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Breast Pathology: A Volume in the Series: Foundations in Diagnostic Pathology (Expert Consult - Online and Print), 2e PDF

396 Pages·2011·150.59 MB·English
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Preview Breast Pathology: A Volume in the Series: Foundations in Diagnostic Pathology (Expert Consult - Online and Print), 2e

BREAST PATHOLOGY Other books in this series: Busam: Dermatopathology, 978-0-443-06654-2 Folpe & Inwards: Bone and Soft Tissue Pathology, 978-0-443-06688-7 Hsi: Hematopathology, 978-0-443-06830-0 Iacobuzio-Donahue & Montgomery: Gastrointestinal and Liver Pathology, 2e, 978-1-4377-0925-4 Nucci & Oliva: Gynecologic Pathology, 978-0-443-06920-8 Prayson: Neuropathology, 978-0-443-06658-0 Sidawy & Ali: Fine Needle Aspiration Cytology, 978-0-443-06731-0 Thompson: Endocrine Pathology, 978-0-443-06685-6 Thompson: Head and Neck Pathology, 978-0-443-06960-4 Tubbs & Stoler: Cell and Tissue Based Molecular Pathology, 978-0-443-06901-7 Zander & Farver: Pulmonary Pathology, 978-0-443-06741-9 Zhou & Magi-Galluzzi: Genitourinary Pathology, 978-0-443-06677-1 BREAST PATHOLOGY A Volume in the Series FOUNDATIONS IN DIAGNOSTIC PATHOLOGY SECOND EDITION EDITED BY SERIES EDITOR Frances P O’Malley, MB, FRCPC John R Goldblum, MD, FCAP, Professor FASCP, FACG Department of Laboratory Medicine and Pathobiology Chairman, Department of Anatomic Pathology University of Toronto The Cleveland Clinic Foundation Surgical Pathologist Cleveland Clinic Lerner College of Medicine Department of Laboratory Medicine and the Keenan Case Western Reserve University Research Centre of the Li Ka Shing Knowledge Cleveland, Ohio Institute United States of America St. Michael’s Hospital Toronto, Ontario Canada Sarah E Pinder, MB ChB, FRCPath Professor of Breast Pathology Department of Cellular Pathology King’s College London Lead Consultant Breast Pathologist Guy’s and St. Thomas’ Hospitals London United Kingdom Anna Marie Mulligan, MB BCh, MSc, FRCPath Assistant Professor Department of Laboratory Medicine and Pathobiology University of Toronto Surgical Pathologist Department of Laboratory Medicine and the Keenan Research Centre of the Li Ka Shing Knowledge Institute St. Michael’s Hospital Toronto, Ontario Canada 1600 John F. Kennedy Blvd. Ste 1800 Philadelphia, PA 19103-2899 BREAST PATHOLOGY ISBN: 978-1-4377-1757-0 Copyright © 2011, 2006 by Saunders, an imprint of Elsevier Inc. All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher. Details on how to seek permission, further information about the Publisher’s permissions policies and our arrangements with organizations such as the Copyright Clearance Center and the Copyright Licensing Agency, can be found at our website: www.elsevier.com/permissions. This book and the individual contributions contained in it are protected under copyright by the Publisher (other than as may be noted herein). Notices Knowledge and best practice in this field are constantly changing. As new research and experience broaden our understanding, changes in research methods, professional practices, or medical treatment may become necessary. Practitioners and researchers must always rely on their own experience and knowledge in evaluating and using any information, methods, compounds, or experiments described herein. In using such information or methods they should be mindful of their own safety and the safety of others, including parties for whom they have a professional responsibility. With respect to any drug or pharmaceutical products identified, readers are advised to check the most current information provided (i) on procedures featured or (ii) by the manufacturer of each product to be administered, to verify the recommended dose or formula, the method and duration of administration, and contraindications. It is the responsibility of practitioners, relying on their own experience and knowledge of their patients, to make diagnoses, to determine dosages and the best treatment for each individual patient, and to take all appropriate safety precautions. To the fullest extent of the law, neither the Publisher nor the authors, contributors, or editors, assume any liability for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas contained in the material herein. Library of Congress Cataloging-in-Publication Data Breast pathology / edited by Frances P. O’Malley, Sarah E. Pinder, Anna Marie Mulligan.