Bruker Almanac 2010 - Pascal-Man

113 Pages·2009·12.5 MB·English

by  Bruker Corporation

Bruker Corporation
Almanac 2010
50 Years of Innovation
www.bruker.com
think forward
1
Bruker – Bruker is the performance leader in
the following technology platforms and
product lines:
the performance leader
Magnetic Resonance Molecular Spectroscopy
in life science and
• Nuclear Magnetic Resonance (NMR) • FT-Infrared Spectroscopy (FT-IR)
• Electron Paramagnetic Resonance (EPR) • Near Infrared Spectroscopy (NIR)
analytical systems.
• Magnetic Resonance Imaging (MRI) • Raman Spectroscopy
• Bench-top TD-NMR Process and
Chemical, Biological, Radiological,
GA Systems
Nuclear and Explosives (CBRNE)
• Superconducting Magnets
Right from the beginning, which is now fifty years ago, Detection
Bruker has been driven by a single idea: to provide the best X-Ray and Elemental Analysis • GC-Mass Spectrometry
• X-RayDiffraction (XRD) • Ion Mobility Spectrometry (IMS)
technological solution for each analytical task.
• X-Ray Spectrometry (XRF) • FT IR Stand-off Detection
• X-Ray Crystallography (SCD) • Biological Classification and
Today, worldwide more than 4,000 employees are • EDS and X-Ray Microanalysis Identification Systems
working on this permanent challenge at over 70 locations • Optical Emission Spectroscopy (OES) • Explosives Detection Systems
• Combustion Analysis for Metals
on all continents. Bruker systems cover a broad spectrum Superconductor Wire Products
Life Sciences Mass Spectrometry and Devices
of applications in all fields of research and development
• MALDI TOF/TOF Mass Spectrometry • Low temperature superconductors (LTS)
and are used in all industrial production processes for the
• Ion Trap Mass Spectrometry • High-temperature superconductors (HTS)
purpose of ensuring quality and process reliability. • ESI-(Q)-TOF Mass Spectrometry • Hydrostatic Extrusions
• ESI/MALDI-FTMS • Magnets
Bruker continues to build upon its extensive range of • UHR-TOF MS • Synchrotron instrumentation
products and solutions, its broad base of installed systems
and a strong reputation amongst its customers. Indeed, as
our customers would expect, Bruker as one of the world's
leading analytical instrumentation companies, continues to
develop state-of-the-art technologies and innovative
solutions for today’s analytical questions.
Bruker. Think forward!
Life Quality & Materials Food & Pharma & Clinical
Science Process Control Research Environment Biotech Research
ISBN 978-3-929431-24-7
2 3
Bruker AXS Bruker BioSpin Bruker EST Bruker Daltonics Bruker Optics
Bruker AXS GmbH Bruker AXS Inc. Bruker AXS K.K. Bruker BioSpin GmbH Bruker BioSpin Corp. Bruker EAS GmbH Bruker Daltonik GmbH Bruker Daltonics Inc. Bruker BioSciences Bruker Optik GmbH Bruker Optics Inc. Bruker Optik
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Additional information
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4 5
Bruker – the group
Bruker Corporation
with analytical excellence,
The Bruker Group is a leading provider of high-performance scientific instru-
ments and solutions for molecular and materials research, as well as for indus-
trial and applied analysis. Bruker Corporation (Nasdaq: BRKR), headquartered in long time experience and
Billerica, Massachusetts, is the publicly traded parent company of Bruker
Scientific Instruments Division (Bruker AXS, Bruker BioSpin, Bruker Daltonics, global presence.
Bruker Optics) and Bruker Energy & Supercon Technologies (BEST) Division.
Bruker AXS
Bruker AXS is a leading global developer and manufacturer of analytical
X-ray systems, optical emission spectrometers and combustion analyzers
for elemental analysis, materials research and crystallographic investigations.
Bruker AXS’ innovative solutions enable a wide range of customers in research
and industry – including chemistry, petrochemistry, pharmacy, metals and
steel, semiconductor, cement, minerals and mining, automotive, forensics,
environmental, art and conservation, nanotechnology and life sciences – to
make technological advancements and to accelerate their progress.
