to do
something about this. Unless those of us impacted by cancer (and that
is the majority of us) do the same, the cancer profit engine will continue
to suck money out of the suffering. Read this book. Cry and yell. Then
demand that national policies change before you, too, suffer and die for
the benefit of Big Pharma.”
— Wayne Jonas, MD
Clinical Professor of Family Medicine, Georgetown School
of Medicine; Former Director, Office of Alternative Medicine
(1995-1999), National Institutes of Health
“ Ralph Moss has nailed his protest to the cathedral door of Big Pharma
for its corruption of oncology. Cancer, Incorporated is a very important
document that could spark a revolt reverberating far into the future.”
— Tibor Bakacs, MD, PhD, DSc
Alfréd Rényi Institute of Mathematics
Hungarian Academy of Sciences, Budapest
“ An extremely important book, which reveals the profoundly corrupting
influence of money on cancer research and treatment. Everyone
involved in cancer care needs to read this book and to act on its
recommendations.”
— Dwight L. McKee, MD
Diplomate, American Board of Medical Oncology
“C ancer, Incorporated presents an amazing array of historical facts on the
relationship of Big Pharma to cancer care in America. I applaud Ralph
Moss’s courage.”
— Damian Dupuy, MD
Professor of Diagnostic Imaging, Warren Alpert
School of Medicine, Brown University
Providence, Rhode Island
“ If you care about cancer research and treatment, read this powerful
critique. When the history of cancer treatment is written, Moss will be
remembered as one of the leading science journalists of our time.”
— Michael Lerner, PhD
Author of Choices in Healing
Director of Commonweal, Bolinas, CA
“ Strong and convincing! It is about time that the hard facts are presented
to the public and the oncology profession. I congratulate Moss for his
courage in showing that sometimes—the king is naked.”
— Professor Shimon Slavin, MD
Biotherapy International, Tel Aviv, Israel
“ A well-documented analysis linking Big Pharma with the outrageous cost
of cancer medicine. At the end, Moss suggests potential ways to reduce
the problem.”
— Michael Retsky, PhD
Harvard T.H. Chan School of Public Health
Boston, Massachusetts
“ Ralph Moss has illuminated the dark side of the cancer industry, where
revenue generation trumps patient outcome.”
— Thomas Seyfried, PhD
Professor of Biology, Boston College
Chestnut Hill, Massachusetts
“ This is an amazing piece of work! Ralph Moss has eloquently delivered a
no-holds-barred, tell-all synopsis of the corruption of the cancer business.
He poses a question to the reader at the end of this book, ‘How would
you propose to improve such a broken system?’ My answer is to begin by
making Moss’ book required reading for all individuals involved in the
cancer industry.”
— Mark A Rosenberg, MD
President and Medical Director, Advanced Medical Therapeutics
Boca Raton, Florida
“ This groundbreaking book will leave the reader in awe. I strongly
recommend it to anyone who has cancer, who cares for cancer patients,
or simply cares for humanity and good health.”
— Ferre Akbarpour, MD
Chief Medical Officer, Orange County Immune Institute
Huntington Beach, California
“ Thank you, Ralph Moss, for exploring and exposing distortions in drug
company data and the potentially painful consequences for cancer
patients.”
— James S. Gordon, MD
Former chair of the White House Commission on
Complementary and Alternative Medicine Policy
Washington, DC
Published by
Equinox Press
A division of The Moss Reports
104 Main Street • Suite 1422
Blue Hill, Maine 04614-1422
United States of America
207-536-9196
[email protected]
© 2020 by Ralph W. Moss
All Rights Reserved, including the right to reproduce this book or portions
thereof in any form whatsoever. For information address Equinox Press
Subsidiary Rights Department, 104 Main Street, Suite 1422, Blue Hill, Maine
04614-1422, USA
Photographs are from iStockPhoto or in the public domain from Wikimedia
Commons.
Library of Congress Cataloging-in-Publication Data
Moss, Ralph W.
Cancer, Incorporated / Ralph W. Moss, PhD. — First edition.
p. cm.