—Ed. 2. p. ; cm.—(Foundations in diagnostic pathology) Includes bibliographical references and index. ISBN 978-1-4377-1757-0 (hardcover : alk. paper) 1. Breast—Pathophysiology. 2. Breast—Dis- eases. I. O’Malley, Frances P. II. Pinder, Sarah E. III. Mulligan, Anna Marie. IV. Series: Founda- tions in diagnostic pathology. [DNLM: 1. Breast—pathology. 2. Breast Diseases. WP 800] RC280.B8B725 2011 618.1’9—dc22 2011006863 Acquisitions Editor: William Schmitt Developmental Editor: Christine Abshire Publishing Services Manager: Patricia Tannian Senior Project Manager: Sarah Wunderly Design Direction: Lou Forgione Working together to grow libraries in developing countries Printed in China www.elsevier.com | www.bookaid.org | www.sabre.org Last digit is the print number: 9 8 7 6 5 4 3 2 1 “The student begins with the patient, continues with the patient, and ends his studies with the patient, using books and lectures as tools, as means to an end.” —Sir William Osler (1849–1919) To my family, Siobhan and Paul, whose love sustains; to my friend and mentor, David L Page, whose wisdom inspires —Frances P O’Malley To my parents, Arthur and Sheila Pinder, thanks for everything To Ian Ellis and Chris Elston, thanks for being friends and mentors To J, J, A, H, J, & R and to Watford Football Club, thanks for the sense of perspective! —Sarah E Pinder To my parents, Barbara and Peter, and to Blaise and Alexandra, thanks for all your love, encouragement, and support —Anna Marie Mulligan This page intentionally left blank Contributors Evdokia Arkoumani, MD, PhD Andrew J Evans, MRCP, FRCR Consultant Pathologist, The Michael Letcher Professor of Breast Imaging, University of Dundee, Department of Cellular Pathology, The Princess Dundee, Scotland, United Kingdom Alexandra Hospital NHS Trust, Harlow, Essex, Overview of Radiologic Aspects of Breast Disease United Kingdom James J Going, MB, PhD Diagnostic Methodologies: Fine Needle Aspiration Institute of Cancer Sciences and Medical School, Cytology University of Glasgow; Consultant Pathologist, Sunil Badve, MD, FRCPath Department of Pathology, Glasgow Royal Infirmary, Professor, Pathology and Laboratory Medicine; Glasgow, Scotland, United Kingdom Professor, Internal Medicine, Indiana University, Normal Breast Indianapolis, Indiana, United States of America Michael A Gonzalez, BMedSci, BMBS, PhD, MRCP Diseases of the Male Breast JB & Millicent Kaye Prize Research Fellow, Christ’s Anita Bane, MB BCh, FRCPath, PhD College, University of Cambridge; Honorary Specialist Assistant Professor, Department of Pathology and Registrar in Medical Oncology, Department of Molecular Medicine, McMaster University; Staff Oncology, Addenbrooke’s Hospital, Cambridge, Pathologist, Juravinski Hospital, Hamilton, Ontario, United Kingdom Canada Invasive Carcinoma: Other Histologic Prognostic Diseases of the Nipple; Familial Breast Cancer Factors, Prognostic Indices, and Application of Prognostic Information for Patient Management John MS Bartlett, BSc (Hons), PhD, FRCPath Professor of Molecular Pathology, Edinburgh Cancer Gavin C Harris, BMBS, FRCPath Research Centre, University of Edinburgh, Edinburgh, Consultant Anatomical Pathologist, Canterbury Health Scotland, United Kingdom Laboratories, Christchurch, New Zealand Breast Cancer Biomarkers: Prognostic and Predictive Invasive Carcinoma: Special Types Value and External Quality Assurance Merdol Ibrahim, BSc, PhD Beverley A Carter, FRCP(C) Manager, UK NEQAS ICC & ISH, UCL Medical Provincial Director