Bruker BioSpin
Bruker BioSpin is the global market and technology leader in analytical
magnetic resonance instruments including NMR, preclinical MRI and EPR. The
company delivers the world's most comprehensive range of magnetic reso-
nance research tools enabling life science, materials science, analytical chem-
istry, process control and clinical research. Bruker BioSpin is also the leading
manufacturer of superconducting high and ultra high field magnets for NMR
and MRI.
Bruker Daltonics
Bruker Daltonics is a leading manufacturer of mass spectrometry (MS)
instruments and accessories for life science, pharmaceutical, biochemical and
chemical research as well as for more routine analytical tasks in forensics and
food safety. Technical solutions are based on a comprehensive range of
MALDI-TOF/TOF, ESI-(Q)-TOF, UHR-TOF, ESI-ITMS, ESI/MALDI-FTMS mass
spectrometry systems, as well as automated sample handling systems and
productivity enhancing software designed to answer our customers’ needs.
Bruker Daltonics is also a global leader in nuclear, biological and chemical de-
tection, with a CBRNE product line based on a broad array of technologies, in-
cluding mass spectrometry and ion mobility spectrometry.
Bruker Optics
Bruker Optics offers the industry's most comprehensive range of product offer-
ings and solutions based on vibrational spectroscopy. Products include FT-IR
spectrometers; from the world's smallest in size to the highest in resolution,
Near Infrared and Raman spectrometers. Whether it’s a high-end research sys-
tem, a life sciences instrument, a routine quality control tool or a process ana-
lyzer, Bruker Optics offers a wide variety of innovative analytical solutions.
Bruker EST
Bruker Energy & Supercon Technologies Division is a leading manufacturer and
developer of a broad range of high-performance superconductor wire products
and devices.
Bruker AXS facilities Bruker BioSpin facilities Bruker Daltonics facilities Bruker Optics facilities Bruker Australia Bruker Japan Bruker Germany Bruker France
6 7
Bruker Corporation
Bruker 1960-2010
50 Years of Innovation
www.bruker.com
think forward
8 9
50 Years of Innovation
The Beginnings Bruker Physik-AG was officially incorporated on In 1962, with competitor systems featuring
September 7, 1960, originally located in the back- significantly higher field strengths, a new spec-
The Bruker group
yard of a Karlsruhe residence. The development of trometer, the KIS 2, was developed based on
of companies owes
NMR spectrometers began with the production of a five-ton magnet that enabled high-resolution
its existence to
laboratory magnets and power supplies. spectroscopy at field strengths up to 90 MHz.
Dr. Günther Laukien,
Around twenty KIS 25 MHz and KIS 2 instru-
who moved to the
ments were installed in Switzerland, France,
Institute for Experi-
Belgium and Germany.
mental Physics in
Stuttgart shortly
When Trüb Täuber fell into financial difficulty
after finishing his
midway through the 1960s, Günther Laukien
studies in Physics
founded Spectrospin AG specifically to preserve
in Tubingen in 1952.
its former NMR department.
From 1952 to 1957, Prof. Günther Laukien
1963: Bruker NMR pulse spectrometer.
he pursed post-doc-
Bruker-Spectrospin Cooperation
toral research in NMR Spectroscopy, and in 1958
High-Resolution NMR at Trüb Täuber;
published a pioneering paper on high-frequency The establishment of Spectrospin AG set the
The Onset of Bruker in Switzerland
nuclear magnetic resonance. This paper described scene for close cooperation and a strong syner-
the theoretical aspects that were known at the Bruker Physik AG’s first operational facility in In Zurich in 1960, Trüb Täuber & Company, a man- gistic relationship with Bruker. The introduction of
time, while also covering the practical aspects of Hardtstraße, Karlsruhe, Germany. ufacturer of complex measuring instruments for manufacturing agreements saw Bruker specialize
constructing experimental systems. In 1960, he the power station industry, had a small research in magnets and power supplies while simultane-
was appointed as a Professor for Experimental By 1963, the rapidly-growing Bruker Physik em- department that focused on NMR spectrometers ously closing down its development of high-
Physics in Karlsruhe. ployed a staff of 30 developing both high-resolution and electron microscopes. resolution instru ments, leaving Spectrospin AG
NMR and EPR. With a rapidly expanding market, to focus on the high-resolution instruments and
At that time, laboratories in the US were already Bruker quickly outgrew its space and moved to an Their NMR research had benefited directly from equally close down its development of EPR.