Includes bibliographical references.
ISBN (alk. paper) 978-1-881025-14-6
1. Oncology. 2. Cancer—Chemotherapy—Research—United States.
3. —Immunotherapy–Research–United States.
4. —Drugs—Research—Corrupt practices—United States.
5. Pharmaceutical policy—United States.
6. American Society of Clinical Oncology.
7. United States Food and Drug Administration.
I. Title.
616.99
Library of Congress Control Number:
2020902007
Printed in the United States of America
ISBN 978-1-881025-14-6
ISBN 978-1-881025-15-3 (ebook)
v.2
Cover art: Ben Moss
If you or someone you love has been diagnosed with
cancer, you may be asking: 
!"#$%"&’%$%"()&%$*(&+,%-"&."$(/+(&+.*0"1’%2."(*/"-3$4%$56
!"#$%"&’%$%"*(&3$()"$%2%/+%-"&’(&"($%"%7%1&+,%6
!"8’+1’"’.-9+&()-0"1)+*+1-".$"/.1&.$-"’(,%"&’%"2.-&"%:9%$+%*1%"
’%)9+*4"9%.9)%";+&’"25"&59%".<"1(*1%$6
!"=-"+223*%"&’%$(95"&’%"$+4’&"1’.+1%"<.$"2%6
!"#$%"-399)%2%*&-"(*/"(*&+.:+/(*&-"’%)9<3)6
!"8’(&">+*/".<"/+%&";+))"’%)9"25"?./5"’%()6
!"#$$!%&’#%($
@’%$%"($%"F.--"G%9.$&-"<.$"2.-&"1(*1%$"&59%-H"
I(1’"F.--"G%9.$&"4+,%-"5.3"JKKL"9(4%-".<"39M&.M/(&%"%:9%$&"
(*()5-+-".*"())"5.3$"&$%(&2%*&".9&+.*-"+*1)3/+*4N
✓" #)&%$*(&+,%"@$%(&2%*&-
✓ A.*,%*&+.*()"@$%(&2%*&-
✓ =223*.&’%$(95
✓ B(&3$.9(&’5
✓ C.1&.$-"(*/"A)+*+1-
✓ A)+*+1()"@$+()-
✓ C+%&"(*/"D+<%-&5)%
✓ E399)%2%*&-
www.mossreports.com
)#*$+,(-(.#*$
Your personal consultation with Dr. Moss will help you
make the best informed treatment decisions. 
!"#$%&’()*+,$-.
!"#$%&’())*&+,-./&0122&/,2&3%%#&
%4.15%6"#7&$,#$%6&.,8"%#82*&8/%"6&
9,4"-"%2&,#:&$,6%7";%62*&3<&/%-."#7&
8/%4&4,=%&8/%"6&3%28&"#9164%:&
86%,84%#8&:%$"2"1#2>
/01&+2&)2&+$3+(4+055.
?#$1-17"282&5"--&@2@,--<&6%$144%#:&
214%&$143"#,8"1#&19&$/%418/%6,.<*&
2@67%6<&,#:&6,:",8"1#>&!":%& !"#$%&’(&)*++,&-%.
%A%$82&,#:&6"2=&81&3%#%9"8&6,8"1&#%%:&
81&3%&$,6%9@--<&$1#2":%6%:>&B/%#&
<&05+=05-&.
"8&$14%2&81&,-8%6#,8";%&86%,84%#82*&
<1@&#%%:&81&=#15&5/"$/&1#%2&/,;%& B%&=#15&8/,8&:%,-"#7&5"8/&$,#$%6&
;,-@%*&,#:&5/"$/&1#%2&,6%&"#%A%$8";%& .12%2&416%&8/,#&F@28&/%,-8/&
16&:,#7%61@2>&C6>&0122&/%-.2&<1@& $/,--%#7%2>&G8&$,#&-%,:&81&2"7#"9"$,#8&
@#:%628,#:&<1@6&1.8"1#2&,#:&4,=%& 9"#,#$",-&3@6:%#2>&0,="#7&"#9164%:&
8/%&3%28&$/1"$%2&.122"3-%>&& :%$"2"1#2&$,#&/%-.&<1@&.6%;%#8&
,&5,28%&19&<1@6&.6%$"1@2&8"4%&
6)$%5&7*&+0)7+&8#&’(&)9&.