of Pathology and Laboratory School, London, United Kingdom Medicine, Government of Newfoundland and Breast Cancer Biomarkers: Prognostic and Predictive Labrador, Health and Community Services, Medical Value and External Quality Assurance Services Branch, St. John’s, Newfoundland, Canada Timothy W Jacobs, MD Usual Epithelial Hyperplasia and Atypical Ductal Deputy Chief of Pathology, Virginia Mason Medical Hyperplasia Center, Seattle, Washington, United States of America Gabriela Dontu, MD, PhD Sclerosing Lesions: Sclerosing Adenosis, Radial Scar/ Reader, King’s College London, School of Medicine, Complex Sclerosing Lesion, and Microglandular London, United Kingdom Adenosis; Atypical Lobular Hyperplasia and Breast Cancer: Emerging Methods for the Assessment Lobular Carcinoma In Situ; An Overview of of Primary Tumors, Including Genomic and Stem Cell Immunohistochemistry in Diagnosis of Breast Lesions Characterization in Breast Cancer Jonathan J James, BMBS, FRCR Ian O Ellis, BMBS, FRCPath Consultant Radiologist, Nottingham Breast Institute, Professor of Cancer Pathology, Nottingham University, Nottingham University Hospitals NHS Trust, Histopathology Department, Nottingham City Hospital Nottingham, United Kingdom NHS Trust, Nottingham, United Kingdom Overview of Radiologic Aspects of Breast Disease Histologic Grade vii viii CONTRIBUTORS Bharat Jasani, BSc (Hons), PhD, MB ChB, FRCPath Frances P O’Malley, MB, FRCPC Professor of Oncological Pathology, School of Professor, Department of Laboratory Medicine and Medicine, Cardiff University; Professor of Oncological Pathobiology, University of Toronto; Surgical Pathology, University Hospital of Wales, Cardiff & Pathologist, Department of Laboratory Medicine and Vale Health Board, Cardiff, South Glamorgan, the Keenan Research Centre of the Li Ka Shing United Kingdom Knowledge Institute, St. Michael’s Hospital, Toronto, Breast Cancer Biomarkers: Prognostic and Predictive Ontario, Canada Value and External Quality Assurance Handling of Surgical Specimens; Core Biopsy: Methodologies, Reporting, and Management Issues; Sunil R Lakhani, MD, FRCPath, FRCPA Papillary Lesions; Fibroepithelial Lesions, Including Professor and Head, Molecular and Cellular Pathology, Fibroadenoma and Phyllodes Tumors; Benign Stromal School of Medicine, University of Queensland; Lesions of the Breast; Diseases of the Nipple; Atypical Director, Anatomical Pathology, Pathology Lobular Hyperplasia and Lobular Carcinoma In Situ; Queensland, The Royal Brisbane and Women’s Morphology of Ductal Carcinoma In Situ; Invasive Hospital, Brisbane, Queensland, Australia Carcinoma: Special Types; Familial Breast Cancer; Molecular Genetics of Ductal Carcinoma In Situ and An Overview of Immunohistochemistry in Diagnosis Lobular Carcinoma In Situ of Breast Lesions Andrew HS Lee, MD, MRCP, FRCPath David L Page, MD Consultant Histopathologist, Nottingham University Professor of Pathology, Division of Anatomical Hospitals, Nottingham, United Kingdom Pathology, Vanderbilt University School of Medicine, Inflammatory Lesions, Infections, and Silicone Nashville, Tennessee, United States of America Granulomas Usual Epithelial Hyperplasia and Atypical Ductal R Douglas Macmillan, MB ChB, MD, FRCS Hyperplasia Honorary Lecturer, Nottingham University Hospitals Sarah E Pinder, MB ChB, FRCPath NHS Trust; Consultant Oncoplastic Breast Surgeon, Professor of Breast Pathology, Department of Cellular Nottingham Breast Institute, Nottingham, United Pathology, King’s College London; Lead Consultant Kingdom Breast Pathologist, Guy’s and St. Thomas’ Hospitals, Overview of Clinical Aspects of Breast Disease London, United Kingdom Keith Miller, FIBMS Handling of Surgical Specimens; Core Biopsy: Chief Scientific Officer, UCL-Advanced Diagnostics; Methodologies, Reporting, and Management Issues; Director, UK National External Quality Assessment Fibroepithelial Lesions, Including Fibroadenoma and Scheme for Immunocytochemistry and