building the first high-resolution systems for use undeveloped parcel in Forchheim, where it was close cooperation with the ETH Swiss Federal
in analytical chemistry. Dr. Laukien recognized the able to build a facility to better meet it’s expand- Institute of Technology in Zurich, namely Profes- An ambitious development project was then
power in this technique and the need for a system ing needs. sors Günthard, Primas and subsequent Nobel launched to exploit valve-free, solid-state technol-
not yet produced commercially. He set out to fill Prize Laureate, Richard Ernst. ogy. By 1967 successful system demonstrations
this need by establishing his own company. of the first fully transistorized instrument immedi-
Operating at 25 MHz, and equipped with a per- ately led to the delivery of the first HFX 90 to the
manent magnet, their first KIS spectrometers Technical University Berlin.
were 2 meters tall.
The HFX 90 was the first production spectrometer
Early NMR Spectrometer in the world to offer three independent channels
Why the Name Bruker?
for locking, recording and decoupling, working
In 1960, university pro- exclusively with frequency sweep.
fessors were not allowed
Multinuclear NMR
to commit to commercial
work whilst in a position
of research and teaching.
This meant that Profes-
sor Laukien could not
be named as a founding
member; thus co-founder
1960: 25 MHz permanent magnet KIS1 NMR system.
Dr. Emil Bruker gave the
Spectra required in 12 hours of acquisition time. 1967: HFX 90, the first fully transistorized NMR
company its name. Spectra courtesy: Prof. R. Ernst system, equipped with three independent channels.
10 11
50 Years of Innovation
New experiments became possible, while previ- Fourier Transform (FT) This was followed in 1971 with the establishment
ously impossible or extremely difficult experi- of Bruker SA in France. Bruker moved into new
In 1964, Richard Ernst was the first to develop
ments became routine. Pioneering innovations production facilities in Wissembourg and quickly
a functioning FT process that delivered a sig-
included spin spectroscopy (homo and hetero), started producing sub-units.
nificant increase in sensitivity. However, skepti-
decoupling, accumulation and completely repro-
cism regarding experiment length and long 13C
ducible scales. To display all the new details made Throughout the early 1970s sales offices appeared
relaxation times meant the system was never
possible by the system, a new recorder with all over Europe, includ ing the UK and Italy.
commercialized.
60 cm paper width had to be developed.
In 1969, during the 25th anniversary of the dis-
Other developments were also rapidly progress- covery of EPR in Kazan, Bruker undertook its first
ing at Bruker, including EPR spectrometers, pulse activities in, what was then, the USSR.
spectrometers and magnets applied in physics. 1973: NMR spectrometer based on superconducting
magnet technology. A new office was also established in Israel,
The first demonstrations for American custom- strengthening relations with the country and with
In 1969, Bruker unveiled the world’s first FT-NMR
ers took place in 1967. Yale University purchased the Weizman Institute in particular.
spectrometer that enabled broadband proton
two systems, with the first spectrometer being
decoupling. Developed in Elmsford, the new
delivered in 1968 by air cargo. In 1972, expansion reached Australia, where
spectrometer delivered sensational results. The
collaboration with local company Selby signified
new, superior and revolutionary 13C spectra made
Bruker’s arrival.
a significant impact when presented at the 13C
conference in Anaheim, California.
1971: WH 90, the first FT-only NMR Spectrometer. Driven by its unmatched FT-NMR technology,
Bruker’s share of the market expanded consid-
Another problem with 13C was the lack of decou-
erably. In addition, the development of pulse
pling to achieve pure shift spectra with improved
spectrometry resulted in the construction of the
signal-to-noise ratio. Richard Ernst was again the
minispec, a spectrometer dedicated to industrial
pioneering figure, being the first to describe noise
applications.
1968: First HFX 90 for the United States (Yale Univ.) decoupling, which solved the problem.
being loaded onto a Boeing 707. First Industrial NMR Applications
Bruker’s continuing development of pulse spec-
trometry saw the first high-power radio frequency
Shortly after this installation, Bruker opened its first
amplifier that could transmit a pulse as well as
US office in Elmsford, New York, and proceeded 1975: Mr. Fanf Yi, PRC Vice President and President
decouple. This was followed by a new form of
to quickly secure a considerable customer base. of the Chinese Academy visits the Bruker stand
at a trade show in Beijing.