,#:&6%21@6$%2>&
C6>&0122&,#:&/"2&8%,4&86,;%-&
!02,+4$+:)7&’240)7.
8/%&516-:&81&;"2"8&$-"#"$2*&
"#8%6;"%5&:1$8162&,#:&.,8"%#82*&,#:& C6>&0122&$144@#"$,8%2&"#&,&5,<&
,#,-<D%&8/%"6&6%2%,6$/&:,8,>&B%&36"#7& 8/,8&"2&$-%,6*&$1#$"2%&,#:&%,2<H81H
8/,8&"#9164,8"1#&3,$=*&$14."-%&"8& @#:%628,#:>&I%&=%%.2&8/%&F,671#&81&,&
,#:&2/,6%&"8&5"8/&<1@>&C@6"#7&<1@6& 4"#"4@4&,#:&2/,6%2&/"2&=#15-%:7%&
$1#2@-8,8"1#&<1@&5"--&-%,6#&5/"$/& ,8&,&.,$%&8/,8&516=2&916&<1@>
86%,84%#82&/,;%&;,-@%&,#:&5/"$/&
>$"#022($)04&+0)7+1()7.
1#%2&-,$=&2$"%#8"9"$&;,-":"8<>&&
J2&,&2@6;";16&19&.6128,8%&$,#$%6&
:);(02&7.
/"42%-9*&C6>&0122&@#:%628,#:2&,#:&
E1@6&-"9%&4,<&:%.%#:&1#&8/%& "2&2%#2"8";%&81&5/,8&<1@&,6%&71"#7&
:%$"2"1#2&<1@&4,=%&#15>&E1@&#%%:& 8/61@7/>&K17%8/%6*&<1@&,#:&C6>&
$14.-%8%-<&@#3",2%:&"#9164,8"1#>&C6>& 0122&5"--&$6%,8%&8/%&4128&%A%$8";%&
0122&4,"#8,"#2&8/%&/"7/%28&28,#:,6:& .-,#&916&<1@6&86%,84%#8>
19&2$"%#8"9"$&"#8%76"8<*&/1#%28<&,#:&
286"$8&"4.,68",-"8<>&&
www.mossreports.com
Table of Contents
Dedication . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . vi
Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . vii
Section I: Conventional Therapy . . . . . . . . . . . . . . . . . . . . . . . . . .1
Chapter 1. The limits of chemotherapy . . . . . . . . . . . . . . . . . . . . 1
Chapter 2. It began with Ehrlich. . . . . . . . . . . . . . . . . . . . . . . . 6
Chapter 3. Drug company indifference . . . . . . . . . . . . . . . . . . . . 8
Chapter 4. A proper and pleasing effect. . . . . . . . . . . . . . . . . . . . 12
Chapter 5. The War on Cancer. . . . . . . . . . . . . . . . . . . . . . . . . 17
Chapter 6. Clinical trials: a sordid history . . . . . . . . . . . . . . . . . . 31
Chapter 7. The high-dose chemo fiasco. . . . . . . . . . . . . . . . . . . . 35
Chapter 8. Precision oncology. . . . . . . . . . . . . . . . . . . . . . . . . 46
Chapter 9. Immune checkpoint inhibitors . . . . . . . . . . . . . . . . . . 67
Section II: Three Complementary Treatments . . . . . . . . . . . . . . . . . 93
Chapter 1. Metabolic therapy . . . . . . . . . . . . . . . . . . . . . . . . . 96
Chapter 2. The Kleef protocol . . . . . . . . . . . . . . . . . . . . . . . . 104
Chapter 3. Coley’s toxins. . . . . . . . . . . . . . . . . . . . . . . . . . . 107
Section III: Scientific Research Methods . . . . . . . . . . . . . . . . . . . 113
Chapter 1. What is an effective treatment? . . . . . . . . . . . . . . . . . 113
Chapter 2. The takeover . . . . . . . . . . . . . . . . . . . . . . . . . . . 132
Chapter 3. Advertising and propaganda. . . . . . . . . . . . . . . . . . . 135
Chapter 4. How to rig a trial . . . . . . . . . . . . . . . . . . . . . . . . . 138
Chapter 5. Case study: Avastin. . . . . . . . . . . . . . . . . . . . . . . . 151
Chapter 6. Tumor responses. . . . . . . . . . . . . . . . . . . . . . . . . 155
Section IV: Corruption of Oncology . . . . . . . . . . . . . . . . . . . . . . 158
Chapter 1. The Cancer Industry revisited . . . . . . . . . . . . . . . . . 158
Chapter 2. The chemotherapy concession . . . . . . . . . . . . . . . . . 172
Chapter 3. Open Payments. . . . . . . . . . . . . . . . . . . . . . . . . . 182
Chapter 4. The case of Dr. Baselga . . . . . . . . . . . . . . . . . . . . . 187
Chapter 5. Regulating the regulators . . . . . . . . . . . . . . . . . . . . 191