In-situ Phyllodes Tumors; Benign Stromal Lesions of the Hybridisation, Department of Pathology, The Cancer Breast; Morphology of Ductal Carcinoma In Situ; Institute, London, United Kingdom Invasive Carcinoma: Special Types; Invasive Breast Cancer Biomarkers: Prognostic and Predictive Carcinoma: Other Histologic Prognostic Factors, Value and External Quality Assurance Prognostic Indices, and Application of Prognostic Information for Patient Management; An Overview of Anna Marie Mulligan, MB BCh, MSc, FRCPath Immunohistochemistry in Diagnosis of Breast Lesions Assistant Professor, Department of Laboratory Medicine and Pathobiology, University of Toronto; Emad A Rakha, MB BCh, MSc, MD, PhD, FRCPath Surgical Pathologist, Department of Laboratory Senior Lecturer, University of Nottingham; Consultant Medicine and the Keenan Research Centre of the Li Pathologist, Nottingham University Hospital NHS Ka Shing Knowledge Institute, St. Michael’s Hospital, Trust, Nottingham, United Kingdom Toronto, Ontario, Canada Histologic Grade Handling of Surgical Specimens; Core Biopsy: Jorge S Reis-Filho, MD, PhD, FRCPath Methodologies, Reporting, and Management Issues; The Breakthrough Breast Cancer Research Centre, Papillary Lesions; Fibroepithelial Lesions, Including The Institute of Cancer Research, London, Fibroadenoma and Phyllodes Tumors; Benign Stromal United Kingdom Lesions of the Breast; Diseases of the Nipple; Molecular Genetics of Ductal Carcinoma In Situ and Fibrocystic Change and Columnar Cell Lesions; Lobular Carcinoma In Situ Familial Breast Cancer Alessandra F Nascimento, MD Assistant Professor, Harvard School of Medicine; Pathologist, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America Other Malignant Lesions of the Breast CONTRIBUTORS ix Emanuele de Rinaldis, PhD, MSc Donald L Weaver, MD Senior Research Fellow, Genome Bioinformatics, Professor of Pathology, University of Vermont College Breakthrough Breast Cancer Research Unit, King’s of Medicine; Attending Pathologist, Fletcher Allen College London, Guy’s Hospital Campus, London, Health Care, Burlington, Vermont, United States of United Kingdom America Breast Cancer: Emerging Methods for the Assessment Handling and Evaluation of Sentinel Lymph Nodes; of Primary Tumors, Including Genomic and Stem Cell Sentinel Node Biopsy and Lymph Node Classification Characterization in Breast Cancer in the 7th Edition Staging Manual Jean F Simpson, MD Clive Wells, MA, MB BChir, FRCPath Professor of Pathology, Division of Anatomical Honorary Senior Lecturer, University College London; Pathology, Vanderbilt University School of Medicine, Consultant Pathologist, University College Hospital, Nashville, Tennessee, United States of America London, United Kingdom Usual Epithelial Hyperplasia and Atypical Ductal Diagnostic Methodologies: Fine Needle Aspiration Hyperplasia Cytology Andrew Tutt, MB ChB, PhD, MRCP, FRCR Bruce J Youngson, MSc, MD, FRCPC Clinical Reader in Breast Translational Oncology, Assistant Professor, Department of Laboratory King’s College London, School of Medicine; Medicine and Pathobiology, University of Toronto; Consultant Clinical Oncologist, Guy’s, King’s, and Staff Pathologist and Consultant in Breast Pathology, St. Thomas’ NHS Foundation Trust, London, Department of Pathology, Toronto General Hospital, United Kingdom University Health Network, Toronto, Ontario, Canada Breast Cancer: Emerging Methods for the Assessment Fibrocystic Change and Columnar Cell Lesions of Primary Tumors, Including Genomic and Stem Cell Characterization in Breast Cancer

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Breast Pathology, a title in the Foundations in Diagnostic Pathology series, provides all of the most essential information on the pathological entities encountered in practice in an easy-to-use format. Drs. Frances P. O'Malley, Sarah E. Pinder, and Anna Marie Mulligan provide unparalleled expert gu
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