Birth of 13C FT NMR 1975:
At the end of 1970, Spectrospin AG moved to minispec p20
In 1975, Bruker arrived in China. A very success-
new, modern premises in Fällanden, near Zurich, NMR
ful appearance at the Swiss Industrial Exhibition
spectrometer.
that provided more space and dedicated produc-
in Beijing led to the immediate sale of two WH 90
tion facilities. Expansion also saw Bruker extend
NMR spectrometers.
its facilities in Forchheim. Consequently, both
The Bruker Group
companies were well equipped to meet the chal- Japan, South Korea and
lenges of the next decade. During the 1960s, it had become evident that to Taiwan sales offices
be a key player in the analytical instrument market, soon followed, and in
1969 : One of the first 13C FT Spectra. a worldwide presence was required with contacts 1976 Bruker opened its
Measuring time now reduced to 200 seconds. for customers and researchers at a local level. first facility in Japan.
broadband decoupling, which was significantly The first step had been toward America, a grow- Bruker was also suc-
more effective than Ernst’s method, and simpler ing hub of NMR research at the time. Despite local cessful in South America,
to implement. The new technology delivered market dominance by US companies, success with the first instrument
unique experimental opportu nities that remained was rapid, driven by Bruker’s unequalled tech- installations taking place
unmatched by Bruker’s competitors right through nologies and the widespread approval of the NMR in Venezuela.
to the 1980s. community. 1975: Ceremony
for breaking ground in
Tsukuba, Japan.
12 13
50 Years of Innovation
FT-IR Over time Bruker shifted its focus towards pre- Expansion at Karlsruhe Mass Spectrometry
clinical instrumentation, a move which saw the
Bruker began the development of new infrared Unable to expand significantly in Forchheim, Industrial production of the first mass spectrom-
company develop as market leader in the field,
spectrometers in the 1970s. Launched in 1974, Karlsruhe became the focus for new production eters began in the 1940s. In Germany, an early
a position maintained by Bruker BioSpin MRI
the IFS 110 was the beginning of a very success- facilities. mass spectrometer was developed in 1948 by
today.
ful product line that ultimately led to the founda- Dr. L. Jenckel, head of Atlas MAT (Mess- und
tion of the Bruker Optics division. Marine Research In 1982 the company purchased a large factory Analysentechnik) in Bremen.
complex in Karlsruhe-Rheinhafen that was per-
Bruker Meerestechnik GmbH was founded in fectly suited to the production of magnets for In 1977 “Dr. Franzen Analysentechnik” was
1977, producing small submersibles for the shelf particle physics research. The site remains the founded in Bremen as a spin-off company from
research and oil exploration sectors, and for ideal location for magnet production. Atlas MAT. Dr. Franzen developed the first table-
tourism (including the largest tourist submarine top mass spectrometer, based on a quadrupole
in the world to date). Bruker's increasing on ana- mass filter and coupled to a GC.
lytical instrumentation led to the later sale of this
division. A few years later, in 1980, Bruker acquired
this company and renamed it “Bruker-Franzen
Analytik”, adding robust quadrupole mass spec-
trometers to the Bruker portfolio. That same year
1974: IFS 110, Bruker's first FT-IR spectrometer. the first mobile detection system, the MM1,
proved successful in both the civilian and military
Today, Bruker Optics offers a comprehensive markets.
vibrational spectroscopy product-line that includes
both the world’s smallest benchtop FT-IR spec-
Mass Spectrometer
trometer for routine use, and the world’s highest
resolution FT-IR for advanced research applica-
tions. 1984: Final assembly of the particle spectroscopy
magnet in the Rheinhafen plant.
Magnetic Resonance Imaging
In 1991 the Ettlingen site witnessed the opening
Bruker Medizintechnik GmbH was founded in 1978: Bruker submersible ‘Meermaid’ in action. of its first building – the Bruker NMR Imaging
1975, offering a product range of mobile defibril- Development and Application Center – an NMR
lators. By the late 1970s, Bruker was producing Partnership with IBM tomography development, production and dem-
NMR tomographs for clinical and pre-clinical onstration center.