Chapter 6. Revelations from Goldman Sachs. . . . . . . . . . . . . . . . 202
Section V: Fixing the Cancer Drug Scandal . . . . . . . . . . . . . . . . . . 203
Chapter 1. Recommendations . . . . . . . . . . . . . . . . . . . . . . . . 203
Chapter 2. Why nationalize? . . . . . . . . . . . . . . . . . . . . . . . . . 206
Section VI: Further Reading . . . . . . . . . . . . . . . . . . . . . . . . . . 213
Acknowledgments . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 215
Endnotes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 216
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 235
To Martha
For nothing is greater or better than this,
than when a man and a woman keep house together
sharing one heart and mind,
a great grief to their foes
and a joy to their friends.
Homer, The Odyssey
A.T. Murray, translator / Loeb Classical Library, Book VI, lines 182–185
vii
Preface
“ We landed in our present mess because of innumerable
mistakes in the past…. They include failure of clinical
scientists, their institutions and the editors of the journals
publishing their science.… I believe it will take a revolution
to sweep away decades of self-dealing by industry.”
— Drummond Rennie, MD, Deputy Editor,
Journal of the American Medical Associaton
To the average person, cancer needs no introduction. It is now one of
the predominant causes of illness, suffering and death in most coun-
tries, including the United States of America. In 2020, the American
Cancer Society (ACS) estimated that there would be more than 1.8
million new cases of invasive cancer. Over 600,000 A mericans die of
cancer in a given year, or 1,660 deaths per day.
Worldwide, the picture is just as bad. This disease accounts for
one in six deaths. Each year there are an estimated 17 million new
cases of cancer diagnosed, and 9.5 million deaths. By 2040, says the
ACS, the global burden is expected to reach 27.5 million new cases
and 16.3 million cancer deaths annually. But bad habits, especially
cigarette addiction fostered by the tobacco industry, will almost
certainly multiply that effect.
In response to this catastrophe, many countries (led by the
United States) have committed significant resources to the search
for reliable cures for cancer. However, despite federal spending of
over six billion dollars in 2019, progress has been painfully slow.
We are told that steady progress is being made. In particular, it is
said that the current system is producing effective ‘targeted’ drugs
almost every day. New drugs are bringing a supposed “world
without cancer” into view. The giant M.D. Anderson Cancer Center
in Houston, Texas has even crossed out the word “cancer” from its
logo, to indicate the imminent demise of the disease.

Disclaimer: The information provided in this book is for general educational purposes only. Neither the
author nor the publisher makes warranties, expressed or implied, that this information is complete nor do
they warrant the fitness of this information for any particular purpose. This information is not intended
as medical advice. We encourage all cancer patients to be under the care of licensed medical providers.
Note to readers: Rather than interrupt the flow of the narrative with footnotes, we have placed all
references in the Endnotes section.