The late 1970s was a time of global diversifica-
environments, leading to whole body clinical
tion, and IBM’s subsidiary, IBM Instruments,
scanner instrumentation. To guarantee the provision of high-quality elec-
sought an interest in Bruker’s wide-ranging prod-
tronic components for numerous Bruker divi- 1980: MM1 the first mobile detection system.
The Onset of Magnetic Resonance Imaging uct range. IBM invested in Bruker in 1978, and
sions, Bruker Elektronik GmbH was established
the partnership witnessed the development of a
in 1985, equipped with state-of-the-art produc- Thanks to Bruker’s existing expertise in NMR
large range of instruments for gas chromatogra-
tion and testing equipment. and supercon ducting magnet technology, Bruker
phy, liquid chromatography and polar graphs, and
Spectrospin in Switzerland successfully devel-
optimized IR, NMR and TD-NMR instruments for
With an ever-increasing number of biological oped a new type of mass spectrometer, with the
routine applications and specific sales initiatives
applications using magnetic resonance spectros- first installa tions of FT-ICR mass spectrometry
in the American markets.
copy, the company formed the Bruker BioSpin systems taking place in 1982.
Group in 2001, bringing together all BioSpin
The relationship lasted for 10 years, until Bruker
companies specializing in magnetic resonance, An innovative collaboration with the Technical
1983: One of the first whole repurchased the IBM holding and integrated a to ensure market-leading focus and commitment. University of Munich in 1983 resulted in a project
body MRI tomographs with air coil portion of the developed systems into its own to investigate resonant laser mass spectrometry.
magnet. product range.
The project’s success ultimately led to Bruker’s
introduction of time-of-flight mass spectrometers,
an intrinsic part of the product range to this day.
14 15
50 Years of Innovation
Mass Spectrometry With the spectrometers being continuously Superconducting Wire Technologies In 2006, the Bruker Optics group followed suit,
enhanced, Bruker mass spectrometry experi- and finally the magnetic resonance business, the
Superconducting magnets, an essential com-
enced unexpected growth. Mass spectrometry Bruker BioSpin Group, in 2008.
ponent in several Bruker product lines, require
became a solid base for ground-breaking research
special qualities of wire critical for high-end per-
in a broad range of sciences, comprising pharma- This unification under one new parent company,
formance. In order to secure a guaranteed quality
ceutical, life sciences and clinical research. the Bruker Corporation, has created one of the
of supply, Bruker acquired the wire manufacturer
strongest brands in analytical instrumentation.
Vacuumschmelze, in Hanau in 2003.
Magnets and power supplies for physics research
have been a key constituent for Bruker since its
beginnings in 1960. In 2009, the acquisition of
ACCEL significantly strengthened Bruker’s position
as a leading developer in the sector. The expand-
ing product range, has resulted in a new division,
1980s: Early FT ICR mass spectrometer.
Bruker Energy and Supercon Technologies.
In 1990, together with scientists from the former
Academy of Science, Bruker founded Bruker
Saxonia in Leipzig. As a subsidiary company of
Bruker-Franzen Analytik, Bruker Saxonia was 1987: Early MS TOF spectrometer.
Bruker Corporation headquarters in Billerica,
dedicated to ion mobility spectrometry.
Moreover, Bruker has recently obtained the Massachusetts, USA.
first IVD-CE mark for the MALDI-TOF-based
In 1997 Bruker-Franzen Analytik GmbH was
renamed Bruker Daltonik GmbH. The name was microbial identification workflow solution, the Bruker Today
MALDI Biotyper. This system is pioneering the
chosen to honor John Dalton for his work in formu-
In 2008 Bruker Corporation revenues exceeded
advancement of mass spectrometry in clinical
lating the theory of the atomic structure of matter.
the US$ 1 billion mark for the first time, directly
diagnostics. Global mass spectrometry opera-
attributable to the company's exceptional cus-
The development of two new ionization proce- tions later fell under the umbrella of the Bruker
tomer service, innovation, continuity, and product
dures in the late 1980s, electrospray and MALDI, Daltonics Group.
quality.
enabled the ionization and analysis of biomol-
ecules. This paved the way for the application X-ray Technologies
The unique scope of the Bruker product range
of mass spectrometry in molecular biology and
In 1997 Bruker acquired the X-ray spectroscopy remains ground-breaking and influential, evi-
molecular medicine. The development of these division of Siemens AG, which included prime 1975: Power supplies for nuclear physics research. denced by the many product lines that lead their
ionization procedures was honored with a Nobel
manufacturing facilities in Karlsruhe and Madi- respective markets.
Prize in 2002. Bruker Corporation
son, Wisconsin. Commercial growth, combined
with additional company acquisitions, quickly The organizational restructuring of Bruker began Bruker’s growth in size has further fueled its
launched Bruker AXS as a leading provider of in 2000, as the company adapted to meet the highly dynamic nature, driving the introduction of
X-ray analytical needs of today’s markets and environments. The many key innovations throughout 2009.
In 1997 the company witnessed a instrumentation, Bruker Daltonics group became the first Bruker
change in leadership, brought about by significantly ex- company to be listed on the NASDAQ stock Positive and committed progress is assured
the death of its founder, Günther Laukien. tending Bruker’s exchange market, followed by the Bruker AXS through reliance on more than 4000 highly moti-
His death was a great loss to the com- technology port- group in 2001. vated employees, and through continuing excel-
pany and the scientific community at folio. lent customer relations.
large because his ideas, his motivation, The synergies generated from the improved
Bruker is convinced that these are the ideal
and his competence as both scientist integration across development, production and
conditions for developing innovative solutions for
and entrepreneur were major driving sales were quickly recognized, leading to the
tomorrow’s analytical questions, thereby secur-
forces behind the company’s success. development of combined systems that would
D8 ADVANCE, ing an ever-successful future.
deliver significant customer benefits. Conse-
His wife and four sons have continued to new generation
quently, in 2003, the Daltonics and AXS groups
lead the company in accordance with his of X-ray powder
vision and beliefs, and the same forward- diffraction were soon merged into a single listed company.
instrument
thinking spirit that drives progress to this
launched in 1997.
day.
16 17
Content
NMR
20 AVANCE III / NMR Magnets
22 NMR Probes / CryoProbes
24 TopSpin / Automation
26 Metabolic Profiler / Hyphenation
28 Biomolecular NMR
29 Complete Molecular Confidence
30 JuiceSreener / Immediate Access
32 Ultra-High Field NMR
33 Solid State NMR
34 Small Molecule Analysis
35 Structure Elucidation
36 Analysis of Natural Products
37 Mixture Analysis
38 Power Supplies / RF Transmitters
MRI Bruker BioSpin
42 BioSpec
44 ClinScan
46 PharmaScan
47 USR Magnets
48 BGA Gradient Series
49 MRI CryoProbe
50 ParaVision / Beyond Standard BioSpecs
52 Micro-Imaging
53 IntraGate
EPR
56 ELEXSYS
62 Multi-Resonance Accessories
63 EMXplus
64 EMXmicro
65 e-scan
MS
68 MALDI-TOF and TOF/TOF
70 ION Trap
72 ESI-TOF
74 UHR-TOF and FTMS
76 Ion Sources EASY-nLC and Compass
78 Proteomics Solutions and Chemistry
80 Small Molecules Applications
CBRN
84 Prepared for a World of Changing Threats
85 Answers for Life
86 Stay Prepared - Prepared for the Worst
87 Expect the Unexpected
Vibrational Spectroscopy
Nuclear Magnetic
90 FT-IR
92 Raman
93 FT-IR & Raman Microscopy
94 FT-NIR Resonance
95 Process Analytical Technologies
Time Domain NMR
98 the minispec TD-NMR Analyzers
100 HyperQuant
X-ray, AFM, OES Solutions for Life Sciences
105 X-ray Diffraction (XRD)
and Analytical Research
108 X-ray Fluorescence Analysis (XRF)
112 Optical Emission Spectrometry (OES)
114 Gas Analyzers
116 Microanalysis (EDS)
117 Chemical Crystallography
118 Crystal-Structure Analysis
119 Biological Crystallography
120 Scanning Probe Microscopy
Advanced Superconductors
124 Manufacturing and Applications
126 Low Temperature Superconductors NMR
127 High-Temperature Superconductors think forward
128 Metal Matrix Extrusions
18 19